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  • *Ecosystem  (159)
  • Crystallography, X-Ray  (86)
  • American Association for the Advancement of Science (AAAS)  (245)
  • 2005-2009  (245)
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  • 1
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    A serpentinite-hosted ecosystem: the Lost City hydrothermal field (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-05
    Description: The serpentinite-hosted Lost City hydrothermal field is a remarkable submarine ecosystem in which geological, chemical, and biological processes are intimately interlinked. Reactions between seawater and upper mantle peridotite produce methane- and hydrogen-rich fluids, with temperatures ranging from 〈40 degrees to 90 degrees C at pH 9 to 11, and carbonate chimneys 30 to 60 meters tall. A low diversity of microorganisms related to methane-cycling Archaea thrive in the warm porous interiors of the edifices. Macrofaunal communities show a degree of species diversity at least as high as that of black smoker vent sites along the Mid-Atlantic Ridge, but they lack the high biomasses of chemosynthetic organisms that are typical of volcanically driven systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelley, Deborah S -- Karson, Jeffrey A -- Fruh-Green, Gretchen L -- Yoerger, Dana R -- Shank, Timothy M -- Butterfield, David A -- Hayes, John M -- Schrenk, Matthew O -- Olson, Eric J -- Proskurowski, Giora -- Jakuba, Mike -- Bradley, Al -- Larson, Ben -- Ludwig, Kristin -- Glickson, Deborah -- Buckman, Kate -- Bradley, Alexander S -- Brazelton, William J -- Roe, Kevin -- Elend, Mitch J -- Delacour, Adelie -- Bernasconi, Stefano M -- Lilley, Marvin D -- Baross, John A -- Summons, Roger E -- Sylva, Sean P -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1428-34.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Oceanography, University of Washington, Seattle, WA 98195, USA. kelley@ocean.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15746419" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaea/classification/*growth & development/isolation & purification/metabolism ; Bacteria/classification/*growth & development/isolation & purification/metabolism ; Biodiversity ; Biomass ; *Carbonates ; Colony Count, Microbial ; *Ecosystem ; Environment ; Fishes ; *Geologic Sediments/chemistry/microbiology ; Hot Temperature ; Hydrogen/analysis/metabolism ; Hydrogen-Ion Concentration ; *Invertebrates ; Lipids/analysis ; Methane/analysis/metabolism ; Phylogeny ; *Seawater
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Ecological dynamics across the Arctic associated with recent climate change (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-12
    Description: At the close of the Fourth International Polar Year, we take stock of the ecological consequences of recent climate change in the Arctic, focusing on effects at population, community, and ecosystem scales. Despite the buffering effect of landscape heterogeneity, Arctic ecosystems and the trophic relationships that structure them have been severely perturbed. These rapid changes may be a bellwether of changes to come at lower latitudes and have the potential to affect ecosystem services related to natural resources, food production, climate regulation, and cultural integrity. We highlight areas of ecological research that deserve priority as the Arctic continues to warm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Post, Eric -- Forchhammer, Mads C -- Bret-Harte, M Syndonia -- Callaghan, Terry V -- Christensen, Torben R -- Elberling, Bo -- Fox, Anthony D -- Gilg, Olivier -- Hik, David S -- Hoye, Toke T -- Ims, Rolf A -- Jeppesen, Erik -- Klein, David R -- Madsen, Jesper -- McGuire, A David -- Rysgaard, Soren -- Schindler, Daniel E -- Stirling, Ian -- Tamstorf, Mikkel P -- Tyler, Nicholas J C -- van der Wal, Rene -- Welker, Jeffrey -- Wookey, Philip A -- Schmidt, Niels Martin -- Aastrup, Peter -- New York, N.Y. -- Science. 2009 Sep 11;325(5946):1355-8. doi: 10.1126/science.1173113.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Penn State University, 208 Mueller Lab, University Park, PA 16802, USA. esp10@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19745143" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arctic Regions ; *Climatic Processes ; *Cold Climate ; *Ecosystem ; Greenhouse Effect ; Ice Cover ; *Plant Development ; Population Dynamics ; Research
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Coastal ecosystem-based management with nonlinear ecological functions and values (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-01-19
    Description: A common assumption is that ecosystem services respond linearly to changes in habitat size. This assumption leads frequently to an "all or none" choice of either preserving coastal habitats or converting them to human use. However, our survey of wave attenuation data from field studies of mangroves, salt marshes, seagrass beds, nearshore coral reefs, and sand dunes reveals that these relationships are rarely linear. By incorporating nonlinear wave attenuation in estimating coastal protection values of mangroves in Thailand, we show that the optimal land use option may instead be the integration of development and conservation consistent with ecosystem-based management goals. This result suggests that reconciling competing demands on coastal habitats should not always result in stark preservation-versus-conversion choices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barbier, Edward B -- Koch, Evamaria W -- Silliman, Brian R -- Hacker, Sally D -- Wolanski, Eric -- Primavera, Jurgenne -- Granek, Elise F -- Polasky, Stephen -- Aswani, Shankar -- Cramer, Lori A -- Stoms, David M -- Kennedy, Chris J -- Bael, David -- Kappel, Carrie V -- Perillo, Gerardo M E -- Reed, Denise J -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):321-3. doi: 10.1126/science.1150349.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics and Finance, University of Wyoming, Laramie, WY 82071, USA. ebarbier@uwyo.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202288" target="_blank"〉PubMed〈/a〉
    Keywords: Alismatidae ; Animals ; Anthozoa ; Aquaculture/economics ; *Conservation of Natural Resources/economics ; Cost-Benefit Analysis ; *Ecology ; *Ecosystem ; Fisheries/economics ; Lythraceae ; Penaeidae ; *Rhizophoraceae ; Thailand ; Trees ; Water Movements ; *Wetlands ; Wood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-30
    Description: Transcribing RNA polymerases oscillate between three stable states, two of which, pre- and posttranslocated, were previously subjected to x-ray crystal structure determination. We report here the crystal structure of RNA polymerase II in the third state, the reverse translocated, or "backtracked" state. The defining feature of the backtracked structure is a binding site for the first backtracked nucleotide. This binding site is occupied in case of nucleotide misincorporation in the RNA or damage to the DNA, and is termed the "P" site because it supports proofreading. The predominant mechanism of proofreading is the excision of a dinucleotide in the presence of the elongation factor SII (TFIIS). Structure determination of a cocrystal with TFIIS reveals a rearrangement whereby cleavage of the RNA may take place.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718261/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718261/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Dong -- Bushnell, David A -- Huang, Xuhui -- Westover, Kenneth D -- Levitt, Michael -- Kornberg, Roger D -- GM036559/GM/NIGMS NIH HHS/ -- GM041455/GM/NIGMS NIH HHS/ -- GM049985/GM/NIGMS NIH HHS/ -- K99 GM085136/GM/NIGMS NIH HHS/ -- K99 GM085136-01/GM/NIGMS NIH HHS/ -- R00 GM085136/GM/NIGMS NIH HHS/ -- R01 GM036659/GM/NIGMS NIH HHS/ -- R01 GM041455/GM/NIGMS NIH HHS/ -- R01 GM049985/GM/NIGMS NIH HHS/ -- R01 GM049985-16/GM/NIGMS NIH HHS/ -- R37 GM036659/GM/NIGMS NIH HHS/ -- R37 GM036659-22/GM/NIGMS NIH HHS/ -- R37 GM041455/GM/NIGMS NIH HHS/ -- R37 GM041455-20/GM/NIGMS NIH HHS/ -- U54 GM072970/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2009 May 29;324(5931):1203-6. doi: 10.1126/science.1168729.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478184" target="_blank"〉PubMed〈/a〉
    Keywords: Base Pair Mismatch ; Crystallography, X-Ray ; Guanosine Monophosphate/chemistry/metabolism ; Models, Molecular ; Nucleic Acid Conformation ; Oligoribonucleotides/chemistry/*metabolism ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA/chemistry/*metabolism ; RNA Polymerase II/*chemistry/*metabolism ; Saccharomyces cerevisiae/*enzymology ; *Transcription, Genetic ; Transcriptional Elongation Factors/chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Drought sensitivity of the Amazon rainforest (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-07
    Description: Amazon forests are a key but poorly understood component of the global carbon cycle. If, as anticipated, they dry this century, they might accelerate climate change through carbon losses and changed surface energy balances. We used records from multiple long-term monitoring plots across Amazonia to assess forest responses to the intense 2005 drought, a possible analog of future events. Affected forest lost biomass, reversing a large long-term carbon sink, with the greatest impacts observed where the dry season was unusually intense. Relative to pre-2005 conditions, forest subjected to a 100-millimeter increase in water deficit lost 5.3 megagrams of aboveground biomass of carbon per hectare. The drought had a total biomass carbon impact of 1.2 to 1.6 petagrams (1.2 x 10(15) to 1.6 x 10(15) grams). Amazon forests therefore appear vulnerable to increasing moisture stress, with the potential for large carbon losses to exert feedback on climate change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phillips, Oliver L -- Aragao, Luiz E O C -- Lewis, Simon L -- Fisher, Joshua B -- Lloyd, Jon -- Lopez-Gonzalez, Gabriela -- Malhi, Yadvinder -- Monteagudo, Abel -- Peacock, Julie -- Quesada, Carlos A -- van der Heijden, Geertje -- Almeida, Samuel -- Amaral, Ieda -- Arroyo, Luzmila -- Aymard, Gerardo -- Baker, Tim R -- Banki, Olaf -- Blanc, Lilian -- Bonal, Damien -- Brando, Paulo -- Chave, Jerome -- de Oliveira, Atila Cristina Alves -- Cardozo, Nallaret Davila -- Czimczik, Claudia I -- Feldpausch, Ted R -- Freitas, Maria Aparecida -- Gloor, Emanuel -- Higuchi, Niro -- Jimenez, Eliana -- Lloyd, Gareth -- Meir, Patrick -- Mendoza, Casimiro -- Morel, Alexandra -- Neill, David A -- Nepstad, Daniel -- Patino, Sandra -- Penuela, Maria Cristina -- Prieto, Adriana -- Ramirez, Fredy -- Schwarz, Michael -- Silva, Javier -- Silveira, Marcos -- Thomas, Anne Sota -- Steege, Hans Ter -- Stropp, Juliana -- Vasquez, Rodolfo -- Zelazowski, Przemyslaw -- Alvarez Davila, Esteban -- Andelman, Sandy -- Andrade, Ana -- Chao, Kuo-Jung -- Erwin, Terry -- Di Fiore, Anthony -- Honorio C, Euridice -- Keeling, Helen -- Killeen, Tim J -- Laurance, William F -- Pena Cruz, Antonio -- Pitman, Nigel C A -- Nunez Vargas, Percy -- Ramirez-Angulo, Hirma -- Rudas, Agustin -- Salamao, Rafael -- Silva, Natalino -- Terborgh, John -- Torres-Lezama, Armando -- New York, N.Y. -- Science. 2009 Mar 6;323(5919):1344-7. doi: 10.1126/science.1164033.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ecology and Global Change, School of Geography, University of Leeds, Leeds LS2 9JT, UK. o.phillips@leeds.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19265020" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; *Biomass ; Brazil ; Carbon ; Carbon Dioxide ; Climate ; *Droughts ; *Ecosystem ; South America ; *Trees/growth & development ; Tropical Climate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Ecology. North Atlantic right whales in crisis (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kraus, Scott D -- Brown, Moira W -- Caswell, Hal -- Clark, Christopher W -- Fujiwara, Masami -- Hamilton, Philip K -- Kenney, Robert D -- Knowlton, Amy R -- Landry, Scott -- Mayo, Charles A -- McLellan, William A -- Moore, Michael J -- Nowacek, Douglas P -- Pabst, D Ann -- Read, Andrew J -- Rolland, Rosalind M -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):561-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Edgerton Research Laboratory, New England Aquarium, Boston, MA 02110-3399, USA. skraus@neaq.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040692" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Ecology ; *Ecosystem ; Environment ; Female ; Fisheries ; Male ; Mortality ; Population Dynamics ; Population Growth ; Public Policy ; Reproduction ; Ships ; *Whales/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Eddy/wind interactions stimulate extraordinary mid-ocean plankton blooms (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-05-19
    Description: Episodic eddy-driven upwelling may supply a significant fraction of the nutrients required to sustain primary productivity of the subtropical ocean. New observations in the northwest Atlantic reveal that, although plankton blooms occur in both cyclones and mode-water eddies, the biological responses differ. Mode-water eddies can generate extraordinary diatom biomass and primary production at depth, relative to the time series near Bermuda. These blooms are sustained by eddy/wind interactions, which amplify the eddy-induced upwelling. In contrast, eddy/wind interactions dampen eddy-induced upwelling in cyclones. Carbon export inferred from oxygen anomalies in eddy cores is one to three times as much as annual new production for the region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGillicuddy, Dennis J Jr -- Anderson, Laurence A -- Bates, Nicholas R -- Bibby, Thomas -- Buesseler, Ken O -- Carlson, Craig A -- Davis, Cabell S -- Ewart, Courtney -- Falkowski, Paul G -- Goldthwait, Sarah A -- Hansell, Dennis A -- Jenkins, William J -- Johnson, Rodney -- Kosnyrev, Valery K -- Ledwell, James R -- Li, Qian P -- Siegel, David A -- Steinberg, Deborah K -- New York, N.Y. -- Science. 2007 May 18;316(5827):1021-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Woods Hole Oceanographic Institution, Woods Hole, MA 02543-1541, USA. dmcgillicuddy@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17510363" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Biomass ; Carbon/analysis ; Chlorophyll/analysis ; Cyanobacteria/growth & development/physiology ; Diatoms/growth & development ; *Ecosystem ; Geologic Sediments ; Oxygen/analysis ; Photosynthesis ; Phytoplankton/growth & development/physiology ; Plankton/*growth & development/physiology ; Seasons ; *Seawater/chemistry ; *Water Movements ; *Wind ; Zooplankton/growth & development/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    One-third of reef-building corals face elevated extinction risk from climate change and local impacts (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-07-26
    Description: The conservation status of 845 zooxanthellate reef-building coral species was assessed by using International Union for Conservation of Nature Red List Criteria. Of the 704 species that could be assigned conservation status, 32.8% are in categories with elevated risk of extinction. Declines in abundance are associated with bleaching and diseases driven by elevated sea surface temperatures, with extinction risk further exacerbated by local-scale anthropogenic disturbances. The proportion of corals threatened with extinction has increased dramatically in recent decades and exceeds that of most terrestrial groups. The Caribbean has the largest proportion of corals in high extinction risk categories, whereas the Coral Triangle (western Pacific) has the highest proportion of species in all categories of elevated extinction risk. Our results emphasize the widespread plight of coral reefs and the urgent need to enact conservation measures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carpenter, Kent E -- Abrar, Muhammad -- Aeby, Greta -- Aronson, Richard B -- Banks, Stuart -- Bruckner, Andrew -- Chiriboga, Angel -- Cortes, Jorge -- Delbeek, J Charles -- Devantier, Lyndon -- Edgar, Graham J -- Edwards, Alasdair J -- Fenner, Douglas -- Guzman, Hector M -- Hoeksema, Bert W -- Hodgson, Gregor -- Johan, Ofri -- Licuanan, Wilfredo Y -- Livingstone, Suzanne R -- Lovell, Edward R -- Moore, Jennifer A -- Obura, David O -- Ochavillo, Domingo -- Polidoro, Beth A -- Precht, William F -- Quibilan, Miledel C -- Reboton, Clarissa -- Richards, Zoe T -- Rogers, Alex D -- Sanciangco, Jonnell -- Sheppard, Anne -- Sheppard, Charles -- Smith, Jennifer -- Stuart, Simon -- Turak, Emre -- Veron, John E N -- Wallace, Carden -- Weil, Ernesto -- Wood, Elizabeth -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):560-3. doi: 10.1126/science.1159196. Epub 2008 Jul 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IUCN (International Union for Conservation of Nature) Species Programme Species Survival Commission (SSC), Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA. kcarpent@odu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653892" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa/classification/growth & development ; Caribbean Region ; *Climate ; Conservation of Natural Resources ; *Ecosystem ; *Extinction, Biological ; Greenhouse Effect ; Indian Ocean ; Pacific Ocean ; Risk Assessment ; *Seawater ; Species Specificity ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Ecology. Tracking progress toward the 2010 biodiversity target and beyond (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walpole, Matt -- Almond, Rosamunde E A -- Besancon, Charles -- Butchart, Stuart H M -- Campbell-Lendrum, Diarmid -- Carr, Genevieve M -- Collen, Ben -- Collette, Linda -- Davidson, Nick C -- Dulloo, Ehsan -- Fazel, Asghar M -- Galloway, James N -- Gill, Michael -- Goverse, Tessa -- Hockings, Marc -- Leaman, Danna J -- Morgan, David H W -- Revenga, Carmen -- Rickwood, Carrie J -- Schutyser, Frederik -- Simons, Sarah -- Stattersfield, Alison J -- Tyrrell, Tristan D -- Vie, Jean-Christophe -- Zimsky, Mark -- New York, N.Y. -- Science. 2009 Sep 18;325(5947):1503-4. doi: 10.1126/science.1175466.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United Nations Environment Programme World Conservation Monitoring Centre (UNEP-WCMC), Cambridge, CB3 0DL, UK. matt.walpole@unep-wcmc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19762630" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Conservation of Natural Resources ; *Ecosystem ; Environment ; Genetic Variation ; Humans ; *International Cooperation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120 (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: The site on HIV-1 gp120 that binds to the CD4 receptor is vulnerable to antibodies. However, most antibodies that interact with this site cannot neutralize HIV-1. To understand the basis of this resistance, we determined co-crystal structures for two poorly neutralizing, CD4-binding site (CD4BS) antibodies, F105 and b13, in complexes with gp120. Both antibodies exhibited approach angles to gp120 similar to those of CD4 and a rare, broadly neutralizing CD4BS antibody, b12. Slight differences in recognition, however, resulted in substantial differences in F105- and b13-bound conformations relative to b12-bound gp120. Modeling and binding experiments revealed these conformations to be poorly compatible with the viral spike. This incompatibility, the consequence of slight differences in CD4BS recognition, renders HIV-1 resistant to all but the most accurately targeted antibodies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862588/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862588/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Lei -- Kwon, Young Do -- Zhou, Tongqing -- Wu, Xueling -- O'Dell, Sijy -- Cavacini, Lisa -- Hessell, Ann J -- Pancera, Marie -- Tang, Min -- Xu, Ling -- Yang, Zhi-Yong -- Zhang, Mei-Yun -- Arthos, James -- Burton, Dennis R -- Dimitrov, Dimiter S -- Nabel, Gary J -- Posner, Marshall R -- Sodroski, Joseph -- Wyatt, Richard -- Mascola, John R -- Kwong, Peter D -- Z99 AI999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2009 Nov 20;326(5956):1123-7. doi: 10.1126/science.1175868.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965434" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antibodies, Neutralizing/chemistry/*immunology/metabolism ; Antigens, CD4/chemistry/*metabolism ; Binding Sites ; Binding Sites, Antibody ; Crystallography, X-Ray ; Epitopes ; HIV Antibodies/*chemistry/*immunology/metabolism ; HIV Envelope Protein gp120/*chemistry/*immunology/metabolism ; Hiv-1 ; Humans ; Hydrophobic and Hydrophilic Interactions ; *Immune Evasion ; Models, Molecular ; Molecular Sequence Data ; Peptide Fragments/chemistry/immunology/metabolism ; Protein Conformation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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