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  • Articles  (51)
  • Springer  (38)
  • BioMed Central  (11)
  • Blackwell Science Ltd
  • 2015-2019  (22)
  • 2005-2009  (18)
  • 2000-2004  (7)
  • 1975-1979
  • 1960-1964
  • 1890-1899  (2)
  • 1870-1879  (2)
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  • Articles  (51)
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  • 1
    Electronic Resource
    Electronic Resource
    DNA endoreduplication in maize endosperm cells: the effect of exposure to short-term high temperature (2000)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 23 (2000), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: DNA endoreduplication in Zea mays L. (cv. A619 × W64A) endosperm peaks between 16 and 18 d after pollination (DAP). The physiological function of DNA endoreduplication is not known but it is believed to be important in maize kernel development. In the present study, we investigated how 2, 4 or 6 d of high temperature (35 °C) affected DNA endoreduplication and maize kernel development in comparison with control kernels grown at 25 °C. Data were collected on fresh weight (FW), nuclei number, mitotic index, and DNA endoreduplication. Maize endosperm FW and nuclei number were reduced by exposure to 4 or 6 d of high temperature. At 18 DAP, the 2 d high temperature treatment (HTT) caused a reduction in FW and nuclei number, but had no effect on DNA endoreduplication and average DNA content per endosperm. However, when the exposure to high temperature was increased to 4 or 6 d, FW, nuclei number and the magnitude of DNA endoreduplication were progressively reduced, and the peak mitotic index was delayed compared with the control endosperm. At 18 DAP, the 4 d treatment showed 54·7% of the cells were 3 or 6 C, whereas only 41·2% were 12 C or higher. Six days of high temperature also resulted in a reduction in endosperm FW, nuclei number and a delay in the peak of mitotic index. DNA endoreduplication occurred in the kernels exposed to this treatment, although the magnitude was severely reduced compared with the control kernels. Nuclear DNA content was highly correlated (r= 0·93) with kernel FW, suggesting an important role of DNA endoreduplication in determining endosperm FW. The data suggest that high temperature during endosperm cell division exerted negative effects on DNA endoreduplication by dramatically reducing the nuclei number, leaving fewer nuclei available for DNA endoreduplication. However, the data also suggest that prolonged exposure to high temperature restricts entry of mitotic cells into the endoreduplication phase of the cell cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3040.2000.00564.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 55 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In the yeast Saccharomyces cerevisiae, PKA and Sch9 exert similar physiological roles in response to nutrient availability. However, their functional redundancy complicates to distinguish properly the target genes for both kinases. In this article, we analysed different phenotypic read-outs. The data unequivocally showed that both kinases act through separate signalling cascades. In addition, genome-wide expression analysis under conditions and with strains in which either PKA and/or Sch9 signalling was specifically affected, demonstrated that both kinases synergistically or oppositely regulate given gene targets. Unlike PKA, which negatively regulates stress-responsive element (STRE)- and post-diauxic shift (PDS)-driven gene expression, Sch9 appears to exert additional positive control on the Rim15-effector Gis1 to regulate PDS-driven gene expression. The data presented are consistent with a cyclic AMP (cAMP)-gating phenomenon recognized in higher eukaryotes consisting of a main gatekeeper, the protein kinase PKA, switching on or off the activities and signals transmitted through primary pathways such as, in case of yeast, the Sch9-controlled signalling route. This mechanism allows fine-tuning various nutritional responses in yeast cells, allowing them to adapt metabolism and growth appropriately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2004.04429.x
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  • 3
    Electronic Resource
    Electronic Resource
    Het eisenacher (katheder-socialistisch) congres (1873)
    Springer
    De economist 22 (1873), S. 459-487 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02183330
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  • 4
    Electronic Resource
    Electronic Resource
    Over arbeiderswoningen, naar aanleiding van het nuts-verslag over dat onderwerp (1891)
    Springer
    De economist 40 (1891), S. 700-719 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02213266
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  • 5
    Electronic Resource
    Electronic Resource
    Over arbeiderswoningen, naar aanleiding van het nuts-verslag over dat onderwerp (1891)
    Springer
    De economist 40 (1891), S. 802-837 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02213275
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  • 6
    Electronic Resource
    Electronic Resource
    Het Eisenacher (Katheder-Socialistisch) Congres (1873)
    Springer
    De economist 22 (1873), S. 321-338 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02183323
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  • 7
    Electronic Resource
    Electronic Resource
    Challenges of the LHC: the detector challenge (2004)
    Springer
    The European physical journal 34 (2004), S. 61-65 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2004-01768-6
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  • 8
    Electronic Resource
    Electronic Resource
    Supporting Timing Analysis by Automatic Bounding of Loop Iterations (2000)
    Springer
    Real-time systems 18 (2000), S. 129-156 
    Details
    ISSN: 1573-1383
    Keywords: hard real-time systems ; worst-case execution time ; static analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Static timing analyzers, which are used to analyze real-time systems, need to know the minimum and maximum number of iterations associated with each loop in a real-time program so accurate timing predictions can be obtained. This paper describes three complementary methods to support timing analysis by bounding the number of loop iterations. First, an algorithm is presented that determines the minimum and maximum number of iterations of loops with multiple exits. Even when the number of iterations cannot be exactly determined, it is desirable to know the lower and upper iteration bounds. Second, when the number of iterations is dependent on unknown values of variables, the user is asked to provide bounds for these variables. These bounds are used to determine the minimum and maximum number of iterations. Specifying the values of variables is less error prone than specifying the number of loop iterations directly. Finally, a method is given to tightly predict the execution time of inner loops whose number of iterations is dependent on counter variables of outer level loops. This is accomplished by formulating the total number of iterations of a loop in terms of summations and solving the resulting equation. These three methods have been successfully integrated in an existing timing analyzer that predicts the performance for optimized code on a machine that exploits caching and pipelining. The result is tighter timing analysis predictions and less work for the user.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008189014032
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  • 9
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    New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin (2016)
    Springer
    Details
    Publication Date: 2016-02-08
    Print ISSN: 0724-8741
    Electronic ISSN: 1573-904X
    Topics: Chemistry and Pharmacology
    Published by Springer
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  • 10
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    Genome assembly using Nanopore-guided long and error-free DNA reads (2015)
    BioMed Central
    Details
    Publication Date: 2015-04-21
    Description: Background: Long-read sequencing technologies were launched a few years ago, and in contrast with short-read sequencing technologies, they offered a promise of solving assembly problems for large and complex genomes. Moreover by providing long-range information, it could also solve haplotype phasing. However, existing long-read technologies still have several limitations that complicate their use for most research laboratories, as well as in large and/or complex genome projects. In 2014, Oxford Nanopore released the MinION® device, a small and low-cost single-molecule nanopore sequencer, which offers the possibility of sequencing long DNA fragments. Results: The assembly of long reads generated using the Oxford Nanopore MinION® instrument is challenging as existing assemblers were not implemented to deal with long reads exhibiting close to 30% of errors. Here, we presented a hybrid approach developed to take advantage of data generated using MinION® device. We sequenced a well-known bacterium, Acinetobacter baylyi ADP1 and applied our method to obtain a highly contiguous (one single contig) and accurate genome assembly even in repetitive regions, in contrast to an Illumina-only assembly. Our hybrid strategy was able to generate NaS (Nanopore Synthetic-long) reads up to 60 kb that aligned entirely and with no error to the reference genome and that spanned highly conserved repetitive regions. The average accuracy of NaS reads reached 99.99% without losing the initial size of the input MinION® reads. Conclusions: We described NaS tool, a hybrid approach allowing the sequencing of microbial genomes using the MinION® device. Our method, based ideally on 20x and 50x of NaS and Illumina reads respectively, provides an efficient and cost-effective way of sequencing microbial or small eukaryotic genomes in a very short time even in small facilities. Moreover, we demonstrated that although the Oxford Nanopore technology is a relatively new sequencing technology, currently with a high error rate, it is already useful in the generation of high-quality genome assemblies.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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