Publication Date:
1998-01-31
Description:
The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads. These structures were shown to contain forms of beta amyloid precursor protein and ubiquitin-B that are aberrant (+1 proteins) in the carboxyl terminus. The +1 proteins were not found in young control patients, whereas the presence of ubiquitin-B+1 in elderly control patients may indicate early stages of neurodegeneration. The two species of +1 proteins displayed cellular colocalization, suggesting a common origin, operating at the transcriptional level or by posttranscriptional editing of RNA. This type of transcript mutation is likely an important factor in the widely occurring nonfamilial early- and late-onset forms of Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Leeuwen, F W -- de Kleijn, D P -- van den Hurk, H H -- Neubauer, A -- Sonnemans, M A -- Sluijs, J A -- Koycu, S -- Ramdjielal, R D -- Salehi, A -- Martens, G J -- Grosveld, F G -- Peter, J -- Burbach, H -- Hol, E M -- New York, N.Y. -- Science. 1998 Jan 9;279(5348):242-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands. f.van.leeuwen@nih.knaw.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9422699" target="_blank"〉PubMed〈/a〉
Keywords:
Aged
;
Aging/genetics
;
Alzheimer Disease/*genetics/metabolism/pathology
;
Amino Acid Sequence
;
Amyloid beta-Protein Precursor/analysis/chemistry/*genetics
;
Base Sequence
;
*Brain Chemistry
;
Cerebral Cortex/chemistry/pathology
;
Cloning, Molecular
;
Down Syndrome/*genetics/metabolism/pathology
;
Female
;
*Frameshift Mutation
;
Hippocampus/chemistry/pathology
;
Humans
;
Male
;
Molecular Sequence Data
;
Neurites/chemistry
;
Neurofibrillary Tangles/chemistry
;
Neuropil/chemistry
;
Polymerase Chain Reaction
;
RNA Editing
;
Repetitive Sequences, Nucleic Acid
;
Sequence Deletion
;
Transcription, Genetic
;
Ubiquitins/analysis/chemistry/*genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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