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  • 1
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    Intron retention in mRNA: No longer nonsense (2015)
    Wiley
    In: BioEssays
    Details
    Publication Date: 2015-11-28
    Description: Until recently, retention of introns in mature mRNAs has been regarded as a consequence of mis-splicing. Intron-retaining transcripts are thought to be non-functional because they are readily degraded by nonsense-mediated decay. However, recent advances in next-generation sequencing technologies have enabled the detection of numerous transcripts that retain introns. As we review herein, intron-retaining mRNAs play an essential conserved role in normal physiology and an emergent role in diverse diseases. Intron retention should no longer be overlooked as a key mechanism that independently reduces gene expression in normal biology. Exploring its contribution to the development and/or maintenance of diseases is of increasing importance. Intron retention was once thought to be a consequence of mis-splicing but it is now established as an important mechanism controlling gene expression within the cell. Here, we review known functions of intron-retaining mRNAs in normal physiology, their role in disease, and explore potential novel cell functions for intron-retaining mRNAs.
    Print ISSN: 0265-9247
    Electronic ISSN: 1521-1878
    Topics: Biology , Medicine
    Published by Wiley
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  • 2
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    SIRT6 promotes DNA repair under stress by activating PARP1 (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-18
    Description: Sirtuin 6 (SIRT6) is a mammalian homolog of the yeast Sir2 deacetylase. Mice deficient for SIRT6 exhibit genome instability. Here, we show that in mammalian cells subjected to oxidative stress SIRT6 is recruited to the sites of DNA double-strand breaks (DSBs) and stimulates DSB repair, through both nonhomologous end joining and homologous recombination. Our results indicate that SIRT6 physically associates with poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimulating PARP1 poly-ADP-ribosylase activity and enhancing DSB repair under oxidative stress.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mao, Zhiyong -- Hine, Christopher -- Tian, Xiao -- Van Meter, Michael -- Au, Matthew -- Vaidya, Amita -- Seluanov, Andrei -- Gorbunova, Vera -- F31 AG041603/AG/NIA NIH HHS/ -- R01 AG027237/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2011 Jun 17;332(6036):1443-6. doi: 10.1126/science.1202723.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Rochester, Rochester, NY 14627, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21680843" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; DNA/metabolism ; *DNA Breaks, Double-Stranded ; *DNA Repair ; Humans ; Mice ; Mice, Knockout ; *Oxidative Stress ; Paraquat/pharmacology ; Point Mutation ; Poly Adenosine Diphosphate Ribose/metabolism ; Poly(ADP-ribose) Polymerases/genetics/*metabolism ; Recombination, Genetic ; Signal Transduction ; Sirtuins/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-02-24
    Description: The genetic control of neuronal differentiation has been studied by examining mutations that affect the development and function of the six touch receptor neurons of the nematode Caenorhabditis elegans. By screening for touch-insensitive mutants, it has been possible to identify 18 genes (represented by 417 mutations) that are required at various stages in the developmental program for touch cell differentiation. Two of the genes are needed for the generation of precursors in the touch cell lineages; without the precursors, touch cells are not made. A third gene, mec-3, specifies the differentiation of the touch cells, probably by acting as a transcription factor. The remaining 15 genes are likely targets of mec-3 action; mutants defective in these genes have nonfunctioning, yet differentiated, touch cells. Some of these latter genes are needed for the formation of cell-specific components of the touch cells, such as a set of microtubules that are only found in these cells. The study of the touch genes should help us understand how touch cell fate is determined, how microtubule form is specified, and, perhaps, how mechanical stimuli are transduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chalfie, M -- Au, M -- GM30997/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1989 Feb 24;243(4894 Pt 1):1027-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Columbia University, New York, NY 10027.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2646709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis/cytology/*genetics/growth & development ; Cell Differentiation ; *Gene Expression Regulation ; Mechanoreceptors/cytology ; Mutation ; Neurons/*cytology ; Touch
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    1,4,7,10-tetramethyl-5,6-didehydrodibenzo [a,e]cyclooctene
    Amsterdam : Elsevier
    Tetrahedron Letters 19 (1978), S. 4269-4272 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(01)95199-8
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Boussinesq's problem for a debonded boundary (1989)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 40 (1989), S. 1-14 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract The present paper examines the problem of the axial loading of a rigid circular punch which is located at the debonded boundary of an elastic medium-rigid boundary interface. The mathematical analysis of the problem focusses primarily on the evaluation of the load-displacement response for the punch boundary of the debonded region. The numerical results presented in the paper illustrate the manner in which the axial stiffness of the punch is influenced by the Poisson's ratio of the elastic medium and the relative dimensions of the debonded region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00945306
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  • 6
    Electronic Resource
    Electronic Resource
    Stress intensity factor for an oblique edge crack in symmetric two-dimensional projections (1989)
    Springer
    Acta mechanica 78 (1989), S. 145-159 
    Details
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary An integral transform method is used to obtain stress-distributions in cracked symmetric two-dimensional projections extending out of the half-plane. These projections are similar to such concrete cases as gear teeth. In this study, the case of a crack normal to the boundary has been considered. Integral equations methods have been used to calculate mode I and II stress intensity factors. Results have been obtained through numerical integration for a given boundary equation. They are shown graphically for typical values of shape parameters. Although a particular shape has been assumed, equations and numerical results may be useful in evaluating fatigue and fracture strength of mechanical elements such as gears.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01174006
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  • 7
    Electronic Resource
    Electronic Resource
    Generalized displacements of a rigid elliptical anchor embedded at a bi-material geological interface (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 10 (1986), S. 633-652 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The present paper examines the class of problems related to a flat rigid anchoring region which is embedded at a geological interface. The analysis focuses on the evaluation of the elastic stiffness of the embedded anchor. A boundary element technique is used estimate the axial, rotational and translational stiffnesses of the anchor. These estimates are compared with a set of bounds which are evaluated in exact closed form. These bounds are obtained by invoking kinematic and/or traction constraintsat the geological interface. The numerical results presented in the paper illstrate the manner in which the various stiffnesses of the anchoring region are influenced by the elastic properties of the surrounding geological media.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610100606
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  • 8
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    T cell chemotaxis to lysophosphatidylcholine through the G2A receptor (2003)
    National Academy of Sciences
    Details
    Publication Date: 2003-12-17
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Efficient Privacy-Preserving Charging Station Reservation System for Electric Vehicles (2016)
    Oxford University Press
    Details
    Publication Date: 2016-07-30
    Description: In this paper, we propose a privacy-preserving reservation system for electric vehicles (EV) charging stations. Due to the short driving range of EV, frequent charging is necessary. A mechanism for charging station reservation for EV owners is desirable. Our proposed system allows the vehicle owner to reserve a number of charging stations along the intended route at different time-slots. Yet it is secure against misuse such that a user can only hold a limited number of reservations simultaneously. More importantly, our system can provide privacy for users. The charging station does not know the identity of the user who has reserved it. Thus location privacy can be protected. We demonstrate the practicality of our system with a prototype implementation on a smart phone. Finally, we also provide a security proof to show that our system is secure under well-known computational assumptions.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Published by Oxford University Press
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  • 10
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    Efficient Generic Construction of CCA-Secure Identity-Based Encryption from Randomness Extraction (2016)
    Oxford University Press
    Details
    Publication Date: 2016-03-29
    Description: We propose a generic construction that yields efficient identity-based encryption (IBE) schemes secure against chosen ciphertext attack (CCA) in the standard model. Our construction extends Kiltz et al. 's (Eurocrypt '09) method of constructing CCA-secure public-key encryption schemes via randomness extraction to the identity-based setting. The main idea of our construction is to transform ‘ $\epsilon _1$ -almost $\kappa $ -entropic’ and valid/invalid ciphertext indistinguishable (VI-IND) identity-based hash proof system to the one that satisfies the stronger ‘ $\epsilon _2$ -universal’ and VI-IND property. This transformation is realized by a randomness extractor based on the 4-wise hash function. We demonstrate that our generic construction can produce CCA-secure IBE schemes whose efficiency is comparable with the most efficient but non-generic CCA-secure IBE schemes without random oracles in the literature.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Published by Oxford University Press
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