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Bone marrow as a potential source of hepatic oval cells (1999)

B. E. Petersen ; W. C. Bowen ; K. D. Patrene ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 284(5417): 1168-70.

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Publikationsdatum: 1999-05-15

Beschreibung: Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petersen, B E -- Bowen, W C -- Patrene, K D -- Mars, W M -- Sullivan, A K -- Murase, N -- Boggs, S S -- Greenberger, J S -- Goff, J P -- New York, N.Y. -- Science. 1999 May 14;284(5417):1168-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. bryon+@pitt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10325227" target="_blank"〉PubMed〈/a〉

Schlagwort(e): 2-Acetylaminofluorene/pharmacology ; Animals ; Bone Marrow Cells/*cytology ; Bone Marrow Transplantation ; Carbon Tetrachloride/pharmacology ; Cell Differentiation ; Cell Division ; DNA-Binding Proteins/genetics ; Dipeptidyl Peptidase 4/metabolism ; Epithelial Cells/cytology ; Female ; Hematopoietic Stem Cells/cytology ; In Situ Hybridization ; Liver/*cytology/drug effects/physiology ; *Liver Regeneration ; Liver Transplantation ; Male ; *Nuclear Proteins ; Polymerase Chain Reaction ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Sex-Determining Region Y Protein ; Stem Cells/*cytology ; *Transcription Factors ; Y Chromosome

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Extending the terrestrial depositional record of marine geohazards in coastal NW British Columbia (2018)

Huntley, D., Bobrowsky, P., Goff, J., Chague, C., Stead, D., Donati, D., Mariampillai, D.

Geological Society of London

In: Geological Society, London, Special Publications

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Publikationsdatum: 2018

Beschreibung: 〈p〉Recurrent storms, floods, landslides, earthquakes and tsunamis challenge the development of resilient infrastructure and communities in coastal northwestern British Columbia. Vulnerability assessment first requires extended and improved understanding of geohazards in the Pacific Basin to constrain modelling of future events. An investigation of soils and bedrock structures in the Douglas Channel provides insight into the distribution of deposits attributed to geohazards in the region. Newly discovered marine inundation deposits corroborate numerical models and suggest that Pacific-sourced storms and earthquake-triggered tsunamis expend much of their energy in the outer coast and rarely reach far up the mainland fjords. Small-volume Folisolic slides and rockfalls do not generate tsunamis of any consequence. In contrast, marine sediments deposited beyond storm berms at the fjord head are a record of local tsunamis generated by large-volume marine slumps. Deep-fractured bedrock mapped upslope from relict submarine features would trigger damaging tsunami waves if rapid failure into the fjord were to occur. The observations above suggest only great earthquakes, large landslides and seasonal storms above a certain threshold volume and impulse energy produce geomorphically significant inundation events. However, even small submarine landslides have tsunamigenic potential in Douglas Channel since they occur in shallow water.〈/p〉

Print ISSN: 0375-6440

Digitale ISSN: 2041-4927

Thema: Geologie und Paläontologie