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  • Geophysics  (450)
  • Female  (238)
  • Astrophysics  (234)
  • Instrumentation and Photography  (197)
  • Amino Acid Sequence  (175)
  • 2000-2004  (1,276)
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  • 11
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    A Systematic Search for Short-term Variability of EGRET Sources (2000)
    In:  CASI
    Details
    Publication Date: 2013-08-29
    Description: The 3rd EGRET Catalog of High-energy Gamma-ray Sources contains 170 unidentified sources, and there is great interest in the nature of these sources. One means of determining source class is the study of flux variability on time scales of days; pulsars are believed to be stable on these time scales while blazers are known to be highly variable. In addition, previous work has demonstrated that 3EG J0241-6103 and 3EG J1837-0606 are candidates for a new gamma-ray source class. These sources near the Galactic plane display transient behavior but cannot be associated with any known blazers. Although, many instances of flaring AGN have been reported, the EGRET database has not been systematically searched for occurrences of short-timescale (approximately 1 day) variability. These considerations have led us to conduct a systematic search for short-term variability in EGRET data, covering all viewing periods through proposal cycle 4. Six 3EG catalog sources are reported here to display variability on short time scales; four of them are unidentified. In addition, three non-catalog variable sources are discussed.
    Keywords: Astrophysics
    Format: application/pdf
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  • 12
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    Probing the interstellar medium in early-type galaxies with Infrared Space Oberservatory observations (2000)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: Four IRAS-detected early-type galaxies were observed with the Infrared Space Observatory (ISO). With the exception of the 15 mu m image of NGC 1052, the mid-IR images of NGC 1052, NGC 1155, NGC 5866, and NGC 6958 at 4.5, 7, and 15 mu m show extended emission.
    Keywords: Astrophysics
    Type: Astrophysical Journal; Volume 543; no. 2; 634-643
    Format: text
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  • 13
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    Dust impacts at Comet P/Borrelly (2002)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Keywords: Geophysics
    Type: European Geophysical Society; Nice; France
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  • 14
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    CHAMP Tracking and Accelerometer Data Analysis Results (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: The CHAMP (Challenging Minisatellite Payload) mission's unique combination of sensors and orbit configuration will enable unprecedented improvements in modeling and understanding the Earth's static gravity field and its temporal variations. CHAMP is the first of two missions (GRACE (Gravity Recovery and Climate Experiment) to be launched in the later part of '01) that combine a new generation of GPS (Global Positioning System) receivers, a high precision three axis accelerometer, and star cameras for the precision attitude determination. In order to isolate the gravity signal for science investigations, it is necessary to perform a detailed reduction and analysis of the GPS and SLR tracking data in conjunction with the accelerometer and attitude data. Precision orbit determination based on the GPS and SLR (Satellite Laser Ranging) tracking data will isolate the orbit perturbations, while the accelerometer data will be used to distinguish the surface forces from those due to the geopotential (static, and time varying). In preparation for the CHAMP and GRACE missions, extensive modifications have been made to NASA/GSFC's GEODYN orbit determination software to enable the simultaneous reduction of spacecraft tracking (e.g. GPS and SLR), three axis accelerometer and precise attitude data. Several weeks of CHAMP tracking and accelerometer data have been analyzed and the results will be presented. Precision orbit determination analysis based on tracking data alone in addition to results based on the simultaneous reduction of tracking and accelerometer data will be discussed. Results from a calibration of the accelerometer will be presented along with the results from various orbit determination strategies. Gravity field modeling status and plans will be discussed.
    Keywords: Geophysics
    Type: 1st CHAMP Science Meeting; Jan 22, 2002 - Jan 25, 2002; Potsdam; Germany
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  • 15
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    An Assessment of Gravity Recovery with CHAMP Data (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: The CHAMP mission, launched in July 2000, is the first in the series of mapping missions for the Earth's geopotential scheduled for the first decade of the new millenium. Its unique contributions compared to all the previous generation of satellites whose data have been included in Earth geopotential models are the precision global tracking with GPS data, and the availability of precision accelerometry data to model the nonconservative forces. Over the past year we have implemented extensive modifications to our GEODYN orbit determination processing code and ancillary data preprocessors to process the GPS and accelerometry data from missions such as CHAMP and GRACE. We report on the analysis of up to 60 days of CHAMP data and how these data contribute to Earth geopotential solutions where the base model is a derivative of EGM96. Preliminary results with only 12.5 days of data processed clearly show the ability of the CHAMP data to improve the modeling of the zonals (1=10 to 40), the m-dailies, the primary resonance terms, and the sectoral harmonics. We will detail the results of our calibrations of the CHAMP accelerometry and assess the quality of test solutions that include these CHAMP data.
    Keywords: Geophysics
    Type: European Geophysical Society (EGS) XXVII General Assembly; Apr 21, 2002 - Apr 26, 2002; Nice; France
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  • 16
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    Extremely Red Objects in the Lockman Hole (2004)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We investigate extremely red objects (EROs) using near- and mid-infrared observations in five passbands (3.6 to 24 microns) obtained from the Spitzer Space Telescope, and deep ground-based R and K imaging. The great sensitivity of the Infrared Array Camera (IRAC) camera allows us to detect 64 EROs (a surface density of 2.90 +/- 0.36 arcmin(exp -2); [3.6](sub AB) is less than 23.7) in only 12 minutes of IRAC exposure time, by means of an R - [3.6] color cut (analogous to the traditional red R - K cut). A pure infrared K - [3.6] red cut detects a somewhat different population and may be more effective at selecting z greater than 1.3 EROs. We find approximately 17% of all galaxies detected by IRAC at 3.6 or 4.5 microns to be EROs. These percentages rise to about 40% at 5.8 microns, and about 60% at 8.0 microns. We utilize the spectral bump at 1.6 microns to divide the EROs into broad redshift slices using only near-infrared colors (2.2/3.6/4.5 microns). We conclude that two-thirds of all EROs lie at redshift z greater than 1.3. Detections at 24 microns imply that at least 11% of 0.6 less than z and less than 1.3 EROs and at least 22% of z greater than 1.3 EROs are dusty star-forming galaxies.
    Keywords: Astrophysics
    Type: The Astrophysical Journal Supplement Series; 154; 107-111
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  • 17
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    Temporal-Spatial Structure of Magnetic Merging at the Magnetopause Inferred from 557.7-nm All-Sky Images (2004)
    In:  Other Sources
    Details
    Publication Date: 2019-08-15
    Description: We demonstrate that high-resolution 557.7-nm all-sky images are useful tools for investigating the spatial and temporal evolution of merging on the dayside magnetopause. Analysis of ground and satellite measurements leads us to conclude that high-latitude merging events can occur at multiple sites simultaneously and vary asynchronously on time scales of 30 s to 3 min. Variations of 557.7 nm emissions were observed at a 10 s cadence at Ny-Alesund on 19 December 2001, while significant changes in the IMF clock angle were reaching the magnetopause. The optical patterns are consistent with a scenario in which merging occurs around the rim of the high-latitude cusp at positions dictated by the IMF clock angle. Electrons energized at merging sites represent plausible sources for 557.7 nm emissions in the cusp. Polar observations at the magnetopause have directly linked enhanced fluxes of 〉 or = 0.5 keV electrons with merging. Spectra of electrons responsible for some of the emissions, measured during a DMSP F15 overflight, exhibit "inverted-V" features, indicating further acceleration above the ionosphere. SuperDARN spectral width boundaries, characteristic of open-closed field line transitions, are located at the equatorward edge of the 557.7nm emissions. Optical data suggest that with IMF B(sub Y) 〉 0, the Northern Hemisphere cusp divides into three source regions. When the IMF clock angle was approx. 150 deg structured 557.7-nm emissions came from east of the 13:00 MLT meridian. At larger clock angles the emissions appeared between 12:00 and 13:00 MLT. No significant 557.7-nm emissions were detected in the prenoon MLT sector. MHD simulations corroborate our scenario, showing that with the observed large dipole-tilt and IMF clock angles, merging sites develop near the front and eastern portions of the high-altitude cusp rim in the Northern Hemisphere and near the western part of the cusp rim in the Southern Hemisphere.
    Keywords: Geophysics
    Type: Annales Geophysicae; 22; 2917-2942
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  • 18
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    Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-02-09
    Description: The protein-protein interaction between leukocyte functional antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) is critical to lymphocyte and immune system function. Here, we report on the transfer of the contiguous, nonlinear epitope of ICAM-1, responsible for its association with LFA-1, to a small-molecule framework. These LFA-1 antagonists bound LFA-1, blocked binding of ICAM-1, and inhibited a mixed lymphocyte reaction (MLR) with potency significantly greater than that of cyclosporine A. Furthermore, in comparison to an antibody to LFA-1, they exhibited significant anti-inflammatory effects in vivo. These results demonstrate the utility of small-molecule mimics of nonlinear protein epitopes and the protein epitopes themselves as leads in the identification of novel pharmaceutical agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gadek, T R -- Burdick, D J -- McDowell, R S -- Stanley, M S -- Marsters, J C Jr -- Paris, K J -- Oare, D A -- Reynolds, M E -- Ladner, C -- Zioncheck, K A -- Lee, W P -- Gribling, P -- Dennis, M S -- Skelton, N J -- Tumas, D B -- Clark, K R -- Keating, S M -- Beresini, M H -- Tilley, J W -- Presta, L G -- Bodary, S C -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1086-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bioorganic Chemistry, Genentech, One DNA Way, South San Francisco, CA 94080, USA. trg@gene.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834839" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical ; synthesis/chemistry/metabolism/pharmacology ; Cyclosporine/pharmacology ; Dermatitis, Irritant/drug therapy ; Dinitrofluorobenzene ; Drug Design ; Enzyme-Linked Immunosorbent Assay ; Epitopes ; Female ; Humans ; Immunoglobulin Fab Fragments/immunology/pharmacology ; Immunosuppressive Agents/chemical synthesis/chemistry/metabolism/*pharmacology ; Intercellular Adhesion Molecule-1/chemistry/*immunology/*metabolism ; Lymphocyte Culture Test, Mixed ; Lymphocyte Function-Associated Antigen-1/immunology/*metabolism ; Mice ; Mice, Inbred BALB C ; Molecular Mimicry ; Mutagenesis ; Protein Structure, Secondary ; Structure-Activity Relationship ; Thiophenes/*chemical synthesis/chemistry/metabolism/*pharmacology ; beta-Alanine/analogs & derivatives/*chemical ; synthesis/chemistry/metabolism/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 19
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    Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-02
    Description: Acetylation of core histone tails plays a fundamental role in transcription regulation. In addition to acetylation, other posttranslational modifications, such as phosphorylation and methylation, occur in core histone tails. Here, we report the purification, molecular identification, and functional characterization of a histone H4-specific methyltransferase PRMT1, a protein arginine methyltransferase. PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300. However, acetylation of H4 inhibits its methylation by PRMT1. Most important, a mutation in the S-adenosyl-l-methionine-binding site of PRMT1 substantially crippled its nuclear receptor coactivator activity. Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, H -- Huang, Z Q -- Xia, L -- Feng, Q -- Erdjument-Bromage, H -- Strahl, B D -- Briggs, S D -- Allis, C D -- Wong, J -- Tempst, P -- Zhang, Y -- GM63067-01/GM/NIGMS NIH HHS/ -- P30 CA08748/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2001 Aug 3;293(5531):853-7. Epub 2001 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11387442" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Amino Acid Sequence ; Animals ; Arginine/*metabolism ; Binding Sites ; Cell Nucleus/metabolism ; HeLa Cells ; Histones/chemistry/*metabolism ; Humans ; Hydroxamic Acids/pharmacology ; Intracellular Signaling Peptides and Proteins ; Lysine/metabolism ; Methylation ; Methyltransferases/chemistry/genetics/isolation & purification/*metabolism ; Molecular Sequence Data ; Mutation ; Oocytes ; Protein-Arginine N-Methyltransferases ; Receptors, Androgen/*metabolism ; Recombinant Proteins/metabolism ; S-Adenosylmethionine/metabolism ; *Transcriptional Activation ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 20
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    Identification of ubiquitin ligases required for skeletal muscle atrophy (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-27
    Description: Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bodine, S C -- Latres, E -- Baumhueter, S -- Lai, V K -- Nunez, L -- Clarke, B A -- Poueymirou, W T -- Panaro, F J -- Na, E -- Dharmarajan, K -- Pan, Z Q -- Valenzuela, D M -- DeChiara, T M -- Stitt, T N -- Yancopoulos, G D -- Glass, D J -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1704-8. Epub 2001 Oct 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591-6707, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679633" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cloning, Molecular ; Creatine Kinase/genetics ; Creatine Kinase, MM Form ; *DNA-Binding Proteins ; Gene Deletion ; *Gene Expression Profiling ; Hindlimb Suspension ; Humans ; Immobilization ; Isoenzymes/genetics ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Muscle Denervation ; Muscle Proteins/genetics ; Muscle, Skeletal/growth & development/*metabolism/pathology/physiopathology ; Muscular Atrophy/*genetics/pathology/physiopathology ; MyoD Protein/genetics ; Myogenic Regulatory Factor 5 ; Myogenin/genetics ; Peptide Synthases/chemistry/deficiency/genetics/*metabolism ; Phenotype ; Protein Binding ; RNA, Messenger/analysis/genetics ; Rats ; Rats, Sprague-Dawley ; SKP Cullin F-Box Protein Ligases ; *Trans-Activators ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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