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  • 1
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    Source-sink plasmid dynamics and gene mobility [Evolution] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-07-21
    Description: Horizontal gene transfer is a fundamental process in bacterial evolution that can accelerate adaptation via the sharing of genes between lineages. Conjugative plasmids are the principal genetic elements mediating the horizontal transfer of genes, both within and between bacterial species. In some species, plasmids are unstable and likely to be...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Experimental Measurements of Trace Element Partitioning Between Lawsonite, Zoisite and Fluid and their Implication for the Composition of Arc Magmas (2011)
    Oxford University Press
    Details
    Publication Date: 2011-06-17
    Description: We present experimental data on the partitioning of Li, Be, B, K, Mg, Sr, Ga, Rb, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Th, U, Hf, Zr, Nb and Ta between lawsonite and fluid, and zoisite and fluid at 3·0–3·5 GPa and 650–850°C. The aim is to provide data bearing on the trace element contents of fluids released during dehydration of subducting oceanic crust. Experimental trace element partition coefficients for lawsonite indicate a preference for the light rare earth elements (LREE) over the heavy REE (HREE) and for Be. These characteristics are consistent with the chemical composition of lawsonite in natural rocks. Experimental trace element partition coefficients for zoisite indicate a preference for HREE relative to LREE. This observation, consistent with earlier experimental data, is the reverse of the observed trace element compositions of natural zoisites, indicating the influence of other factors on the trace element contents of this phase. Lattice strain theory explains well the experimentally derived partitioning of divalent cations in the Ca-site between lawsonite and fluid. However, the weak relative fractionation of REE between lawsonite and fluid cannot be explained by lattice strain theory, as previously observed for zoisite–fluid REE partitioning. We combine our experimental data with thermodynamic models of mineral stability to model the compositions of fluids released during subduction of altered normal mid-ocean ridge basalt. The low La/Sm ratio associated with very high Ba/Th in arc magmas can be explained only if allanite is stable in the subducting oceanic crust. This suggests that the crustal fluid component involved in arc magma petrogenesis results from processes occurring in the warm, top part of the subducting slab. Decreasing lawsonite modal proportion with depth is associated with a large release of fluid characterized by low B/Be ratios that could explain the decreasing B/Be ratios in arc magmas with increasing distance from the trench. This implies that an important Be input in arc magma originates from the fluid generated during oceanic crust dehydration.
    Print ISSN: 0022-3530
    Electronic ISSN: 1460-2415
    Topics: Geosciences
    Published by Oxford University Press
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  • 3
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    Targeted genome editing across species using ZFNs and TALENs (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-28
    Description: Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489282/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489282/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wood, Andrew J -- Lo, Te-Wen -- Zeitler, Bryan -- Pickle, Catherine S -- Ralston, Edward J -- Lee, Andrew H -- Amora, Rainier -- Miller, Jeffrey C -- Leung, Elo -- Meng, Xiangdong -- Zhang, Lei -- Rebar, Edward J -- Gregory, Philip D -- Urnov, Fyodor D -- Meyer, Barbara J -- GM30702/GM/NIGMS NIH HHS/ -- R01 GM030702/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):307. doi: 10.1126/science.1207773. Epub 2011 Jun 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700836" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis/*genetics ; Caenorhabditis elegans/*genetics ; Deoxyribonucleases, Type II Site-Specific/genetics/*metabolism ; Gene Targeting ; Genes, Helminth ; *Genetic Techniques ; *Genome, Helminth ; INDEL Mutation ; Mutagenesis ; Regulatory Elements, Transcriptional/*genetics ; Transcription Factors/chemistry ; Transgenes ; *Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-12-06
    Description: During differentiation, thousands of genes are repositioned toward or away from the nuclear envelope. These movements correlate with changes in transcription and replication timing. Using synthetic (TALE) transcription factors, we found that transcriptional activation of endogenous genes by a viral trans-activator is sufficient to induce gene repositioning toward the nuclear interior in embryonic stem cells. However, gene relocation was also induced by recruitment of an acidic peptide that decondenses chromatin without affecting transcription, indicating that nuclear reorganization is driven by chromatin remodeling rather than transcription. We identified an epigenetic inheritance of chromatin decondensation that maintained central nuclear positioning through mitosis even after the TALE transcription factor was lost. Our results also demonstrate that transcriptional activation, but not chromatin decondensation, is sufficient to change replication timing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Therizols, Pierre -- Illingworth, Robert S -- Courilleau, Celine -- Boyle, Shelagh -- Wood, Andrew J -- Bickmore, Wendy A -- 102560/Wellcome Trust/United Kingdom -- MC_PC_U127527202/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1238-42. doi: 10.1126/science.1259587.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. ; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. wendy.bickmore@igmm.ed.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/*genetics ; Cell Line ; Cell Nucleus/*genetics/metabolism/ultrastructure ; Chromatin/*metabolism ; *Chromatin Assembly and Disassembly ; DNA Replication ; Embryonic Stem Cells/*cytology/metabolism ; *Epigenesis, Genetic ; Mice ; Nuclear Envelope/genetics/metabolism/ultrastructure ; Trans-Activators/*metabolism ; *Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    CHANGES IN BODY COMPOSITION OF THE PIG DURING EARLY GROWTH BASED ON DEUTERIUM OXIDE DILUTION TECHNIQUE (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 110 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb17100.x
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  • 6
    Electronic Resource
    Electronic Resource
    A RAPID TEST FOR DETECTION OF SPOILAGE IN SEA FISH (1944)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 9 (1944), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1944.tb16676.x
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  • 7
    Electronic Resource
    Electronic Resource
    Longevity in Mice with a genetically determined Muscular Dystrophy (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 552-552 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The value of such therapeutic work is three-fold. First, by prolonging the life-span of these animals it becomes possible to obtain critical details on the mechanism of the disease as it progresses. Secondly, effective therapeutic agents may give valuable leads regarding the primary metabolic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/190552a0
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  • 8
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    J.C. Boyajian, "Portuguese Trade in Asia under the Habsburgs, 1580-1640" (Book Review) (1993)
    Saskatoon : Periodicals Archive Online (PAO)
    Canadian journal of history/Annales canadiennes d'histoire. 28:3 (1993:Dec./déc.) 636 
    Details
    ISSN: 0008-4107
    Topics: History , Economics
    Description / Table of Contents: General and International/Général et International
    Notes: Reviews/comptes rendus
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:b059-1993-028-03-000046
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  • 9
    Electronic Resource
    Electronic Resource
    Tris(acetato-O,O')(2,4-dimethoxyphenyl)lead(IV) (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 1600-1602 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S010827019700574X
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  • 10
    Electronic Resource
    Electronic Resource
    The analysis of plutonium uranium carbide-iron cermets by electrochemical method (1966)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 224 (1966), S. 346-356 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Elektrochemische Verfahren wurden ausgearbeitet zur direkten Bestimmung der metallischen Hauptbestandteile in Metall-keramischen Materialien (Cermets) der Zusammensetzung 15% (Pu,U)C-10% Fe. Hierbei wird die Probe in Salpetersäure aufgelöst und anschließend zur Zerstörung organischer Substanz einer nassen Oxydation mit einem Gemisch von Schwefel- und Salpetersäure unterworfen. Plutonium wird mit Hilfe eines potentiometrischen Verfahrens bestimmt, das auf der Reduktion von PuVI zu PuIV mit FeII in geringem Überschluß und nachfolgender Titration des Überschusses mit CerIV-sulfatlösung beruht. Die Genauigkeit beträgt hierbei 0,1% bei Mengen von 4 mg Pu. Uran und Eisen werden durch Coulometrie mit Potentialkontrolle bestimmt; jedoch wird bei der Eisenbestimmung Plutonium miterfaßt und muß bei der Berechnung berücksichtigt werden. Die Genauigkeit der Uranbestimmung beträgt 0,25% bei 10 mg U, die der Eisenbestimmung 0,25% bei 1 mg Fe. Ergebnisse von vollständigen Analysen typischer Cermetproben werden angeführt.
    Notes: Summary Electrochemical methods have been developed for the direct determination of the main metallic constituents of 15 w/o (Pu, U) C — 10 w/o Fe cermets. Samples are dissolved in nitric acid, followed by wet oxidation with a mixture of sulphuric and nitric acids to destroy organic matter. Plutonium is determined by a potentiometric titration procedure based upon the reduction of PuVI to PuIV with ferrous iron added in slight excess, followed by the titration of this excess with ceric sulphate. The precision of this determination on 4 mg amounts of plutonium is 0.1%. Both uranium and iron are determined by controlled-potential coulometry, but the method for iron includes a contribution from plutonium and allowance has to be made for this. The precision of the uranium determination on 10 mg amounts is 0.25%, and the value for iron on 1 mg amounts is also 0.25%. Results for the complete analysis of typical cermet samples are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502663
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