Publication Date:
2013-11-02
Description:
Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863450/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863450/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Lu O -- Jiang, Zheng -- Rivlin-Etzion, Michal -- Hand, Randal -- Brady, Colleen M -- Matsuoka, Ryota L -- Yau, King-Wai -- Feller, Marla B -- Kolodkin, Alex L -- EY013528/EY/NEI NIH HHS/ -- EY019498/EY/NEI NIH HHS/ -- EY06837/EY/NEI NIH HHS/ -- NS35165/NS/NINDS NIH HHS/ -- P30 NS050274/NS/NINDS NIH HHS/ -- R01 EY006837/EY/NEI NIH HHS/ -- R01 EY019498/EY/NEI NIH HHS/ -- R01 NS035165/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):1241974. doi: 10.1126/science.1241974.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179230" target="_blank"〉PubMed〈/a〉
Keywords:
Amacrine Cells/cytology/metabolism/*physiology
;
Animals
;
Dendrites/metabolism/physiology
;
Mice
;
Mice, Mutant Strains
;
Motion
;
*Motion Perception
;
Nerve Tissue Proteins/genetics/*metabolism
;
Receptors, Cell Surface/genetics/*metabolism
;
Retina/metabolism/*physiology
;
Semaphorins/genetics/*metabolism
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
