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  • Humans  (20)
  • American Association for the Advancement of Science (AAAS)  (20)
  • American Geophysical Union (AGU)
  • American Institute of Physics
  • Cambridge University Press
  • National Academy of Sciences
  • 1980-1984  (20)
  • 1945-1949
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  • American Association for the Advancement of Science (AAAS)  (20)
  • American Geophysical Union (AGU)
  • American Institute of Physics
  • Cambridge University Press
  • National Academy of Sciences
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  • 1
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    Familial studies of intelligence: a review (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-29
    Beschreibung: A summary of 111 studies identified in a survey of the world literature on familial resemblances in measured intelligence reveals a profile of average correlations consistent with a polygenic mode of inheritance. There is, however, a marked degree of heterogeneity of the correlations within familial groupings, which is not moderated by sex of familial pairing or by type of intelligence test used.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bouchard, T J Jr -- McGue, M -- 5 T32 MH14647/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 May 29;212(4498):1055-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7195071" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Family ; Female ; *Genetics, Medical ; Humans ; *Intelligence ; Intelligence Tests ; Male ; Pregnancy ; Sex Factors ; Twins
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Associative Learning in Aplysia: evidence for conditioned fear in an invertebrate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-30
    Beschreibung: Aversive classical conditioning of Aplysia californica, a gastropod mollusk suited for neurobiological study, produces a learned reaction to the chemosensory conditioned stimulus that is expressed as a marked facilitation of four defensive responses: two graded reflexes (head and siphon withdrawal), an all-or-none fixed act (inking), and a complex fixed action pattern (escape locomotion). In addition, the conditioned stimulus produces a concomitant depression of at least one appetitive response, feeding. These extensive and selective actions of the conditioned stimulus in Aplysia resemble the actions of conditioned fear stimuli in higher mammals and suggest that the functional equivalent of fear occurs in invertebrates and thus may be an adaptive mechanism that is widespread in the animal kingdom.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walters, E T -- Carew, T J -- Kandel, E R -- 5K02MH0081/MH/NIMH NIH HHS/ -- 5K05MH18558/MH/NIMH NIH HHS/ -- 5T32MH1574/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):504-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7192881" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aplysia/*physiology ; Association Learning/*physiology ; Avoidance Learning/physiology ; Behavior, Animal/physiology ; Conditioning (Psychology)/physiology ; Defense Mechanisms ; Fear/*physiology ; Humans ; Learning/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Type II collagen autoimmunity in otosclerosis and Meniere's Disease (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-09-17
    Beschreibung: Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoo, T J -- Stuart, J M -- Kang, A H -- Townes, A S -- Tomoda, K -- Dixit, S -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1153-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112122" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Autoantibodies/analysis ; Autoimmune Diseases/*immunology ; Collagen/classification/*immunology ; Humans ; Meniere Disease/*immunology ; Osteosclerosis/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-28
    Beschreibung: The defensive siphon and gill withdrawal reflex of Aplysia is a simple reflex mediated by a well-defined neural circuit. This reflex exhibits classical conditioning when a weak tactile stimulus to the siphon is used as a conditioned stimulus and a strong shock to the tail is used as an unconditioned stimulus. The siphon withdrawal component of this reflex can be differentially conditioned when stimuli applied to two different sites on the mantle skin (the mantle shelf and the siphon) are used as discriminative stimuli. The differential conditioning can be acquired in a single trial, is retained for more than 24 hours, and increases in strength with increased trials. Differential conditioning can also be produced within the field of innervation of a single cluster of sensory neurons (the LE cluster) since two separate sites on the siphon skin can serve as discriminative stimuli. The finding that two independent afferent inputs that activate a common set of interneurons and motor neurons can be differentially conditioned restricts the possible cellular loci involved in the associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carew, T J -- Hawkins, R D -- Kandel, E R -- 5KO2 M0081/PHS HHS/ -- 5KO5 MH18558/MH/NIMH NIH HHS/ -- NS 12744/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):397-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681571" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Afferent Pathways/physiology ; Animals ; Aplysia/*physiology ; Conditioning, Classical/*physiology ; *Defense Mechanisms ; Humans ; Memory ; Reflex
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-07-20
    Beschreibung: Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalyanaraman, V S -- Cabradilla, C D -- Getchell, J P -- Narayanan, R -- Braff, E H -- Chermann, J C -- Barre-Sinoussi, F -- Montagnier, L -- Spira, T J -- Kaplan, J -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330889" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/immunology/*microbiology ; Antibodies, Viral/*immunology ; Blood Donors ; Deltaretrovirus/immunology ; Homosexuality ; Humans ; Male ; Retroviridae/*immunology ; Retroviridae Infections/*immunology ; Viral Proteins/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-04
    Beschreibung: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, R C -- Salahuddin, S Z -- Popovic, M -- Shearer, G M -- Kaplan, M -- Haynes, B F -- Palker, T J -- Redfield, R -- Oleske, J -- Safai, B -- New York, N.Y. -- Science. 1984 May 4;224(4648):500-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200936" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/blood/*microbiology ; Adult ; Antigens, Viral/analysis ; Cells, Cultured ; Cytopathogenic Effect, Viral ; Deltaretrovirus/*isolation & purification/physiology/ultrastructure ; Female ; Homosexuality ; Humans ; Immune Sera/pharmacology ; Interferon Type I/immunology ; Male ; RNA-Directed DNA Polymerase/metabolism ; Risk ; T-Lymphocytes/microbiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Identification of an erythrocyte component carrying the Duffy blood group Fya antigen (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-10
    Beschreibung: The erythrocyte component carrying the Duffy blood group antigen Fya has been identified as a 35- to 43-kilodalton protein. The protein is degraded by proteases, chymotrypsin, and Pronase, which destroy its antigenicity on intact erythrocytes. Its unusual property of aggregating on being boiled in 5 percent sodium dodecyl sulfate with 5 percent 2-mercaptoethanol distinguishes it from other erythrocyte membrane proteins described to date.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hadley, T J -- David, P H -- McGinniss, M H -- Miller, L H -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):597-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695171" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Blood Group Antigens/*isolation & purification ; Duffy Blood-Group System/*isolation & purification ; Electrophoresis, Polyacrylamide Gel ; Erythrocyte Membrane/*immunology ; Hemagglutination Inhibition Tests ; Humans ; Molecular Weight
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Transfusion-associated AIDS: serologic evidence of human T-cell leukemia virus infection of donors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-23
    Beschreibung: An assay for antibodies to membrane antigens of cells infected by human T-cell leukemia virus was used to examine serum from persons who donated blood to 12 patients with acquired immunodeficiency syndrome (AIDS) associated with blood transfusions. The occurrence of positive results in the assay was significantly greater among donors to the AIDS patients (9 of 117; 7.7 percent) than among random donors (1 of 298; 0.3 percent). Of 12 sets of donors examined, 9 sets included a donor whose serum gave positive results for the presence of the antibodies. In six of these nine sets, the seropositive donor was an individual who was also identified as a possible source of AIDS transmission when epidemiologic and immunologic criteria were used.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaffe, H W -- Francis, D P -- McLane, M F -- Cabradilla, C -- Curran, J W -- Kilbourne, B W -- Lawrence, D N -- Haverkos, H W -- Spira, T J -- Dodd, R Y -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1309-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322301" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*etiology/immunology/transmission ; Adult ; Aged ; Antibodies, Viral/*analysis ; Antigens, Surface/immunology ; Antigens, Viral/immunology ; *Blood Donors ; Blood Transfusion/*adverse effects ; Deltaretrovirus/immunology/*pathogenicity ; Female ; Homosexuality ; Humans ; Male ; Middle Aged ; Retroviridae/*immunology ; Retroviridae Infections/*epidemiology ; Risk
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Genetic variation in the human insulin gene (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-08-01
    Beschreibung: Four recombinant lambda phages containing nucleotide sequences complementary to a cloned human preproinsulin DNA probe have been isolated from human DNA. Restriction analyses in conjunction with Southern hybridizations reveal two types of gene sequences. One isolate of each type was subjected to complete nucleotide sequence determination. The sequences contain the entire preproinsulin messenger RNA region, two intervening sequence. 260 nucleotides upstream from the messenger RNA capping site, and 35 nucleotides beyond the polyadenylate attachment site. Our results strongly suggest that these two gene types are allelic variants of a single insulin gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ullrich, A -- Dull, T J -- Gray, A -- Brosius, J -- Sures, I -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):612-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248962" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular ; *Dna ; DNA Restriction Enzymes ; DNA, Recombinant/metabolism ; *Genes ; Genetic Code ; *Genetic Variation ; Humans ; Insulin/*biosynthesis ; Nucleic Acid Hybridization ; Proinsulin/biosynthesis ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    DNA sequence of two closely linked human leukocyte interferon genes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-05
    Beschreibung: A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or alpha type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawn, R M -- Adelman, J -- Dull, T J -- Gross, M -- Goeddel, D -- Ullrich, A -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1159-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6165082" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bacteriophage lambda/genetics ; Base Sequence ; DNA Restriction Enzymes ; DNA, Recombinant/*metabolism ; *Genes ; Humans ; Interferons/*genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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