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  • 1
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    Inheritance of proliferative breast disease in breast cancer kindreds (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-12-21
    Description: Previous studies have emphasized that genetic susceptibility to breast cancer is rare and is expressed primarily as premenopausal breast cancer, bilateral breast cancer, or both. Proliferative breast disease (PBD) is a significant risk factor for the development of breast cancer and appears to be a precursor lesion. PBD and breast cancer were studied in 103 women from 20 kindreds that were selected for the presence of two first degree relatives with breast cancer and in 31 control women. Physical examination, screening mammography, and four-quadrant fine-needle breast aspirates were performed. Cytologic analysis of breast aspirates revealed PBD in 35% of clinically normal female first degree relatives of breast cancer cases and in 13% of controls. Genetic analysis suggests that genetic susceptibility causes both PBD and breast cancer in these kindreds. This study supports the hypothesis that this susceptibility is responsible for a considerable portion of breast cancer, including unilateral and postmenopausal breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, M H -- Cannon-Albright, L A -- Goldgar, D E -- Ward, J H -- Marshall, C J -- Schumann, G B -- Hogle, H -- McWhorter, W P -- Wright, E C -- Tran, T D -- CA-28854/CA/NCI NIH HHS/ -- CA-42014/CA/NCI NIH HHS/ -- CA-48711/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Dec 21;250(4988):1715-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Utah Regional Cancer Center, University of Utah Medical Center, Salt Lake City 84132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2270486" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Breast Diseases/*genetics/pathology ; Breast Neoplasms/*genetics/pathology ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Menopause ; Middle Aged ; Pedigree
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Fusing and disaggregating models, data and analysis tools for a dynamic science-society interface (2014)
    Geological Society (of London)
    Details
    Publication Date: 2014-06-25
    Description: Society requires rapid, most-probable predictions for specific and/or multifaceted questions related to environmental and geological science. In principle, models that encapsulate disciplinary knowledge are useful tools for making predictions and testing theory, but academic rewards favour disciplinary specialism and a proliferation of often insufficiently tested models. Decision makers have to assess the quality and robustness of predictions for complex environmental issues, and may prefer a model that performs accurately in a case study to a more parsimonious and generalizable model. Predictive ecosystem models tend to grow, as more processes are considered, even when a simpler model may be more appropriate and give results that are easier to interpret within a policy-relevant timeframe. Model fusion provides a practical way to combine knowledge from different disciplines, but can accelerate model growth. How then can we facilitate the evolution of useful predictive models? Coherent design is essential. When combining models it is often necessary to resolve overlapping scope, so tools need to allow for the disaggregation of model implementations as well as their fusion. Modelling software and integration frameworks can help resolve technical constraints, but to make models useful and used it is essential to involve stakeholders in their design and interpretation.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society (of London)
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  • 3
    Electronic Resource
    Electronic Resource
    Carbohydrate Composition of Wort and the Biochemistry of Fermentation (1951)
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 560-561 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In Fig. 1 the qualitative results of a top-fermentation of a pale ale infusion wort are shown. In addition to the sugars maltose, sucrose, glucose and fructose, two other unknown reducing sugars were discovered to be present. These we have labelled tentatively substances A and B. No evidence for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/167560a0
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  • 4
    Electronic Resource
    Electronic Resource
    Discussion - "Chromium and Its Alloys" (1936)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 28 (1936), S. 1387-1387 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50324a009
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  • 5
    Electronic Resource
    Electronic Resource
    Nicotinic Acid in Sugary and Starchy Maize (1946)
    [s.l.] : Nature Publishing Group
    Nature 157 (1946), S. 109-110 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN 1944 Barton-Wright1 reported the nicotinic acid contents (expressed in µgm./gm.) of the grain of a number of cereals, including eleven strains (varieties and hybrids) of maize. Four of the eleven were sweet corns grown in Britain, and the other seven flint corns of various origins. It appeared ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/157109a0
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  • 6
    Electronic Resource
    Electronic Resource
    New Components of the Vitamin B Complex (1944)
    [s.l.] : Nature Publishing Group
    Nature 153 (1944), S. 771-771 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AN attempt to prepare a concentrate of folic acid from liver by the method of Hutchings et al.1 resulted, as already noted in a recent review2, in the preparation of a fraction probably containing folic acid, together with another fraction soluble in chloroform, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/153771a0
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of Barley from King Tuthankhamen's Tomb (1944)
    [s.l.] : Nature Publishing Group
    Nature 153 (1944), S. 288-288 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THROUGH the kindness of Mr. J. Philp, chief botanist of the Ministry of Agriculture, Egypt, we recently obtained a small sample of ancient Egyptian barley from the Museum of Antiquities, Cairo, which came originally from the tomb of Tuthankhamen (c. 1350 B.C.). The barley is extensively ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/153288b0
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  • 8
    Electronic Resource
    Electronic Resource
    Riboflavin and Vitamin B 1 in Nineteenth Century Buns and Ale (1943)
    [s.l.] : Nature Publishing Group
    Nature 152 (1943), S. 273-273 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECENTLY, one of us (H.S.S.) was presented by Mr. H. W. Hedges, of Fairford, Gloucester, with two currant buns; one was baked in 1863 to celebrate the wedding of the Prince of Wales and the other in 1887 for Queen Victoria's jubilee. Both had been kept as souvenirs of the “Cakes and Ales” ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/152273a0
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  • 9
    Electronic Resource
    Electronic Resource
    Microbiological Assay of Amino-Acids with Leuconostoc mesenteroides P.60 (1946)
    [s.l.] : Nature Publishing Group
    Nature 157 (1946), S. 628-628 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DUNN et al.1,2,3 have described four different media, varying in their amino-acid contents, for the microbiological assay of amino-acids by means of the lactic organism Leuconostoc mesenteroides P.60, and consider that one of these media (medium D) is suitable for the assay of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/157628a0
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  • 10
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    Analysis of Barley from King Tuthankhamen's Tomb (1944)
    Springer Nature
    Details
    Publication Date: 1944-03-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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