Publication Date:
2002-01-12
Description:
Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finotto, Susetta -- Neurath, Markus F -- Glickman, Jonathan N -- Qin, Shixin -- Lehr, Hans A -- Green, Francis H Y -- Ackerman, Kate -- Haley, Kathleen -- Galle, Peter R -- Szabo, Susanne J -- Drazen, Jeffrey M -- De Sanctis, George T -- Glimcher, Laurie H -- HL-36110/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2002 Jan 11;295(5553):336-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11786643" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Allergens/immunology
;
Animals
;
*Asthma/immunology/metabolism/pathology
;
Bronchial Hyperreactivity/immunology/metabolism/pathology
;
Bronchoalveolar Lavage Fluid/immunology
;
CD4-Positive T-Lymphocytes/immunology/transplantation
;
Collagen Type III/metabolism
;
Cytokines/metabolism
;
Disease Models, Animal
;
Gene Targeting
;
Humans
;
Interleukin-4/metabolism
;
Interleukin-5/metabolism
;
Lung/immunology/metabolism/pathology
;
Mice
;
Mice, Knockout
;
Mice, SCID
;
T-Box Domain Proteins
;
Transcription Factors/deficiency/*genetics/metabolism/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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