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  • Cell Press  (7)
  • American Association for the Advancement of Science (AAAS)  (5)
  • American Association for the Advancement of Science  (4)
  • Blackwell Science Ltd  (3)
  • 2000-2004  (15)
  • 1995-1999  (4)
  • 1
    Electronic Resource
    Electronic Resource
    A multivariate study on the effects of dietary vitamin K, vitamin D3 and calcium, and dissolved carbon dioxide on growth, bone minerals, vitamin status and health performance in smolting Atlantic salmon Salmo salar L. (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish diseases 25 (2002), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Bone deformities represent an increasing, unsolved problem for intensive farming of Atlantic salmon, Salmo salar L. To increase insight into nutritional and environmental impacts on bone mineralization, 16 groups of Atlantic salmon parr were fed diets with different levels of menadione sodium bisulphite (MSB), vitamin D3, and calcium (Ca), and exposed to different levels of dissolved carbon dioxide (CO2) based on a multivariate factorial design (24). The composition of the experimental diets was either a high or low level of each of the design variables. In addition, four groups (centre points) were fed a diet with intermediate levels of all dietary parameters and exposed to an intermediate level of dissolved CO2 to record the variation among tanks. After 6 weeks in fresh water, fish were marked according to group, transferred to a common net pen in sea water and fed commercial feed for another 11 weeks. High levels of CO2 decreased fish growth both in fresh water and sea water. No visible bone deformities were recorded at any time. Dry matter, protein and ash compositions of bone and concentrations of Ca, phosphorus (P) and magnesium (Mg) in bone were not significantly affected by any of the design variables. Minor effects were observed in clinical parameters recording health performance, stress and plasma Ca homeostasis. The mean level of vitamin D3 measured as cholecalciferol in fish organs increased significantly during the freshwater period and reflected dietary vitamin D3, whereas the level decreased when fish were fed commercial feed in sea water. The level of menaquinone in liver increased significantly in response to high dietary levels of MSB, indicating that dietary MSB was converted to menaquinone in salmon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2761.2002.00403.x
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro hydroxylation of vitamin D3 and 25-hydroxy vitamin D3 in tissues of Atlantic salmon Salmo salar, Atlantic mackerel Scomber scombrus, Atlantic halibut Hippoglossus hippoglossus and Atlantic cod Gadus morhua (1999)
    Oxford UK : Blackwell Science Ltd
    Aquaculture nutrition 5 (1999), S. 0 
    Details
    ISSN: 1365-2095
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The in vitro metabolism of 14CD3 and 3H25OHD3 was investigated in different tissues from Atlantic salmon Salmo salar, Atlantic mackerel Scomber scombrus, Atlantic halibut Hippoglossus hippoglossus and Atlantic cod Gadus morhua. The tissues analysed were liver, kidney, head kidney, gills, spleen and intestine. The metabolites were extracted in methanol–chloroform and separated by normal-phase high-pressure liquid chromatography (HPLC) followed by scintillation counting. Identification of the metabolites was by comigration with standards on normal and reversed-phase HPLC systems and by protein-binding assays. All tissues from all species analysed produced hydroxylated derivatives identified as 25OHD3, 24,25(OH)2D3 and 1,25(OH)2D3. In addition, some unidentified derivatives were recorded, one probably being 25,26(OH)2D3. Organs producing great amounts of one metabolite also produced considerable amounts of the other possible derivatives, suggesting a lower degree of specificity in fish organs than in human organs. The predominating metabolite was 24,25(OH)2D3 in all organs from salmon and mackerel during incubation with 14CD3 and within most organs from all species during 3H25OHD3 incubation. The latter observation probably results from the need for decreasing rather than increasing the calcium absorption in these species, which live at least some periods of life in a marine environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2095.1999.00084.x
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  • 3
    Electronic Resource
    Electronic Resource
    Three different levels of dietary vitamin D3 fed to first-feeding fry of Atlantic salmon (Salmo salar L.): effect on growth, mortality, calcium content and bone formation (2002)
    Oxford UK : Blackwell Science Ltd
    Aquaculture nutrition 8 (2002), S. 0 
    Details
    ISSN: 1365-2095
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Atlantic salmon (Salmo salar L.) fry were reared on a fishmeal-based diet with three different levels of vitamin D3 (0.2, 5 and 57 mg vitamin D3 kg–1 feed, ww) from first-feeding for 14 weeks. No significant differences were recorded in weight, length, specific growth rate, mortality, or kidney calcium concentration between the different dietary groups. No skeletal malformations or histopathological changes were recorded in any of the dietary groups. These results suggest Atlantic salmon fry to be highly tolerant of megadoses of vitamin D3 over a limited period of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2095.2002.00197.x
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  • 4
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    Addendum (2004)
    Cell Press
    Details
    Publication Date: 2004-12-01
    Print ISSN: 0969-2126
    Electronic ISSN: 1878-4186
    Topics: Biology , Medicine
    Published by Cell Press
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  • 5
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    Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-12-23
    Description: Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ertekin-Taner, N -- Graff-Radford, N -- Younkin, L H -- Eckman, C -- Baker, M -- Adamson, J -- Ronald, J -- Blangero, J -- Hutton, M -- Younkin, S G -- AG06656/AG/NIA NIH HHS/ -- MH59490/MH/NIMH NIH HHS/ -- P50 AG16574/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2303-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125143" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*blood/*genetics ; Amyloid beta-Peptides/*blood/genetics ; Chromosomes, Human, Pair 10/*genetics ; Female ; *Genetic Linkage ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Lod Score ; Male ; Middle Aged ; Pedigree ; Peptide Fragments/*blood/genetics ; Phenotype ; *Quantitative Trait, Heritable
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    White dwarfs and dark matter (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graff, D S -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2211.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astonomy, University of Michigan, Ann Arbor, MI 48109, USA. graff@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11424939" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Initial results from the Mini-TES experiment in Gusev Crater from the Spirit Rover (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-07
    Description: The Miniature Thermal Emission Spectrometer (Mini-TES) on Spirit has studied the mineralogy and thermophysical properties at Gusev crater. Undisturbed soil spectra show evidence for minor carbonates and bound water. Rocks are olivinerich basalts with varying degrees of dust and other coatings. Dark-toned soils observed on disturbed surfaces may be derived from rocks and have derived mineralogy (+/-5 to 10%) of 45% pyroxene (20% Ca-rich pyroxene and 25% pigeonite), 40% sodic to intermediate plagioclase, and 15% olivine (forsterite 45% +/-5 to 10). Two spectrally distinct coatings are observed on rocks, a possible indicator of the interaction of water, rock, and airfall dust. Diurnal temperature data indicate particle sizes from 40 to 80 microm in hollows to approximately 0.5 to 3 mm in soils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christensen, P R -- Ruff, S W -- Fergason, R L -- Knudson, A T -- Anwar, S -- Arvidson, R E -- Bandfield, J L -- Blaney, D L -- Budney, C -- Calvin, W M -- Glotch, T D -- Golombek, M P -- Gorelick, N -- Graff, T G -- Hamilton, V E -- Hayes, A -- Johnson, J R -- McSween, H Y Jr -- Mehall, G L -- Mehall, L K -- Moersch, J E -- Morris, R V -- Rogers, A D -- Smith, M D -- Squyres, S W -- Wolff, M J -- Wyatt, M B -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):837-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geological Sciences, Arizona State University, Tempe, AZ 85287, USA. phil.christensen@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297667" target="_blank"〉PubMed〈/a〉
    Keywords: Carbonates ; Geologic Sediments ; Interferometry ; Iron Compounds ; Magnesium Compounds ; *Mars ; *Minerals ; Oxides ; Silicates ; Spectrum Analysis ; Temperature ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Basaltic rocks analyzed by the Spirit Rover in Gusev Crater (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-07
    Description: The Spirit landing site in Gusev Crater on Mars contains dark, fine-grained, vesicular rocks interpreted as lavas. Pancam and Mini-Thermal Emission Spectrometer (Mini-TES) spectra suggest that all of these rocks are similar but have variable coatings and dust mantles. Magnified images of brushed and abraded rock surfaces show alteration rinds and veins. Rock interiors contain 〈/=25% megacrysts. Chemical analyses of rocks by the Alpha Particle X-ray Spectrometer are consistent with picritic basalts, containing normative olivine, pyroxenes, plagioclase, and accessory FeTi oxides. Mossbauer, Pancam, and Mini-TES spectra confirm the presence of olivine, magnetite, and probably pyroxene. These basalts extend the known range of rock compositions composing the martian crust.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McSween, H Y -- Arvidson, R E -- Bell, J F 3rd -- Blaney, D -- Cabrol, N A -- Christensen, P R -- Clark, B C -- Crisp, J A -- Crumpler, L S -- Des Marais, D J -- Farmer, J D -- Gellert, R -- Ghosh, A -- Gorevan, S -- Graff, T -- Grant, J -- Haskin, L A -- Herkenhoff, K E -- Johnson, J R -- Jolliff, B L -- Klingelhoefer, G -- Knudson, A T -- McLennan, S -- Milam, K A -- Moersch, J E -- Morris, R V -- Rieder, R -- Ruff, S W -- De Souza, P A Jr -- Squyres, S W -- Wanke, H -- Wang, A -- Wyatt, M B -- Yen, A -- Zipfel, J -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):842-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Planetary Sciences, University of Tennessee, Knoxville, TN 37996-1410, USA. mcsween@utk.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297668" target="_blank"〉PubMed〈/a〉
    Keywords: Extraterrestrial Environment ; Geologic Sediments ; Iron Compounds ; Magnesium Compounds ; *Mars ; *Minerals ; Oxides ; *Silicates ; Spectroscopy, Mossbauer ; Spectrum Analysis ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Mineralogy at Meridiani Planum from the Mini-TES Experiment on the Opportunity Rover (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-04
    Description: The Miniature Thermal Emission Spectrometer (Mini-TES) on Opportunity investigated the mineral abundances and compositions of outcrops, rocks, and soils at Meridiani Planum. Coarse crystalline hematite and olivine-rich basaltic sands were observed as predicted from orbital TES spectroscopy. Outcrops of aqueous origin are composed of 15 to 35% by volume magnesium and calcium sulfates [a high-silica component modeled as a combination of glass, feldspar, and sheet silicates (approximately 20 to 30%)], and hematite; only minor jarosite is identified in Mini-TES spectra. Mini-TES spectra show only a hematite signature in the millimeter-sized spherules. Basaltic materials have more plagioclase than pyroxene, contain olivine, and are similar in inferred mineral composition to basalt mapped from orbit. Bounce rock is dominated by clinopyroxene and is close in inferred mineral composition to the basaltic martian meteorites. Bright wind streak material matches global dust. Waterlain rocks covered by unaltered basaltic sands suggest a change from an aqueous environment to one dominated by physical weathering.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christensen, P R -- Wyatt, M B -- Glotch, T D -- Rogers, A D -- Anwar, S -- Arvidson, R E -- Bandfield, J L -- Blaney, D L -- Budney, C -- Calvin, W M -- Fallacaro, A -- Fergason, R L -- Gorelick, N -- Graff, T G -- Hamilton, V E -- Hayes, A G -- Johnson, J R -- Knudson, A T -- McSween, H Y Jr -- Mehall, G L -- Mehall, L K -- Moersch, J E -- Morris, R V -- Smith, M D -- Squyres, S W -- Ruff, S W -- Wolff, M J -- New York, N.Y. -- Science. 2004 Dec 3;306(5702):1733-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geological Sciences, Arizona State University, Tempe, AZ 85287, USA. phil.christensen@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15576609" target="_blank"〉PubMed〈/a〉
    Keywords: Calcium Sulfate ; Extraterrestrial Environment ; Ferric Compounds ; Geologic Sediments ; Iron Compounds ; Magnesium Compounds ; Magnesium Sulfate ; *Mars ; *Minerals ; Silicates ; Spacecraft ; Sulfates ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    C. elegans (2003)
    Cell Press
    Details
    Publication Date: 2003-01-01
    Print ISSN: 1534-5807
    Electronic ISSN: 1878-1551
    Topics: Biology , Medicine
    Published by Cell Press
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