ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    MicroRNA-128 governs neuronal excitability and motor behavior in mice (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932786/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932786/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tan, Chan Lek -- Plotkin, Joshua L -- Veno, Morten T -- von Schimmelmann, Melanie -- Feinberg, Philip -- Mann, Silas -- Handler, Annie -- Kjems, Jorgen -- Surmeier, D James -- O'Carroll, Donal -- Greengard, Paul -- Schaefer, Anne -- 1DP2MH100012-01/DP/NCCDPHP CDC HHS/ -- DA025962/DA/NIDA NIH HHS/ -- DA10044/DA/NIDA NIH HHS/ -- DP2 MH100012/MH/NIMH NIH HHS/ -- NS34696/NS/NINDS NIH HHS/ -- P01 DA010044/DA/NIDA NIH HHS/ -- P50 MH090963/MH/NIMH NIH HHS/ -- P50MH090963/MH/NIMH NIH HHS/ -- R01 NS034696/NS/NINDS NIH HHS/ -- R03 DA025962/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1254-8. doi: 10.1126/science.1244193.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311694" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corpus Striatum/cytology ; Dendrites/physiology ; Epilepsy/metabolism ; Hyperkinesis/metabolism ; MAP Kinase Signaling System ; Mice ; MicroRNAs/genetics/*metabolism ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolism ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors/metabolism ; *Motor Activity ; Neurons/*physiology ; Parkinsonian Disorders/metabolism/physiopathology ; Prosencephalon/cytology/*physiology ; RNA, Messenger/genetics/metabolism ; RNA-Induced Silencing Complex/metabolism ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Reversal of bone loss in mice by nongenotropic signaling of sex steroids (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-26
    Description: We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actions of sex steroid receptors are dispensable for their bone protective effects, but essential for their effects on reproductive tissues. A synthetic ligand (4-estren-3alpha,17beta-diol) that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription, increases bone mass and strength in ovariectomized females above the level of the estrogen-replete state and is at least as effective as dihydrotestosterone in orchidectomized males, without affecting reproductive organs. Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected].〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kousteni, S -- Chen, J R -- Bellido, T -- Han, L -- Ali, A A -- O'Brien, C A -- Plotkin, L -- Fu, Q -- Mancino, A T -- Wen, Y -- Vertino, A M -- Powers, C C -- Stewart, S A -- Ebert, R -- Parfitt, A M -- Weinstein, R S -- Jilka, R L -- Manolagas, S C -- KO2-AR02127/AR/NIAMS NIH HHS/ -- P01-AG13918/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):843-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Bone Density/*drug effects ; Bone and Bones/*drug effects/physiology ; Breast Neoplasms/pathology ; Cell Division/drug effects ; Cells, Cultured ; Compressive Strength/drug effects ; Dihydrotestosterone/pharmacology ; Estradiol/pharmacology ; Estrenes/metabolism/*pharmacology ; Female ; Humans ; Male ; Mice ; Orchiectomy ; Organ Size/drug effects ; Osteoblasts/*drug effects/physiology ; Osteocalcin/blood ; Osteoclasts/*drug effects/physiology ; Osteogenesis/drug effects ; Osteoporosis/drug therapy ; Ovariectomy ; Pyrazoles/pharmacology ; Receptors, Estrogen/metabolism ; Seminal Vesicles/drug effects ; Transcription, Genetic/drug effects ; Tumor Cells, Cultured ; Uterus/drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...