ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Nonlinearity  (2)
  • Branching asymmetry  (1)
  • 1
    ISSN: 1573-9686
    Keywords: Airway impedance ; Airway resistance ; Airway acoustics ; Airway wall properties ; Airway geometry ; Branching asymmetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Indirect measures of airway diameter such as respiratory system input impedance (Z in) have been widely used to infer or quantify bronchoconstriction, or bronchodilation. One such measure, Z in above 100 Hz has been shown to be primarily influenced by airway geometry and airway walls but not by lung and chest wall tissues. We used a recently developed method based on a complex asymmetrically branched network of tubes with nonrigid walls to analyze Z in from 100 to 2,000 Hz in control and bronchoconstricted (histamine injection) dogs. The resulting estimates of airway diameters indicated that peripheral airways were constricted far more (≈30% of their control diameters) than central airways (i.e., 0% in the trachea). Separate measurements of changes in airway diameters were made in an excised dog lung using high resolution computed tomography. The observed changes in airway diameter between lung volumes of total lung capacity (TLC) and functional residual capacity (FRC) were quantitatively consistent with those obtained from Z indata in our control dogs at FRC. We conclude that this systems identification method can be used to estimate the distribution of airway diameters from Z in.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 26 (1998), S. 230-241 
    ISSN: 1573-9686
    Keywords: Lung resistance ; Lung elastance ; Airway inhomogeneities ; Viscoelasticity ; Nonlinearity ; Confidence bound ; Sensitivity analysis ; Nonlinear models ; Lung: mechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract We present a combined theoretical and numerical procedure for sensitivity analyses of lung mechanics models that are nonlinear in both state variables and parameters. We apply the analyses to a recently proposed nonlinear lung model which incorporates a wide range of potential nonlinear identification conditions including nonlinear viscoelastic tissues, airway inhomogeneities via a parallel airway resistance distribution function, and a nonlinear block-structure paradigm. Additionally, we examine a system identification procedure which fits time- and frequency-domain data simultaneously. Model nonlinearities motivate sensitivity analyses involving numerical approximation of sensitivity coefficients. Examination of the normalized sensitivity coefficients provides direct insight on the relative importance of each model parameter, and hence the respective mechanism. More formal quantification of parameter uniqueness requires approximation of the paired and multidimensional parameter confidence regions. Combined with parameter estimation, we use the sensitivity analyses to justify tissue nonlinearities in modeling of lung mechanics for healthy and airway constricted conditions, and to justify both airway inhomogeneities and tissue nonlinearities during broncoconstriction. The tools in this paper are general and can be applied to a wide class of nonlinear models. © 1998 Biomedical Engineering Society. PAC98: 8745Hw, 8710+e
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 26 (1998), S. 103-116 
    ISSN: 1573-9686
    Keywords: Memory length ; Nonlinearity ; Measurement noise ; Ventilatory wave form ; Stress relaxation ; Volterra kernel ; Lung ; Tissue viscoelasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The goal of this study is to quantitatively investigate how the memory length, order of nonlinearity, type of input, and measurement noise can affect the identification of the Volterra kernels of a nonlinear viscoelastic system, and hence the inference on system structure. We explored these aspects with emphasis on nonlinear lung tissue mechanics around breathing frequencies, where the memory length issue can be critical and a ventilatory input is clinically demanded. We adopted and examined Korenberg's fast orthogonal algorithm since it is a least-squares technique that does not demand white Gaussian noise input and makes no presumptions on the kernel shape and system structure. We then propose a memory autosearch method, which incorporates Akaike's final production error criterion into Korenberg's fast orthogonal algorithm to identify the memory length simultaneously with the kernels. Finally, we designed a special ventilatory flow input and evaluated its potential for the kernel identification of the nonlinear systems requiring oscillatory forcing. We found that the long memory associated with soft tissue viscoelasticity may prohibit correct identification of the higher-order kernels of the lung. However, the key characteristics of the first-order kernel may be revealed through averaging over multiple experiments and estimations. © 1998 Biomedical Engineering Society. PAC98: 8745Bp, 8710+e, 8350Gd, 8380Lz
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...