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  • Superfluidity and superconductivity  (3)
  • Binding Sites  (2)
  • Electronic structure and strongly correlated systems  (2)
  • Mice  (2)
  • 2010-2014  (9)
  • 2013  (9)
  • 1
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    Electronic structure of Ca_{10}(Pt_{4}As_{8})(Fe_{2−x}Pt_{x}As_{2})_{5} with metallic Pt_{4}As_{8} layers: An angle-resolved photoemission spectroscopy study (2013)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2013-09-14
    Beschreibung: Author(s): X. P. Shen, S. D. Chen, Q. Q. Ge, Z. R. Ye, F. Chen, H. C. Xu, S. Y. Tan, X. H. Niu, Q. Fan, B. P. Xie, and D. L. Feng We studied the low-lying electronic structure of the newly discovered iron-platinum-arsenide superconductor, Ca 10 (Pt 4 As 8 )(Fe 2− x Pt x As 2 ) 5 ( T c =22 K) with angle-resolved photoemission spectroscopy. We found that the Pt 4 As 8 layer contributes to a small electronlike Fermi surface, indicative of metallic c... [Phys. Rev. B 88, 115124] Published Fri Sep 13, 2013
    Schlagwort(e): Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
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  • 2
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    Distinct in-plane resistivity anisotropy in a detwinned FeTe single crystal: Evidence for a Hund's metal (2013)
    American Physical Society (APS)
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    Publikationsdatum: 2013-09-18
    Beschreibung: Author(s): Juan Jiang (姜娟), C. He (贺诚), Y. Zhang (张焱), M. Xu (徐敏), Q. Q. Ge (葛青亲), Z. R. Ye (叶子荣), F. Chen (陈飞), B. P. Xie (谢斌平), and D. L. Feng (封东来) The in-plane resistivity anisotropy has been studied with the Montgomery method on the detwinned parent compound of the iron-based superconductor FeTe. The observed resistivity in the antiferromagnetic (AFM) direction is larger than that in the ferromagnetic (FM) direction, which is different from t... [Phys. Rev. B 88, 115130] Published Tue Sep 17, 2013
    Schlagwort(e): Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
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  • 3
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    Peak effect in optimally doped p-type single-crystal Ba_{0.5}K_{0.5}Fe_{2}As_{2} studied by ac magnetization measurements (2013)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2013-10-15
    Beschreibung: Author(s): J. Ge, J. Gutierrez, J. Li, J. Yuan, H.-B. Wang, K. Yamaura, E. Takayama-Muromachi, and V. V. Moshchalkov We have used the ac magnetic susceptibility to investigate the vortex state in an optimally doped p -type Ba 0.5 K 0.5 Fe 2 As 2 single crystal under various ac and dc fields. A peak effect is observed in the temperature dependence of the in-phase ac susceptibility, indicating an order-disorder transition o... [Phys. Rev. B 88, 144505] Published Mon Oct 14, 2013
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
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  • 4
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    Probing allostery through DNA (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-16
    Beschreibung: Allostery is well documented for proteins but less recognized for DNA-protein interactions. Here, we report that specific binding of a protein on DNA is substantially stabilized or destabilized by another protein bound nearby. The ternary complex's free energy oscillates as a function of the separation between the two proteins with a periodicity of ~10 base pairs, the helical pitch of B-form DNA, and a decay length of ~15 base pairs. The binding affinity of a protein near a DNA hairpin is similarly dependent on their separation, which-together with molecular dynamics simulations-suggests that deformation of the double-helical structure is the origin of DNA allostery. The physiological relevance of this phenomenon is illustrated by its effect on gene expression in live bacteria and on a transcription factor's affinity near nucleosomes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586787/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586787/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Sangjin -- Brostromer, Erik -- Xing, Dong -- Jin, Jianshi -- Chong, Shasha -- Ge, Hao -- Wang, Siyuan -- Gu, Chan -- Yang, Lijiang -- Gao, Yi Qin -- Su, Xiao-dong -- Sun, Yujie -- Xie, X Sunney -- DP1 OD000277/OD/NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 15;339(6121):816-9. doi: 10.1126/science.1229223.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23413354" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Allosteric Regulation ; Base Sequence ; Binding Sites ; DNA, B-Form/*chemistry ; DNA-Binding Proteins/*chemistry ; DNA-Directed RNA Polymerases/chemistry ; Escherichia coli/genetics/metabolism ; Gene Expression ; *Gene Expression Regulation, Bacterial ; Lac Repressors/chemistry ; Molecular Dynamics Simulation ; Nucleosomes/chemistry ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Glucocorticoid/chemistry ; Transcription Factors/*chemistry ; Viral Proteins/chemistry
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-12-21
    Beschreibung: The duration of a woman's reproductive period is determined by the size and persistence of a dormant oocyte pool. Specific oocyte genes are essential for follicle maintenance and female fertility. The mechanisms that regulate the expression of these genes are poorly understood. We found that a cullin-ring finger ligase-4 (CRL4) complex was crucial in this process. Oocyte-specific deletion of the CRL4 linker protein DDB1 or its substrate adaptor VPRBP (also known as DCAF1) caused rapid oocyte loss, premature ovarian insufficiency, and silencing of fertility maintaining genes. CRL4(VPRBP) activates the TET methylcytosine dioxygenases, which are involved in female germ cell development and zygote genome reprogramming. Hence, CRL4(VPRBP) ubiquitin ligase is a guardian of female reproductive life in germ cells and a maternal reprogramming factor after fertilization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, Chao -- Zhang, Yin-Li -- Pan, Wei-Wei -- Li, Xiao-Meng -- Wang, Zhong-Wei -- Ge, Zhao-Jia -- Zhou, Jian-Jie -- Cang, Yong -- Tong, Chao -- Sun, Qing-Yuan -- Fan, Heng-Yu -- New York, N.Y. -- Science. 2013 Dec 20;342(6165):1518-21. doi: 10.1126/science.1244587.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357321" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carrier Proteins/genetics/*metabolism ; Cell Survival/genetics/physiology ; Cellular Reprogramming/*genetics ; Cullin Proteins/genetics/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Dioxygenases/genetics/*metabolism ; Female ; Fertility/*genetics ; Gene Silencing ; Gonadal Dysgenesis/genetics ; HeLa Cells ; Humans ; Mice ; Mice, Knockout ; Oocytes/*physiology ; Ovary/physiopathology ; Proto-Oncogene Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine (2013)
    Nature Publishing Group (NPG)
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    Publikationsdatum: 2013-04-05
    Beschreibung: The Sir2 family of enzymes or sirtuins are known as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases and have been implicated in the regulation of transcription, genome stability, metabolism and lifespan. However, four of the seven mammalian sirtuins have very weak deacetylase activity in vitro. Here we show that human SIRT6 efficiently removes long-chain fatty acyl groups, such as myristoyl, from lysine residues. The crystal structure of SIRT6 reveals a large hydrophobic pocket that can accommodate long-chain fatty acyl groups. We demonstrate further that SIRT6 promotes the secretion of tumour necrosis factor-alpha (TNF-alpha) by removing the fatty acyl modification on K19 and K20 of TNF-alpha. Protein lysine fatty acylation has been known to occur in mammalian cells, but the function and regulatory mechanisms of this modification were unknown. Our data indicate that protein lysine fatty acylation is a novel mechanism that regulates protein secretion. The discovery of SIRT6 as an enzyme that controls protein lysine fatty acylation provides new opportunities to investigate the physiological function of a protein post-translational modification that has been little studied until now.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635073/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635073/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Hong -- Khan, Saba -- Wang, Yi -- Charron, Guillaume -- He, Bin -- Sebastian, Carlos -- Du, Jintang -- Kim, Ray -- Ge, Eva -- Mostoslavsky, Raul -- Hang, Howard C -- Hao, Quan -- Lin, Hening -- R01 CA175727/CA/NCI NIH HHS/ -- R01 DK088190/DK/NIDDK NIH HHS/ -- R01 GM086703/GM/NIGMS NIH HHS/ -- R01 GM087544/GM/NIGMS NIH HHS/ -- R01 GM093072/GM/NIGMS NIH HHS/ -- R01GM086703/GM/NIGMS NIH HHS/ -- R01GM087544/GM/NIGMS NIH HHS/ -- R01GM093072/GM/NIGMS NIH HHS/ -- England -- Nature. 2013 Apr 4;496(7443):110-3. doi: 10.1038/nature12038.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23552949" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acylation ; Binding Sites ; Crystallography, X-Ray ; Fatty Acids/*chemistry/*metabolism ; Humans ; Hydrolysis ; Hydrophobic and Hydrophilic Interactions ; Lysine/*analogs & derivatives/chemistry/*metabolism ; Protein Processing, Post-Translational ; Sirtuins/chemistry/*metabolism ; Tumor Necrosis Factor-alpha/chemistry/metabolism/*secretion
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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  • 7
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    Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-23
    Beschreibung: Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clinical applications. Here, we show that pluripotent stem cells can be generated from mouse somatic cells at a frequency up to 0.2% using a combination of seven small-molecule compounds. The chemically induced pluripotent stem cells resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. By using small molecules, exogenous "master genes" are dispensable for cell fate reprogramming. This chemical reprogramming strategy has potential use in generating functional desirable cell types for clinical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hou, Pingping -- Li, Yanqin -- Zhang, Xu -- Liu, Chun -- Guan, Jingyang -- Li, Honggang -- Zhao, Ting -- Ye, Junqing -- Yang, Weifeng -- Liu, Kang -- Ge, Jian -- Xu, Jun -- Zhang, Qiang -- Zhao, Yang -- Deng, Hongkui -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23868920" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cadherins/genetics ; Cell Engineering/*methods ; Cellular Reprogramming/*drug effects/genetics ; Epithelial-Mesenchymal Transition/drug effects/genetics ; Fibroblasts/cytology/*drug effects ; Gene Expression Profiling ; Green Fluorescent Proteins/genetics ; Induced Pluripotent Stem Cells/*cytology/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Octamer Transcription Factor-3/genetics/metabolism ; Promoter Regions, Genetic/drug effects ; Small Molecule Libraries/chemistry/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Temperature dependence of lower critical field H_{c1}(T) shows nodeless superconductivity in FeSe (2013)
    American Physical Society (APS)
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    Publikationsdatum: 2013-11-19
    Beschreibung: Author(s): M. Abdel-Hafiez, J. Ge, A. N. Vasiliev, D. A. Chareev, J. Van de Vondel, V. V. Moshchalkov, and A. V. Silhanek We investigate the temperature dependence of the lower critical field H c 1 ( T ) of a high-quality FeSe single crystal under static magnetic fields H parallel to the c axis. The temperature dependence of the first vortex penetration field has been experimentally obtained by two independent methods and t... [Phys. Rev. B 88, 174512] Published Mon Nov 18, 2013
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
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  • 9
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    Observation of single flux quantum vortices in the intermediate state of a type-I superconducting film (2013)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2013-11-08
    Beschreibung: Author(s): Junyi Ge, Joffre Gutierrez, Jo Cuppens, and Victor V. Moshchalkov The flux quantization in the intermediate state of a type-I superconducting Pb film is studied by using scanning Hall probe microscopy. The vorticity of flux tubes can be tuned by changing the cooling field through the flux expulsion process, and single flux quantum vortices coexisting with multiple... [Phys. Rev. B 88, 174503] Published Thu Nov 07, 2013
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
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