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  • 1
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    Gas-phase hydrolysis of triplet SO〈sub〉2〈/sub〉: A possible direct route to atmospheric acid formation (2016)
    Springer Nature
    Details
    Publication Date: 2016-07-16
    Description: Gas-phase hydrolysis of triplet SO〈sub〉2〈/sub〉: A possible direct route to atmospheric acid formation Scientific Reports, Published online: 15 July 2016; doi:10.1038/srep30000
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 2
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    Aftershocks of the 2010 Mw 7.2 El Mayor-Cucapah Earthquake Reveal Complex Faulting in the Yuha Desert, California (2013)
    Wiley
    Details
    Publication Date: 2013-10-24
    Description: [1]  We detect and precisely locate over 9,500 aftershocks that occurred in the Yuha Desert region during a two-month period following the 4 April 2010 M w 7.2 El Mayor-Cucapah (EMC) earthquake. Events are relocated using a series of absolute and relative relocation procedures that include HYPOINVERSE, VELEST, and hypoDD. Location errors are reduced to ~40 m horizontally and ~120 m vertically. Aftershock locations reveal a complex pattern of faulting with en echelon fault segments trending toward the northwest, approximately parallel to the North American-Pacific plate boundary and en echelon , conjugate features trending to the northeast. The relocated seismicity is highly correlated with published surface mapping of faults that experienced triggered surface slip in response to the EMC mainshock. Aftershocks occur between 2 km and 11 km depth, consistent with previous studies of seismogenic thickness in the region. Three-dimensional analysis reveals individual and intersecting fault planes that are limited in their along-strike length. These fault planes remain distinct structures at depth, indicative of conjugate faulting, and do not appear to coalesce onto a through-going fault segment. We observe a complex spatiotemporal migration of aftershocks, with seismicity that jumps between individual fault segments that are active for only a few days to weeks. Aftershock rates are roughly consistent with the expected earthquake production rates of Dieterich [1994]. The conjugate pattern of faulting and non-uniform aftershock migration patterns suggest that strain in the Yuha Desert is being accommodated in a complex manner.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
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    Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4 (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-05-02
    Description: Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing centers of animal cells. Extra centrosomes are a common feature of cancer cells. To investigate the importance of centrosomes in the proliferation of normal and cancer cells, we developed centrinone, a reversible inhibitor of Polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole assembly. Centrinone treatment caused centrosome depletion in human and other vertebrate cells. Centrosome loss irreversibly arrested normal cells in a senescence-like G1 state by a p53-dependent mechanism that was independent of DNA damage, stress, Hippo signaling, extended mitotic duration, or segregation errors. In contrast, cancer cell lines with normal or amplified centrosome numbers could proliferate indefinitely after centrosome loss. Upon centrinone washout, each cancer cell line returned to an intrinsic centrosome number "set point." Thus, cells with cancer-associated mutations fundamentally differ from normal cells in their response to centrosome loss.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764081/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764081/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, Yao Liang -- Anzola, John V -- Davis, Robert L -- Yoon, Michelle -- Motamedi, Amir -- Kroll, Ashley -- Seo, Chanmee P -- Hsia, Judy E -- Kim, Sun K -- Mitchell, Jennifer W -- Mitchell, Brian J -- Desai, Arshad -- Gahman, Timothy C -- Shiau, Andrew K -- Oegema, Karen -- GM074207/GM/NIGMS NIH HHS/ -- GM089970/GM/NIGMS NIH HHS/ -- GM103403/GM/NIGMS NIH HHS/ -- R01 GM089970/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Jun 5;348(6239):1155-60. doi: 10.1126/science.aaa5111. Epub 2015 Apr 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA. ; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA. ; Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. ; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA. koegema@ucsd.edu ashiau@ucsd.edu. ; Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA. koegema@ucsd.edu ashiau@ucsd.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25931445" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor ; Cell Proliferation ; Centrioles/*drug effects ; Humans ; Mice ; Piperazines/pharmacology ; Protein Kinase Inhibitors/chemistry/*pharmacology ; Protein-Serine-Threonine Kinases/*antagonists & inhibitors ; Pyrimidines/chemistry/*pharmacology ; Sulfones/chemistry/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Delayed Seismicity Rate Changes Controlled by Static Stress Transfer (2017)
    Wiley
    Details
    Publication Date: 2017-09-01
    Description: On 15 June 2010, a M w 5.7 earthquake occurred near Ocotillo, California in the Yuha Desert. This event was the largest aftershock of the 4 April 2010 M w 7.2 El Mayor-Cucapah (EMC) earthquake in this region. The EMC mainshock and subsequent Ocotillo aftershock provide an opportunity to test the Coulomb failure hypothesis (CFS). We explore the spatiotemporal correlation between seismicity rate changes and regions of positive and negative CFS change imparted by the Ocotillo event. Based on simple CFS calculations we divide the Yuha Desert into three subregions, one triggering zone and two stress shadow zones. We find the nominal triggering zone displays immediate triggering, one stress shadowed region experiences immediate quiescence, and the other nominal stress shadow undergoes an immediate rate increase followed by a delayed shutdown. We quantitatively model the spatiotemporal variation of earthquake rates by combining calculations of CFS change with the rate-state earthquake rate formulation of [?Dieterich1994], assuming that each subregion contains a mixture of nucleating sources that experienced a CFS change of differing signs. Our modelling reproduces the observations, including the observed delay in the stress shadow effect in the third region following the Ocotillo aftershock. The delayed shadow effect occurs because of intrinsic differences in the amplitude of the rate response to positive and negative stress changes and the time constants for return to background rates for the two populations. We find that rate-state models of time-dependent earthquake rates are in good agreement with the observed rates and thus explain the complex spatiotemporal patterns of seismicity.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    Sensitivity of Induced Seismic Sequences to Rate-and-State Frictional Processes (2017)
    Wiley
    Details
    Publication Date: 2017-11-10
    Description: It is well established that subsurface injection of fluids increases pore-fluid pressures that may lead to shear failure along a pre-existing fault surface. Concern amongst oil and gas, geothermal, and carbon storage operators has risen dramatically over the past decade due to the increase in the number and magnitude of induced earthquakes. Efforts to mitigate the risk associated with injection induced earthquakes include modeling of the interaction between fluids and earthquake faults. Here, we investigate this relationship with simulations that couple a geomechanical reservoir model and RSQSim, a physics-based earthquake simulator. RSQSim employs rate-and state-dependent friction (RSF) which enables the investigation of the time-dependent nature of earthquake sequences. We explore the effect of two RSF parameters and normal stress on the spatiotemporal characteristics of injection induced seismicity. We perform 〉200 simulations to systematically investigate the effect of these model components on the evolution of induced seismic sequences and compare spatiotemporal characteristics of our synthetic catalogs to observations of induced earthquakes. We find that the RSF parameters control the ability of seismicity to migrate away from the injection well, the total number and maximum magnitude of induced events. Additionally, the RSF parameters control the occurrence/absence of premonitory events. Lastly, we find that earthquake stress drops can be modulated by the normal stress and/or the RSF parameters. Insight gained from this study can aid in further development of models that address best practice protocols for injection operations, site-specific models of injection induced earthquakes, and probabilistic hazard and risk assessments of induced earthquakes.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
    Electronic Resource
    Electronic Resource
    Globe-Valve Flow Coefficients for Valve Meters. (1945)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 37 (1945), S. 588-591 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50426a024
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  • 7
    Electronic Resource
    Electronic Resource
    Nonlinear Black Box Modelling – Fuzzy Networks versus Neural Networks (1999)
    Springer
    Neural computing & applications 8 (1999), S. 151-162 
    Details
    ISSN: 1433-3058
    Keywords: Key words: Flexible robot; Fuzzy networks; Hydraulic drive; Identification; Neural networks; Pneumatic drive
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Fuzzy networks and neural networks offer two different approaches of nonlinear black box modelling. Efficient identification methods have been developed to calculate the parameters for a given structure and have been applied successfully in many examples. But the applications proposed in the literature usually miss the comparison of the alternative method, so that the selection of the more suitable approach for a given task is difficult. This paper aims to ease the decision for one of the two methodologies by considering one well-known high quality approximator of each network type, and presenting a fair comparison. For this purpose, two mathematical and three complex technical examples of nonlinear systems are considered. Generally, fuzzy networks and neural networks face the problem of overtraining causing poor validation/generalisation results. A modification of the established identification methods is proposed as a significant improvement for both approaches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005210050017
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  • 8
    Electronic Resource
    Electronic Resource
    Small cytoplasmic RNAs from rat liver mRNP particles (1983)
    Springer
    Molecular biology reports 9 (1983), S. 65-74 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Free cytoplasmic 40S mRNP particles from rat liver were treated with EDTA and separated into two populations of RNP particles with sedimentation maxima of 20S and 35S, respectively. A characteristic set of distinct scRNAs is found for 20S and 35S RNP particles. The sequences of two of the most abundant scRNAs from 20S RNP particles with chain lengths of 104 (α1-RNA) and 124 (β1-RNA) nucleotides, respectively, are presented. α1-RNA shows a high sequence homology to the 3′-end of 18S rRNA. Since α1-RNA carries a cap, it cannot be a degradation product of 18S rRNA. The β1-RNA is strongly post-transcriptionally modified, but uncapped. When the individual scRNAs of 20S and 35S RNP particles isolated from preparative polyacrylamide gels were assayed for their capability to inhibit in vitro protein synthesis, several potent translational inhibitory RNAs were detected. Particularly, the scRNAs of 147, 203 and 263 nucleotide length associated with the 35S RNP particles turned out to be strong inhibitors of protein synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00777475
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  • 9
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    Potential of remotely-sensed data for mapping sediment connectivity pathways and their seasonal changes in dryland environments (2014)
    In:  Geophysical Research Abstracts, Vol. 16, EGU2014-6409, 2014
    Details
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/conferenceObject
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  • 10
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    Lab, field and imaging spectroscopy for assessing sediment connectivity and provenance in drylands (2014)
    In:  Presentations
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    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/conferenceObject
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