Publication Date:
2000-07-07
Description:
Domestication of many plants has correlated with dramatic increases in fruit size. In tomato, one quantitative trait locus (QTL), fw2.2, was responsible for a large step in this process. When transformed into large-fruited cultivars, a cosmid derived from the fw2.2 region of a small-fruited wild species reduced fruit size by the predicted amount and had the gene action expected for fw2.2. The cause of the QTL effect is a single gene, ORFX, that is expressed early in floral development, controls carpel cell number, and has a sequence suggesting structural similarity to the human oncogene c-H-ras p21. Alterations in fruit size, imparted by fw2.2 alleles, are most likely due to changes in regulation rather than in the sequence and structure of the encoded protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frary, A -- Nesbitt, T C -- Grandillo, S -- Knaap, E -- Cong, B -- Liu, J -- Meller, J -- Elber, R -- Alpert, K B -- Tanksley, S D -- New York, N.Y. -- Science. 2000 Jul 7;289(5476):85-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Breeding and Department of Plant Biology, 252 Emerson Hall, Cornell University, Ithaca, NY 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10884229" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Amino Acid Sequence
;
Biological Evolution
;
Cell Count
;
Cell Division
;
Cloning, Molecular
;
Contig Mapping
;
Fruit/growth & development
;
*Genes, Plant
;
Genetic Complementation Test
;
Humans
;
Lycopersicon esculentum/cytology/*genetics/growth & development
;
Molecular Sequence Data
;
Mutation
;
Oncogene Protein p21(ras)/chemistry/genetics
;
Plant Proteins/chemistry/*genetics
;
Plant Structures/cytology/genetics
;
Plants, Genetically Modified
;
Protein Structure, Secondary
;
*Quantitative Trait, Heritable
;
Sequence Alignment
;
Transformation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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