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  • 1
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    Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns. The representation of each odor by activity patterns across the MC population thus changes continuously throughout a stimulus, in an odor-specific manner. In the zebrafish OB, we found that this distributed temporal patterning progressively reduced the similarity between ensemble representations of related odors, thereby making each odor's representation more specific over time. The tuning of individual MCs was not sharpened during this process. Hence, the individual responses of MCs did not become more specific, but the odor-coding MC assemblies changed such that their overlap decreased. This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedrich, R W -- Laurent, G -- New York, N.Y. -- Science. 2001 Feb 2;291(5505):889-94.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, Division of Biology, MC 139-74, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11157170" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids ; Animals ; Dendrites/physiology ; In Vitro Techniques ; Interneurons/physiology ; Membrane Potentials ; Neural Conduction ; Neural Inhibition ; Neurons/physiology ; *Odors ; Olfactory Bulb/*cytology/*physiology ; Olfactory Pathways/physiology ; Olfactory Receptor Neurons/physiology ; Patch-Clamp Techniques ; Receptors, Odorant/physiology ; Smell/*physiology ; Time Factors ; Zebrafish
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Olfactory pattern classification by discrete neuronal network states (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-16
    Description: The categorial nature of sensory, cognitive and behavioural acts indicates that the brain classifies neuronal activity patterns into discrete representations. Pattern classification may be achieved by abrupt switching between discrete activity states of neuronal circuits, but few experimental studies have directly tested this. We gradually varied the concentration or molecular identity of odours and optically measured responses across output neurons of the olfactory bulb in zebrafish. Whereas population activity patterns were largely insensitive to changes in odour concentration, morphing of one odour into another resulted in abrupt transitions between odour representations. These transitions were mediated by coordinated response changes among small neuronal ensembles rather than by shifts in the global network state. The olfactory bulb therefore classifies odour-evoked input patterns into many discrete and defined output patterns, as proposed by attractor models. This computation is consistent with perceptual phenomena and may represent a general information processing strategy in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niessing, Jorn -- Friedrich, Rainer W -- England -- Nature. 2010 May 6;465(7294):47-52. doi: 10.1038/nature08961. Epub 2010 Apr 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, Maulbeerstr. 66, CH-4058 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393466" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Nerve Net/*physiology ; Odors ; Olfactory Bulb/*physiology ; Sensation/*physiology ; Zebrafish/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    NompC TRP channel required for vertebrate sensory hair cell mechanotransduction (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-14
    Description: The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sidi, Samuel -- Friedrich, Rainer W -- Nicolson, Teresa -- New York, N.Y. -- Science. 2003 Jul 4;301(5629):96-9. Epub 2003 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Entwicklungsbiologie, Spemannstrasse 35, 72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12805553" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cochlear Microphonic Potentials ; Computational Biology ; Deafness ; Ear, Inner/embryology ; Endocytosis ; Gene Expression ; Hair Cells, Auditory/*physiology ; Hearing ; In Situ Hybridization ; Ion Channels/chemistry/genetics/*physiology ; *Mechanotransduction, Cellular ; Molecular Sequence Data ; Oligonucleotides, Antisense ; Phenotype ; Phylogeny ; Postural Balance ; Reflex, Startle ; Reverse Transcriptase Polymerase Chain Reaction ; Transient Receptor Potential Channels ; Zebrafish ; Zebrafish Proteins/chemistry/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Neuronal filtering of multiplexed odour representations (2011)
    Nature Publishing Group (NPG)
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    Publication Date: 2011-11-15
    Description: Neuronal activity patterns contain information in their temporal structure, indicating that information transfer between neurons may be optimized by temporal filtering. In the zebrafish olfactory bulb, subsets of output neurons (mitral cells) engage in synchronized oscillations during odour responses, but information about odour identity is contained mostly in non-oscillatory firing rate patterns. Using optogenetic manipulations and odour stimulation, we found that firing rate responses of neurons in the posterior zone of the dorsal telencephalon (Dp), a target area homologous to olfactory cortex, were largely insensitive to oscillatory synchrony of mitral cells because passive membrane properties and synaptic currents act as low-pass filters. Nevertheless, synchrony influenced spike timing. Moreover, Dp neurons responded primarily during the decorrelated steady state of mitral cell activity patterns. Temporal filtering therefore tunes Dp neurons to components of mitral cell activity patterns that are particularly informative about precise odour identity. These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blumhagen, Francisca -- Zhu, Peixin -- Shum, Jennifer -- Scharer, Yan-Ping Zhang -- Yaksi, Emre -- Deisseroth, Karl -- Friedrich, Rainer W -- England -- Nature. 2011 Nov 13;479(7374):493-8. doi: 10.1038/nature10633.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22080956" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Models, Neurological ; Neurons/*physiology ; Odors/*analysis ; Olfactory Bulb/*cytology/*physiology ; Olfactory Pathways/physiology ; Photic Stimulation ; Physical Stimulation ; Time Factors ; Zebrafish/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Amygdala interneuron subtypes control fear learning through disinhibition (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-05-13
    Description: Learning is mediated by experience-dependent plasticity in neuronal circuits. Activity in neuronal circuits is tightly regulated by different subtypes of inhibitory interneurons, yet their role in learning is poorly understood. Using a combination of in vivo single-unit recordings and optogenetic manipulations, we show that in the mouse basolateral amygdala, interneurons expressing parvalbumin (PV) and somatostatin (SOM) bidirectionally control the acquisition of fear conditioning--a simple form of associative learning--through two distinct disinhibitory mechanisms. During an auditory cue, PV(+) interneurons are excited and indirectly disinhibit the dendrites of basolateral amygdala principal neurons via SOM(+) interneurons, thereby enhancing auditory responses and promoting cue-shock associations. During an aversive footshock, however, both PV(+) and SOM(+) interneurons are inhibited, which boosts postsynaptic footshock responses and gates learning. These results demonstrate that associative learning is dynamically regulated by the stimulus-specific activation of distinct disinhibitory microcircuits through precise interactions between different subtypes of local interneurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolff, Steffen B E -- Grundemann, Jan -- Tovote, Philip -- Krabbe, Sabine -- Jacobson, Gilad A -- Muller, Christian -- Herry, Cyril -- Ehrlich, Ingrid -- Friedrich, Rainer W -- Letzkus, Johannes J -- Luthi, Andreas -- England -- Nature. 2014 May 22;509(7501):453-8. doi: 10.1038/nature13258. Epub 2014 May 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland [2] University of Basel, 4000 Basel, Switzerland [3]. ; 1] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland [2]. ; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. ; INSERM U862, Neurocentre Magendie, 146 rue Leo Saignat, 33077 Bordeaux, France. ; Hertie Institute for Clinical Brain Research, 72076 Tubingen, Germany. ; 1] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland [2] Max-Planck Institute for Brain Research, 60438 Frankfurt, Germany. [3].〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24814341" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*cytology/*physiology ; Animals ; Conditioning, Classical ; Electroshock ; Fear/*physiology ; Hindlimb ; *Inhibition (Psychology) ; Interneurons/*metabolism ; Learning/*physiology ; Male ; Mice ; Optogenetics ; Parvalbumins/metabolism ; Somatostatin/metabolism ; Synapses/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Neurobiology: Individuality sniffed out in flies (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-09-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frank, Thomas -- Friedrich, Rainer W -- England -- Nature. 2015 Oct 8;526(7572):200-1. doi: 10.1038/nature15636. Epub 2015 Sep 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland. ; University of Basel, Basel 4003, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26416743" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
    Electronic Resource
    Electronic Resource
    Visual control of wing beat frequency in Drosophila (1994)
    Springer
    Journal of comparative physiology 175 (1994), S. 587-596 
    Details
    ISSN: 1432-1351
    Keywords: Wing beat frequency ; Optomotor responses ; Landing response ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The present study shows that the wing beat frequency of Drosophila is visually controlled and modulated in response to different optomotor stimuli. Whereas rotational large field stimuli do not appear to modulate wing beat frequency, single rotating vertical stripes increase or decrease wing beat frequency when moving back-to-front or front-to-back, respectively. Maximal modulations occur at lateral stripe positions. Expansion stimuli eliciting the landing response cause a marked increase in wing beat frequency. Parameters of this frequency response depend in a graded fashion on certain stimulus properties, and the frequency response co-habituates with the landing response. Several results indicate that the frequency response is an integral component of the landing response, although it can also occur when the characteristic front leg extension is not observed. The complex spatial input integration underlying the frequency response and other motor components of the landing response cannot easily be explained by a system of large field integration units, but might indicate the existence of local expansion detectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199480
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