Publication Date:
2017-09-06
Description:
Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ Nature Communications, Published online: 5 September 2017; doi:10.1038/s41467-017-00439-1 Thiopeptides such as nosiheptide are clinically-interesting antimicrobial natural products. Here the authors show the functional dissection of a series of enzymes involved in nosiheptide biosynthesis, revealing a unique biosynthetic pathway that centers on a previously-unknown carrier protein.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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