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  • Articles  (71)
  • Biology  (71)
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  • Articles  (71)
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  • 1
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    Characterization of a Novel Peptide Toxin from Acanthoscurria paulensis Spider Venom: A Distinct Cysteine Assignment to the HWTX-II Family (2013)
    American Chemical Society (ACS)
    Details
    Publication Date: 2013-03-31
    Description: Biochemistry DOI: 10.1021/bi4000035
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 2
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    Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations (2012)
    Oxford University Press
    Details
    Publication Date: 2012-02-17
    Description: Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The strength of the NMD response appears to reflect multiple determinants on a target mRNA. We have previously reported that mRNAs containing PTCs in close proximity to the translation initiation codon (AUG-proximal PTCs) can substantially evade NMD. Here, we explore the mechanistic basis for this NMD resistance. We demonstrate that translation termination at an AUG-proximal PTC lacks the ribosome stalling that is evident in an NMD-sensitive PTC. This difference is associated with demonstrated interactions of the cytoplasmic poly(A)-binding protein 1, PABPC1, with the cap-binding complex subunit, eIF4G and the 40S recruitment factor eIF3 as well as the ribosome release factor, eRF3. These interactions, in combination, underlie critical 3'–5' linkage of translation initiation with efficient termination at the AUG-proximal PTC and contribute to an NMD-resistant PTC definition at an early phase of translation elongation.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Support for a colleague (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alatalo, R V -- Aragon, S -- Aviles, J M -- Barbosa, A -- Gomes, C Bessa -- Cadee, N -- Christe, P -- Cuervo, J J -- Diaz, M -- Erritzoe, J -- Galeotti, P -- Garamszegi, L Z -- Gil, D -- Gontard-Danek, M -- Legendre, S -- Martin, T E -- Martinez, J -- Martin-Vivaldi, M -- Martinez, J G -- Merino, S -- Moreno, J -- Mousseau, Tim -- Ninni, P -- Petrie, M -- Pulido, F -- Rubolini, D -- Saino, N -- Soler, J J -- Soler, M -- Spottiswoode, C -- Szep, T -- Thornhill, R -- Zamora, C -- Sacchi, Roberto -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1612.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15016981" target="_blank"〉PubMed〈/a〉
    Keywords: *Ecology ; Publishing ; *Scientific Misconduct
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-08-01
    Description: Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasis and function remain largely unknown. Here we show that the neurotrophic factor receptor RET (rearranged during transfection) drives haematopoietic stem cell survival, expansion and function. We find that haematopoietic stem cells express RET and that its neurotrophic factor partners are produced in the haematopoietic stem cell environment. Ablation of Ret leads to impaired survival and reduced numbers of haematopoietic stem cells with normal differentiation potential, but loss of cell-autonomous stress response and reconstitution potential. Strikingly, RET signals provide haematopoietic stem cells with critical Bcl2 and Bcl2l1 surviving cues, downstream of p38 mitogen-activated protein (MAP) kinase and cyclic-AMP-response element binding protein (CREB) activation. Accordingly, enforced expression of RET downstream targets, Bcl2 or Bcl2l1, is sufficient to restore the activity of Ret null progenitors in vivo. Activation of RET results in improved haematopoietic stem cell survival, expansion and in vivo transplantation efficiency. Remarkably, human cord-blood progenitor expansion and transplantation is also improved by neurotrophic factors, opening the way for exploration of RET agonists in human haematopoietic stem cell transplantation. Our work shows that neurotrophic factors are novel components of the haematopoietic stem cell microenvironment, revealing that haematopoietic stem cells and neurons are regulated by similar signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fonseca-Pereira, Diogo -- Arroz-Madeira, Silvia -- Rodrigues-Campos, Mariana -- Barbosa, Ines A M -- Domingues, Rita G -- Bento, Teresa -- Almeida, Afonso R M -- Ribeiro, Helder -- Potocnik, Alexandre J -- Enomoto, Hideki -- Veiga-Fernandes, Henrique -- England -- Nature. 2014 Oct 2;514(7520):98-101. doi: 10.1038/nature13498. Epub 2014 Jul 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz, Edificio Egas Moniz, 1649-028 Lisboa, Portugal [2]. ; Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz, Edificio Egas Moniz, 1649-028 Lisboa, Portugal. ; 1] Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK [2] Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK. ; 1] Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan [2] Graduate School of Medicine, Kobe University7-5-1 Kusunoki-cho, Chuo-ku, Kobe City, Hyogo 650-0017, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25079320" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Survival ; Cyclic AMP Response Element-Binding Protein/metabolism ; Enzyme Activation ; Female ; Hematopoiesis ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*cytology/*metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Growth Factors/*metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-ret/deficiency/genetics/*metabolism ; Signal Transduction ; Stem Cell Niche ; bcl-X Protein/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Three-color entanglement (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-19
    Description: Entanglement is an essential quantum resource for the acceleration of information processing as well as for sophisticated quantum communication protocols. Quantum information networks are expected to convey information from one place to another by using entangled light beams. We demonstrated the generation of entanglement among three bright beams of light, all of different wavelengths (532.251, 1062.102, and 1066.915 nanometers). We also observed disentanglement for finite channel losses, the continuous variable counterpart to entanglement sudden death.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coelho, A S -- Barbosa, F A S -- Cassemiro, K N -- Villar, A S -- Martinelli, M -- Nussenzveig, P -- New York, N.Y. -- Science. 2009 Nov 6;326(5954):823-6. doi: 10.1126/science.1178683. Epub 2009 Sep 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Instituto de Fisica, Universidade de Sao Paulo, Post Office Box 66318, Sao Paulo, SP 05314-970, Brazil.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19762598" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    A Route from Darkness to Light: Emergence and Evolution of Luciferase Activity in AMP-CoA-Ligases Inferred from a Mealworm Luciferase-like Enzyme (2013)
    American Chemical Society (ACS)
    Details
    Publication Date: 2013-05-31
    Description: Biochemistry DOI: 10.1021/bi400141u
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 7
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    Congenital myasthenic syndrome with mild intellectual disability caused by a recurrent SLC25A1 variant (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1018-4813
    Electronic ISSN: 1476-5438
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 8
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    Seasonality of freshwater bacterioplankton diversity in two tropical shallow lakes from the Brazilian Atlantic Forest (2016)
    Oxford University Press
    Details
    Publication Date: 2016-11-12
    Description: Bacteria are highly important for the cycling of organic and inorganic matter in freshwater environments; however, little is known about the diversity of bacterioplankton in tropical systems. Studies on carbon and nutrient cycling in tropical lakes suggest a very different seasonality from that of temperate climates. Here, we used 16S rRNA gene next-generation sequencing (NGS) to investigate seasonal changes in bacterioplankton communities of two tropical lakes, which differed in trophic status and mixing regime. Our findings revealed seasonally and depth-wise highly dynamic bacterioplankton communities. Differences in richness and structure appeared strongly related to the physicochemical characteristics of the water column, especially phosphate, pH and oxygen. Bacterioplankton communities were dominated by common taxonomic groups, such as Synechococcus and Actinobacteria acI, as well as rare and poorly characterized taxa such as ‘ Candidatus Methylacidiphilum’ (Verrucomicrobia). Stratification and oxygen depletion during the rainy season promoted the occurrence of anoxygenic phototrophic and methanotrophic bacteria important for carbon and nutrient cycling. Differences in lake mixing regime were associated with seasonal beta diversity. Our study is the first attempt to use NGS for cataloging the diversity of bacterioplankton communities in Brazilian lakes and thus contributes to the ongoing worldwide endeavor to characterize freshwater lake bacterioplankton signatures.
    Print ISSN: 0168-6496
    Electronic ISSN: 1574-6941
    Topics: Biology
    Published by Oxford University Press
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  • 9
    Electronic Resource
    Electronic Resource
    Infection of sardine eggs by the protistan endoparasite Ichthyodinium chabelardi off Portugal (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 57 (2000), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: In 1997 and 1999 around 30% of the stations off Portugal sampled for sardine eggs Sardina pilchardus included eggs infected with Ichthyodinium chabelardi. A randomization test on the mean nearest neighbour distances of parasitized stations did not reveal evidence of significant spatial clustering. The mean prevalence of infection was c. 0·05 for both years, but the probability of parasite detection increased considerably with egg age. Eggs in their first day of development (before the embryo is formed) were not parasitized; most parasitized eggs were in the cohorts close to hatching. Although the reasons for age-dependent detection are unknown, if all parasitized eggs of the cohort ready to hatch were to die, infection by Ichthyodinium chabelardi would lead to mortality rates similar to those reported for the average daily mortality of sardine eggs and early larvae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2000.tb02186.x
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  • 10
    Electronic Resource
    Electronic Resource
    Immunocytochemical identification of neuroendocrine markers in human cardiac paraganglion — like structures (1991)
    Springer
    Histochemistry and cell biology 95 (1991), S. 337-340 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Paraganglion-like structures (PLS) containing chromaffin-positive cells have been reported to be present in the adult human heart. The present work was initiated in order to evaluate the densitity of these structures in the interatrial septum and to study the presence of immunoreactivity of their cells to NSE and PGP 9,5 antibodies, two neuroendocrine markers. Six hundred 6-μm paraffin serial sections were obtained from the upper third of the interatrial septum from six adult human hearts. From 2 to 12 paraganglia were found in each case, and their principal cells stained positively with NSE and PGP 9,5 antibodies. Depending on how these PLS related to other cardiac structures, four different types were identified: Type I — “True paraganglia” (located adjacent to ganglia or nerve fibers); Type II — “Free paraganglia” (immersed in the interatrial adipose tissue, without evident connection to other structures); Type III — “Intraganglionic paraganglia” (located within the nervous ganglia); Type IV — “Intramyocardic paraganglia” (small nests of immunoreactive cells closely related to myocardiocyte bundles). These cardiac paraganglia, which probably belong to the visceral-autonomic group, may have a role in the regulation of the cardiac function and in the adaptive mechanisms of the heart. Its is also possible that they originate functioning and non-functioning tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266960
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