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  • 1
    Electronic Resource
    Electronic Resource
    Serum bone Gla protein as a marker of bone turnover in acromegaly (1993)
    Springer
    Calcified tissue international 52 (1993), S. 419-421 
    Details
    ISSN: 1432-0827
    Keywords: Acromegaly ; Bone metabolism ; Osteocalcin ; Insulin-like growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Serum bone Gla protein, a sensitive and specific marker of bone turnover, was measured in 35 acromegalic patients (14 untreated, 8 clinically active, and 13 cured) and 21 controls. We also examined 10 acromegalic patients before and after transsphenoidal surgery. Untreated and clinically active acromegalic patients had significantly higher serum bone Gla protein concentrations than the control subjects. Other nonspecific biochemical markers of bone metabolism, such as urinary hydroxyproline and urinary calcium, were also present in significantly greater amounts in active acromegalic patients. After treatment, a significant decrease in levels was observed, with return to control levels. In acromegalic patients, positive correlations were found among serum bone Gla protein and serum growth hormone and serum insulin-like growth factor I levels, as well as among levels of insulin-like growth factor I and serum phosphorus, serum alkaline phosphatase, and urinary hydroxyproline. These results suggest that serum bone Gla protein is a sensitive marker of the action of growth hormone in bone metabolism in acromegaly, a role that is probably mediated by insulin-like growth factor I.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571329
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  • 2
    Electronic Resource
    Electronic Resource
    Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5 (2005)
    Oxford, UK : Blackwell Science Ltd
    International journal of immunogenetics 32 (2005), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Two novel interleukin-24 (IL-24) splice variants were identified in normal human melanocytes by sequencing cloned polymerase chain reaction (PCR) products that are not expressed in metastatic melanoma. These gene products have been generated by differential skipping of exons 3 (IL-24 delE3) and 5 (IL-24 delE5). IL-24 delE3 has limited sequence identity to the IL-24-interacting protein mda-7s, and IL-24 delE5 is homologous to IL-24.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.2005.00540.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immersion Chilling and Freezing: Phase Change and Mass Transfer in Model Food (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 61 (1996), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The influence of immersion chilling and freezing process variables (temperature, concentration, agitation) on phase change and salt gain, was studied on a gelatin gel dipped into a NaCl solution, with particular emphasis on unsteady state (first hour). Under freezing conditions, water loss was 〈2 g/100g initial gel and salt gain remained low (〈1 g/100g initial gel). Salt penetration was hindered by formation of an ice barrier, which was favored by high concentration and low temperature. Under chilling conditions, salt gain was higher (up to 2 g/100g initial gel), and was enhanced when temperature or concentration increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1996.tb14741.x
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  • 4
    Electronic Resource
    Electronic Resource
    Relation between Thrombosis on Metal Electrodes and the Position of Metal in the Electromotive Series (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 1494-1494 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The electrodes were carefully cleaned to ensure the absence of any oxides or other impurities on their surfaces, and their spontaneous potentials were measured in normal (0.9 per cent) saline solution. In the first series of experiments four electrodes of the same metal were inserted through side ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2151494a0
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  • 5
    Electronic Resource
    Electronic Resource
    New aspects of the electrochemistry of heteropolyacids - Reduction currents as a probe of solvent-electrolyte interactions
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 208 (1986), S. 343-356 
    Details
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0728(86)80542-3
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  • 6
    Electronic Resource
    Electronic Resource
    Spatial and Temporal Ozone Pattern Concentrations in a NW Region of Spain (2000)
    Springer
    Water, air & soil pollution 117 (2000), S. 289-303 
    Details
    ISSN: 1573-2932
    Keywords: air pollution ; air quality ; ozonemonitoring ; ozone trends ; photochemical oxidant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Measurements of ozone were carried out at two different sites in the area surrounding a thermal power plant located in the Northwest of Spain during 1993–1995. The concentration of O3 in the ambient air varied from 6 to 257 μg m-3 exhibiting a wide temporal, seasonal and spatial variation. On a few occasions 1-hr ozone concentration was more than 180 μg m-3, which represents the maximum 1-hr limit of ozone in ambient air as prescribed by the European Commission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005125910361
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of varying electrolyte concentration on in vitro streaming potentials across canine aortae and carotid arteriesPaper presented at the Federation of American Societies for Experimental Biology Meeting (Abstract No. 1646), April 1967. (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 355-367 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Knowledge of the characteristics of the blood-intima interface is important because it leads to information concerning (a) the normal antithrombotic mechanism (b) nature of interreactions between blood and intima (c) testing and selection of vascular wall substitutes which are antithrombotic and inhibit clotting. A technique for obtaining the electrical interfacial characteristics of blood vessel walls is by measuring streaming potentials. Experiments described in the present work are extensions of original in vivo streaming potential measurements. In vitro streaming potentials were measured across fresh canine aortae and carotid arteries using Krebs saline serum substitute, logarithmically varying both internal and external electrolyte concentrations. Positive streaming potentials were measured indicating that the blood vessel wall is negatively charged. Streaming potentials increased linearly with increasing flow rate, decreased with increasing internal electrolyte concentration, decreased with increasing external electrolyte concentration, and reversed, becoming positive, with aging of exteriorized artery. Thus the electrical characteristics of the blood vessel wall are dependent on an ionic balance between the blood vessel wall, flowing blood stream, and external environment. The information demonstrates the importance of electrochemical and physicochemical phenomena in the structure and function of the vascular interface and helps explain in vivo conditions conducive to or inhibitory of intravascular thrombosis.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010306
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  • 8
    Electronic Resource
    Electronic Resource
    Electrochemistry of thrombosis - An aid in the selection of prosthetic materialsSupported in part by Grants in Aid, No's HE 07371, HE 07821 and HE 10795 from NHI, NIH, Bethesda, Maryland. (1970)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 4 (1970), S. 43-55 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820040106
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  • 9
    Electronic Resource
    Electronic Resource
    Antithrombogenic characteristics of cathodically polarized copper prostheses (1972)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 6 (1972), S. 489-498 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In previous studies from our laboratories, it was shown that metals and alloys which register negative potentials in blood vs. the normal hydrogen electrode (NHE) tend to be antithrombogenic, while those with positive potentials are invariably thrombogenic. Of the metals, only the corrodible ones fall in the first group and the noble ones in the second. Blood compatible metals appear to be essential for some types of medical devices. This paper deals with a novel approach of maintaining an implanted metallic prostheses at a negative potential. A copper vascular prostheses in a dog was made the cathode in a polarizing circuit, which in addition consists of a smal mercury battery, a resistor and an auxiliary electrode. Such experiments were conducted in three animals, and the potentials ranged from -60 to -160 mV/NHE. The three dogs were sacrificed after 6, 8, and 14 days and the tubes were examined. All tubes were free of thrombus deposits; minimal junctional thrombi were found. Two copper tubes with no polarizing circuit and registering positive potentials were occluded after 8 and 14 days, respectively. Histologic and electron-microscopic studies of the thrombus deposits in tubes at spontaneous potentials and of the junctional thrombus deposits in the tube at negative potentials showed similar structures. The present experiments further confirm the view that the potential across the conductive material-blood interface is a more basic parameter than the chemical nature of the surface in determining its blood-compatible characteristic.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820060603
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  • 10
    Electronic Resource
    Electronic Resource
    Thromboresistance of glass after glow discharge treatment in argon (1975)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 9 (1975), S. 547-560 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Glow discharge treated (GDT) inorganic materials are sterile and free of all organic contaminants. Such materials implanted in the canine inferior vena cava often demonstrate significant thromboresistance. Standard Pyrex glass tubing was GDT in argon to provide a surface free energy above 70 dynes/cm, slight surface negativity, and other surface-physical modifications of its interface. Chromic acid cleaned lengths of the same tubing, and short segments whose edges were not fire-polished were used as controls. Upon canine implantation, the in vivo results were similar in independent surgical laboratories. The glass was implanted as 1.4 cm long rings or as 5 cm long tubes in separate medical centers according to different protocols. GDT specimens remained patent; all controls accumulated thrombi. A remarkably pure, low critical surface tension, labile protein coating covered all cylindrical lumens after 2 hr in vivo. This coating diminished within 2 weeks and was essentially absent after 480 days, even though scanning EM showed evidence of a micron thick luminal film, probably eroding glass. No emboli were found in the implant animal's kidney or lungs at any stage.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820090603
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