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  • Artikel  (18.862)
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  • American Association for the Advancement of Science (AAAS)  (2.510)
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  • 1980-1984  (9.736)
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  • Artikel  (18.862)
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  • 1
    Digitale Medien
    Digitale Medien
    A study of ozone in the Colorado mountains (1983)
    Springer
    Journal of atmospheric chemistry 1 (1983), S. 87-105 
    Details
    ISSN: 1573-0662
    Schlagwort(e): Tropospheric ozone ; ozone precursors ; photochemistry ; nitrogen oxides ; rural ozone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Geologie und Paläontologie
    Notizen: Abstract The seasonal and diurnal variations of ozone mixing ratios have been observed at Niwot Ridge. Colorado. The ozone mixing ratios have been correlated with the NO x (NO+NO2) mixing ratios measured concurrently at the site. The seasonal and diurnal variations in O3 can be reasonably well understood by considering photochemistry and transport. In the winter there is no apparent systematic diurnal variation in the O3 mixing ratio because there is little diurnal change of transport and a slow photochemistry. In the summer, the O3 levels at the site are suppressed at night due to the presence of a nocturnal inversion layer that isolated ozone near the surface, where it is destroyed. Ozone is observed to increase in the summer during the day. The increases in ozone correlate with increasing NO x levels, as well as with the levels of other compounds of anthropogenic origin. We interpret this correlation as in-situ or in-transit photochemical production of ozone from these precursors that are transported to our site. The levels of ozone recorded approach 100 ppbv at NO x mixing ratios of approximately 3 ppbv. Calculations made using a simple clean tropospheric chemical model are consistent with the NO x -related trend observed for the daytime ozone mixing ratio. However, the chemistry, which does not include nonmethane hydrocarbon photochemistry, underestimates the observed O3 production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00113981
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of zimelidine (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 111-116 
    Details
    ISSN: 1432-1041
    Schlagwort(e): zimelidine ; norzimelidine ; antidepressants ; pharmacokinetics ; bioavailability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The systemic availability of a new antidepressant, zimelidine, and of its pharmacologically active metabolite, norzimelidine, was studied in six healthy male volunteers. Three single doses of zimelidine (25 mg and 100 mg orally and 25 mg i.v.) and two single doses of norzimelidine (25 mg orally and i. v.) were given to each volunteer allowing at least seven days between administrations. Plasma concentrations of zimelidine and norzimelidine were determined in serial blood samples by HPLC. Following oral zimelidine peak plasma concentrations of the metabolite were attained about 3 h after dosing. Oral administration of norzimelidine itself resulted in a plasma concentration profile for this compound that was similar to that observed after oral zimelidine. Utilising the plasma concentration data following intravenous infusion of each compound, the elimination half-lives for zimelidine and norzimelidine were calculated to be 5.1 h (range 4.3–6.0) and 15.5 h (range 10.6–22.9) respectively. The total body clearances of the 2 compounds were similar at 0.52 l · min−1 (range 0.26–0.70) for zimelidine and 0.56 l · min−1 (range 0.28–0.83) for norzimelidine. The substantially longer elimination half-life of norzimelidine was apparently the result of a larger volume of distribution (9.4 l · kg−1; range 7.8–11.4) for this metabolite, as compared to zimelidine (3.21 · kg−1; range 1.6–4.9). The calculated bioavailability of zimelidine was 26% (range 9.1–39) after the 25 mg oral dose, and 29% (range 14–46) after the 100 mg dose. The bioavailability of norzimelidine was 66% (range 36–91). However, oral administration of zimelidine resulted in as much or more norzimelidine reaching the systemic circulation, as the oral administration of norzimelidine itself. This is important as a large part of the activity of the drug may be due to the metabolite.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00562618
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Buchbesprechungen (1975)
    Springer
    Naturwissenschaften 62 (1975), S. 100-104 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00592191
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Abstracts of papers (1982)
    Springer
    Pharmacy world & science 4 (1982), S. 205-212 
    Details
    ISSN: 1573-739X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01959141
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    A material isolated from human hands that attracts female mosquitoes (1982)
    Springer
    Journal of chemical ecology 8 (1982), S. 429-438 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Attractants ; human ; mosquito ; collection ; concentration ; Aedes aegypti ; Anopheles quadrimaculatus ; Diptera ; Culicidae
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The residue left on glass surfaces by human hands was found to be attractive to femaleAedes aegypti (L.) andAnopheles quadrimaculatus Say mosquitoes. The material lost half of its activity in 1 hr. A solvent wash technique was developed to recover and concentrate the residuum from handled glass beads. The residuum could be recovered effectively with absolute ethanol and less effectively with several other solvents. More mosquitoes were attracted to heated than to unheated residuum, an indication of its volatility. Also, attraction of the residuum decreased with decreasing concentration or dose. Concentrated residuum collections, stored under refrigeration and tested for longevity, showed no appreciable loss of attractiveness up to 60 days of storage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00987791
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Comparative mechanical performances of some new devices for fixation of unstable pelvic ring fractures (1983)
    Springer
    Medical & biological engineering & computing 21 (1983), S. 657-663 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Biomechanical stability ; External fixation ; Pelvic fractures
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract A laboratory cadaveric model, developed previously for the study of currently employed external fixation devices used for unstable pelvic fractures was used to evaluate rigidity improvements associated with a number of fixation design innovations. Based on quasistatic shearing displacements measured at the sacro-iliac joint and symphysis pubis disruption sites, otherwise identical anterior frameworks constructed on 5 mm fixation halfpins, rather than upon standard 4 mm halfpins, were able to sustain markedly (58% to 210%) greater loadings. A new and very simple traingular framework was designed and constructed for which the fixation rigidity was found to rival that of much more complex and cumbersome double anterior frames. When used as the posterior component of combined anterior/posterior fixation systems, a new double cobra-type (internal) plate allowed the injury model pelvises to sustain near-physiological load levels. A pair of dynamic compression plates attached across a disrupted symphysis pubis was found to be a biomechanically acceptable substitute for an anterior external fixator.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02464027
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Phosphorylated ethyleneamide derivatives of uracils, their preparation and biological activity (1982)
    Springer
    Pharmaceutical chemistry journal 16 (1982), S. 744-750 
    Details
    ISSN: 1573-9031
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00772154
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  • 8
    facet.materialart.
    Unbekannt
    Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: A DNA sequence coding for the immunogenic capsid protein VP3 of foot-and-mouth disease virus A12, prepared from the virion RNA, was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system. When Escherichia coli transformed with this plasmid was grown in tryptophan-depleted media, approximately 17 percent of the total cellular protein was found to be an insoluble and stable chimeric protein. The purified chimeric protein competed equally on a molar basis with VP3 for specific antibodies to foot-and-mouth disease virus. When inoculated into six cattle and two swine, this protein elicited high levels of neutralizing antibody and protection against challenge with foot-and-mouth disease virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleid, D G -- Yansura, D -- Small, B -- Dowbenko, D -- Moore, D M -- Grubman, M J -- McKercher, P D -- Morgan, D O -- Robertson, B H -- Bachrach, H L -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1125-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272395" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibody Formation ; Base Sequence ; Cattle ; Cattle Diseases/*prevention & control ; *Cloning, Molecular ; DNA Restriction Enzymes ; DNA, Recombinant/metabolism ; Foot-and-Mouth Disease/*prevention & control ; Immunity, Cellular ; Protein Biosynthesis ; Swine ; Swine Diseases/*prevention & control ; Transcription, Genetic ; *Vaccines ; Viral Proteins/genetics/*therapeutic use
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    facet.materialart.
    Unbekannt
    Plea to the scientific community (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-06-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baltimore, D -- Berg, P -- Bloch, K E -- Brown, D D -- Kornberg, A -- Nathans, D -- Smith, H O -- Watson, J D -- Thomas, L -- New York, N.Y. -- Science. 1982 Jun 4;216(4550):1046.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17808459" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    facet.materialart.
    Unbekannt
    Hayflick-NIH Settlement (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-01-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strehler, B L -- Abraham, S -- Bayreuther, K -- Bienenstock, A -- Binstock, R -- Birren, J -- Blumenthal, H T -- Brautbar, C -- Brody, E M -- Brody, H -- Comfort, A -- Cottle, R W -- Danielli, J F -- Danon, D -- Datan, N -- Ebbesen, P -- Elsen, A -- Freundt, E A -- Gallop, P M -- Girardi, A J -- Glenn, P F -- Goheen, J D -- Goldstein, S -- Good, R A -- Goodlin, R C -- Granoff, A -- Gray, A -- Haber, P A -- Hamparian, V V -- Hijmans, W -- Holliday, R -- Horvath, S M -- Houck, J C -- Huebner, R J -- Itoh, H -- Jukes, T -- Kaplan, H S -- Kirkman, H -- Kuwert, E -- Leiderman, P H -- Liss, A -- Litwin, J -- Lubin, B -- Macieira-Coelho, A -- Madoff, S -- Maletta, G J -- Maramorosch, K -- Martin, G M -- Masover, G -- Matsumura, T -- Medvedev, Z -- Melnick, J L -- Merchant, D J -- Namba, M -- Neter, E -- Neugarten, B -- Orgel, L -- Outschoorn, A S -- Pace, D M -- Packer, L -- Parker, J C -- Patterson, M D Jr -- Pollard, M -- Portnuff, J -- Razin, S -- Reiff, T R -- Robert, L -- Rockstein, M -- Rosamoff, H -- Rosanoff, E I -- Rottem, S -- Schachter, J -- Schwartz, H -- Shanas, E -- Shimkin, M B -- Smith, J R -- Somerson, N L -- Stinebring, W -- Textor, R -- Thomas, L -- Viidik, A -- Weg, R -- Yabrov, A -- Yanofsky, C -- Zatz, L M -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):240-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17784330" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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