ALBERT

Description: Strong evidence exists that water is carried from the surface into the upper mantle by hydrous minerals in the uppermost 10-12 km of subducting lithosphere, and more water may be added as the lithosphere bends and goes downwards. Significant amounts of that water are released as the lithosphere heats up, triggering earthquakes and fluxing arc volcanism. In addition, there is experimental evidence for high solubility of water in olivine, the most abundant mineral in the upper mantle, for even higher solubility in olivine's high-pressure polymorphs, wadsleyite and ringwoodite, and for the existence of dense hydrous magnesium silicates that potentially could carry water well into the lower mantle (deeper than 1,000 km). Here we compare experimental and seismic evidence to test whether patterns of seismicity and the stabilities of these potentially relevant hydrous phases are consistent with a wet lithosphere. We show that there is nearly a one-to-one correlation between dehydration of minerals and seismicity at depths less than about 250 km, and conclude that the dehydration of minerals is the trigger of instability that leads to seismicity. At greater depths, however, we find no correlation between occurrences of earthquakes and depths where breakdown of hydrous phases is expected. Lastly, we note that there is compelling evidence for the existence of metastable olivine (which, if present, can explain the distribution of deep-focus earthquakes) west of and within the subducting Tonga slab and also in three other subduction zones, despite metastable olivine being incompatible with even extremely small amounts of water (of the order of 100 p.p.m. by weight). We conclude that subducting slabs are essentially dry at depths below 400 km and thus do not provide a pathway for significant amounts of water to enter the mantle transition zone or the lower mantle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, Harry W 2nd -- Chen, Wang-Ping -- Brudzinski, Michael R -- England -- Nature. 2010 Oct 14;467(7317):828-31. doi: 10.1038/nature09401. Epub 2010 Oct 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Geophysics and Planetary Physics and Department of Earth Sciences, University of California, Riverside, California 92521, USA. harry.green@ucr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20927105" target="_blank"〉PubMed〈/a〉

Description: Apoptosis is a conserved form of programmed cell death firmly established in the aetiology, pathogenesis and treatment of many human diseases. Central to the core machinery of apoptosis are the caspases and their proximal regulators. Current models for caspase control involve a balance of opposing elements, with variable contributions from positive and negative regulators among different cell types and species. To advance a comprehensive view of components that support caspase-dependent cell death, we conducted a genome-wide silencing screen in the Drosophila model. Our strategy used a library of double-stranded RNAs together with a chemical antagonist of Inhibitor of apoptosis proteins (IAPs) that simulates the action of native regulators in the Reaper and Smac (also known as Diablo) families. Here we present a highly validated set of targets that is necessary for death provoked by several stimuli. Among these, Tango7 is identified as a new effector. Cells depleted for this gene resisted apoptosis at a step before the induction of effector caspase activity, and the directed silencing of Tango7 in Drosophila prevented caspase-dependent programmed cell death. Unlike known apoptosis regulators in this model system, Tango7 activity did not influence stimulus-dependent loss of Drosophila DIAP1 (also known as th and IAP1), but instead regulated levels of the apical caspase Dronc (Nc). Similarly, the human Tango7 counterpart, PCID1 (also known as EIF3M), impinged on caspase 9, revealing a new regulatory axis affecting the apoptosome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777527/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777527/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chew, Su Kit -- Chen, Po -- Link, Nichole -- Galindo, Kathleen A -- Pogue, Kristi -- Abrams, John M -- R01 AA017328/AA/NIAAA NIH HHS/ -- R01 AA017328-01/AA/NIAAA NIH HHS/ -- R01 AA017328-02/AA/NIAAA NIH HHS/ -- R01 GM072124/GM/NIGMS NIH HHS/ -- R01 GM072124-10/GM/NIGMS NIH HHS/ -- R01 GM072124-11/GM/NIGMS NIH HHS/ -- R01 GM072124-12/GM/NIGMS NIH HHS/ -- R01 GM072124-13/GM/NIGMS NIH HHS/ -- R01 GM072124-14A1/GM/NIGMS NIH HHS/ -- R56 GM072124/GM/NIGMS NIH HHS/ -- R56 GM072124-14/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Jul 2;460(7251):123-7. doi: 10.1038/nature08087. Epub 2009 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19483676" target="_blank"〉PubMed〈/a〉

Description: Detection of molecules using infrared spectroscopy probes the conditions and compositions of exoplanet atmospheres. Water (H(2)O), methane (CH(4)), carbon dioxide (CO(2)), and carbon monoxide (CO) have been detected in two hot Jupiters. These previous results relied on space-based telescopes that do not provide spectroscopic capability in the 2.4-5.2 microm spectral region. Here we report ground-based observations of the dayside emission spectrum for HD 189733b between 2.0-2.4 microm and 3.1-4.1 microm, where we find a bright emission feature. Where overlap with space-based instruments exists, our results are in excellent agreement with previous measurements. A feature at approximately 3.25 microm is unexpected and difficult to explain with models that assume local thermodynamic equilibrium (LTE) conditions at the 1 bar to 1 x 10(-6) bar pressures typically sampled by infrared measurements. The most likely explanation for this feature is that it arises from non-LTE emission from CH(4), similar to what is seen in the atmospheres of planets in our own Solar System. These results suggest that non-LTE effects may need to be considered when interpreting measurements of strongly irradiated exoplanets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swain, Mark R -- Deroo, Pieter -- Griffith, Caitlin A -- Tinetti, Giovanna -- Thatte, Azam -- Vasisht, Gautam -- Chen, Pin -- Bouwman, Jeroen -- Crossfield, Ian J -- Angerhausen, Daniel -- Afonso, Cristina -- Henning, Thomas -- England -- Nature. 2010 Feb 4;463(7281):637-9. doi: 10.1038/nature08775.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109-8099, USA. mark.r.swain@jpl.nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20130645" target="_blank"〉PubMed〈/a〉

Description: High-throughput single-cell transcriptomics offers an unbiased approach for understanding the extent, basis and function of gene expression variation between seemingly identical cells. Here we sequence single-cell RNA-seq libraries prepared from over 1,700 primary mouse bone-marrow-derived dendritic cells spanning several experimental conditions. We find substantial variation between identically stimulated dendritic cells, in both the fraction of cells detectably expressing a given messenger RNA and the transcript's level within expressing cells. Distinct gene modules are characterized by different temporal heterogeneity profiles. In particular, a 'core' module of antiviral genes is expressed very early by a few 'precocious' cells in response to uniform stimulation with a pathogenic component, but is later activated in all cells. By stimulating cells individually in sealed microfluidic chambers, analysing dendritic cells from knockout mice, and modulating secretion and extracellular signalling, we show that this response is coordinated by interferon-mediated paracrine signalling from these precocious cells. Notably, preventing cell-to-cell communication also substantially reduces variability between cells in the expression of an early-induced 'peaked' inflammatory module, suggesting that paracrine signalling additionally represses part of the inflammatory program. Our study highlights the importance of cell-to-cell communication in controlling cellular heterogeneity and reveals general strategies that multicellular populations can use to establish complex dynamic responses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193940/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193940/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shalek, Alex K -- Satija, Rahul -- Shuga, Joe -- Trombetta, John J -- Gennert, Dave -- Lu, Diana -- Chen, Peilin -- Gertner, Rona S -- Gaublomme, Jellert T -- Yosef, Nir -- Schwartz, Schraga -- Fowler, Brian -- Weaver, Suzanne -- Wang, Jing -- Wang, Xiaohui -- Ding, Ruihua -- Raychowdhury, Raktima -- Friedman, Nir -- Hacohen, Nir -- Park, Hongkun -- May, Andrew P -- Regev, Aviv -- 1F32HD075541-01/HD/NICHD NIH HHS/ -- 1P50HG006193-01/HG/NHGRI NIH HHS/ -- 5DP1OD003893-03/OD/NIH HHS/ -- DP1 CA174427/CA/NCI NIH HHS/ -- DP1OD003958-01/OD/NIH HHS/ -- F32 HD075541/HD/NICHD NIH HHS/ -- P50 HG006193/HG/NHGRI NIH HHS/ -- U54 AI057159/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 Jun 19;510(7505):363-9. doi: 10.1038/nature13437. Epub 2014 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA [3] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [4]. ; 1] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2]. ; 1] Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA [2]. ; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. ; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA. ; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA. ; School of Computer Science and Engineering, Hebrew University, 91904 Jerusalem, Israel. ; 1] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Center for Immunology and Inflammatory Diseases & Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. ; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA [3] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. ; 1] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02140, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24919153" target="_blank"〉PubMed〈/a〉

Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Yi-Ping -- Lin, Yi-Shan -- Zhang, Yi -- England -- Nature. 2014 Nov 27;515(7528):492. doi: 10.1038/515492e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25428487" target="_blank"〉PubMed〈/a〉

Description: Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, with oesophageal squamous cell carcinoma (ESCC) being the histopathological form in the vast majority of cases (〉90%). Currently, there are limited clinical approaches for the early diagnosis and treatment of ESCC, resulting in a 10% five-year survival rate for patients. However, the full repertoire of genomic events leading to the pathogenesis of ESCC remains unclear. Here we describe a comprehensive genomic analysis of 158 ESCC cases, as part of the International Cancer Genome Consortium research project. We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases, plus an additional 70 ESCC cases not used in the whole-genome and whole-exome sequencing, were subjected to array comparative genomic hybridization analysis. We identified eight significantly mutated genes, of which six are well known tumour-associated genes (TP53, RB1, CDKN2A, PIK3CA, NOTCH1, NFE2L2), and two have not previously been described in ESCC (ADAM29 and FAM135B). Notably, FAM135B is identified as a novel cancer-implicated gene as assayed for its ability to promote malignancy of ESCC cells. Additionally, MIR548K, a microRNA encoded in the amplified 11q13.3-13.4 region, is characterized as a novel oncogene, and functional assays demonstrate that MIR548K enhances malignant phenotypes of ESCC cells. Moreover, we have found that several important histone regulator genes (MLL2 (also called KMT2D), ASH1L, MLL3 (KMT2C), SETD1B, CREBBP and EP300) are frequently altered in ESCC. Pathway assessment reveals that somatic aberrations are mainly involved in the Wnt, cell cycle and Notch pathways. Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking. This study has explored novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Song, Yongmei -- Li, Lin -- Ou, Yunwei -- Gao, Zhibo -- Li, Enmin -- Li, Xiangchun -- Zhang, Weimin -- Wang, Jiaqian -- Xu, Liyan -- Zhou, Yong -- Ma, Xiaojuan -- Liu, Lingyan -- Zhao, Zitong -- Huang, Xuanlin -- Fan, Jing -- Dong, Lijia -- Chen, Gang -- Ma, Liying -- Yang, Jie -- Chen, Longyun -- He, Minghui -- Li, Miao -- Zhuang, Xuehan -- Huang, Kai -- Qiu, Kunlong -- Yin, Guangliang -- Guo, Guangwu -- Feng, Qiang -- Chen, Peishan -- Wu, Zhiyong -- Wu, Jianyi -- Ma, Ling -- Zhao, Jinyang -- Luo, Longhai -- Fu, Ming -- Xu, Bainan -- Chen, Bo -- Li, Yingrui -- Tong, Tong -- Wang, Mingrong -- Liu, Zhihua -- Lin, Dongxin -- Zhang, Xiuqing -- Yang, Huanming -- Wang, Jun -- Zhan, Qimin -- England -- Nature. 2014 May 1;509(7498):91-5. doi: 10.1038/nature13176. Epub 2014 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China [2]. ; 1] BGI-Shenzhen, Shenzhen 518083, Guangdong 518083, China [2]. ; 1] State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China [2] Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China [3]. ; 1] Department of Biochemistry and Molecular Biology, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, Guangdong, China [2]. ; State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. ; BGI-Shenzhen, Shenzhen 518083, Guangdong 518083, China. ; Institute of Oncologic Pathology, Shantou University Medical College, Shantou 515041, Guangdong, China. ; Department of Tumor Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, Guangdong, China. ; Department of Biochemistry and Molecular Biology, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, Guangdong, China. ; Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24670651" target="_blank"〉PubMed〈/a〉

Description: In immune responses, activated T cells migrate to B-cell follicles and develop into follicular T-helper (TFH) cells, a recently identified subset of CD4(+) T cells specialized in providing help to B lymphocytes in the induction of germinal centres. Although Bcl6 has been shown to be essential in TFH-cell function, it may not regulate the initial migration of T cells or the induction of the TFH program, as exemplified by C-X-C chemokine receptor type 5 (CXCR5) upregulation. Here we show that expression of achaete-scute homologue 2 (Ascl2)--a basic helix-loop-helix (bHLH) transcription factor--is selectively upregulated in TFH cells. Ectopic expression of Ascl2 upregulates CXCR5 but not Bcl6, and downregulates C-C chemokine receptor 7 (CCR7) expression in T cells in vitro, as well as accelerating T-cell migration to the follicles and TFH-cell development in vivo in mice. Genome-wide analysis indicates that Ascl2 directly regulates TFH-related genes whereas it inhibits expression of T-helper cell 1 (TH1) and TH17 signature genes. Acute deletion of Ascl2, as well as blockade of its function with the Id3 protein in CD4(+) T cells, results in impaired TFH-cell development and germinal centre response. Conversely, mutation of Id3, known to cause antibody-mediated autoimmunity, greatly enhances TFH-cell generation. Thus, Ascl2 directly initiates TFH-cell development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012617/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012617/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Xindong -- Chen, Xin -- Zhong, Bo -- Wang, Aibo -- Wang, Xiaohu -- Chu, Fuliang -- Nurieva, Roza I -- Yan, Xiaowei -- Chen, Ping -- van der Flier, Laurens G -- Nakatsukasa, Hiroko -- Neelapu, Sattva S -- Chen, Wanjun -- Clevers, Hans -- Tian, Qiang -- Qi, Hai -- Wei, Lai -- Dong, Chen -- AI106654/AI/NIAID NIH HHS/ -- P30 CA016672/CA/NCI NIH HHS/ -- R01 AI106654/AI/NIAID NIH HHS/ -- R01 AR050772/AR/NIAMS NIH HHS/ -- RC2 AR059010/AR/NIAMS NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2014 Mar 27;507(7493):513-8. doi: 10.1038/nature12910. Epub 2014 Jan 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Tsinghua University School of Medicine, Beijing 100084, China [2] Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77054, USA. ; Tsinghua University School of Medicine, Beijing 100084, China. ; 1] Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77054, USA [2] College of Life Sciences, Wuhan University, Wuhan 430072, China (B.Z.); SomantiX B.V., Padualaan 8, 3584 CH Utrecht, the Netherlands (L.G.v.d.F.). ; Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, Texas 77054, USA. ; Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77054, USA. ; Institute for Systems Biology, Seattle, Washington 98103, USA. ; Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892-1858, USA. ; 1] Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands [2] College of Life Sciences, Wuhan University, Wuhan 430072, China (B.Z.); SomantiX B.V., Padualaan 8, 3584 CH Utrecht, the Netherlands (L.G.v.d.F.). ; National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-2190, USA. ; Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands. ; State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510275, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24463518" target="_blank"〉PubMed〈/a〉

Description: Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens. Although the first outbreak wave that was centred on eastern China was seemingly averted, human infections recurred in October 2013 (refs 3-7). It is unclear how the H7N9 virus re-emerged and how it will develop further; potentially it may become a long-term threat to public health. Here we show that H7N9 viruses have spread from eastern to southern China and become persistent in chickens, which has led to the establishment of multiple regionally distinct lineages with different reassortant genotypes. Repeated introductions of viruses from Zhejiang to other provinces and the presence of H7N9 viruses at live poultry markets have fuelled the recurrence of human infections. This rapid expansion of the geographical distribution and genetic diversity of the H7N9 viruses poses a direct challenge to current disease control systems. Our results also suggest that H7N9 viruses have become enzootic in China and may spread beyond the region, following the pattern previously observed with H5N1 and H9N2 influenza viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lam, Tommy Tsan-Yuk -- Zhou, Boping -- Wang, Jia -- Chai, Yujuan -- Shen, Yongyi -- Chen, Xinchun -- Ma, Chi -- Hong, Wenshan -- Chen, Yin -- Zhang, Yanjun -- Duan, Lian -- Chen, Peiwen -- Jiang, Junfei -- Zhang, Yu -- Li, Lifeng -- Poon, Leo Lit Man -- Webby, Richard J -- Smith, David K -- Leung, Gabriel M -- Peiris, Joseph S M -- Holmes, Edward C -- Guan, Yi -- Zhu, Huachen -- HHSN272201400006C/PHS HHS/ -- England -- Nature. 2015 Jun 4;522(7554):102-5. doi: 10.1038/nature14348. Epub 2015 Mar 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen 518112, China [2] Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College (SUMC), Shantou 515041, China [3] Centre of Influenza Research, School of Public Health, The University of Hong Kong (HKU), Hong Kong, China. ; State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen 518112, China. ; 1] Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College (SUMC), Shantou 515041, China [2] Centre of Influenza Research, School of Public Health, The University of Hong Kong (HKU), Hong Kong, China. ; Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College (SUMC), Shantou 515041, China. ; Key Laboratory of Emergency Detection for Public Health of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China. ; 1] State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen 518112, China [2] Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College (SUMC), Shantou 515041, China. ; 1] State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People's Hospital, Shenzhen 518112, China [2] Centre of Influenza Research, School of Public Health, The University of Hong Kong (HKU), Hong Kong, China. ; Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. ; Centre of Influenza Research, School of Public Health, The University of Hong Kong (HKU), Hong Kong, China. ; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, New South Wales 2006, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25762140" target="_blank"〉PubMed〈/a〉

Description: Tropical mountains are hot spots of biodiversity and endemism, but the evolutionary origins of their unique biotas are poorly understood. In varying degrees, local and regional extinction, long-distance colonization, and local recruitment may all contribute to the exceptional character of these communities. Also, it is debated whether mountain endemics mostly originate from local lowland taxa, or from lineages that reach the mountain by long-range dispersal from cool localities elsewhere. Here we investigate the evolutionary routes to endemism by sampling an entire tropical mountain biota on the 4,095-metre-high Mount Kinabalu in Sabah, East Malaysia. We discover that most of its unique biodiversity is younger than the mountain itself (6 million years), and comprises a mix of immigrant pre-adapted lineages and descendants from local lowland ancestors, although substantial shifts from lower to higher vegetation zones in this latter group were rare. These insights could improve forecasts of the likelihood of extinction and 'evolutionary rescue' in montane biodiversity hot spots under climate change scenarios.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merckx, Vincent S F T -- Hendriks, Kasper P -- Beentjes, Kevin K -- Mennes, Constantijn B -- Becking, Leontine E -- Peijnenburg, Katja T C A -- Afendy, Aqilah -- Arumugam, Nivaarani -- de Boer, Hugo -- Biun, Alim -- Buang, Matsain M -- Chen, Ping-Ping -- Chung, Arthur Y C -- Dow, Rory -- Feijen, Frida A A -- Feijen, Hans -- Feijen-van Soest, Cobi -- Geml, Jozsef -- Geurts, Rene -- Gravendeel, Barbara -- Hovenkamp, Peter -- Imbun, Paul -- Ipor, Isa -- Janssens, Steven B -- Jocque, Merlijn -- Kappes, Heike -- Khoo, Eyen -- Koomen, Peter -- Lens, Frederic -- Majapun, Richard J -- Morgado, Luis N -- Neupane, Suman -- Nieser, Nico -- Pereira, Joan T -- Rahman, Homathevi -- Sabran, Suzana -- Sawang, Anati -- Schwallier, Rachel M -- Shim, Phyau-Soon -- Smit, Harry -- Sol, Nicolien -- Spait, Maipul -- Stech, Michael -- Stokvis, Frank -- Sugau, John B -- Suleiman, Monica -- Sumail, Sukaibin -- Thomas, Daniel C -- van Tol, Jan -- Tuh, Fred Y Y -- Yahya, Bakhtiar E -- Nais, Jamili -- Repin, Rimi -- Lakim, Maklarin -- Schilthuizen, Menno -- England -- Nature. 2015 Aug 20;524(7565):347-50. doi: 10.1038/nature14949. Epub 2015 Aug 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The Netherlands. ; Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands. ; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborg 7, 9747 AG Groningen, The Netherlands. ; Wageningen University &Research centre, Marine Animal Ecology Group, PO Box 338, 6700 AH Wageningen, The Netherlands. ; Department of Environmental Science, Policy, &Management, University of California Berkeley, 130 Mulford Hall #3114, Berkeley, California 94720, USA. ; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands. ; Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia. ; Faculty of Earth Science, Universiti Malaysia Kelantan, Jeli Campus, Locked bag No.100, 17600 Jeli, Kelantan Darul Naim, Malaysia. ; Department of Organismal Biology, Uppsala University, Norbyvagen 18D, 75236 Uppsala, Sweden. ; Natural History Museum, University of Oslo, P.O. Box 1172 Blindern, NO-0318 Oslo, Norway. ; Sabah Parks, Lot 45 &46, Level 1-5, Blok H, KK Times Square, 88806 Kota Kinabalu, Sabah, Malaysia. ; Forest Research Centre, Sabah Forestry Department, P.O. Box 1407, 90175 Sandakan, Sabah, Malaysia. ; Wageningen University, Department of Plant Sciences, Laboratory of Molecular Biology, 6700AP Wageningen, The Netherlands. ; University of Applied Sciences Leiden, Zernikedreef 11, 2333 CK Leiden, The Netherlands. ; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia. ; Botanic Garden Meise, Nieuwelaan 38, 1860 Meise, Belgium. ; Royal Belgian Institute of Natural Sciences, Aquatic and Terrestrial Ecology, Vautierstraat 29, 1000 Brussels, Belgium. ; Rutgers, The State University of New Jersey, Department of Biological Sciences, 195 University Avenue, Boyden Hall, Newark, New Jersey 07102, USA. ; Zoological Institute, University of Cologne, Zulpicher Strasse 47b, D-50674 Cologne, Germany. ; Natuurmuseum Fryslan, Schoenmakersperk 2, 8911 EM Leeuwarden, The Netherlands. ; EEB Department, University of Connecticut, 75 N. Eagleville Road, Storrs, Connecticut 06269-3043, USA. ; School of Biological Sciences, University of Hong Kong, Pok Fu Lam Road, Hong Kong, China. ; Singapore Botanic Gardens, 1 Cluny Road, 259569 Singapore, Republic of Singapore.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26266979" target="_blank"〉PubMed〈/a〉

Description: How black holes accrete surrounding matter is a fundamental yet unsolved question in astrophysics. It is generally believed that matter is absorbed into black holes via accretion disks, the state of which depends primarily on the mass-accretion rate. When this rate approaches the critical rate (the Eddington limit), thermal instability is supposed to occur in the inner disk, causing repetitive patterns of large-amplitude X-ray variability (oscillations) on timescales of minutes to hours. In fact, such oscillations have been observed only in sources with a high mass-accretion rate, such as GRS 1915+105 (refs 2, 3). These large-amplitude, relatively slow timescale, phenomena are thought to have physical origins distinct from those of X-ray or optical variations with small amplitudes and fast timescales (less than about 10 seconds) often observed in other black-hole binaries-for example, XTE J1118+480 (ref. 4) and GX 339-4 (ref. 5). Here we report an extensive multi-colour optical photometric data set of V404 Cygni, an X-ray transient source containing a black hole of nine solar masses (and a companion star) at a distance of 2.4 kiloparsecs (ref. 8). Our data show that optical oscillations on timescales of 100 seconds to 2.5 hours can occur at mass-accretion rates more than ten times lower than previously thought. This suggests that the accretion rate is not the critical parameter for inducing inner-disk instabilities. Instead, we propose that a long orbital period is a key condition for these large-amplitude oscillations, because the outer part of the large disk in binaries with long orbital periods will have surface densities too low to maintain sustained mass accretion to the inner part of the disk. The lack of sustained accretion--not the actual rate--would then be the critical factor causing large-amplitude oscillations in long-period systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kimura, Mariko -- Isogai, Keisuke -- Kato, Taichi -- Ueda, Yoshihiro -- Nakahira, Satoshi -- Shidatsu, Megumi -- Enoto, Teruaki -- Hori, Takafumi -- Nogami, Daisaku -- Littlefield, Colin -- Ishioka, Ryoko -- Chen, Ying-Tung -- King, Sun-Kun -- Wen, Chih-Yi -- Wang, Shiang-Yu -- Lehner, Matthew J -- Schwamb, Megan E -- Wang, Jen-Hung -- Zhang, Zhi-Wei -- Alcock, Charles -- Axelrod, Tim -- Bianco, Federica B -- Byun, Yong-Ik -- Chen, Wen-Ping -- Cook, Kem H -- Kim, Dae-Won -- Lee, Typhoon -- Marshall, Stuart L -- Pavlenko, Elena P -- Antonyuk, Oksana I -- Antonyuk, Kirill A -- Pit, Nikolai V -- Sosnovskij, Aleksei A -- Babina, Julia V -- Baklanov, Aleksei V -- Pozanenko, Alexei S -- Mazaeva, Elena D -- Schmalz, Sergei E -- Reva, Inna V -- Belan, Sergei P -- Inasaridze, Raguli Ya -- Tungalag, Namkhai -- Volnova, Alina A -- Molotov, Igor E -- de Miguel, Enrique -- Kasai, Kiyoshi -- Stein, William L -- Dubovsky, Pavol A -- Kiyota, Seiichiro -- Miller, Ian -- Richmond, Michael -- Goff, William -- Andreev, Maksim V -- Takahashi, Hiromitsu -- Kojiguchi, Naoto -- Sugiura, Yuki -- Takeda, Nao -- Yamada, Eiji -- Matsumoto, Katsura -- James, Nick -- Pickard, Roger D -- Tordai, Tamas -- Maeda, Yutaka -- Ruiz, Javier -- Miyashita, Atsushi -- Cook, Lewis M -- Imada, Akira -- Uemura, Makoto -- England -- Nature. 2016 Jan 7;529(7584):54-8. doi: 10.1038/nature16452.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, Graduate School of Science, Kyoto University, Oiwakecho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. ; JEM Mission Operations and Integration Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan. ; MAXI team, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. ; The Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8302, Japan. ; Astronomy Department, Wesleyan University, Middletown, Connecticut 06459, USA. ; Institute of Astronomy and Astrophysics, Academia Sinica, 11F of Astronomy-Mathematics Building, AS/NTU No. 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan. ; Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19125, USA. ; Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, Massachusetts 02138, USA. ; Steward Observatory, University of Arizona, Tucson, Arizona 85721, USA. ; Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, New York 10003, USA. ; Department of Astronomy and University Observatory, Yonsei University, Seoul 120-749, South Korea. ; Institute of Astronomy and Department of Physics, National Central University, Chung-Li 32054, Taiwan. ; Max Planck Institute for Astronomy, Konigstuhl 17, 69117 Heidelberg, Germany. ; Kavli Institute for Particle Astrophysics and Cosmology (KIPAC), Stanford University, 452 Lomita Mall, Stanford, California 94309, USA. ; Crimean Astrophysical Observatory, 298409 Nauchny, Crimea. ; Space Research Institute, Russian Academy of Sciences, 117997 Moscow, Russia. ; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia. ; Leibniz Institute for Astrophysics, Potsdam, Germany. ; Fesenkov Astrophysical Institute, Almaty, Kazakhstan. ; Kharadze Abastumani Astrophysical Observatory, Ilia State University, Tbilisi, Georgia. ; Institute of Astronomy and Geophysics, Mongolian Academy of Sciences, Ulaanbaatar 13343, Mongolia. ; Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, Moscow, Russia. ; Departamento de Fisica Aplicada, Facultad de Ciencias Experimentales, Universidad de Huelva, 21071 Huelva, Spain. ; Center for Backyard Astrophysics, Observatorio del CIECEM, Parque Dunar, Matalascanas, 21760 Almonte, Huelva, Spain. ; Baselstrasse 133D, CH-4132 Muttenz, Switzerland. ; 6025 Calle Paraiso, Las Cruces, New Mexico 88012, USA. ; Vihorlat Observatory, Mierova 4, Humenne, Slovakia. ; Variable Star Observers League in Japan (VSOLJ), 7-1 Kitahatsutomi, Kamagaya, Chiba 273-0126, Japan. ; Furzehill House, Ilston, Swansea SA2 7LE, UK. ; Physics Department, Rochester Institute of Technology, Rochester, New York 14623, USA. ; American Association of Variable Star Observers (AAVSO), 13508 Monitor Lane, Sutter Creek, California 95685, USA. ; Institute of Astronomy, Russian Academy of Sciences, 361605 Peak Terskol, Kabardino-Balkaria, Russia. ; International Center for Astronomical, Medical and Ecological Research of National Academy of Sciences of Ukraine (NASU), 27 Akademika Zabolotnoho street, 03680 Kiev, Ukraine. ; Department of Physical Science, School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan. ; Osaka Kyoiku University, 4-698-1 Asahigaoka, Kashiwara, Osaka 582-8582, Japan. ; 1 Tavistock Road, Chelmsford, Essex CM1 6JL, UK. ; The British Astronomical Association, Variable Star Section (BAA VSS), Burlington House, Piccadilly, London W1J 0DU, UK. ; 3 The Birches, Shobdon, Leominster, Herefordshire HR6 9NG, UK. ; Polaris Observatory, Hungarian Astronomical Association, Laborc utca 2/c, 1037 Budapest, Hungary. ; 112-14 Kaminishiyama-machi, Nagasaki, Nagasaki 850-0006, Japan. ; Observatorio de Cantabria, Carretera de Rocamundo sin numero, Valderredible, Cantabria, Spain. ; Instituto de Fisica de Cantabria (CSIC-UC), Avenida Los Castros sin numero, E-39005 Santander, Cantabria, Spain. ; Agrupacion Astronomica Cantabra, Apartado 573, 39080 Santander, Spain. ; Seikei Meteorological Observatory, Seikei High School, Kichijoji-kitamachi 3-10-13, Musashino, Tokyo 180-8633, Japan. ; Center for Backyard Astrophysics (Concord), 1730 Helix Court, Concord, California 94518, USA. ; Kwasan and Hida Observatories, Kyoto University, Kitakazan-Ohmine-cho, Yamashina-ku, Kyoto 607-8471, Japan. ; Hiroshima Astrophysical Science Center, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima, Hiroshima 739-8526, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26738590" target="_blank"〉PubMed〈/a〉