Publication Date:
1996-11-22
Description:
Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to fatty acids such as oleic and retinoic acid. Mice with a null mutation in aP2, the gene encoding the adipocyte FABP, were developmentally and metabolically normal. The aP2-deficient mice developed dietary obesity but, unlike control mice, they did not develop insulin resistance or diabetes. Also unlike their obese wild-type counterparts, obese aP2-/- animals failed to express in adipose tissue tumor necrosis factor-alpha (TNF-alpha), a molecule implicated in obesity-related insulin resistance. These results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-alpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hotamisligil, G S -- Johnson, R S -- Distel, R J -- Ellis, R -- Papaioannou, V E -- Spiegelman, B M -- DK31405/DK/NIDDK NIH HHS/ -- HD27295/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1377-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8910278" target="_blank"〉PubMed〈/a〉
Keywords:
Adipose Tissue/*metabolism
;
Animals
;
Blood Glucose/metabolism
;
Carrier Proteins/genetics/metabolism/*physiology
;
Dietary Fats/administration & dosage
;
Fatty Acid-Binding Proteins
;
Fatty Acids/*metabolism
;
Female
;
Gene Expression Regulation
;
Gene Targeting
;
Glucose Tolerance Test
;
Homeostasis
;
Insulin/blood
;
*Insulin Resistance
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mutation
;
Myelin P2 Protein/genetics/metabolism/*physiology
;
*Neoplasm Proteins
;
*Nerve Tissue Proteins
;
Obesity/*metabolism
;
Triglycerides/blood
;
Tumor Necrosis Factor-alpha/*biosynthesis/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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