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  • Animals  (18)
  • *Geographic Mapping
  • 2010-2014  (13)
  • 2000-2004  (5)
  • 1980-1984  (1)
  • 1940-1944
  • 1930-1934
  • 1
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    Sex-biased hatching order and adaptive population divergence in a passerine bird (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-12
    Beschreibung: Most species of birds can lay only one egg per day until a clutch is complete, and the order in which eggs are laid often has strong and sex-specific effects on offspring growth and survival. In two recently established populations of the house finch (Carpodacus mexicanus) in Montana and Alabama, breeding females simultaneously adjusted the sex and growth of offspring in relation to their position in the laying order, thereby reducing the mortality of sons and daughters by 10 to 20% in both environments. We show experimentally that the reduction in mortality is produced by persistent and sex-specific maternal effects on the growth and morphology of offspring. These strong parental effects may have facilitated the rapid adaptive divergence among populations of house finches.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Badyaev, Alexander V -- Hill, Geoffrey E -- Beck, Michelle L -- Dervan, Anne A -- Duckworth, Renee A -- McGraw, Kevin J -- Nolan, Paul M -- Whittingham, Linda A -- New York, N.Y. -- Science. 2002 Jan 11;295(5553):316-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA. abadyaev@selway.umt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11786641" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Adaptation, Physiological ; Alabama ; Animals ; Behavior, Animal ; *Biological Evolution ; Body Weight ; Ecosystem ; Environment ; Female ; Male ; Montana ; Oviposition ; *Reproduction ; Selection, Genetic ; *Sex Characteristics ; Sex Ratio ; Songbirds/anatomy & histology/growth & development/*physiology ; Tarsus, Animal/anatomy & histology/growth & development
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Miniature genome in the marine chordate Oikopleura dioica (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-12-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seo, H C -- Kube, M -- Edvardsen, R B -- Jensen, M F -- Beck, A -- Spriet, E -- Gorsky, G -- Thompson, E M -- Lehrach, H -- Reinhardt, R -- Chourrout, D -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sars [corrected] Centre for Marine Molecular Biology, Thormo- hlensgt. 55, 5020 Bergen, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752568" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chromosomes, Artificial, Bacterial ; Ciona intestinalis/genetics ; Cloning, Molecular ; DNA, Complementary ; DNA, Intergenic ; Expressed Sequence Tags ; Genes ; *Genome ; Introns ; Male ; Repetitive Sequences, Nucleic Acid ; Sequence Analysis, DNA ; Spermatozoa/chemistry ; Urochordata/anatomy & histology/*genetics/growth & development
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Intravascular danger signals guide neutrophils to sites of sterile inflammation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2010-10-16
    Beschreibung: Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage. By using spinning disk confocal intravital microscopy, we examined the kinetics and molecular mechanisms of neutrophil recruitment to sites of focal hepatic necrosis in vivo. Adenosine triphosphate released from necrotic cells activated the Nlrp3 inflammasome to generate an inflammatory microenvironment that alerted circulating neutrophils to adhere within liver sinusoids. Subsequently, generation of an intravascular chemokine gradient directed neutrophil migration through healthy tissue toward foci of damage. Lastly, formyl-peptide signals released from necrotic cells guided neutrophils through nonperfused sinusoids into the injury. Thus, dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonald, Braedon -- Pittman, Keir -- Menezes, Gustavo B -- Hirota, Simon A -- Slaba, Ingrid -- Waterhouse, Christopher C M -- Beck, Paul L -- Muruve, Daniel A -- Kubes, Paul -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2010 Oct 15;330(6002):362-6. doi: 10.1126/science.1195491.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology Research Group, University of Calgary, Alberta T2N 4N1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20947763" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Animals ; Carrier Proteins/metabolism ; Cell Adhesion ; Chemokine CXCL2/metabolism ; Chemokines/metabolism ; Chemotaxis, Leukocyte ; Cues ; Endothelium, Vascular/physiology ; Inflammation/*immunology/metabolism/*pathology ; Kinetics ; Liver/blood supply/*immunology/metabolism/*pathology ; Liver Diseases/*immunology/metabolism/*pathology ; Macrophage-1 Antigen/physiology ; Mice ; Microscopy/methods ; Microscopy, Confocal ; Microvessels/physiology ; Necrosis ; *Neutrophil Infiltration ; Neutrophils/physiology ; Peptides/metabolism ; Receptors, Formyl Peptide/metabolism ; Receptors, Interleukin-8B/metabolism ; Receptors, Purinergic P2/metabolism ; Receptors, Purinergic P2X7 ; Signal Transduction
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    The C-terminal domain of RNA polymerase II is modified by site-specific methylation (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2011-04-02
    Beschreibung: The carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) in mammals undergoes extensive posttranslational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the coactivator-associated arginine methyltransferase 1 (CARM1). Although methylation at R1810 is present on the hyperphosphorylated form of RNAPII in vivo, Ser2 or Ser5 phosphorylation inhibits CARM1 activity toward this site in vitro, suggesting that methylation occurs before transcription initiation. Mutation of R1810 results in the misexpression of a variety of small nuclear RNAs and small nucleolar RNAs, an effect that is also observed in Carm1(-/-) mouse embryo fibroblasts. These results demonstrate that CTD methylation facilitates the expression of select RNAs, perhaps serving to discriminate the RNAPII-associated machinery recruited to distinct gene types.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773223/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773223/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sims, Robert J 3rd -- Rojas, Luis Alejandro -- Beck, David -- Bonasio, Roberto -- Schuller, Roland -- Drury, William J 3rd -- Eick, Dirk -- Reinberg, Danny -- F32 GM071166/GM/NIGMS NIH HHS/ -- GM-37120/GM/NIGMS NIH HHS/ -- GM-71166/GM/NIGMS NIH HHS/ -- R01 GM037120/GM/NIGMS NIH HHS/ -- R37 GM037120/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Apr 1;332(6025):99-103. doi: 10.1126/science.1202663.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Biochemistry, New York University School of Medicine, 522 First Avenue, Smilow 211, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21454787" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arginine/metabolism ; Cell Line ; HeLa Cells ; Humans ; Methylation ; Mice ; Mutation ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Protein-Arginine N-Methyltransferases/metabolism ; RNA Polymerase II/genetics/*metabolism ; RNA, Small Nuclear/metabolism ; RNA, Small Nucleolar/metabolism ; Recombinant Proteins
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    The structures of COPI-coated vesicles reveal alternate coatomer conformations and interactions (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2012-05-26
    Beschreibung: Transport between compartments of eukaryotic cells is mediated by coated vesicles. The archetypal protein coats COPI, COPII, and clathrin are conserved from yeast to human. Structural studies of COPII and clathrin coats assembled in vitro without membranes suggest that coat components assemble regular cages with the same set of interactions between components. Detailed three-dimensional structures of coated membrane vesicles have not been obtained. Here, we solved the structures of individual COPI-coated membrane vesicles by cryoelectron tomography and subtomogram averaging of in vitro reconstituted budding reactions. The coat protein complex, coatomer, was observed to adopt alternative conformations to change the number of other coatomers with which it interacts and to form vesicles with variable sizes and shapes. This represents a fundamentally different basis for vesicle coat assembly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faini, Marco -- Prinz, Simone -- Beck, Rainer -- Schorb, Martin -- Riches, James D -- Bacia, Kirsten -- Brugger, Britta -- Wieland, Felix T -- Briggs, John A G -- New York, N.Y. -- Science. 2012 Jun 15;336(6087):1451-4. doi: 10.1126/science.1221443. Epub 2012 May 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22628556" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; COP-Coated Vesicles/*chemistry/*ultrastructure ; Coat Protein Complex I/*chemistry ; Coatomer Protein/*chemistry ; Cryoelectron Microscopy ; Electron Microscope Tomography ; Image Processing, Computer-Assisted ; Mice ; Models, Molecular ; Protein Conformation
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Molecular mechanics of cardiac myosin-binding protein C in native thick filaments (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2012-08-28
    Beschreibung: The heart's pumping capacity results from highly regulated interactions of actomyosin molecular motors. Mutations in the gene for a potential regulator of these motors, cardiac myosin-binding protein C (cMyBP-C), cause hypertrophic cardiomyopathy. However, cMyBP-C's ability to modulate cardiac contractility is not well understood. Using single-particle fluorescence imaging techniques, transgenic protein expression, proteomics, and modeling, we found that cMyBP-C slowed actomyosin motion generation in native cardiac thick filaments. This mechanical effect was localized to where cMyBP-C resides within the thick filament (i.e., the C-zones) and was modulated by phosphorylation and site-specific proteolytic degradation. These results provide molecular insight into why cMyBP-C should be considered a member of a tripartite complex with actin and myosin that allows fine tuning of cardiac muscle contraction.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561468/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561468/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Previs, M J -- Beck Previs, S -- Gulick, J -- Robbins, J -- Warshaw, D M -- 8P20GM103449/GM/NIGMS NIH HHS/ -- HL007647/HL/NHLBI NIH HHS/ -- HL059408/HL/NHLBI NIH HHS/ -- P01 HL059408/HL/NHLBI NIH HHS/ -- P20 GM103449/GM/NIGMS NIH HHS/ -- R01 HL086728/HL/NHLBI NIH HHS/ -- T32 HL007647/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2012 Sep 7;337(6099):1215-8. doi: 10.1126/science.1223602. Epub 2012 Aug 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22923435" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actin Cytoskeleton/*physiology ; Actomyosin/metabolism ; Amino Acid Motifs ; Animals ; Carrier Proteins/chemistry/*metabolism ; Mice ; Mice, Transgenic ; *Myocardial Contraction ; Myocardium/*metabolism/ultrastructure ; Myofibrils/*metabolism ; Myosins/*metabolism ; Phosphorylation ; Proteolysis ; Sarcomeres/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Comment on "High-resolution global maps of 21st-century forest cover change" (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2014-05-31
    Beschreibung: Hansen et al. (Reports, 15 November 2013, p. 850) published a high-resolution global forest map with detailed information on local forest loss and gain. We show that their product does not distinguish tropical forests from plantations and even herbaceous crops, which leads to a substantial underestimate of forest loss and compromises its value for local policy decisions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tropek, Robert -- Sedlacek, Ondrej -- Beck, Jan -- Keil, Petr -- Musilova, Zuzana -- Simova, Irena -- Storch, David -- New York, N.Y. -- Science. 2014 May 30;344(6187):981. doi: 10.1126/science.1248753.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Science (Biogeography), University of Basel, St. Johanns-Vorstadt 10, CH-4056 Basel, Switzerland. Institute of Entomology, Biology Centre, Academy of Sciences of the Czech Republic, Branisovska 31, CZ-370 05 Ceske Budejovice, Czech Republic. robert.tropek@gmail.com. ; Department of Ecology, Faculty of Science, Charles University in Prague, Vinicna 7, CZ-128 44 Praha 2, Czech Republic. ; Department of Environmental Science (Biogeography), University of Basel, St. Johanns-Vorstadt 10, CH-4056 Basel, Switzerland. ; Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06520, USA. Center for Theoretical Study, Charles University in Prague and Academy of Sciences of the Czech Republic, Jilska 1, CZ-110 00 Praha 1, Czech Republic. ; Zoological Institute, University of Basel, Vesalgasse 1, CH-4051 Basel, Switzerland. ; Department of Ecology, Faculty of Science, Charles University in Prague, Vinicna 7, CZ-128 44 Praha 2, Czech Republic. Center for Theoretical Study, Charles University in Prague and Academy of Sciences of the Czech Republic, Jilska 1, CZ-110 00 Praha 1, Czech Republic.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876487" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Conservation of Natural Resources ; *Geographic Mapping ; *Maps as Topic ; *Trees
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-12
    Beschreibung: Kuru is an acquired prion disease largely restricted to the Fore linguistic group of the Papua New Guinea Highlands, which was transmitted during endocannibalistic feasts. Heterozygosity for a common polymorphism in the human prion protein gene (PRNP) confers relative resistance to prion diseases. Elderly survivors of the kuru epidemic, who had multiple exposures at mortuary feasts, are, in marked contrast to younger unexposed Fore, predominantly PRNP 129 heterozygotes. Kuru imposed strong balancing selection on the Fore, essentially eliminating PRNP 129 homozygotes. Worldwide PRNP haplotype diversity and coding allele frequencies suggest that strong balancing selection at this locus occurred during the evolution of modern humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mead, Simon -- Stumpf, Michael P H -- Whitfield, Jerome -- Beck, Jonathan A -- Poulter, Mark -- Campbell, Tracy -- Uphill, James B -- Goldstein, David -- Alpers, Michael -- Fisher, Elizabeth M C -- Collinge, John -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):640-3. Epub 2003 Apr 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Prion Unit, and Department of Neurodegenerative Disease, Institute of Neurology, University College, Queen Square, London WC1N 3BG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690204" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Cannibalism ; Child ; Codon ; Creutzfeldt-Jakob Syndrome/genetics ; Disease Outbreaks/*history ; Ethnic Groups/*genetics ; Female ; Gene Frequency ; Haplotypes ; Heterozygote ; History, 19th Century ; History, 20th Century ; History, Ancient ; Homozygote ; Humans ; Immunity, Innate ; Kuru/epidemiology/genetics/*history/transmission ; Linkage Disequilibrium ; Male ; Methionine/genetics ; Middle Aged ; Mutation ; Papua New Guinea/epidemiology ; *Polymorphism, Genetic ; PrPC Proteins/*genetics ; *Selection, Genetic ; Valine/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Acquired dendritic channelopathy in temporal lobe epilepsy (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-07-27
    Beschreibung: Inherited channelopathies are at the origin of many neurological disorders. Here we report a form of channelopathy that is acquired in experimental temporal lobe epilepsy (TLE), the most common form of epilepsy in adults. The excitability of CA1 pyramidal neuron dendrites was increased in TLE because of decreased availability of A-type potassium ion channels due to transcriptional (loss of channels) and posttranslational (increased channel phosphorylation by extracellular signal-regulated kinase) mechanisms. Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernard, Christophe -- Anderson, Anne -- Becker, Albert -- Poolos, Nicholas P -- Beck, Heinz -- Johnston, Daniel -- MH44754/MH/NIMH NIH HHS/ -- MH48432/MH/NIMH NIH HHS/ -- NS37444/NS/NINDS NIH HHS/ -- NS39943/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. cbernard@inmed.univ-mrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15273397" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; 4-Aminopyridine/pharmacology ; Action Potentials/drug effects ; Animals ; Butadienes/pharmacology ; Dendrites/*physiology ; Enzyme Inhibitors/pharmacology ; Epilepsy, Temporal Lobe/*physiopathology ; Hippocampus/cytology/*physiopathology ; Male ; Membrane Potentials ; Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism ; Nitriles/pharmacology ; Phosphorylation ; Pilocarpine/administration & dosage ; Potassium Channel Blockers/pharmacology ; Potassium Channels/drug effects/metabolism/*physiology ; *Potassium Channels, Voltage-Gated ; Protein Kinase C/antagonists & inhibitors/metabolism ; Pyramidal Cells/*physiology ; Rats ; Rats, Sprague-Dawley ; Shal Potassium Channels
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Nuclear pore complex structure and dynamics revealed by cryoelectron tomography (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-10-30
    Beschreibung: Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. To analyze their structure in a close-to-life state, we studied transport-active, intact nuclei from Dictyostelium discoideum by means of cryoelectron tomography. Subvolumes of the tomograms containing individual NPCs were extracted in silico and subjected to three-dimensional classification and averaging, whereby distinct structural states were observed. The central plug/transporter (CP/T) was variable in volume and could occupy different positions along the nucleocytoplasmic axis, which supports the notion that it essentially represents cargo in transit. Changes in the position of the CP/T were accompanied by structural rearrangements in the NPC scaffold.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beck, Martin -- Forster, Friedrich -- Ecke, Mary -- Plitzko, Jurgen M -- Melchior, Frauke -- Gerisch, Gunther -- Baumeister, Wolfgang -- Medalia, Ohad -- New York, N.Y. -- Science. 2004 Nov 19;306(5700):1387-90. Epub 2004 Oct 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514115" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Active Transport, Cell Nucleus ; Animals ; Cell Nucleus/ultrastructure ; Cryoelectron Microscopy ; Cytoskeleton/ultrastructure ; Dictyostelium/chemistry/metabolism/*ultrastructure ; Image Processing, Computer-Assisted ; *Imaging, Three-Dimensional ; Nuclear Pore/chemistry/*ultrastructure ; Tomography/*methods
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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