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  • Cell Differentiation  (2)
  • Methylation  (2)
  • *Genome  (1)
  • *Membrane Transport Proteins  (1)
  • *Saccharomyces cerevisiae Proteins  (1)
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  • 1
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    Protein transport by purified yeast Sec complex and Kar2p without membranes (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-08-15
    Beschreibung: Posttranslational protein translocation across the endoplasmic reticulum membrane of yeast requires a seven-component transmembrane complex (the Sec complex) in collaboration with the lumenal Kar2 protein (Kar2p). A translocation substrate was initially bound to the cytosolic face of the purified Sec complex in a signal-sequence-dependent but Kar2p- and nucleotide-independent manner. In a subsequent reaction, in which Kar2p interacted with the lumenal face of the Sec complex and hydrolyzed adenosine triphosphate, the substrate moved through a channel formed by the Sec complex and was released at the lumenal end. Movement through the channel occurred in detergent solution in the absence of a lipid bilayer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matlack, K E -- Plath, K -- Misselwitz, B -- Rapoport, T A -- GM54238-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):938-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9252322" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Biological Transport ; Cross-Linking Reagents ; Cytosol/metabolism ; Detergents ; Digitonin ; Endoplasmic Reticulum/metabolism ; Fungal Proteins/*metabolism ; HSP70 Heat-Shock Proteins/*metabolism ; *Heat-Shock Proteins ; Lipid Bilayers ; Liposomes/metabolism ; Membrane Proteins/*metabolism ; *Membrane Transport Proteins ; Protein Precursors/*metabolism ; Protein Sorting Signals/metabolism ; Proteolipids/metabolism ; RNA, Transfer/metabolism ; *Saccharomyces cerevisiae Proteins ; Solubility ; Succinimides
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Chd1 regulates open chromatin and pluripotency of embryonic stem cells (2009)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2009-07-10
    Beschreibung: An open chromatin largely devoid of heterochromatin is a hallmark of stem cells. It remains unknown whether an open chromatin is necessary for the differentiation potential of stem cells, and which molecules are needed to maintain open chromatin. Here we show that the chromatin remodelling factor Chd1 is required to maintain the open chromatin of pluripotent mouse embryonic stem cells. Chd1 is a euchromatin protein that associates with the promoters of active genes, and downregulation of Chd1 leads to accumulation of heterochromatin. Chd1-deficient embryonic stem cells are no longer pluripotent, because they are incapable of giving rise to primitive endoderm and have a high propensity for neural differentiation. Furthermore, Chd1 is required for efficient reprogramming of fibroblasts to the pluripotent stem cell state. Our results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891576/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891576/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaspar-Maia, Alexandre -- Alajem, Adi -- Polesso, Fanny -- Sridharan, Rupa -- Mason, Mike J -- Heidersbach, Amy -- Ramalho-Santos, Joao -- McManus, Michael T -- Plath, Kathrin -- Meshorer, Eran -- Ramalho-Santos, Miguel -- DP2 OD004698/OD/NIH HHS/ -- R01 GM080783/GM/NIGMS NIH HHS/ -- R01 GM080783-01/GM/NIGMS NIH HHS/ -- R01 GM080783-02/GM/NIGMS NIH HHS/ -- R01 GM080783-03/GM/NIGMS NIH HHS/ -- R01 GM080783-04/GM/NIGMS NIH HHS/ -- R01 GM080783-05/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Aug 13;460(7257):863-8. doi: 10.1038/nature08212. Epub 2009 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ob/Gyn and Pathology, Center for Reproductive Sciences and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0525, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19587682" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biomarkers ; Cell Proliferation ; Cells, Cultured ; Cellular Reprogramming ; *Chromatin Assembly and Disassembly ; DNA-Binding Proteins/deficiency/genetics/*metabolism ; Embryonic Stem Cells/*cytology/*metabolism ; Endoderm/metabolism ; Euchromatin/genetics/*metabolism ; Fibroblasts/cytology/metabolism ; GATA6 Transcription Factor/genetics/metabolism ; Histones/metabolism ; Methylation ; Mice ; Neurogenesis ; Neurons/cytology/metabolism ; Octamer Transcription Factor-3/genetics ; Pluripotent Stem Cells/*cytology/*metabolism ; Promoter Regions, Genetic/genetics ; RNA Interference
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-06
    Beschreibung: Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maintenance of XCI, Xist binds broadly across the X chromosome. During initiation of XCI, Xist initially transfers to distal regions across the X chromosome that are not defined by specific sequences. Instead, Xist identifies these regions by exploiting the three-dimensional conformation of the X chromosome. Xist requires its silencing domain to spread across actively transcribed regions and thereby access the entire chromosome. These findings suggest a model in which Xist coats the X chromosome by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible locations.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778663/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778663/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Engreitz, Jesse M -- Pandya-Jones, Amy -- McDonel, Patrick -- Shishkin, Alexander -- Sirokman, Klara -- Surka, Christine -- Kadri, Sabah -- Xing, Jeffrey -- Goren, Alon -- Lander, Eric S -- Plath, Kathrin -- Guttman, Mitchell -- 1F32GM103139-01/GM/NIGMS NIH HHS/ -- DP5 OD012190/OD/NIH HHS/ -- DP5OD012190/OD/NIH HHS/ -- P01 GM099134/GM/NIGMS NIH HHS/ -- P01GM099134/GM/NIGMS NIH HHS/ -- P50HG006193/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):1237973. doi: 10.1126/science.1237973. Epub 2013 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828888" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Line ; Chromatin/chemistry/metabolism ; Female ; *Genome ; Male ; Mice ; Models, Genetic ; RNA, Long Noncoding/chemistry/*metabolism ; Transcription, Genetic ; X Chromosome/*metabolism/ultrastructure ; *X Chromosome Inactivation
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Role of histone H3 lysine 27 methylation in X inactivation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-22
    Beschreibung: The Polycomb group (PcG) protein Eed is implicated in regulation of imprinted X-chromosome inactivation in extraembryonic cells but not of random X inactivation in embryonic cells. The Drosophila homolog of the Eed-Ezh2 PcG protein complex achieves gene silencing through methylation of histone H3 on lysine 27 (H3-K27), which suggests a role for H3-K27 methylation in imprinted X inactivation. Here we demonstrate that transient recruitment of the Eed-Ezh2 complex to the inactive X chromosome (Xi) occurs during initiation of X inactivation in both extraembryonic and embryonic cells and is accompanied by H3-K27 methylation. Recruitment of the complex and methylation on the Xi depend on Xist RNA but are independent of its silencing function. Together, our results suggest a role for Eed-Ezh2-mediated H3-K27 methylation during initiation of both imprinted and random X inactivation and demonstrate that H3-K27 methylation is not sufficient for silencing of the Xi.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plath, Kathrin -- Fang, Jia -- Mlynarczyk-Evans, Susanna K -- Cao, Ru -- Worringer, Kathleen A -- Wang, Hengbin -- de la Cruz, Cecile C -- Otte, Arie P -- Panning, Barbara -- Zhang, Yi -- New York, N.Y. -- Science. 2003 Apr 4;300(5616):131-5. Epub 2003 Mar 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12649488" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blastocyst/metabolism/*physiology ; Cell Differentiation ; Cell Nucleus/metabolism ; Cells, Cultured ; *Dosage Compensation, Genetic ; Female ; Fluorescent Antibody Technique ; Genomic Imprinting ; HeLa Cells ; Histones/*metabolism ; Humans ; In Situ Hybridization, Fluorescence ; Lysine/metabolism ; Male ; Methylation ; Mice ; Mutation ; Polycomb Repressive Complex 2 ; RNA, Long Noncoding ; RNA, Untranslated/genetics/metabolism ; Repressor Proteins/metabolism ; Stem Cells/metabolism/*physiology ; Transgenes ; Trophoblasts/*physiology ; X Chromosome/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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