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  • 1
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    Pressure-induced spin reorientation and spin state transition in SrCoO_{3} (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-11-26
    Description: Author(s): J.-Y. Yang, C. Terakura, M. Medarde, J. S. White, D. Sheptyakov, X.-Z. Yan, N.-N. Li, W.-G. Yang, H.-L. Xia, J.-H. Dai, Y.-Y. Yin, Y.-Y. Jiao, J.-G. Cheng, Y.-L. Bu, Q.-F. Zhang, X.-D. Li, C.-Q. Jin, Y. Taguchi, Y. Tokura, and Y.-W. Long A series of high-pressure measurements including resistivity, ac and dc magnetic susceptibility, neutron powder diffraction, and synchrotron x-ray diffraction were performed to investigate the crystal structure and electronic states of the itinerant ferromagnet SrCo O 3 . Two pressure-induced phase tra… [Phys. Rev. B 92, 195147] Published Tue Nov 24, 2015
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    destiny: diffusion maps for large-scale single-cell data in R (2016)
    Oxford University Press
    Details
    Publication Date: 2016-04-08
    Description: : Diffusion maps are a spectral method for non-linear dimension reduction and have recently been adapted for the visualization of single-cell expression data. Here we present destiny , an efficient R implementation of the diffusion map algorithm. Our package includes a single-cell specific noise model allowing for missing and censored values. In contrast to previous implementations, we further present an efficient nearest-neighbour approximation that allows for the processing of hundreds of thousands of cells and a functionality for projecting new data on existing diffusion maps. We exemplarily apply destiny to a recent time-resolved mass cytometry dataset of cellular reprogramming. Availability and implementation : destiny is an open-source R/Bioconductor package "bioconductor.org/packages/destiny" also available at www.helmholtz-muenchen.de/icb/destiny . A detailed vignette describing functions and workflows is provided with the package. Contact: carsten.marr@helmholtz-muenchen.de or f.buettner@helmholtz-muenchen.de Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 3
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    Resetting histone modifications during human parental-to-zygotic transition (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks in human oocytes and early embryos. Unlike that in mouse, the permissive mark H3K4me3 largely exhibits canonical patterns at promoters in human oocytes. After fertilization, pre-zygotic genome activation (ZGA) embryos acquire permissive chromatin and widespread H3K4me3 in CpG-rich regulatory regions. By contrast, the repressive mark H3K27me3 undergoes global depletion. CpG-rich regulatory regions then resolve to either active or repressed states upon ZGA, followed by subsequent restoration of H3K27me3 at developmental genes. Finally, through combining chromatin and transcriptome maps, we revealed transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification. Collectively, our data unveil a priming phase connecting human parental-to-zygotic epigenetic transition.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Regulation of amyloidogenesis by {alpha}2AAR [Neuroscience] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-12-03
    Description: Accumulation of amyloid β (Aβ) peptides in the brain is the key pathogenic factor driving Alzheimer’s disease (AD). Endocytic sorting of amyloid precursor protein (APP) mediated by the vacuolar protein sorting (Vps10) family of receptors plays a decisive role in controlling the outcome of APP proteolytic processing and Aβ generation....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    A myocardial lineage derives from Tbx18 epicardial cells (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-16
    Description: Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cai, Chen-Leng -- Martin, Jody C -- Sun, Yunfu -- Cui, Li -- Wang, Lianchun -- Ouyang, Kunfu -- Yang, Lei -- Bu, Lei -- Liang, Xingqun -- Zhang, Xiaoxue -- Stallcup, William B -- Denton, Christopher P -- McCulloch, Andrew -- Chen, Ju -- Evans, Sylvia M -- P41 RR005351/RR/NCRR NIH HHS/ -- T32 HL007444/HL/NHLBI NIH HHS/ -- England -- Nature. 2008 Jul 3;454(7200):104-8. doi: 10.1038/nature06969. Epub 2008 May 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18480752" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; *Cell Lineage ; Gene Expression Regulation, Developmental ; Heart/growth & development ; Lac Operon/genetics ; Mice ; Myocardium/*cytology/metabolism ; Myocytes, Cardiac/*cytology/metabolism ; Myocytes, Smooth Muscle/metabolism ; Pericardium/*cytology/*metabolism ; Stem Cells/*cytology/metabolism ; T-Box Domain Proteins/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-07-03
    Description: The generation and expansion of diverse cardiovascular cell lineages is a critical step during human cardiogenesis, with major implications for congenital heart disease. Unravelling the mechanisms for the diversification of human heart cell lineages has been hampered by the lack of genetic tools to purify early cardiac progenitors and define their developmental potential. Recent studies in the mouse embryo have identified a multipotent cardiac progenitor that contributes to all of the major cell types in the murine heart. In contrast to murine development, human cardiogenesis has a much longer onset of heart cell lineage diversification and expansion, suggesting divergent pathways. Here we identify a diverse set of human fetal ISL1(+) cardiovascular progenitors that give rise to the cardiomyocyte, smooth muscle and endothelial cell lineages. Using two independent transgenic and gene-targeting approaches in human embryonic stem cell lines, we show that purified ISL1(+) primordial progenitors are capable of self-renewal and expansion before differentiation into the three major cell types in the heart. These results lay the foundation for the generation of human model systems for cardiovascular disease and novel approaches for human regenerative cardiovascular medicine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bu, Lei -- Jiang, Xin -- Martin-Puig, Silvia -- Caron, Leslie -- Zhu, Shenjun -- Shao, Ying -- Roberts, Drucilla J -- Huang, Paul L -- Domian, Ibrahim J -- Chien, Kenneth R -- England -- Nature. 2009 Jul 2;460(7251):113-7. doi: 10.1038/nature08191.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19571884" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Division ; Cell Line ; *Cell Lineage ; Coculture Techniques ; Embryonic Stem Cells/cytology/metabolism ; Endothelial Cells/cytology ; Fetus/cytology/embryology ; Heart/embryology ; Homeodomain Proteins/*metabolism ; Humans ; LIM-Homeodomain Proteins ; Multipotent Stem Cells/*cytology/*metabolism ; Muscle, Smooth/cytology ; Myocardium/*cytology ; Myocytes, Cardiac/cytology ; Transcription Factors ; Wnt Proteins/metabolism ; Wnt3 Protein
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Resetting histone modifications during human parental-to-zygotic transition (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks in human oocytes and early embryos. Unlike that in mouse oocytes, the permissive mark trimethylated histone H3 lysine 4 (H3K4me3) largely exhibits canonical patterns at promoters in human oocytes. After fertilization, prezygotic genome activation (pre-ZGA) embryos acquire permissive chromatin and widespread H3K4me3 in CpG-rich regulatory regions. By contrast, the repressive mark H3K27me3 undergoes global depletion. CpG-rich regulatory regions then resolve to either active or repressed states upon ZGA, followed by subsequent restoration of H3K27me3 at developmental genes. Finally, by combining chromatin and transcriptome maps, we revealed transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification. Collectively, our data unveil a priming phase connecting human parental-to-zygotic epigenetic transition.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Estimation of QTL heritability based on pooled sequencing data (2018)
    Oxford University Press
    Details
    Publication Date: 2018-03-14
    Description: Motivation Bulked segregant analysis combined with next generation sequencing has proven to be a simple and efficient approach for fast mapping of quantitative trait loci (QTLs). However, how to estimate the proportion of phenotypic variance explained by a QTL (or termed QTL heritability) in such pooled QTL mapping is an unsolved problem. Results In this paper, we propose a method called PQHE to estimate QTL heritability using pooled sequencing data obtained under different experimental designs. Simulation studies indicated that our method is correct and feasible. Four practical examples from rice and yeast are demonstrated, each representing a different situation. Availability and implementation The R scripts of our method are open source under GPLv3 license at http://genetics.fafu.edu.cn/PQHE or https://github.com/biotangweiqi/PQHE . The R scripts require the R package rootSolve. Contact wuwr@fafu.edu.cn Supplementary information Supplementary dataSupplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 9
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    Research on Automatic Positioning System of Ultrasonic Testing of Wind Turbine Blade Flaws (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-11-10
    Description: Ultrasonic testing technology has been used essentially in non-destructive testing of wind turbine blades. However, it is fact that the ultrasonic flaw detection method has inefficiently employed in recent years. This is because the testing result will illustrate a small deviation due to the artificial, environmental and technical factors. Therefore, it is an urgent technical demand for engineers to test the various flaws efficiently and quickly. An automatic positioning system has been designed in this paper to record the moving coordinates and the target distance in real time. Simultaneously, it could launch and acquire the sonic wave automatically. The ADNS-3080 optoelectronic chip is manufactured by Agilent Technologies Inc, which is also utilized in the system. With the combination of the chip, the power conversion module and the USB transmission module, the collected data can be transmitted from the upper monitor to the hardware that could process and control the data thro...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 10
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    Impact of evaporation in Yangtze river valley on heat stress in north China (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-04-25
    Description: In North China (NC), heat stress, which can be quantitatively characterized by wet-bulb globe temperature (WBGT), is closely related to specific humidity. This study focuses on the total days for NC averaged daily maximum WBGT exceeding 26°C (WGBT26) per summer (June to August) from 1979 to 2017. Rather than local precipitation or evaporation in NC, the NC WBGT26 is significantly related to the nonlocal evaporation around the Yangtze River Valley (YR). The abnormal positive evaporated water vapor in YR, associated with anomalously high water vapor flux from south to north at 925 hPa, is continuously transported to NC in the above-normal WBGT26 years. Such an abnormal “evaporation and transportation” process can significantly increase the water vapor in NC and therefore enhance WBGT26. The evaporation in YR peaks in mid to late July and is closely associated with the occurrence days for daily maximum WBGT exceeding 26°C and maximum daily mean specific humidity at 925 hPa in summer. The main driver for the strongest YR evaporation anomaly from July 15th to August 15th is the simultaneous surface air temperature rather than the simultaneous or earlier soil moisture, precipitation, and vapor pressure deficit (VPD) anomaly. This condition is due to the continuously abundant soil moisture in the YR from April to September. The results of this study provide new ideas for studying heat stress in NC, indicating that nonlocal land-atmosphere interactions are crucial.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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