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  • Astronomy  (22)
  • Aerospace Medicine  (2)
  • Mice
  • Nitric Oxide Synthase
  • 2005-2009  (10)
  • 2000-2004  (11)
  • 1990-1994  (5)
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Year
  • 1
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    Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-23
    Description: The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the neurological deficits were less than those in normal mice. This result could not be accounted for by differences in blood flow or vascular anatomy. However, infarct size in the mutant became larger after endothelial NOS inhibition by nitro-L-arginine administration. Hence, neuronal NO production appears to exacerbate acute ischemic injury, whereas vascular NO protects after middle cerebral artery occlusion. The data emphasize the importance of developing selective inhibitors of the neuronal isoform.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Z -- Huang, P L -- Panahian, N -- Dalkara, T -- Fishman, M C -- Moskowitz, M A -- NS10828/NS/NINDS NIH HHS/ -- NS2636/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 Sep 23;265(5180):1883-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7522345" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/deficiency/*metabolism ; Animals ; Arginine/analogs & derivatives/pharmacology ; Brain/enzymology/*metabolism ; Brain Ischemia/complications/*metabolism ; Cerebral Infarction/*etiology ; Cerebrovascular Circulation ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Neurons/*enzymology ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-22
    Description: Long-term potentiation (LTP) is a persistent increase in synaptic strength implicated in certain forms of learning and memory. In the CA1 region of the hippocampus, LTP is thought to involve the release of one or more retrograde messengers from the postsynaptic cell that act on the presynaptic terminal to enhance transmitter release. One candidate retrograde messenger is the membrane-permeant gas nitric oxide (NO), which in the brain is released after activation of the neuronal-specific NO synthase isoform (nNOS). To assess the importance of NO in hippocampal synaptic plasticity, LTP was examined in mice where the gene encoding nNOS was disrupted by gene targeting. In nNOS- mice, LTP induced by weak intensity tetanic stimulation was normal except for a slight reduction in comparison to that in wild-type mice and was blocked by NOS inhibitors, just as it was in wild-type mice. Immunocytochemical studies indicate that in the nNOS- mice as in wild-type mice, the endothelial form of NOS (eNOS) is expressed in CA1 neurons. These findings suggest that eNOS, rather than nNOS, generates NO within the postsynaptic cell during LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Dell, T J -- Huang, P L -- Dawson, T M -- Dinerman, J L -- Snyder, S H -- Kandel, E R -- Fishman, M C -- DA-00074/DA/NIDA NIH HHS/ -- DA-00266/DA/NIDA NIH HHS/ -- MH-45923/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Jul 22;265(5171):542-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7518615" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/genetics/*metabolism ; Animals ; Arginine/*analogs & derivatives/pharmacology ; Electric Stimulation ; Endothelium/enzymology ; Hippocampus/drug effects/enzymology/*physiology ; In Vitro Techniques ; *Long-Term Potentiation/drug effects ; Mice ; Mutation ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine ; Pyramidal Cells/drug effects/enzymology/*physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Tools for Coordinated Planning Between Observatories (2001)
    In:  CASI
    Details
    Publication Date: 2013-08-29
    Description: With the realization of NASA's era of great observatories, there are now more than three space-based telescopes operating in different wavebands. This situation provides astronomers with a unique opportunity to simultaneously observe with multiple observatories. Yet scheduling multiple observatories simultaneously is highly inefficient when compared to observations using only one single observatory. Thus, programs using multiple observatories are limited not due to scientific restrictions, but due to operational inefficiencies. At present, multi-observatory programs are conducted by submitting observing proposals separately to each concerned observatory. To assure that the proposed observations can be scheduled, each observatory's staff has to check that the observations are valid and meet all the constraints for their own observatory; in addition, they have to verify that the observations satisfy the constraints of the other observatories. Thus, coordinated observations require painstaking manual collaboration among the observatory staff at each observatory. Due to the lack of automated tools for coordinated observations, this process is time consuming, error-prone, and the outcome of the requests is not certain until the very end. To increase observatory operations efficiency, such manpower intensive processes need to undergo re-engineering. To overcome this critical deficiency, Goddard Space Flight Center's Advanced Architectures and Automation Branch is developing a prototype effort called the Visual Observation Layout Tool (VOLT). The main objective of the VOLT project is to provide visual tools to help automate the planning of coordinated observations by multiple astronomical observatories, as well as to increase the scheduling probability of all observations.
    Keywords: Astronomy
    Type: ADASS Conference; Boston, MA; United States
    Format: application/pdf
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  • 4
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    The Burst and Transient Source Experiment (BATSE) Earth Occultation Catalog of Low-Energy Gamma-Ray Sources (2004)
    In:  Other Sources
    Details
    Publication Date: 2018-06-12
    Description: The Burst and Transient Source Experiment (BATSE), aboard the Compton Gamma Ray Observatory (CGRO), provided a record of the low-energy gamma-ray sky (approx. 20-1000 keV) between 1991 April and 2000 May (9.1 yr). BATSE monitored the high-energy sky using the Earth occultation technique (EOT) for point sources whose emission extended for times on the order of the CGRO orbital period (approx. 92 min) or greater. Using the EOT to extract flux information, a catalog of sources using data from the BATSE Large Area Detectors has been prepared. The first part of the catalog consists of results from the all-sky monitoring of 58 sources, mostly Galactic, with intrinsic variability on timescales of hours to years. For these sources, we have included tables of flux and spectral data, and outburst times for transients. Light curves (or flux histories) have been placed on the World Wide Web. We then performed a deep sampling of these 58 objects, plus a selection of 121 more objects, combining data from the entire 9.1 yr BATSE data set. Source types considered were primarily accreting binaries, but a small number of representative active galaxies, X-ray-emitting stars, and supernova remnants were also included. The sample represents a compilation of sources monitored and/or discovered with BATSE and other high-energy instruments between 1991 and 2000, known sources taken from the HEAO 1 A-4 and Macomb & Gehrels catalogs. The deep sample results include definite detections of 83 objects and possible detections of 36 additional objects. The definite detections spanned three classes of sources: accreting black hole and neutron star binaries, active galaxies, and Supernova remnants. The average fluxes measured for the fourth class, the X-ray emitting stars, were below the confidence limit for definite detection.
    Keywords: Astronomy
    Type: The Astrophysical Journal Supplement Series; Volume 154; 585-622
    Format: text
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  • 5
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    EXIST: The Next Large GRB Observatory (2003)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: Studies have begun on the EXIST (Energetic X-ray Imaging Survey Telescope) Mission as a Black Hole Survey 'Einstein Probe', a major element in the new NASA Beyond Einstein Program in the Office of Space Science. This program was approved by the US Congress, in February 2003 as part of the NASA FY2004 NASA budget. EXIST is planned as a very wide-field coded aperture telescope and a positional accuracy for GRBs better than one arc-minute. The baseline detectors are Cadmium-Zinc-Telluride (CZT), with a total sensitive area of approximately 8 m2. EXIST will use SWIFT as a pathfinder mission; the findings of SWIFT will refine the scientific objectives of EXIST and will help to determine many of its design parameters. EXIST will study early star and galaxy formation at high redshifts through observations of thousands of GRBs, their afterglows and host galaxies. It is intended that the international GRB community will play a large role in EXIST through direct participation as well as with complementary observational programs, both space-based and ground-based. Some preliminary design features and capabilities of the EXIST Mission will be presented.
    Keywords: Astronomy
    Type: EXIST Science Working Group Meeting; Mar 23, 2003 - Mar 26, 2003; Mt. Tremblant, Quebec; Canada
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  • 6
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    EXIST (Energetic X-ray Imaging Survey Telescope): The Next Large GRB Observatory (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: Studies have begun on the EXIST (Energetic X-ray Imaging Survey Telescope) Mission. It is planned as a very wide-field, sensitive coded aperture telescope with a sensitive area of the order of 6-8 m^2 and having a positional accuracy for GRBs (Gamma ray bursts) better than one arc-minute. EXIST will use SWIFT as a pathfinder mission; the findings of SWIFT will refine the scientific objectives of EXIST and will help to determine many of its design parameters. It would study early star formation and early galaxy formation at very high redshifts through observations of thousands of GRBs, their afterglows and environments. It is intended that the international GRB community will play as large role in EXIST through direct participation as well as with complementary observational programs, both space-based and ground-based. Some preliminary design features and capabilities of the EXIST Mission will be presented.
    Keywords: Astronomy
    Type: Rome Gamma-Ray Burst Conference; Sep 17, 2002 - Sep 22, 2002; Rome; Italy
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  • 7
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    Gamma-Ray Burst Observations with BATSE (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: The observed gamma-ray temporal, spectral, and duration distribution characteristics of GRBs (Gamma Ray Bursts) from data obtained from the BATSE/Compton Gamma-Ray Observatory will be described. The talk will concentrate on studies of burst properties, correlations of GRB parameters and other statistical properties from the unprecedented sample of over 2700 GRBs.
    Keywords: Astronomy
    Type: COSPAR and World Space Congress; Oct 10, 2002 - Oct 19, 2002; Houston, TX; United States
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  • 8
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    Gamma-ray Bursts: The Prompt Emission (2005)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: Gamma-ray bursts are the largest explosions in the Universe. The radiation is thought to come from a hypernova initiated from the collapse of a massive star or perhaps the merger of two compact stars such s neutron stars and/or black holes. Most of the observed energy is radiated as gamma rays, usually lasting from a fraction of a second to several hundred seconds. The energy generation process is usually referred to as the "central engine". Observed properties of this prompt emission, including spectra, time profiles and durations will be discussed. The history of these observations and future GRB spacecraft will also be described.
    Keywords: Astronomy
    Type: AAVSO-HEA3 , The 3rd American Association of Variable Star Obervers High Energy Astrophysics Workshop; Mar 21, 2005; Las Cruces, NM; United States
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  • 9
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    Considerations for a Next Generation GRB Observatory (2000)
    In:  Other Sources
    Details
    Publication Date: 2019-07-17
    Description: A framework will be described for the planning of a Next Generation Burst Observatory. This Observatory, using Swift as a pathfinder mission, would study early star formation and early galaxy formation at very high redshifts through observations of thousands of GRBS, their afterglows and environments. It is suggested that the international GRB community should begin some initial studies for such an observatory.
    Keywords: Astronomy
    Type: Apr 29, 2000 - May 02, 2000; Long Beach, CA; United States
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  • 10
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    LDEF radiation measurements: preliminary results (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The Long Duration Exposure Facility (LDEF), retrieved by the Space Shuttle mission STS-32 after nearly 6 yr in orbit, is the focus of a broad-based study of the radiation environment in low Earth orbit (LEO) and its effects on materials. A combination of passive techniques has been used to study this environment via detectors which were contained in experiments aboard the LDEF spacecraft and through analysis of induced radioactivities. Preliminary results for absorbed dose measurements and for induced activities in various materials are presented. A number of effects have been observed which reflect the anisotropy of the charged particle flux in low Earth orbit. Quantitative results from these measurements should provide an accurate means of confirming environmental flux models and techniques for predicting radiation encountered in future LEO missions, particularly those of extended duration.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 20; 1; 131-6
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