ALBERT

Description: Phenolic compounds and antioxidant activities of ten juices from arils and whole pomegranate cultivars grown in Iran were studied. Phenolic contents and antioxidant activities of juices from whole pomegranate fruit were significantly higher than juices from pomegranate arils, but the variety has a greater influence than the processing method. The main phenolics in the studied juices were punicalagin A (5.40–285 mg/L), punicalagin B (25.9–884 mg/L), and ellagic acid (17.4–928 mg/L). The major and minor anthocyanins of cyanidin 3,5-diglucoside (0.7–94.7 mg/L), followed by cyanidin 3-glucoside (0.5–52.5 mg/L), pelargonidin 3,5-diglucoside + delphinidin 3-glucoside (0–10.3 mg/L), delphinidin 3,5-diglucoside (0–7.68 mg/L), pelargonidin 3-glucoside (0–9.40 mg/L), and cyanidin-pentoside (0–1.13 mg/L) were identified; the latter anthocyanin as well as cyanidin-pentoside-hexoside and delphinidin-pentoside were detected for the first time in Iranian pomegranates. The total phenolic contents were in the range of 220–2931 mg/100 mL. The results indicate that the pomegranate phenolics are not only influenced by extraction method but also—and even more—affected by the cultivar. Moreover, a good correlation was observed between total phenolic content and ABTS and FRAP methods in all pomegranate juices (〉0.90). The results of current research can help to select the pomegranate cultivars for commercial juice production.

Description: Null mutations in genes involved in V(D)J recombination cause a block in B- and T-cell development, clinically presenting as severe combined immunodeficiency (SCID). Hypomorphic mutations in the non-homologous end-joining gene DCLRE1C (encoding ARTEMIS) have been described to cause atypical SCID, Omenn syndrome, Hyper IgM syndrome and inflammatory bowel disease—all with severely impaired T-cell immunity. By whole-exome sequencing, we investigated the molecular defect in a consanguineous family with three children clinically diagnosed with antibody deficiency. We identified perfectly segregating homozygous variants in DCLRE1C in three index patients with recurrent respiratory tract infections, very low B-cell numbers and serum IgA levels. In patients, decreased colony survival after irradiation, impaired proliferative response and reduced counts of naïve T cells were observed in addition to a restricted T-cell receptor repertoire, increased palindromic nucleotides in the complementarity determining regions 3 and long stretches of microhomology at switch junctions. Defective V(D)J recombination was complemented by wild-type ARTEMIS protein in vitro . Subsequently, homozygous or compound heterozygous DCLRE1C mutations were identified in nine patients from the same geographic region. We demonstrate that DCLRE1C mutations can cause a phenotype presenting as only antibody deficiency. This novel association broadens the clinical spectrum associated with ARTEMIS mutations. Clinicians should consider the possibility that an immunodeficiency with a clinically mild initial presentation could be a combined immunodeficiency, so as to provide appropriate care for affected patients.

Description: Author(s): K. Ohmi, R. Tomás, Y. Funakoshi, R. Calaga, T. Ieiri, Y. Morita, K. Nakanishi, K. Oide, Y. Ohnishi, Y. Sun, M. Tobiyama, and F. Zimmermann [Phys. Rev. ST Accel. Beams 14, 111003] Published Mon Nov 28, 2011

Description: Glial cells produce myelin and contribute to axonal morphology in the nervous system. Two myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity of myelinated axons. In the absence of PLP-DM20, mice assembled compact myelin sheaths but subsequently developed widespread axonal swellings and degeneration, associated predominantly with small-caliber nerve fibers. Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants. Thus, fiber degeneration, which was probably secondary to impaired axonal transport, could indicate that myelinated axons require local oligodendroglial support.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffiths, I -- Klugmann, M -- Anderson, T -- Yool, D -- Thomson, C -- Schwab, M H -- Schneider, A -- Zimmermann, F -- McCulloch, M -- Nadon, N -- Nave, K A -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1998 Jun 5;280(5369):1610-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Applied Neurobiology Group, Department of Veterinary Clinical Studies, University of Glasgow, Glasgow G61 1QH, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9616125" target="_blank"〉PubMed〈/a〉

Description: The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to calcium. The codon for this arginine is introduced at the precursor messenger RNA (pre-mRNA) stage by site-selective adenosine editing of a glutamine codon. Heterozygous mice engineered by gene targeting to harbor an editing-incompetent GluR-B allele synthesized unedited GluR-B subunits and, in principal neurons and interneurons, expressed AMPA receptors with increased calcium permeability. These mice developed seizures and died by 3 weeks of age, showing that GluR-B pre-mRNA editing is essential for brain function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brusa, R -- Zimmermann, F -- Koh, D S -- Feldmeyer, D -- Gass, P -- Seeburg, P H -- Sprengel, R -- New York, N.Y. -- Science. 1995 Dec 8;270(5242):1677-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502080" target="_blank"〉PubMed〈/a〉

Description: The conservation of large carnivores is a formidable challenge for biodiversity conservation. Using a data set on the past and current status of brown bears (Ursus arctos), Eurasian lynx (Lynx lynx), gray wolves (Canis lupus), and wolverines (Gulo gulo) in European countries, we show that roughly one-third of mainland Europe hosts at least one large carnivore species, with stable or increasing abundance in most cases in 21st-century records. The reasons for this overall conservation success include protective legislation, supportive public opinion, and a variety of practices making coexistence between large carnivores and people possible. The European situation reveals that large carnivores and people can share the same landscape.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapron, Guillaume -- Kaczensky, Petra -- Linnell, John D C -- von Arx, Manuela -- Huber, Djuro -- Andren, Henrik -- Lopez-Bao, Jose Vicente -- Adamec, Michal -- Alvares, Francisco -- Anders, Ole -- Balciauskas, Linas -- Balys, Vaidas -- Bedo, Peter -- Bego, Ferdinand -- Blanco, Juan Carlos -- Breitenmoser, Urs -- Broseth, Henrik -- Bufka, Ludek -- Bunikyte, Raimonda -- Ciucci, Paolo -- Dutsov, Alexander -- Engleder, Thomas -- Fuxjager, Christian -- Groff, Claudio -- Holmala, Katja -- Hoxha, Bledi -- Iliopoulos, Yorgos -- Ionescu, Ovidiu -- Jeremic, Jasna -- Jerina, Klemen -- Kluth, Gesa -- Knauer, Felix -- Kojola, Ilpo -- Kos, Ivan -- Krofel, Miha -- Kubala, Jakub -- Kunovac, Sasa -- Kusak, Josip -- Kutal, Miroslav -- Liberg, Olof -- Majic, Aleksandra -- Mannil, Peep -- Manz, Ralph -- Marboutin, Eric -- Marucco, Francesca -- Melovski, Dime -- Mersini, Kujtim -- Mertzanis, Yorgos -- Myslajek, Robert W -- Nowak, Sabina -- Odden, John -- Ozolins, Janis -- Palomero, Guillermo -- Paunovic, Milan -- Persson, Jens -- Potocnik, Hubert -- Quenette, Pierre-Yves -- Rauer, Georg -- Reinhardt, Ilka -- Rigg, Robin -- Ryser, Andreas -- Salvatori, Valeria -- Skrbinsek, Tomaz -- Stojanov, Aleksandar -- Swenson, Jon E -- Szemethy, Laszlo -- Trajce, Aleksander -- Tsingarska-Sedefcheva, Elena -- Vana, Martin -- Veeroja, Rauno -- Wabakken, Petter -- Wolfl, Manfred -- Wolfl, Sybille -- Zimmermann, Fridolin -- Zlatanova, Diana -- Boitani, Luigi -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1517-9. doi: 10.1126/science.1257553.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Grimso Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, 73091 Riddarhyttan, Sweden. gchapron@carnivoreconservation.org guillaume.chapron@slu.se. ; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria. ; Norwegian Institute for Nature Research, Post Office Box 5685 Sluppen, 7485 Trondheim, Norway. ; KORA, Thunstrasse 31, 3074 Muri bei Bern, Switzerland. ; Biology Department of the Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia. ; Grimso Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, 73091 Riddarhyttan, Sweden. ; Grimso Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, 73091 Riddarhyttan, Sweden. Research Unit of Biodiversity (UO/CSIC/PA), Oviedo University, 33600 Mieres, Spain. ; State Nature Conservancy of Slovak Republic, Tajovskeho 28B, 974 01 Banska Bystrica, Slovakia. ; CIBIO/InBio, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, 4485-661 Vairao, Portugal. ; Harz Nationalpark, Lindenallee 35, 38855 Wernigerode, Germany. ; Nature Research Centre, Akademijos 2, 08412 Vilnius, Lithuania. ; Association for Nature Conservation "Baltijos vilkas," Visoriu 6A-54, 08300 Vilnius, Lithuania. ; Slovak Wildlife Society, Post Office Box 72, 03301 Liptovsky Hradok, Slovakia. ; Biology Department of the Faculty of Natural Sciences, University of Tirana, Boulevard Zog I, Tirana, Albania. ; Wolf Project, Consultores en Biologia de la Conservacion, Calle Manuela Malasana 24, 28004 Madrid, Spain. ; KORA, Thunstrasse 31, 3074 Muri bei Bern, Switzerland. Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Langgassstrasse 122, 3012 Bern, Switzerland. ; Department of Game Management and Wildlife Biology, Czech University of Life Sciences in Prague, Kamycka 129, 165 21 Prague, Czech Republic. ; Ministry of Environment of the Republic of Lithuania, Jaksto 4/9, 01105 Vilnius, Lithuania. ; Department of Biology and Biotechnologies, University of Rome "La Sapienza," Viale dell'Universita 32, 00185 Roma, Italy. ; Balkani Wildlife Society, Boulevard Dragan Tzankov 8, 1164 Sofia, Bulgaria. ; Lynx Project Austria Northwest, Linzerstrasse 14, 4170 Haslach/Muhl, Austria. ; Nationalpark Kalkalpen, Nationalpark Zentrum Molln, Nationalpark Allee 1, 4591 Molln, Austria. ; Provincia Autonoma di Trento - Servizio Foreste e Fauna, Via Trener no. 3, 38100 Trento, Italy. ; Finnish Game and Fisheries Research Institute, Viikinkaari 4, 00790 Helsinki, Finland. ; Protection and Preservation of Natural Environment in Albania, Rruga Vangjush Furxhi 16/1/10, Tirana, Albania. ; Callisto Wildlife and Nature Conservation Society, Mitropoleos 123, 54621 Thessaloniki, Greece. ; Faculty of Silviculture and Forest Engineering, Department of Silviculture, Transilvania University, 1 Beethoven Lane, 500123 Brasov, Romania. Forest Research Institute (ICAS) Bulevardul Eroilor Number 128, Voluntari, Ilfov, 077190 Romania. ; State Institute for Nature Protection, Trg Mazuranica 5, 10000 Zagreb, Croatia. ; University of Ljubljana, Biotechnical Faculty, Jamnikarjeva 101, 1000 Ljubljana, Slovenia. ; LUPUS - German Institute for Wolf Mnitoring and Research, Dorfstrasse 20, 02979 Spreewitz, Germany. ; Finnish Game and Fisheries Research Institute, Oulu Game and Fisheries Research, Tutkijantie 2E, 90570 Oulu, Finland. ; Department of Forest Protection and Game Management, Faculty of Forestry, Technical University of Zvolen, T.G. Masaryka 20, 960 53 Zvolen, Slovakia. ; Faculty of Forestry, University of Sarajevo, Zagrebacka 20, 71000 Sarajevo, Bosnia and Herzegovina. ; Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Mendel University in Brno, Zemedelska 3, 61300 Brno, Czech Republic. Friends of the Earth Czech Republic, Olomouc Branch, Dolni Namesti 38, 77900 Olomouc, Czech Republic. ; Estonian Environment Agency, Roomu tee 2, 51013 Tartu, Estonia. ; Office National de la Chasse et de la Faune Sauvage, ZI Mayencin, 5 Allee de Bethleem, 38610 Gieres, France. ; Centro Gestione e Conservazione Grandi Carnivori, Piazza Regina Elena 30, Valdieri 12010, Italy. ; Macedonian Ecological Society, Arhimedova 5, Skopje 1000, FYR Macedonia. Department of Wildlife Sciences, Georg-August University, Busgenweg 3, 37077 Gottingen, Germany. ; National Veterinary Epidemiology Unit, Food Safety and Veterinary Institute, Rruga Aleksander Moisiu 10 Tirana, Albania. ; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warszawa, Poland. ; Association for Nature "Wolf," Twardorzeczka 229, 34-324 Lipowa, Poland. ; Latvian State Forest Research Institute "Silava," Rigas Iela 111, Salaspils, 2169 Latvia. ; Fundacion Oso Pardo, Calle San Luis 17, 4 degrees A, 39010 Santander, Spain. ; Natural History Museum, Njegoseva 51, 11000 Belgrade, Serbia. ; ONCFS-CNERA PAD, Equipe Ours, Chef de Projet, Impasse de la Chapelle, 31800 Villeneuve de Riviere, France. ; Istituto di Ecologia Applicata, Via B. Eustachio 10, 00161 Rome, Italy. ; Macedonian Ecological Society, Arhimedova 5, Skopje 1000, FYR Macedonia. ; Norwegian Institute for Nature Research, Post Office Box 5685 Sluppen, 7485 Trondheim, Norway. Department of Ecology and Natural Resource Management, Norwegian University of Life Sciences, Postbox 5003, 1432 As, Norway. ; St. Istvan Unversity Institute for Wildlife Conservation, Pater Karoly 1, 2103 Godollo, Hungary. ; Friends of the Earth Czech Republic, Olomouc Branch, Dolni Namesti 38, 77900 Olomouc, Czech Republic. ; Hedmark University College, Evenstad, 2480 Koppang, Norway. ; Bavarian Agency of Environment, Hans-Hogn-Strasse 12, 95030 Hof/Saale, Germany. ; Lynx Project Bavaria, Trailling 1a, 93462 Lam, Germany. ; Department of Zoology and Anthropology, Faculty of Biology/Sofia University "St. Kliment Ohridski," Boulevard Dragan Tzankov 8, 1164 Sofia, Bulgaria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525247" target="_blank"〉PubMed〈/a〉

Description: Author(s): K. Ohmi, N. Kuroo, K. Oide, D. Zhou, and F. Zimmermann In recent years the “crab-waist collision” scheme [P. Raimondi, Proceedings of 2nd SuperB Workshop, Frascati, 2006.; M. Zobov et al. , Phys. Rev. Lett. 104 , 174801 (2010) ] has become popular for circular e + e − colliders. The designs of several future colliders are based on this scheme. So far the bea... [Phys. Rev. Lett. 119, 134801] Published Tue Sep 26, 2017

Description: Author(s): G. Franchetti and F. Zimmermann Time-varying nonlinear oscillatory systems produce phenomena of resonance crossing and trapping of particles in resonance islands. Traditionally, such processes have been analyzed in terms of adiabatic conditions. Considering, as an example, a simplified one-dimensional model describing the “electro... [Phys. Rev. Lett. 109, 234102] Published Tue Dec 04, 2012

Description: Author(s): O. Domínguez, K. Li, G. Arduini, E. Métral, G. Rumolo, F. Zimmermann, and H. Maury Cuna During the beam commissioning of the Large Hadron Collider (LHC) [LHC Design Report No. CERN-2004-003-V-1, 2004 [ http://cds.cern.ch/record/782076?ln=en ]; O. Brüning, H. Burkhardt and S. Myers Prog. Part. Nucl. Phys. 67 705 (2012) ] with 150, 75, 50, and 25-ns bunch spacing, important electron-cloud... [Phys. Rev. ST Accel. Beams 16, 011003] Published Wed Jan 09, 2013