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  • 1
    Publication Date: 2014-03-21
    Description: The Crab nebula pulsar was observed in 2009 January and December with a novel very fast optical photon counter, Iqueye, mounted at the ESO 3.5 m New Technology Telescope. Thanks to the exquisite quality of the Iqueye data, we computed accurate phase coherent timing solutions for the two observing runs and over the entire year 2009. Our statistical uncertainty on the determination of the phase of the main pulse and the rotational period of the pulsar for short (a few days) time intervals are 1 μs and ~0.5 ps, respectively. Comparison with the Jodrell Bank radio ephemerides shows that the optical pulse leads the radio one by ~ 240 μs in January and ~ 160 μs in December, in agreement with a number of other measurements performed after 1996. A third-order polynomial fit adequately describes the spin-down for the 2009 January plus December optical observations. The phase noise is consistent with being Gaussian distributed with a dispersion of 15 μs in most observations, in agreement with theoretical expectations for photon noise-induced phase variability.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 2
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    In:  Phys. Earth Plan. Int., Potsdam, ZIPE, vol. 153, no. 4, pp. 175-180, pp. 2156, (ISBN: 0-12-018847-3)
    Publication Date: 2005
    Keywords: Aftershocks ; Earthquake ; Statistical investigations ; Seismicity ; power ; law ; decay ; PEPI ; Seismicity ; Earthquake ; Precursors ; Non-linear effects ; Least-squares
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  • 3
    Publication Date: 2018
    Print ISSN: 1097-6256
    Electronic ISSN: 1546-1726
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 4
    Publication Date: 2016-08-20
    Description: Author(s): J. Sperling, T. J. Bartley, G. Donati, M. Barbieri, X.-M. Jin, A. Datta, W. Vogel, and I. A. Walmsley We study, in theory and experiment, the quantum properties of correlated light fields measured with click-counting detectors providing incomplete information on the photon statistics. We establish a correlation parameter for the conditional statistics, and we derive the corresponding nonclassicality… [Phys. Rev. Lett. 117, 083601] Published Fri Aug 19, 2016
    Keywords: Atomic, Molecular, and Optical Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 5
    Publication Date: 2008-09-12
    Description: Cell growth and proliferation require coordinated ribosomal biogenesis and translation. Eukaryotic initiation factors (eIFs) control translation at the rate-limiting step of initiation. So far, only two eIFs connect extracellular stimuli to global translation rates: eIF4E acts in the eIF4F complex and regulates binding of capped messenger RNA to 40S subunits, downstream of growth factors, and eIF2 controls loading of the ternary complex on the 40S subunit and is inhibited on stress stimuli. No eIFs have been found to link extracellular stimuli to the activity of the large 60S ribosomal subunit. eIF6 binds 60S ribosomes precluding ribosome joining in vitro. However, studies in yeasts showed that eIF6 is required for ribosome biogenesis rather than translation. Here we show that mammalian eIF6 is required for efficient initiation of translation, in vivo. eIF6 null embryos are lethal at preimplantation. Heterozygous mice have 50% reduction of eIF6 levels in all tissues, and show reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression. eIF6(+/-) cells retain sufficient nucleolar eIF6 and normal ribosome biogenesis. The liver of eIF6(+/-) mice displays an increase of 80S in polysomal profiles, indicating a defect in initiation of translation. Consistently, isolated hepatocytes have impaired insulin-stimulated translation. Heterozygous mouse embryonic fibroblasts recapitulate the organism phenotype and have normal ribosome biogenesis, reduced insulin-stimulated translation, and delayed G1/S phase progression. Furthermore, eIF6(+/-) cells are resistant to oncogene-induced transformation. Thus, eIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753212/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753212/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gandin, Valentina -- Miluzio, Annarita -- Barbieri, Anna Maria -- Beugnet, Anne -- Kiyokawa, Hiroaki -- Marchisio, Pier Carlo -- Biffo, Stefano -- GGP05043/Telethon/Italy -- R01/PHS HHS/ -- R01 CA112282/CA/NCI NIH HHS/ -- R01 CA112282-04/CA/NCI NIH HHS/ -- England -- Nature. 2008 Oct 2;455(7213):684-8. doi: 10.1038/nature07267. Epub 2008 Sep 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18784653" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/cytology ; Animals ; Body Weight ; Cell Division/drug effects ; Cell Nucleolus/metabolism ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Cytoplasm/metabolism ; Fibroblasts ; G1 Phase/drug effects ; Heterozygote ; Insulin/pharmacology ; Liver/cytology/growth & development ; Mice ; NIH 3T3 Cells ; Oncogenes/genetics ; *Peptide Chain Initiation, Translational/drug effects ; Peptide Initiation Factors/deficiency/genetics/*metabolism ; Ribosomes/chemistry/metabolism ; *S Phase/drug effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2010-03-20
    Description: Of the over 400 known exoplanets, there are about 70 planets that transit their central star, a situation that permits the derivation of their basic parameters and facilitates investigations of their atmospheres. Some short-period planets, including the first terrestrial exoplanet (CoRoT-7b), have been discovered using a space mission designed to find smaller and more distant planets than can be seen from the ground. Here we report transit observations of CoRoT-9b, which orbits with a period of 95.274 days on a low eccentricity of 0.11 +/- 0.04 around a solar-like star. Its periastron distance of 0.36 astronomical units is by far the largest of all transiting planets, yielding a 'temperate' photospheric temperature estimated to be between 250 and 430 K. Unlike previously known transiting planets, the present size of CoRoT-9b should not have been affected by tidal heat dissipation processes. Indeed, the planet is found to be well described by standard evolution models with an inferred interior composition consistent with that of Jupiter and Saturn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deeg, H J -- Moutou, C -- Erikson, A -- Csizmadia, Sz -- Tingley, B -- Barge, P -- Bruntt, H -- Havel, M -- Aigrain, S -- Almenara, J M -- Alonso, R -- Auvergne, M -- Baglin, A -- Barbieri, M -- Benz, W -- Bonomo, A S -- Borde, P -- Bouchy, F -- Cabrera, J -- Carone, L -- Carpano, S -- Ciardi, D -- Deleuil, M -- Dvorak, R -- Ferraz-Mello, S -- Fridlund, M -- Gandolfi, D -- Gazzano, J-C -- Gillon, M -- Gondoin, P -- Guenther, E -- Guillot, T -- den Hartog, R -- Hatzes, A -- Hidas, M -- Hebrard, G -- Jorda, L -- Kabath, P -- Lammer, H -- Leger, A -- Lister, T -- Llebaria, A -- Lovis, C -- Mayor, M -- Mazeh, T -- Ollivier, M -- Patzold, M -- Pepe, F -- Pont, F -- Queloz, D -- Rabus, M -- Rauer, H -- Rouan, D -- Samuel, B -- Schneider, J -- Shporer, A -- Stecklum, B -- Street, R -- Udry, S -- Weingrill, J -- Wuchterl, G -- England -- Nature. 2010 Mar 18;464(7287):384-7. doi: 10.1038/nature08856.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Instituto de Astrofisica de Canarias, C. Via Lactea S/N, E-38205 La Laguna, Tenerife, Spain. hdeeg@iac.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20237564" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2012-12-22
    Description: Although universal quantum computers ideally solve problems such as factoring integers exponentially more efficiently than classical machines, the formidable challenges in building such devices motivate the demonstration of simpler, problem-specific algorithms that still promise a quantum speedup. We constructed a quantum boson-sampling machine (QBSM) to sample the output distribution resulting from the nonclassical interference of photons in an integrated photonic circuit, a problem thought to be exponentially hard to solve classically. Unlike universal quantum computation, boson sampling merely requires indistinguishable photons, linear state evolution, and detectors. We benchmarked our QBSM with three and four photons and analyzed sources of sampling inaccuracy. Scaling up to larger devices could offer the first definitive quantum-enhanced computation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spring, Justin B -- Metcalf, Benjamin J -- Humphreys, Peter C -- Kolthammer, W Steven -- Jin, Xian-Min -- Barbieri, Marco -- Datta, Animesh -- Thomas-Peter, Nicholas -- Langford, Nathan K -- Kundys, Dmytro -- Gates, James C -- Smith, Brian J -- Smith, Peter G R -- Walmsley, Ian A -- New York, N.Y. -- Science. 2013 Feb 15;339(6121):798-801. doi: 10.1126/science.1231692. Epub 2012 Dec 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. j.spring1@physics.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23258407" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2013-10-19
    Description: Stars hosting hot Jupiters are often observed to have high obliquities, whereas stars with multiple coplanar planets have been seen to have low obliquities. This has been interpreted as evidence that hot-Jupiter formation is linked to dynamical disruption, as opposed to planet migration through a protoplanetary disk. We used asteroseismology to measure a large obliquity for Kepler-56, a red giant star hosting two transiting coplanar planets. These observations show that spin-orbit misalignments are not confined to hot-Jupiter systems. Misalignments in a broader class of systems had been predicted as a consequence of torques from wide-orbiting companions, and indeed radial velocity measurements revealed a third companion in a wide orbit in the Kepler-56 system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Carter, Joshua A -- Barbieri, Mauro -- Miglio, Andrea -- Deck, Katherine M -- Fabrycky, Daniel C -- Montet, Benjamin T -- Buchhave, Lars A -- Chaplin, William J -- Hekker, Saskia -- Montalban, Josefina -- Sanchis-Ojeda, Roberto -- Basu, Sarbani -- Bedding, Timothy R -- Campante, Tiago L -- Christensen-Dalsgaard, Jorgen -- Elsworth, Yvonne P -- Stello, Dennis -- Arentoft, Torben -- Ford, Eric B -- Gilliland, Ronald L -- Handberg, Rasmus -- Howard, Andrew W -- Isaacson, Howard -- Johnson, John Asher -- Karoff, Christoffer -- Kawaler, Steven D -- Kjeldsen, Hans -- Latham, David W -- Lund, Mikkel N -- Lundkvist, Mia -- Marcy, Geoffrey W -- Metcalfe, Travis S -- Silva Aguirre, Victor -- Winn, Joshua N -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):331-4. doi: 10.1126/science.1242066.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Ames Research Center, MS 244-30, Moffett Field, CA 94035, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136961" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2015-09-30
    Description: Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene expression. As such, riboswitches serve as a novel, yet largely unexploited, class of emerging drug targets. Demonstrating this potential, however, has proven difficult and is restricted to structurally similar antimetabolites and semi-synthetic analogues of their cognate ligand, thus greatly restricting the chemical space and selectivity sought for such inhibitors. Here we report the discovery and characterization of ribocil, a highly selective chemical modulator of bacterial riboflavin riboswitches, which was identified in a phenotypic screen and acts as a structurally distinct synthetic mimic of the natural ligand, flavin mononucleotide, to repress riboswitch-mediated ribB gene expression and inhibit bacterial cell growth. Our findings indicate that non-coding RNA structural elements may be more broadly targeted by synthetic small molecules than previously expected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howe, John A -- Wang, Hao -- Fischmann, Thierry O -- Balibar, Carl J -- Xiao, Li -- Galgoci, Andrew M -- Malinverni, Juliana C -- Mayhood, Todd -- Villafania, Artjohn -- Nahvi, Ali -- Murgolo, Nicholas -- Barbieri, Christopher M -- Mann, Paul A -- Carr, Donna -- Xia, Ellen -- Zuck, Paul -- Riley, Dan -- Painter, Ronald E -- Walker, Scott S -- Sherborne, Brad -- de Jesus, Reynalda -- Pan, Weidong -- Plotkin, Michael A -- Wu, Jin -- Rindgen, Diane -- Cummings, John -- Garlisi, Charles G -- Zhang, Rumin -- Sheth, Payal R -- Gill, Charles J -- Tang, Haifeng -- Roemer, Terry -- England -- Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Merck Research Laboratories, Kenilworth, New Jersey 07033, USA. ; Merck Research Laboratories, West Point, Pennsylvania 19486, USA. ; Merck Research Laboratories, North Wales, Pennsylvania 19454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26416753" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2016-12-29
    Description: Our work focuses on the spectrophotometric analysis of selected terrain and bright patches in the Khonsu region on the comet 67P/Churyumov–Gerasimenko. Despite the variety of geological features, their spectrophotometric properties appear to indicate a similar composition. It is noticeable that the smooth areas in Khonsu possess similar spectrophotometric behaviour to some other regions of the comet. We observed bright patches on Khonsu with an estimation of 〉40 per cent of normal albedo and suggest that they are associated with H 2 O ice. One of the studied bright patches has been observed to exist on the surface for more than 5 months without a major decay of its size, implying the existence of potential sub-surface icy layers. Its location may be correlated with a cometary outburst during the perihelion passage of the comet in 2015 August, and we interpret it to have triggered the surface modifications necessary to unearth the stratified icy layers beneath the surface. A boulder analysis on Khonsu leads to a power-law index of –3.1 +0.2/–0.3 suggesting a boulder formation, shaped by varying geological processes for different morphological units.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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