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  • 1
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    Acquired dendritic channelopathy in temporal lobe epilepsy (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-27
    Description: Inherited channelopathies are at the origin of many neurological disorders. Here we report a form of channelopathy that is acquired in experimental temporal lobe epilepsy (TLE), the most common form of epilepsy in adults. The excitability of CA1 pyramidal neuron dendrites was increased in TLE because of decreased availability of A-type potassium ion channels due to transcriptional (loss of channels) and posttranslational (increased channel phosphorylation by extracellular signal-regulated kinase) mechanisms. Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernard, Christophe -- Anderson, Anne -- Becker, Albert -- Poolos, Nicholas P -- Beck, Heinz -- Johnston, Daniel -- MH44754/MH/NIMH NIH HHS/ -- MH48432/MH/NIMH NIH HHS/ -- NS37444/NS/NINDS NIH HHS/ -- NS39943/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. cbernard@inmed.univ-mrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15273397" target="_blank"〉PubMed〈/a〉
    Keywords: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; 4-Aminopyridine/pharmacology ; Action Potentials/drug effects ; Animals ; Butadienes/pharmacology ; Dendrites/*physiology ; Enzyme Inhibitors/pharmacology ; Epilepsy, Temporal Lobe/*physiopathology ; Hippocampus/cytology/*physiopathology ; Male ; Membrane Potentials ; Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism ; Nitriles/pharmacology ; Phosphorylation ; Pilocarpine/administration & dosage ; Potassium Channel Blockers/pharmacology ; Potassium Channels/drug effects/metabolism/*physiology ; *Potassium Channels, Voltage-Gated ; Protein Kinase C/antagonists & inhibitors/metabolism ; Pyramidal Cells/*physiology ; Rats ; Rats, Sprague-Dawley ; Shal Potassium Channels
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Critical mass flux through short Borda type inlets of various cross sections (1979)
    In:  Other Sources
    Details
    Publication Date: 2019-07-27
    Description: Mass flux measurements associated with choked flows through four Borda-type inlet geometries: circular, square, triangular, and rectangular (two-dimensional) and two sharp-edged geometries are discussed for a wide range of inlet stagnation conditions. The results obtained indicate that the mass flux is independent of the inlet cross-section geometry, while it is dependent on the inlet stagnation conditions. The results also suggest that parallel surfaces as found in seals, dampers, bearings, and heat exchanger tubes of rectangular cross section with Borda-type inlet configurations are subject to large forces. It is noted that the reduced mass flux is independent of working fluid.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: International Congress of Refrigeration; Sept. 23-29, 1979; Venice; Italy
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Prolonging thermal barrier coated specimen life by thermal cycle management (1981)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Thermal barrier coatings applied to the heated side of engine components such as seals, combustor, and blades of a gas turbine offer a potential increase in efficiency through the use of higher gas temperatures or less cooling air or benefits arising from extended component life by reducing component metal temperatures. The considered investigation has the objective to show that while a thermal barrier coated (TBC) specimen can be brought to a fixed temperature using various fuel-air ratio (F/A) values, lower calculated stresses are associated with lower (F/A) values. This implies that control of (F/A) values (i.e., rates of heat input) during the starting transient and to a lesser extent during shutdown and operation, offers a potential method of improving TBC lifetime through thermal cycle management.
    Keywords: NONMETALLIC MATERIALS
    Type: International Conference on Metallurgical Coatings; Apr 06, 1981 - Apr 10, 1981; San Francisco, CA
    Format: text
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  • 4
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    Prolonging thermal barrier coated specimen life by thermal cycle management (1981)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Measurements were made of the rate of increase in temperature of a ZrO2-8Y2O3 thermal barrier coated (TBC) specimen for various values of fuel/air (F/A) ratios when the specimen is exposed to a 0.3 Mach burner flame. For rod specimens in a carousel, the heating rates increased with (F/A) ratio and were higher at the inward facing surface for a given (F/A). Plate specimens were more sensitive to burner variations. Calculated results are given for the radial stress in the coated rod specimens for variations in (F/A) ratios from 0.04 to 0.065. Over this range, the radial stress varies from 4.3 to 5.3 MPa. The results indicate that controlling the heating rate of a TBC by controlling the (F/A) ratio offers a potential method to prolong TBC cyclic life; uncontrolled (F/A) ratios will produce scatter in experimental results. Geometric arrangement can have an equivalent effect, but is usually fixed by design.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA-TM-81742 , E-795 , Intern. Conf. on Met. Coatings,; Apr 06, 1981 - Apr 10, 1981; San Francisco, CA; United States
    Format: application/pdf
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  • 5
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    Critical mass flux through short Borda type inlets of various cross sections (1979)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Mass flux measurements associated with chocked flows through four Borda type inlet geometries: circular, square, triangular and rectangular (two-dimensional) and two sharp edged geometries taken over a very wide range of inlet stagnation conditions. The measurements indicate that: (1) the mass flux is independent of the inlet cross-section geometry and (2) the mass flux is dependent only on the inlet stagnation conditions. Also by using choked flow results found in the literature, the reduced mass flux is independent of working fluid. Two implications are drawn which remain to be verified: (1) since seal leak rates are weakly dependent on geometry but pressure distribution is strongly dependent on geometry, seal design efforts should be directed more toward controlling the dynamics, and (2) high-L/D ducts of arbitrary cross section and Borda type inlets can possess free jets.
    Keywords: METALLIC MATERIALS
    Type: NASA-TM-79017 , E-9868 , Intern. Congr. of Refrigeration; Sep 23, 1979 - Sep 29, 1979; Venice; Italy
    Format: application/pdf
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