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  • Articles  (332)
  • *Ecosystem  (158)
  • Temperature  (108)
  • Transfection  (89)
  • American Association for the Advancement of Science (AAAS)  (332)
  • 2000-2004  (332)
  • Biology  (332)
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  • Articles  (332)
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  • American Association for the Advancement of Science (AAAS)  (332)
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  • 1
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    The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-02
    Description: Diatoms are unicellular algae with plastids acquired by secondary endosymbiosis. They are responsible for approximately 20% of global carbon fixation. We report the 34 million-base pair draft nuclear genome of the marine diatom Thalassiosira pseudonana and its 129 thousand-base pair plastid and 44 thousand-base pair mitochondrial genomes. Sequence and optical restriction mapping revealed 24 diploid nuclear chromosomes. We identified novel genes for silicic acid transport and formation of silica-based cell walls, high-affinity iron uptake, biosynthetic enzymes for several types of polyunsaturated fatty acids, use of a range of nitrogenous compounds, and a complete urea cycle, all attributes that allow diatoms to prosper in aquatic environments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armbrust, E Virginia -- Berges, John A -- Bowler, Chris -- Green, Beverley R -- Martinez, Diego -- Putnam, Nicholas H -- Zhou, Shiguo -- Allen, Andrew E -- Apt, Kirk E -- Bechner, Michael -- Brzezinski, Mark A -- Chaal, Balbir K -- Chiovitti, Anthony -- Davis, Aubrey K -- Demarest, Mark S -- Detter, J Chris -- Glavina, Tijana -- Goodstein, David -- Hadi, Masood Z -- Hellsten, Uffe -- Hildebrand, Mark -- Jenkins, Bethany D -- Jurka, Jerzy -- Kapitonov, Vladimir V -- Kroger, Nils -- Lau, Winnie W Y -- Lane, Todd W -- Larimer, Frank W -- Lippmeier, J Casey -- Lucas, Susan -- Medina, Monica -- Montsant, Anton -- Obornik, Miroslav -- Parker, Micaela Schnitzler -- Palenik, Brian -- Pazour, Gregory J -- Richardson, Paul M -- Rynearson, Tatiana A -- Saito, Mak A -- Schwartz, David C -- Thamatrakoln, Kimberlee -- Valentin, Klaus -- Vardi, Assaf -- Wilkerson, Frances P -- Rokhsar, Daniel S -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):79-86.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Oceanography, University of Washington, Seattle, WA 98195, USA. armbrust@ocean.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459382" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Algal Proteins/chemistry/genetics/physiology ; Animals ; *Biological Evolution ; Cell Nucleus/genetics ; Chromosomes ; DNA/genetics ; Diatoms/chemistry/cytology/*genetics/metabolism ; *Ecosystem ; Energy Metabolism ; *Genome ; Iron/metabolism ; Light ; Light-Harvesting Protein Complexes/chemistry/genetics/metabolism ; Mitochondria/genetics ; Molecular Sequence Data ; Nitrogen/metabolism ; Photosynthesis ; Plastids/genetics ; Restriction Mapping ; Sequence Alignment ; *Sequence Analysis, DNA ; Silicic Acid/metabolism ; Symbiosis ; Urea/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Contribution of increasing CO2 and climate to carbon storage by ecosystems in the United States (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-17
    Description: The effects of increasing carbon dioxide (CO2) and climate on net carbon storage in terrestrial ecosystems of the conterminous United States for the period 1895-1993 were modeled with new, detailed historical climate information. For the period 1980-1993, results from an ensemble of three models agree within 25%, simulating a land carbon sink from CO2 and climate effects of 0.08 gigaton of carbon per year. The best estimates of the total sink from inventory data are about three times larger, suggesting that processes such as regrowth on abandoned agricultural land or in forests harvested before 1980 have effects as large as or larger than the direct effects of CO2 and climate. The modeled sink varies by about 100% from year to year as a result of climate variability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schimel, D -- Melillo, J -- Tian, H -- McGuire, A D -- Kicklighter, D -- Kittel, T -- Rosenbloom, N -- Running, S -- Thornton, P -- Ojima, D -- Parton, W -- Kelly, R -- Sykes, M -- Neilson, R -- Rizzo, B -- New York, N.Y. -- Science. 2000 Mar 17;287(5460):2004-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institute for Biogeochemistry, Postfach 10 01 64, D-07701 Jena, Germany. dschimel@bgc-jena.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10720324" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Atmosphere ; Carbon/*metabolism ; Carbon Dioxide/*metabolism ; *Climate ; Computer Simulation ; *Ecosystem ; Geography ; Trees ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Forecasting agriculturally driven global environmental change (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-17
    Description: During the next 50 years, which is likely to be the final period of rapid agricultural expansion, demand for food by a wealthier and 50% larger global population will be a major driver of global environmental change. Should past dependences of the global environmental impacts of agriculture on human population and consumption continue, 10(9) hectares of natural ecosystems would be converted to agriculture by 2050. This would be accompanied by 2.4- to 2.7-fold increases in nitrogen- and phosphorus-driven eutrophication of terrestrial, freshwater, and near-shore marine ecosystems, and comparable increases in pesticide use. This eutrophication and habitat destruction would cause unprecedented ecosystem simplification, loss of ecosystem services, and species extinctions. Significant scientific advances and regulatory, technological, and policy changes are needed to control the environmental impacts of agricultural expansion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tilman, D -- Fargione, J -- Wolff, B -- D'Antonio, C -- Dobson, A -- Howarth, R -- Schindler, D -- Schlesinger, W H -- Simberloff, D -- Swackhamer, D -- New York, N.Y. -- Science. 2001 Apr 13;292(5515):281-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Evolution and Behavior, University of Minnesota, 1987 Upper Buford Circle, St. Paul, MN 55108, USA. tilman@lter.umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11303102" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; *Ecosystem ; *Environment ; Eutrophication ; Fertilizers ; Forecasting ; Fresh Water ; Nitrogen ; Pesticides ; Phosphorus ; Regression Analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Biogeography and ecological setting of Indian Ocean hydrothermal vents (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-15
    Description: Within the endemic invertebrate faunas of hydrothermal vents, five biogeographic provinces are recognized. Invertebrates at two Indian Ocean vent fields (Kairei and Edmond) belong to a sixth province, despite ecological settings and invertebrate-bacterial symbioses similar to those of both western Pacific and Atlantic vents. Most organisms found at these Indian Ocean vent fields have evolutionary affinities with western Pacific vent faunas, but a shrimp that ecologically dominates Indian Ocean vents closely resembles its Mid-Atlantic counterpart. These findings contribute to a global assessment of the biogeography of chemosynthetic faunas and indicate that the Indian Ocean vent community follows asymmetric assembly rules biased toward Pacific evolutionary alliances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Dover, C L -- Humphris, S E -- Fornari, D -- Cavanaugh, C M -- Collier, R -- Goffredi, S K -- Hashimoto, J -- Lilley, M D -- Reysenbach, A L -- Shank, T M -- Von Damm, K L -- Banta, A -- Gallant, R M -- Gotz, D -- Green, D -- Hall, J -- Harmer, T L -- Hurtado, L A -- Johnson, P -- McKiness, Z P -- Meredith, C -- Olson, E -- Pan, I L -- Turnipseed, M -- Won, Y -- Young, C R 3rd -- Vrijenhoek, R C -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):818-23. Epub 2001 Sep 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, College of William & Mary, Williamsburg, VA 23187, USA. cindy_vandover@wm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557843" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/classification/isolation & purification ; *Bacterial Physiological Phenomena ; Biological Evolution ; Biomass ; Decapoda (Crustacea)/classification/physiology ; *Ecosystem ; Euryarchaeota/classification/isolation & purification/physiology ; Geography ; *Geologic Sediments/microbiology ; Hot Temperature ; Invertebrates/classification/microbiology/*physiology ; Molecular Sequence Data ; Mollusca/classification/physiology ; Oceans and Seas ; Seawater ; Symbiosis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Biodiversity and ecosystem functioning: current knowledge and future challenges (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-27
    Description: The ecological consequences of biodiversity loss have aroused considerable interest and controversy during the past decade. Major advances have been made in describing the relationship between species diversity and ecosystem processes, in identifying functionally important species, and in revealing underlying mechanisms. There is, however, uncertainty as to how results obtained in recent experiments scale up to landscape and regional levels and generalize across ecosystem types and processes. Larger numbers of species are probably needed to reduce temporal variability in ecosystem processes in changing environments. A major future challenge is to determine how biodiversity dynamics, ecosystem processes, and abiotic factors interact.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loreau, M -- Naeem, S -- Inchausti, P -- Bengtsson, J -- Grime, J P -- Hector, A -- Hooper, D U -- Huston, M A -- Raffaelli, D -- Schmid, B -- Tilman, D -- Wardle, D A -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):804-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire d'Ecologie, UMR 7625, Ecole Normale Superieure, 46 rue d'Ulm, F-75230 Paris Cedex 05, France. Loreau@ens.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679658" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecology ; *Ecosystem ; *Environment ; Plant Physiological Phenomena
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Collapse of the California Current during glacial maxima linked to climate change on land (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-07
    Description: Time series of alkenone unsaturation indices gathered along the California margin reveal large (4 degrees to 8 degrees C) glacial-interglacial changes in sea surface temperature (SST) over the past 550,000 years. Interglacial times with SSTs equal to or exceeding that of the Holocene contain peak abundances in the pollen of redwood, the distinctive component of the temperate rainforest of the northwest coast of California. In the region now dominated by the California Current, SSTs warmed 10,000 to 15,000 years in advance of deglaciation at each of the past five glacial maxima. SSTs did not rise in advance of deglaciation south of the modern California Current front. Glacial warming along the California margin therefore is a regional signal of the weakening of the California Current during times when large ice sheets reorganized wind systems over the North Pacific. Both the timing and magnitude of the SST estimates suggest that the Devils Hole (Nevada) calcite record represents regional but not global paleotemperatures, and hence does not pose a fundamental challenge to the orbital ("Milankovitch") theory of the Ice Ages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herbert, T D -- Schuffert, J D -- Andreasen, D -- Heusser, L -- Lyle, M -- Mix, A -- Ravelo, A C -- Stott, L D -- Herguera, J C -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):71-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geological Sciences, Brown University, Providence, RI 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441174" target="_blank"〉PubMed〈/a〉
    Keywords: Calcium Carbonate ; California ; *Climate ; Diatoms/physiology ; *Ice ; Models, Biological ; Nevada ; Pacific Ocean ; Pollen ; *Seawater/analysis ; Temperature ; Trees/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    A natural product that lowers cholesterol as an antagonist ligand for FXR (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-04
    Description: Extracts of the resin of the guggul tree (Commiphora mukul) lower LDL (low-density lipoprotein) cholesterol levels in humans. The plant sterol guggulsterone [4,17(20)-pregnadiene-3,16-dione] is the active agent in this extract. We show that guggulsterone is a highly efficacious antagonist of the farnesoid X receptor (FXR), a nuclear hormone receptor that is activated by bile acids. Guggulsterone treatment decreases hepatic cholesterol in wild-type mice fed a high-cholesterol diet but is not effective in FXR-null mice. Thus, we propose that inhibition of FXR activation is the basis for the cholesterol-lowering activity of guggulsterone. Other natural products with specific biologic effects may modulate the activity of FXR or other relatively promiscuous nuclear hormone receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urizar, Nancy L -- Liverman, Amy B -- Dodds, D'Nette T -- Silva, Frank Valentin -- Ordentlich, Peter -- Yan, Yingzhuo -- Gonzalez, Frank J -- Heyman, Richard A -- Mangelsdorf, David J -- Moore, David D -- New York, N.Y. -- Science. 2002 May 31;296(5573):1703-6. Epub 2002 May 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Caco-2 Cells ; Carrier Proteins/genetics/metabolism ; Cells, Cultured ; Chenodeoxycholic Acid/pharmacology ; Cholesterol/*metabolism ; Cholesterol, Dietary/administration & dosage ; DNA/metabolism ; DNA-Binding Proteins/*antagonists & inhibitors/chemistry/genetics/*metabolism ; Hepatocytes/metabolism ; Histone Acetyltransferases ; Humans ; *Hydroxysteroid Dehydrogenases ; Hypolipidemic Agents/metabolism/*pharmacology ; Ligands ; Liver/metabolism ; *Membrane Glycoproteins ; Mice ; Nuclear Receptor Coactivator 1 ; Pregnenediones/metabolism/*pharmacology ; Promoter Regions, Genetic ; Protein Structure, Tertiary ; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors/genetics/metabolism ; Receptors, Steroid/antagonists & inhibitors/metabolism ; Transcription Factors/*antagonists & inhibitors/chemistry/genetics/*metabolism ; Transcriptional Activation/drug effects ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Observations of comet 19P/Borrelly by the miniature integrated camera and spectrometer aboard Deep Space 1 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-06
    Description: The nucleus of the Jupiter-family comet 19P/Borrelly was closely observed by the Miniature Integrated Camera and Spectrometer aboard the Deep Space 1 spacecraft on 22 September 2001. The 8-kilometer-long body is highly variegated on a scale of 200 meters, exhibiting large albedo variations (0.01 to 0.03) and complex geologic relationships. Short-wavelength infrared spectra (1.3 to 2.6 micrometers) show a slope toward the red and a hot, dry surface (〈/=345 kelvin, with no trace of water ice or hydrated minerals), consistent with approximately 10% or less of the surface actively sublimating. Borrelly's coma exhibits two types of dust features: fans and highly collimated jets. At encounter, the near-nucleus coma was dominated by a prominent dust jet that resolved into at least three smaller jets emanating from a broad basin in the middle of the nucleus. Because the major dust jet remained fixed in orientation, it is evidently aligned near the rotation axis of the nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soderblom, L A -- Becker, T L -- Bennett, G -- Boice, D C -- Britt, D T -- Brown, R H -- Buratti, B J -- Isbell, C -- Giese, B -- Hare, T -- Hicks, M D -- Howington-Kraus, E -- Kirk, R L -- Lee, M -- Nelson, R M -- Oberst, J -- Owen, T C -- Rayman, M D -- Sandel, B R -- Stern, S A -- Thomas, N -- Yelle, R V -- New York, N.Y. -- Science. 2002 May 10;296(5570):1087-91. Epub 2002 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United States Geological Survey, 2255 North Gemini Drive, Flagstaff, AZ 86001, USA. lsoderblom@usgs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934989" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon/analysis ; Cosmic Dust ; Hydrocarbons/analysis ; *Meteoroids ; Spectrum Analysis ; Temperature
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Jupiter's atmospheric composition from the Cassini thermal infrared spectroscopy experiment (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-21
    Description: The Composite Infrared Spectrometer observed Jupiter in the thermal infrared during the swing-by of the Cassini spacecraft. Results include the detection of two new stratospheric species, the methyl radical and diacetylene, gaseous species present in the north and south auroral infrared hot spots; determination of the variations with latitude of acetylene and ethane, the latter a tracer of atmospheric motion; observations of unexpected spatial distributions of carbon dioxide and hydrogen cyanide, both considered to be products of comet Shoemaker-Levy 9 impacts; characterization of the morphology of the auroral infrared hot spot acetylene emission; and a new evaluation of the energetics of the northern auroral infrared hot spot.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kunde, V G -- Flasar, F M -- Jennings, D E -- Bezard, B -- Strobel, D F -- Conrath, B J -- Nixon, C A -- Bjoraker, G L -- Romani, P N -- Achterberg, R K -- Simon-Miller, A A -- Irwin, P -- Brasunas, J C -- Pearl, J C -- Smith, M D -- Orton, G S -- Gierasch, P J -- Spilker, L J -- Carlson, R C -- Mamoutkine, A A -- Calcutt, S B -- Read, P L -- Taylor, F W -- Fouchet, T -- Parrish, P -- Barucci, A -- Courtin, R -- Coustenis, A -- Gautier, D -- Lellouch, E -- Marten, A -- Prange, R -- Biraud, Y -- Ferrari, C -- Owen, T C -- Abbas, M M -- Samuelson, R E -- Raulin, F -- Ade, P -- Cesarsky, C J -- Grossman, K U -- Coradini, A -- New York, N.Y. -- Science. 2004 Sep 10;305(5690):1582-6. Epub 2004 Aug 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, University of Maryland, College Park, MD 20742, USA. Virgil.G.Kunde.1@gsfc.nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15319491" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylene ; Atmosphere ; *Carbon Dioxide ; Ethane ; Extraterrestrial Environment ; *Hydrocarbons ; *Hydrogen Cyanide ; *Jupiter ; Spacecraft ; Spectrum Analysis ; Temperature
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Oscillations in NF-kappaB signaling control the dynamics of gene expression (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-23
    Description: Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscillations in NF-kappaB translocation. Single-cell time-lapse imaging and computational modeling of NF-kappaB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IkappaBalpha transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-kappaB signaling may thus depend on number, period, and amplitude of oscillations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, D E -- Ihekwaba, A E C -- Elliott, M -- Johnson, J R -- Gibney, C A -- Foreman, B E -- Nelson, G -- See, V -- Horton, C A -- Spiller, D G -- Edwards, S W -- McDowell, H P -- Unitt, J F -- Sullivan, E -- Grimley, R -- Benson, N -- Broomhead, D -- Kell, D B -- White, M R H -- New York, N.Y. -- Science. 2004 Oct 22;306(5696):704-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown Street, Liverpool, L69 7ZB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15499023" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Computer Simulation ; Cytoplasm/metabolism ; Etoposide/pharmacology ; Feedback, Physiological ; *Gene Expression Regulation ; HeLa Cells ; Humans ; I-kappa B Proteins/genetics/metabolism ; Models, Biological ; NF-kappa B/*metabolism ; Phosphorylation ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Transcription Factor RelA ; Transcription, Genetic ; Transfection ; Tumor Necrosis Factor-alpha/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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