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  • 1995-1999  (371)
  • 1
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    Stress directions along the Alaska Wadati-Benioff zone from inversion of focal mechanism data (1995)
    In:  Tectonophys., Chengdu, Sichuan, China, 4, vol. 246, no. 4, pp. 163-170, pp. L12S06, (ISSN: 1340-4202)
    Details
    Publication Date: 1995
    Keywords: Stress ; Plate tectonics ; Subduction zone ; Inversion ; Fault plane solution, focal mechanism ; Benioff zone
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Discovery of a small molecule insulin mimetic with antidiabetic activity in mice (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-13
    Description: Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin receptor tyrosine kinase, a nonpeptidyl fungal metabolite (L-783,281) was identified that acted as an insulin mimetic in several biochemical and cellular assays. The compound was selective for insulin receptor versus insulin-like growth factor I (IGFI) receptor and other receptor tyrosine kinases. Oral administration of L-783,281 to two mouse models of diabetes resulted in significant lowering in blood glucose levels. These results demonstrate the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, B -- Salituro, G -- Szalkowski, D -- Li, Z -- Zhang, Y -- Royo, I -- Vilella, D -- Diez, M T -- Pelaez, F -- Ruby, C -- Kendall, R L -- Mao, X -- Griffin, P -- Calaycay, J -- Zierath, J R -- Heck, J V -- Smith, R G -- Moller, D E -- New York, N.Y. -- Science. 1999 May 7;284(5416):974-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Endocrinology, Merck Research Laboratories, R80W250, Post Office Box 2000, Rahway, NJ 07065, USA. bei_zhang@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10320380" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Ascomycota/*metabolism ; Binding Sites ; Blood Glucose/metabolism ; CHO Cells ; Cricetinae ; Diabetes Mellitus, Type 2/*drug therapy ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Enzyme Activation ; Glucose Tolerance Test ; Hyperglycemia/drug therapy ; Hypoglycemic Agents/chemistry/metabolism/*pharmacology/therapeutic use ; Indoles/chemistry/metabolism/*pharmacology/therapeutic use ; Insulin/blood/metabolism/*pharmacology ; Insulin Receptor Substrate Proteins ; Mice ; Mice, Mutant Strains ; Mice, Obese ; Molecular Mimicry ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Conformation/drug effects ; Receptor, Epidermal Growth Factor/metabolism ; Receptor, IGF Type 1/metabolism ; Receptor, Insulin/chemistry/*metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Convergent domestication of cereal crops by independent mutations at corresponding genetic Loci (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-22
    Description: Independent domestication of sorghum, rice, and maize involved convergent selection for large seeds, reduced disarticulation of the mature inflorescence, and daylength-insensitive flowering. These similar phenotypes are largely determined by a small number of quantitative trait loci (QTLs) that correspond closely in the three taxa. The correspondence of these QTLs transcends 65 million years of reproductive isolation. This finding supports models of quantitative inheritance that invoke relatively few genes, obviates difficulties in map-based cloning of QTLs, and impels the comparative mapping of complex pheno-types across large evolutionary distances, such as those that separate humans from rodents and domesticated mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paterson, A H -- Lin, Y R -- Li, Z -- Schertz, K F -- Doebley, J F -- Pinson, S R -- Liu, S C -- Stansel, J W -- Irvine, J E -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1714-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17821643" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 4
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    RAG mutations in human B cell-negative SCID (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-04
    Description: Patients with human severe combined immunodeficiency (SCID) can be divided into those with B lymphocytes (B+ SCID) and those without (B- SCID). Although several genetic causes are known for B+ SCID, the etiology of B- SCID has not been defined. Six of 14 B- SCID patients tested were found to carry a mutation of the recombinase activating gene 1 (RAG-1), RAG-2, or both. This mutation resulted in a functional inability to form antigen receptors through genetic recombination and links a defect in one of the site-specific recombination systems to a human disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarz, K -- Gauss, G H -- Ludwig, L -- Pannicke, U -- Li, Z -- Lindner, D -- Friedrich, W -- Seger, R A -- Hansen-Hagge, T E -- Desiderio, S -- Lieber, M R -- Bartram, C R -- New York, N.Y. -- Science. 1996 Oct 4;274(5284):97-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Molecular Biology, University of Ulm, D-89070 Ulm, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8810255" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/immunology ; Cell Line ; Consanguinity ; *DNA-Binding Proteins ; Female ; Genes, Immunoglobulin ; Genes, Recessive ; *Homeodomain Proteins ; Humans ; Immunophenotyping ; Male ; Mutation ; Nuclear Proteins ; Polymorphism, Single-Stranded Conformational ; Proteins/*genetics ; Receptors, Antigen, T-Cell/genetics ; Recombination, Genetic ; Sequence Deletion ; Severe Combined Immunodeficiency/*genetics/immunology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 5
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    Large-Scale Synthesis of Aligned Carbon Nanotubes (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-06
    Description: Large-scale synthesis of aligned carbon nanotubes was achieved by using a method based on chemical vapor deposition catalyzed by iron nanoparticles embedded in mesoporous silica. Scanning electron microscope images show that the nanotubes are approximately perpendicular to the surface of the silica and form an aligned array of isolated tubes with spacings between the tubes of about 100 nanometers. The tubes are up to about 50 micrometers long and well graphitized. The growth direction of the nanotubes may be controlled by the pores from which the nanotubes grow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li -- Xie -- Qian -- Chang -- Zou -- Zhou -- Zhao -- Wang -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1701-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉W. Z. Li, S. S. Xie, B. H. Chang, B. S. Zou, W. Y. Zhou, R. A. Zhao, G. Wang, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China. L. X. Qian, Department of Physics, Central University of Nationalities, Beijing 100081, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939858" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 6
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    Effects of a prepulse on γ-ray radiation produced by a femtosecond laser with only 5-mJ energy (1998)
    American Physical Society
    Details
    Publication Date: 1998-04-01
    Print ISSN: 1063-651X
    Electronic ISSN: 1095-3787
    Topics: Physics
    Published by American Physical Society
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    PAPER CURRENT
  • 7
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    Evolution of the decay of highly excited nuclei (1998)
    American Physical Society
    Details
    Publication Date: 1998-06-01
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society
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  • 8
    Electronic Resource
    Electronic Resource
    Carrier concentration and mobility in GaN epilayers on sapphire substrate studied by infrared reflection spectroscopy (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 2691-2695 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report the measurement of carrier concentration and mobility of metalorganic chemical vapor deposited GaN thin films on the sapphire substrate by an infrared reflection technique. By fitting with the experimental data we obtain all the parameters of the lattice vibration oscillators and of the plasmon. From the plasmon frequency and the damping constant we have derived the carrier concentration and the electron mobility. The concentration agrees with the Hall data very well while the mobility values are smaller than that of the Hall measurement by a factor of about 0.5. We attribute such mobility lowering to the increase of scattering for the electrons coupling with the incident photons. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.371112
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    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Pulsed laser deposition of hydrogenated amorphous diamond-like carbon films from a polymer target (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 5398-5403 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Hydrogenated amorphous diamond-like carbon (a-DLC:H) films have been prepared by pulsed laser ablation of a polymer target in the presence of hydrogen (H2) gas. The growth rate of these films was found to be highly dependent on the deposition temperature and the amount of H2 gas used during the deposition process. The optical band gap of these a-DLC:H films changed in a wide range (0.25–2.5 eV) with substrate temperature and H2 pressure, and was found to be highly correlated to the ratio of sp3/sp2 in the film. The gap reached a maximum in a temperature range between 100 and 200 °C and had small values at either lower or higher temperatures. With increasing H2 pressure, the band gap increased monotonically and saturated around 0.5 mbar. It was found that the refractive index and the imaginary part of dielectric constant of these a-DLC:H films monotonically increased with decreases in the wavelength of the probing beam. It was also found that these laser derived a-DLC:H films could be made either completely insulating [∼10−11 (Ω cm)−1] or conducting [∼1 (Ω cm)−1] by simply varying the deposition temperature and H2 pressure. Very little photoconduction has been observed in these a-DLC:H films. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362726
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  • 10
    Electronic Resource
    Electronic Resource
    The formation of ternary compound Fe3Mo3C by ball milling (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 78 (1995), S. 4118-4122 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Ball milling of Mo in nitrogen and ammonia gases has been studied. After heating, the formation of an intriguing ternary compound, Fe3Mo3C1−x, was observed as a result of Fe (and C) contamination from the milling apparatus. For a comparison, mechanical alloying of Fe–Mo–C powders with a stoichiometric composition of Fe3Mo3C was also performed and again an Fe–Mo–C alloy was obtained after milling. Thermal analysis shows a single transition peak for the formation of both the Fe3Mo3C phase in the latter case and also for Fe3Mo3C1−x formed as a result of contamination from the mill. The lattice parameter for the Fe3Mo3C1−x phase obtained by Mo-gas reaction is smaller than for the Fe3Mo3C phase obtained by mechanical alloying of stoichiometric Fe–Mo–C powders. It is suggested that, in the Fe3Mo3C1−x phase produced by milling of Mo in gases, a high concentration of C vacancies exists. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.360705
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