Publication Date:
2010-10-30
Description:
The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter gamma-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243732/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243732/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Del Bene, Filippo -- Wyart, Claire -- Robles, Estuardo -- Tran, Amanda -- Looger, Loren -- Scott, Ethan K -- Isacoff, Ehud Y -- Baier, Herwig -- PN2 EY018241/EY/NEI NIH HHS/ -- R01 EY012406/EY/NEI NIH HHS/ -- R01 EY012406-06A2/EY/NEI NIH HHS/ -- R01 EY012406-07/EY/NEI NIH HHS/ -- R01 EY012406-08/EY/NEI NIH HHS/ -- R01 EY012406-09/EY/NEI NIH HHS/ -- R01 MH060711/MH/NIMH NIH HHS/ -- R01 NS050833/NS/NINDS NIH HHS/ -- R01 NS053358/NS/NINDS NIH HHS/ -- R01 NS053358-01A2/NS/NINDS NIH HHS/ -- R01 NS053358-02/NS/NINDS NIH HHS/ -- R01 NS053358-02S1/NS/NINDS NIH HHS/ -- R01 NS053358-03/NS/NINDS NIH HHS/ -- R01 NS053358-04/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):669-73. doi: 10.1126/science.1192949.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of California, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21030657" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Genetically Modified
;
Axons/physiology
;
Bicuculline/pharmacology
;
Dendrites/physiology
;
GABA Antagonists/pharmacology
;
Interneurons/*physiology
;
Neural Inhibition
;
Neurons/*physiology
;
Neuropil/physiology
;
Optic Lobe, Nonmammalian/cytology/*physiology
;
Photic Stimulation
;
Retina/*physiology
;
Retinal Neurons/physiology
;
Synaptic Transmission
;
Visual Pathways/*physiology
;
*Visual Perception
;
Zebrafish
;
gamma-Aminobutyric Acid/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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