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  • Chemistry  (13)
  • LUNAR AND PLANETARY EXPLORATION  (12)
  • Animals  (5)
  • Mice  (4)
  • BIOTECHNOLOGY  (2)
  • 2015-2019  (2)
  • 1980-1984  (22)
  • 1970-1974  (5)
  • 1925-1929  (3)
  • 1
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    HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-06-27
    Description: Cardiac progenitor cells are multipotent and give rise to cardiac endothelium, smooth muscle, and cardiomyocytes. Here, we define and characterize the cardiomyoblast intermediate that is committed to the cardiomyocyte fate, and we characterize the niche signals that regulate commitment. Cardiomyoblasts express Hopx, which functions to coordinate local Bmp signals to inhibit the Wnt pathway, thus promoting cardiomyogenesis. Hopx integrates Bmp and Wnt signaling by physically interacting with activated Smads and repressing Wnt genes. The identification of the committed cardiomyoblast that retains proliferative potential will inform cardiac regenerative therapeutics. In addition, Bmp signals characterize adult stem cell niches in other tissues where Hopx-mediated inhibition of Wnt is likely to contribute to stem cell quiescence and to explain the role of Hopx as a tumor suppressor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jain, Rajan -- Li, Deqiang -- Gupta, Mudit -- Manderfield, Lauren J -- Ifkovits, Jamie L -- Wang, Qiaohong -- Liu, Feiyan -- Liu, Ying -- Poleshko, Andrey -- Padmanabhan, Arun -- Raum, Jeffrey C -- Li, Li -- Morrisey, Edward E -- Lu, Min Min -- Won, Kyoung-Jae -- Epstein, Jonathan A -- 5-T32-GM-007170/GM/NIGMS NIH HHS/ -- K08 HL119553/HL/NHLBI NIH HHS/ -- K08 HL119553-02/HL/NHLBI NIH HHS/ -- R01 HL071546/HL/NHLBI NIH HHS/ -- U01 HL100405/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2015 Jun 26;348(6242):aaa6071. doi: 10.1126/science.aaa6071.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Penn Cardiovascular Institute, Institute of Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Genetics, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Cell and Developmental Biology, Penn Cardiovascular Institute, Institute of Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. epsteinj@upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26113728" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Bone Morphogenetic Proteins/genetics/*metabolism ; Cell Lineage/genetics ; Gene Expression ; *Gene Expression Regulation, Developmental ; Heart/*embryology ; Homeodomain Proteins/genetics/*metabolism ; Mice ; Mice, Mutant Strains ; Molecular Sequence Data ; Muscle, Smooth/cytology/metabolism ; Myoblasts, Cardiac/cytology/*metabolism ; Organogenesis/*genetics ; Stem Cell Niche/genetics/physiology ; Tumor Suppressor Proteins/genetics/*metabolism ; Wnt Signaling Pathway/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Polyene toxicity in renal medulla: injury mediated by transport activity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-06
    Description: Polyene antibiotics such as amphotericin and nystatin increase membrane permeability and thus increase the amount of oxygen consumed in active electrolyte transport. In isolated perfused rat kidneys, the polyenes produced extensive injury to the medullary thick ascending limb, a segment of the nephron with limited oxygen supply. This damage was prevented if reabsorptive transport was inhibited by ouabain. Cell death under these circumstances thus appears to be mediated by increased oxygen demand for transport activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brezis, M -- Rosen, S -- Silva, P -- Spokes, K -- Epstein, F H -- AM18078/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322305" target="_blank"〉PubMed〈/a〉
    Keywords: Amphotericin B/adverse effects ; Animals ; Biological Transport, Active/drug effects ; Cell Membrane Permeability/drug effects ; Furosemide/pharmacology ; Glomerular Filtration Rate/drug effects ; Kidney Medulla/*drug effects/pathology ; Loop of Henle/drug effects ; Nystatin/adverse effects ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Polyenes/*adverse effects ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Hydrogen isotope ratios of mouse tissues are influenced by a variety of factors other than diet (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeNiro, M J -- Epstein, S -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1374-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deuterium/*metabolism ; *Diet ; Hydrogen/*metabolism ; Mice ; Water/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: Groups of three to four mice were gavaged with aqueous solutions of 2 milligrams of morpholine, after which they were exposed to nitrogen dioxide in inhalation chambers at concentrations of 0.2 to 50 parts per million for up to 4 hours. At sequential intervals during the exposure, mice were frozen and pulverized in liquid nitrogen, and the mice powder was extracted with ice-cold 35 percent aqueous methanol and dichloromethane; organic-phase concentrates were analyzed for N-nitrosomorpholine with a thermal energy analyzer interfaced to a gas chromatograph. The N-nitrosomorpholine yields, ranging up to about 2.3 micrograms per mouse, were time-dependent relative to the duration of exposure to nitrogen dioxide and dose-dependent relative to the concentrations of nitrogen dioxide; control levels (in mice that were gavaged with morpholine or distilled water and then exposed to air instead of nitrogen dioxide) were less than 5 nanograms per mouse. These preliminary studies demonstrate the in vivo nitrosating potential of nitrogen oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iqbal, Z M -- Dahl, K -- Epstein, S S -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1475-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361099" target="_blank"〉PubMed〈/a〉
    Keywords: Amines/metabolism ; Animals ; Ascorbic Acid/pharmacology ; Biotransformation ; Dose-Response Relationship, Drug ; Mice ; Morpholines/*metabolism ; Nitrogen Dioxide/antagonists & inhibitors/*metabolism ; Nitrosamines/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    A new antibiotic kills pathogens without detectable resistance (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-01-07
    Description: Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ling, Losee L -- Schneider, Tanja -- Peoples, Aaron J -- Spoering, Amy L -- Engels, Ina -- Conlon, Brian P -- Mueller, Anna -- Schaberle, Till F -- Hughes, Dallas E -- Epstein, Slava -- Jones, Michael -- Lazarides, Linos -- Steadman, Victoria A -- Cohen, Douglas R -- Felix, Cintia R -- Fetterman, K Ashley -- Millett, William P -- Nitti, Anthony G -- Zullo, Ashley M -- Chen, Chao -- Lewis, Kim -- AI085612/AI/NIAID NIH HHS/ -- T-RO1AI085585/AI/NIAID NIH HHS/ -- England -- Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA. ; 1] Institute of Medical Microbiology, Immunology and Parasitology-Pharmaceutical Microbiology Section, University of Bonn, Bonn 53115, Germany [2] German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, 53115 Bonn, Germany. ; Antimicrobial Discovery Center, Northeastern University, Department of Biology, Boston, Massachusetts 02115, USA. ; 1] German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, 53115 Bonn, Germany [2] Institute for Pharmaceutical Biology, University of Bonn, Bonn 53115, Germany. ; Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA. ; Selcia, Ongar, Essex CM5 0GS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25561178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/biosynthesis/chemistry/isolation & ; purification/*pharmacology ; Betaproteobacteria/chemistry/genetics ; Biological Products/chemistry/isolation & purification/pharmacology ; Cell Wall/chemistry/drug effects/metabolism ; Depsipeptides/biosynthesis/chemistry/isolation & purification/*pharmacology ; Disease Models, Animal ; *Drug Resistance, Microbial/genetics ; Female ; Mice ; Microbial Sensitivity Tests ; Microbial Viability/*drug effects ; Molecular Sequence Data ; Multigene Family/genetics ; Mycobacterium tuberculosis/cytology/*drug effects/genetics ; Peptidoglycan/biosynthesis ; Staphylococcal Infections/drug therapy/microbiology ; Staphylococcus aureus/chemistry/cytology/*drug effects/genetics ; Teichoic Acids/biosynthesis ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Interstellar organic matter in meteorites (1983)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Deuterium-enriched hydrogen is present in organic matter in such meteorites as noncarbonaceous chondrites. The majority of the unequilibrated primitive meteorites contain hydrogen whose D/H ratios are greater than 0.0003, requiring enrichment (relative to cosmic hydrogen) by isotope exchange reactions taking place below 150 K. The D/H values presented are the lower limits for the organic compounds derived from interstellar molecules, since all processes subsequent to their formation, including terrestrial contamination, decrease their D/H ratios. In contrast, the D/H ratios of hydrogen associated with hydrated silicates are relatively uniform for the meteorites analyzed. The C-13/C-12 ratios of organic matter, irrespective of D/H ratio, lie well within those observed for the earth. Present findings suggest that other interstellar material, in addition to organic matter, is preserved and is present in high D/H ratio meteorites.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Geochimica et Cosmochimica Acta (ISSN 0016-7037); 47; 2199-221
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  • 7
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    Saturn's rings - 3-mm observations and derived properties (1980)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Three-millimeter Saturn observations, obtained from 1965 through 1977 and with Jupiter as a reference, have been used to derive a ring brightness temperature of 18 + or - 8 K. The brightness temperature of the disk of Saturn is 156 + or - 9 K. Part of the ring brightness (approximately 6 K) may be accounted for as disk emission which is scattered from the rings; the remainder (12 + or - 8K) is attributed to ring particle thermal emission. Because this thermal component brightness temperature is so much less than the particle physical temperature, limits are placed on the mean size and composition of the ring particles. In particular, as found by others, the particles cannot be rocky, but must be either metallic or composed of extremely low-loss dielectric material such as water ice. If the particles are pure water ice, for example, then a simple slab model and a multiple-scattering model both give upper limits to the particle sizes of approximately 1 m, a value three times smaller than previously available. The multiple-scattering model gives a particle single-scattering albedo at 3 mm of 0.83 + or - 0.13.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Icarus; 41; Jan. 198
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    NASA TECHNICAL REPORTS
  • 8
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    Millimeter-wave studies of the surfaces of Mercury and Mars and the atmosphere of Venus (1983)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Disk average brightness temperatures of Mercury were obtained using a 4.6 m radio telescopes. The data was searched for periodicities which correlate with phase angle, hermocentric longitude and beat frequencies produced by modulations of various celestial mechanical parameters. Spectral line observations were made of Venus with the NRAO 11 m radio telescope. The total CO content and the CO vertical profile, and their variability were observed. Large scale thermophysical properties of the surface of Mars were studied.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA-CR-169867 , NAS 1.26:169867
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  • 9
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    Carbon, hydrogen and nitrogen isotopes in solvent-extractable organic matter from carbonaceous chondrites (1982)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: CCl4 and CH3OH solvent extractions were performed on the Murray, Murchison, Orgueil and Renazzo carbonaceous chondrites. Delta-D values of +300-+500% are found in the case of the CH3OH-soluble organic matter. The combined C, H and N isotope data makes it unlikely that the CH3OH-soluble components are derivable from, or simply related to, the insoluble organic polymer found in the same meteorites. A relation between the event that formed hydrous minerals in CI1 and CM2 meteorites and the introduction of water- and methanol-soluble organic compounds is suggested. Organic matter soluble in CCl4 has no N, and delta-C-13 values are lower than for CH3OH-soluble phases. It is concluded that there either are large isotopic fractionations for carbon and hydrogen between different soluble organic phases, or the less polar components are partially of terrestrial origin.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Geochimica et Cosmochimica Acta; 46; Jan. 198
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  • 10
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    The concentration and isotopic composition of hydrogen, carbon and nitrogen in carbonaceous meteorites (1982)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Stepwise pyrolysis was used to extract H2, N2 and C from powdered meteorites and from meteorite residues resulting from partial dissolution in aqueous HF or from reaction with HF-HCl solutions. Concentrations and isotopic compositions were determined for the cases of the carbonaceous chondrites Orgueil, Murray, Murchison, Renazzo and Cold Bokkeveld. Acidification of the meteorites removed the organic sources of H2, so that H2 in the HF-HCl acid residues came mostly from the insoluble organic matter making up 70-80% of the total carbon in carbonaceous meteorites. Good correlation is found between delta-D and the concentration of H2 in the acid residues, but no correlation exists between the delta-D, delta-C-13 and delta-N-15 in them. A model is proposed for both the high delta-D values and the relationship between those values and the H2 concentration.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Geochimica et Cosmochimica Acta; 46; Jan. 198
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