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  • 1
    Publication Date: 2015-12-11
    Description: Corrigendum Nature Communications doi: 10.1038/ncomms10203 Authors: Elad Ziv, Eric Dean, Donglei Hu, Alessandro Martino, Daniel Serie, Karen Curtin, Daniele Campa, Blake Aftab, Paige Bracci, Gabriele Buda, Yi Zhao, Jennifer Caswell-Jin, Robert Diasio, Charles Dumontet, Marek Dudziński, Laura Fejerman, Alexandra Greenberg, Scott Huntsman, Krzysztof Jamroziak, Artur Jurczyszyn, Shaji Kumar, Djordje Atanackovic, Martha Glenn, Lisa A. Cannon-Albright, Brandt Jones, Adam Lee, Herlander Marques, Thomas Martin, Joaquin Martinez-Lopez, Vincent Rajkumar, Juan Sainz, Annette Juul Vangsted, Marzena Watek, Jeffrey Wolf, Susan Slager, Nicola J. Camp, Federico Canzian, Celine Vachon
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
    Publication Date: 2011-03-30
    Description: Internal ionizable groups in proteins are relatively rare but they are essential for catalysis and energy transduction. To examine molecular determinants of their unusual and functionally important properties, we engineered 25 variants of staphylococcal nuclease with lysine residues at internal positions. Nineteen of the Lys residues have depressed pKa values, some as low as 5.3, and 20 titrate without triggering any detectable conformational reorganization. Apparently, simply by being buried in the protein interior, these Lys residues acquired pKa values comparable to those of naturally occurring internal ionizable groups involved in catalysis and biological H+ transport. The pKa values of some of the internal Lys residues were affected by interactions with surface carboxylic groups. The apparent polarizability reported by the pKa values varied significantly from location to location inside the protein. These data will enable an unprecedented examination of the positional dependence of the dielectric response of a protein. This study also shows that the ability of proteins to withstand the presence of charges in their hydrophobic interior is a fundamental property inherent to all stable proteins, not a specialized adaptation unique to proteins that evolved to depend on internal charges for function.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2014-03-21
    Description: The oil and gas industry has been active in the West of Shetlands area for the last 40 years, but less than 200 wells have been drilled and only four fields have been developed. In the last ten years activity has picked up significantly with very active licensing rounds and increased drilling; however, the challenges of the complex geology and deep-water location, environmental constraints and commercial considerations have also increased at the same time. To fully develop the region successfully an attitude of compromise and collaboration between all the stakeholders must be nurtured, but with the scale of investment required this will remain a challenge for the future.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 4
    Publication Date: 1990-12-21
    Description: Previous studies have emphasized that genetic susceptibility to breast cancer is rare and is expressed primarily as premenopausal breast cancer, bilateral breast cancer, or both. Proliferative breast disease (PBD) is a significant risk factor for the development of breast cancer and appears to be a precursor lesion. PBD and breast cancer were studied in 103 women from 20 kindreds that were selected for the presence of two first degree relatives with breast cancer and in 31 control women. Physical examination, screening mammography, and four-quadrant fine-needle breast aspirates were performed. Cytologic analysis of breast aspirates revealed PBD in 35% of clinically normal female first degree relatives of breast cancer cases and in 13% of controls. Genetic analysis suggests that genetic susceptibility causes both PBD and breast cancer in these kindreds. This study supports the hypothesis that this susceptibility is responsible for a considerable portion of breast cancer, including unilateral and postmenopausal breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, M H -- Cannon-Albright, L A -- Goldgar, D E -- Ward, J H -- Marshall, C J -- Schumann, G B -- Hogle, H -- McWhorter, W P -- Wright, E C -- Tran, T D -- CA-28854/CA/NCI NIH HHS/ -- CA-42014/CA/NCI NIH HHS/ -- CA-48711/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Dec 21;250(4988):1715-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Utah Regional Cancer Center, University of Utah Medical Center, Salt Lake City 84132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2270486" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Breast Diseases/*genetics/pathology ; Breast Neoplasms/*genetics/pathology ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Menopause ; Middle Aged ; Pedigree
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1992-11-13
    Description: Linkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p21, previously implicated by the presence of homozygous deletions in melanoma tumors and by the presence of a germline deletion in an individual with eight independent melanomas. Multipoint linkage analysis was performed between the familial melanoma susceptibility locus (MLM) and two short tandem repeat markers, D9S126 and the interferon-alpha (IFNA) gene, which reside in the region of somatic loss in melanoma tumors. An analysis incorporating a partially penetrant dominant melanoma susceptibility locus places MLM near IFNA and D9S126 with a maximum location score of 12.71. Therefore, the region frequently deleted in melanoma tumors on 9p21 presumably contains a locus that plays a critical role in predisposition to familial melanoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cannon-Albright, L A -- Goldgar, D E -- Meyer, L J -- Lewis, C M -- Anderson, D E -- Fountain, J W -- Hegi, M E -- Wiseman, R W -- Petty, E M -- Bale, A E -- CA 42014/CA/NCI NIH HHS/ -- CA 48711/CA/NCI NIH HHS/ -- RR 00064/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Nov 13;258(5085):1148-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1439824" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Base Sequence ; Child ; Chromosome Aberrations ; *Chromosomes, Human, Pair 9 ; Dysplastic Nevus Syndrome/genetics ; Female ; Genes, Tumor Suppressor ; Genetic Markers ; Humans ; Lod Score ; Male ; Melanoma/*genetics ; Middle Aged ; Molecular Sequence Data ; Pedigree ; Skin Neoplasms/*genetics ; Texas ; Utah
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2009-07-04
    Description: The accretion of matter onto a massive black hole is believed to feed the relativistic plasma jets found in many active galactic nuclei (AGN). Although some AGN accelerate particles to energies exceeding 10(12) electron volts and are bright sources of very-high-energy (VHE) gamma-ray emission, it is not yet known where the VHE emission originates. Here we report on radio and VHE observations of the radio galaxy Messier 87, revealing a period of extremely strong VHE gamma-ray flares accompanied by a strong increase of the radio flux from its nucleus. These results imply that charged particles are accelerated to very high energies in the immediate vicinity of the black hole.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉VERITAS Collaboration -- VLBA 43 GHz M87 Monitoring Team -- H.E.S.S. Collaboration -- MAGIC Collaboration -- Acciari, V A -- Aliu, E -- Arlen, T -- Bautista, M -- Beilicke, M -- Benbow, W -- Bradbury, S M -- Buckley, J H -- Bugaev, V -- Butt, Y -- Byrum, K -- Cannon, A -- Celik, O -- Cesarini, A -- Chow, Y C -- Ciupik, L -- Cogan, P -- Cui, W -- Dickherber, R -- Fegan, S J -- Finley, J P -- Fortin, P -- Fortson, L -- Furniss, A -- Gall, D -- Gillanders, G H -- Grube, J -- Guenette, R -- Gyuk, G -- Hanna, D -- Holder, J -- Horan, D -- Hui, C M -- Humensky, T B -- Imran, A -- Kaaret, P -- Karlsson, N -- Kieda, D -- Kildea, J -- Konopelko, A -- Krawczynski, H -- Krennrich, F -- Lang, M J -- LeBohec, S -- Maier, G -- McCann, A -- McCutcheon, M -- Millis, J -- Moriarty, P -- Ong, R A -- Otte, A N -- Pandel, D -- Perkins, J S -- Petry, D -- Pohl, M -- Quinn, J -- Ragan, K -- Reyes, L C -- Reynolds, P T -- Roache, E -- Rose, H J -- Schroedter, M -- Sembroski, G H -- Smith, A W -- Swordy, S P -- Theiling, M -- Toner, J A -- Varlotta, A -- Vincent, S -- Wakely, S P -- Ward, J E -- Weekes, T C -- Weinstein, A -- Williams, D A -- Wissel, S -- Wood, M -- Walker, R C -- Davies, F -- Hardee, P E -- Junor, W -- Ly, C -- Aharonian, F -- Akhperjanian, A G -- Anton, G -- Barres de Almeida, U -- Bazer-Bachi, A R -- Becherini, Y -- Behera, B -- Bernlohr, K -- Bochow, A -- Boisson, C -- Bolmont, J -- Borrel, V -- Brucker, J -- Brun, F -- Brun, P -- Buhler, R -- Bulik, T -- Busching, I -- Boutelier, T -- Chadwick, P M -- Charbonnier, A -- Chaves, R C G -- Cheesebrough, A -- Chounet, L-M -- Clapson, A C -- Coignet, G -- Dalton, M -- Daniel, M K -- Davids, I D -- Degrange, B -- Deil, C -- Dickinson, H J -- Djannati-Atai, A -- Domainko, W -- Drury, L O'C -- Dubois, F -- Dubus, G -- Dyks, J -- Dyrda, M -- Egberts, K -- Emmanoulopoulos, D -- Espigat, P -- Farnier, C -- Feinstein, F -- Fiasson, A -- Forster, A -- Fontaine, G -- Fussling, M -- Gabici, S -- Gallant, Y A -- Gerard, L -- Gerbig, D -- Giebels, B -- Glicenstein, J F -- Gluck, B -- Goret, P -- Gohring, D -- Hauser, D -- Hauser, M -- Heinz, S -- Heinzelmann, G -- Henri, G -- Hermann, G -- Hinton, J A -- Hoffmann, A -- Hofmann, W -- Holleran, M -- Hoppe, S -- Horns, D -- Jacholkowska, A -- de Jager, O C -- Jahn, C -- Jung, I -- Katarzynski, K -- Katz, U -- Kaufmann, S -- Kendziorra, E -- Kerschhaggl, M -- Khangulyan, D -- Khelifi, B -- Keogh, D -- Kluzniak, W -- Kneiske, T -- Komin, Nu -- Kosack, K -- Lamanna, G -- Lenain, J-P -- Lohse, T -- Marandon, V -- Martin, J M -- Martineau-Huynh, O -- Marcowith, A -- Maurin, D -- McComb, T J L -- Medina, M C -- Moderski, R -- Moulin, E -- Naumann-Godo, M -- de Naurois, M -- Nedbal, D -- Nekrassov, D -- Nicholas, B -- Niemiec, J -- Nolan, S J -- Ohm, S -- Olive, J-F -- de Ona Wilhelmi, E -- Orford, K J -- Ostrowski, M -- Panter, M -- Paz Arribas, M -- Pedaletti, G -- Pelletier, G -- Petrucci, P-O -- Pita, S -- Puhlhofer, G -- Punch, M -- Quirrenbach, A -- Raubenheimer, B C -- Raue, M -- Rayner, S M -- Renaud, M -- Rieger, F -- Ripken, J -- Rob, L -- Rosier-Lees, S -- Rowell, G -- Rudak, B -- Rulten, C B -- Ruppel, J -- Sahakian, V -- Santangelo, A -- Schlickeiser, R -- Schock, F M -- Schroder, R -- Schwanke, U -- Schwarzburg, S -- Schwemmer, S -- Shalchi, A -- Sikora, M -- Skilton, J L -- Sol, H -- Spangler, D -- Stawarz, L -- Steenkamp, R -- Stegmann, C -- Stinzing, F -- Superina, G -- Szostek, A -- Tam, P H -- Tavernet, J-P -- Terrier, R -- Tibolla, O -- Tluczykont, M -- van Eldik, C -- Vasileiadis, G -- Venter, C -- Venter, L -- Vialle, J P -- Vincent, P -- Vivier, M -- Volk, H J -- Volpe, F -- Wagner, S J -- Ward, M -- Zdziarski, A A -- Zech, A -- Anderhub, H -- Antonelli, L A -- Antoranz, P -- Backes, M -- Baixeras, C -- Balestra, S -- Barrio, J A -- Bastieri, D -- Becerra Gonzalez, J -- Becker, J K -- Bednarek, W -- Berger, K -- Bernardini, E -- Biland, A -- Bock, R K -- Bonnoli, G -- Bordas, P -- Borla Tridon, D -- Bosch-Ramon, V -- Bose, D -- Braun, I -- Bretz, T -- Britvitch, I -- Camara, M -- Carmona, E -- Commichau, S -- Contreras, J L -- Cortina, J -- Costado, M T -- Covino, S -- Curtef, V -- Dazzi, F -- De Angelis, A -- De Cea del Pozo, E -- Delgado Mendez, C -- De los Reyes, R -- De Lotto, B -- De Maria, M -- De Sabata, F -- Dominguez, A -- Dorner, D -- Doro, M -- Elsaesser, D -- Errando, M -- Ferenc, D -- Fernandez, E -- Firpo, R -- Fonseca, M V -- Font, L -- Galante, N -- Garcia Lopez, R J -- Garczarczyk, M -- Gaug, M -- Goebel, F -- Hadasch, D -- Hayashida, M -- Herrero, A -- Hildebrand, D -- Hohne-Monch, D -- Hose, J -- Hsu, C C -- Jogler, T -- Kranich, D -- La Barbera, A -- Laille, A -- Leonardo, E -- Lindfors, E -- Lombardi, S -- Longo, F -- Lopez, M -- Lorenz, E -- Majumdar, P -- Maneva, G -- Mankuzhiyil, N -- Mannheim, K -- Maraschi, L -- Mariotti, M -- Martinez, M -- Mazin, D -- Meucci, M -- Miranda, J M -- Mirzoyan, R -- Miyamoto, H -- Moldon, J -- Moles, M -- Moralejo, A -- Nieto, D -- Nilsson, K -- Ninkovic, J -- Oya, I -- Paoletti, R -- Paredes, J M -- Pasanen, M -- Pascoli, D -- Pauss, F -- Pegna, R G -- Perez-Torres, M A -- Persic, M -- Peruzzo, L -- Prada, F -- Prandini, E -- Puchades, N -- Reichardt, I -- Rhode, W -- Ribo, M -- Rico, J -- Rissi, M -- Robert, A -- Rugamer, S -- Saggion, A -- Saito, T Y -- Salvati, M -- Sanchez-Conde, M -- Satalecka, K -- Scalzotto, V -- Scapin, V -- Schweizer, T -- Shayduk, M -- Shore, S N -- Sidro, N -- Sierpowska-Bartosik, A -- Sillanpaa, A -- Sitarek, J -- Sobczynska, D -- Spanier, F -- Stamerra, A -- Stark, L S -- Takalo, L -- Tavecchio, F -- Temnikov, P -- Tescaro, D -- Teshima, M -- Torres, D F -- Turini, N -- Vankov, H -- Wagner, R M -- Zabalza, V -- Zandanel, F -- Zanin, R -- Zapatero, J -- New York, N.Y. -- Science. 2009 Jul 24;325(5939):444-8. doi: 10.1126/science.1175406. Epub 2009 Jul 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574351" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2011-01-08
    Description: A young and energetic pulsar powers the well-known Crab Nebula. Here, we describe two separate gamma-ray (photon energy greater than 100 mega-electron volts) flares from this source detected by the Large Area Telescope on board the Fermi Gamma-ray Space Telescope. The first flare occurred in February 2009 and lasted approximately 16 days. The second flare was detected in September 2010 and lasted approximately 4 days. During these outbursts, the gamma-ray flux from the nebula increased by factors of four and six, respectively. The brevity of the flares implies that the gamma rays were emitted via synchrotron radiation from peta-electron-volt (10(15) electron volts) electrons in a region smaller than 1.4 x 10(-2) parsecs. These are the highest-energy particles that can be associated with a discrete astronomical source, and they pose challenges to particle acceleration theory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Allafort, A -- Baldini, L -- Ballet, J -- Barbiellini, G -- Bastieri, D -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bouvier, A -- Brandt, T J -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Buehler, R -- Buson, S -- Caliandro, G A -- Cameron, R A -- Cannon, A -- Caraveo, P A -- Casandjian, J M -- Celik, O -- Charles, E -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Costamante, L -- Cutini, S -- D'Ammando, F -- Dermer, C D -- de Angelis, A -- de Luca, A -- de Palma, F -- Digel, S W -- do Couto e Silva, E -- Drell, P S -- Drlica-Wagner, A -- Dubois, R -- Dumora, D -- Favuzzi, C -- Fegan, S J -- Ferrara, E C -- Focke, W B -- Fortin, P -- Frailis, M -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giglietto, N -- Giordano, F -- Giroletti, M -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guiriec, S -- Hadasch, D -- Hanabata, Y -- Harding, A K -- Hayashi, K -- Hayashida, M -- Hays, E -- Horan, D -- Itoh, R -- Johannesson, G -- Johnson, A S -- Johnson, T J -- Khangulyan, D -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kerr, M -- Knodlseder, J -- Kuss, M -- Lande, J -- Latronico, L -- Lee, S-H -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lubrano, P -- Madejski, G M -- Makeev, A -- Marelli, M -- Mazziotta, M N -- McEnery, J E -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Naumann-Godo, M -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohsugi, T -- Okumura, A -- Omodei, N -- Ormes, J F -- Ozaki, M -- Paneque, D -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Pierbattista, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Ray, P S -- Razzano, M -- Reimer, A -- Reimer, O -- Reposeur, T -- Ritz, S -- Romani, R W -- Sadrozinski, H F-W -- Sanchez, D -- Saz Parkinson, P M -- Scargle, J D -- Schalk, T L -- Sgro, C -- Siskind, E J -- Smith, P D -- Spandre, G -- Spinelli, P -- Strickman, M S -- Suson, D J -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Thayer, J B -- Thompson, D J -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Troja, E -- Uchiyama, Y -- Vandenbroucke, J -- Vasileiou, V -- Vianello, G -- Vitale, V -- Wang, P -- Wood, K S -- Yang, Z -- Ziegler, M -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):739-42. doi: 10.1126/science.1199705. Epub 2011 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Research Council Research Associate, National Academy of Sciences, Washington, DC 20001, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212321" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Sonja I. Berndt; Nicola J. Camp; Christine F. Skibola; Joseph Vijai; Zhaoming Wang; Jian Gu; Alexandra Nieters; Rachel S. Kelly; Karin E. Smedby; Alain Monnereau; Wendy Cozen; Angela Cox; Sophia S. Wang; Qing Lan; Lauren R. Teras; Moara Machado; Meredith Yeager; Angela R. Brooks-Wilson; Patricia Hartge; Mark P. Purdue; Brenda M. Birmann; Claire M. Vajdic; Pierluigi Cocco; Yawei Zhang; Graham G. Giles; Anne Zeleniuch-Jacquotte; Charles Lawrence; Rebecca Montalvan; Laurie Burdett; Amy Hutchinson; Yuanqing Ye; Timothy G. Call; Tait D. Shanafelt; Anne J. Novak; Neil E. Kay; Mark Liebow; Julie M. Cunningham; Cristine Allmer; Henrik Hjalgrim; Hans-Olov Adami; Mads Melbye; Bengt Glimelius; Ellen T. Chang; Martha Glenn; Karen Curtin; Lisa A. Cannon-Albright; W Ryan Diver; Brian K. Link; George J. Weiner; Lucia Conde; Paige M. Bracci; Jacques Riby; Donna K. Arnett; Degui Zhi; Justin M. Leach; Elizabeth A. Holly; Rebecca D. Jackson; Lesley F. Tinker; Yolanda Benavente; Núria Sala; Delphine Casabonne; Nikolaus Becker; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; Kari G. Chaffee; Sara J. Achenbach; Celine M. Vachon; Lynn R. Goldin; Sara S. Strom; Jose F. Leis; J. Brice Weinberg; Neil E. Caporaso; Aaron D. Norman; Anneclaire J. De Roos; Lindsay M. Morton; Richard K. Severson; Elio Riboli; Paolo Vineis; Rudolph Kaaks; Giovanna Masala; Elisabete Weiderpass; María- Dolores Chirlaque; Roel C. H. Vermeulen; Ruth C. Travis; Melissa C. Southey; Roger L. Milne; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Jacqueline Clavel; Tongzhang Zheng; Theodore R. Holford; Danylo J. Villano; Ann Maria; John J. Spinelli; Randy D. Gascoyne; Joseph M. Connors; Kimberly A. Bertrand; Edward Giovannucci; Peter Kraft; Anne Kricker; Jenny Turner; Maria Grazia Ennas; Giovanni M. Ferri; Lucia Miligi; Liming Liang; Baoshan Ma; Jinyan Huang; Simon Crouch; Ju-Hyun Park; Nilanjan Chatterjee; Kari E. North; John A. Snowden; Josh Wright; Joseph F. Fraumeni; Kenneth Offit; Xifeng Wu; Silvia de Sanjose; James R. Cerhan; Stephen J. Chanock; Nathaniel Rothman; Susan L. Slager
    Springer Nature
    Publication Date: 2016-03-11
    Description: Article Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES , SERPINB6 and LPP associated with risk of this disease. Nature Communications doi: 10.1038/ncomms10933 Authors: Sonja I. Berndt, Nicola J. Camp, Christine F. Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, Rachel S. Kelly, Karin E. Smedby, Alain Monnereau, Wendy Cozen, Angela Cox, Sophia S. Wang, Qing Lan, Lauren R. Teras, Moara Machado, Meredith Yeager, Angela R. Brooks-Wilson, Patricia Hartge, Mark P. Purdue, Brenda M. Birmann, Claire M. Vajdic, Pierluigi Cocco, Yawei Zhang, Graham G. Giles, Anne Zeleniuch-Jacquotte, Charles Lawrence, Rebecca Montalvan, Laurie Burdett, Amy Hutchinson, Yuanqing Ye, Timothy G. Call, Tait D. Shanafelt, Anne J. Novak, Neil E. Kay, Mark Liebow, Julie M. Cunningham, Cristine Allmer, Henrik Hjalgrim, Hans-Olov Adami, Mads Melbye, Bengt Glimelius, Ellen T. Chang, Martha Glenn, Karen Curtin, Lisa A. Cannon-Albright, W Ryan Diver, Brian K. Link, George J. Weiner, Lucia Conde, Paige M. Bracci, Jacques Riby, Donna K. Arnett, Degui Zhi, Justin M. Leach, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yolanda Benavente, Núria Sala, Delphine Casabonne, Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, Kari G. Chaffee, Sara J. Achenbach, Celine M. Vachon, Lynn R. Goldin, Sara S. Strom, Jose F. Leis, J. Brice Weinberg, Neil E. Caporaso, Aaron D. Norman, Anneclaire J. De Roos, Lindsay M. Morton, Richard K. Severson, Elio Riboli, Paolo Vineis, Rudolph Kaaks, Giovanna Masala, Elisabete Weiderpass, María- Dolores Chirlaque, Roel C. H. Vermeulen, Ruth C. Travis, Melissa C. Southey, Roger L. Milne, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Jacqueline Clavel, Tongzhang Zheng, Theodore R. Holford, Danylo J. Villano, Ann Maria, John J. Spinelli, Randy D. Gascoyne, Joseph M. Connors, Kimberly A. Bertrand, Edward Giovannucci, Peter Kraft, Anne Kricker, Jenny Turner, Maria Grazia Ennas, Giovanni M. Ferri, Lucia Miligi, Liming Liang, Baoshan Ma, Jinyan Huang, Simon Crouch, Ju-Hyun Park, Nilanjan Chatterjee, Kari E. North, John A. Snowden, Josh Wright, Joseph F. Fraumeni, Kenneth Offit, Xifeng Wu, Silvia de Sanjose, James R. Cerhan, Stephen J. Chanock, Nathaniel Rothman, Susan L. Slager
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
    Publication Date: 2011-10-08
    Description: We report the detection of pulsed gamma rays from the Crab pulsar at energies above 100 giga-electron volts (GeV) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) array of atmospheric Cherenkov telescopes. The detection cannot be explained on the basis of current pulsar models. The photon spectrum of pulsed emission between 100 mega-electron volts and 400 GeV is described by a broken power law that is statistically preferred over a power law with an exponential cutoff. It is unlikely that the observation can be explained by invoking curvature radiation as the origin of the observed gamma rays above 100 GeV. Our findings require that these gamma rays be produced more than 10 stellar radii from the neutron star.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉VERITAS Collaboration -- Aliu, E -- Arlen, T -- Aune, T -- Beilicke, M -- Benbow, W -- Bouvier, A -- Bradbury, S M -- Buckley, J H -- Bugaev, V -- Byrum, K -- Cannon, A -- Cesarini, A -- Christiansen, J L -- Ciupik, L -- Collins-Hughes, E -- Connolly, M P -- Cui, W -- Dickherber, R -- Duke, C -- Errando, M -- Falcone, A -- Finley, J P -- Finnegan, G -- Fortson, L -- Furniss, A -- Galante, N -- Gall, D -- Gibbs, K -- Gillanders, G H -- Godambe, S -- Griffin, S -- Grube, J -- Guenette, R -- Gyuk, G -- Hanna, D -- Holder, J -- Huan, H -- Hughes, G -- Hui, C M -- Humensky, T B -- Imran, A -- Kaaret, P -- Karlsson, N -- Kertzman, M -- Kieda, D -- Krawczynski, H -- Krennrich, F -- Lang, M J -- Lyutikov, M -- Madhavan, A S -- Maier, G -- Majumdar, P -- McArthur, S -- McCann, A -- McCutcheon, M -- Moriarty, P -- Mukherjee, R -- Nunez, P -- Ong, R A -- Orr, M -- Otte, A N -- Park, N -- Perkins, J S -- Pizlo, F -- Pohl, M -- Prokoph, H -- Quinn, J -- Ragan, K -- Reyes, L C -- Reynolds, P T -- Roache, E -- Rose, H J -- Ruppel, J -- Saxon, D B -- Schroedter, M -- Sembroski, G H -- Senturk, G D -- Smith, A W -- Staszak, D -- Tesic, G -- Theiling, M -- Thibadeau, S -- Tsurusaki, K -- Tyler, J -- Varlotta, A -- Vassiliev, V V -- Vincent, S -- Vivier, M -- Wakely, S P -- Ward, J E -- Weekes, T C -- Weinstein, A -- Weisgarber, T -- Williams, D A -- Zitzer, B -- New York, N.Y. -- Science. 2011 Oct 7;334(6052):69-72. doi: 10.1126/science.1208192.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21980105" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2014-03-06
    Description: The Glenlivet gas field was discovered in 2009 with well 214/30a-2, drilled to test a seismically defined stratigraphic and faulted closure at intra-Tertiary level. A sequence of gas-bearing Vaila Formation sands was penetrated comprising high-density turbidite flows with excellent reservoir properties. The discovery was immediately appraised by two sidetracks that tested the updip and downdip extent of the accumulation: the downdip location penetrated the water leg of the field. A comprehensive programme of data acquisition was carried out on all three penetrations, leading to a series of post-well studies designed to fully appraise the field. Based on post-drilling seismic interpretation and extensive analysis of the well data, a revised depositional model was formulated that allowed the construction of a robust 3D static model used in development planning.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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