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  • Male  (6)
  • Solar Physics  (4)
  • Earth Resources and Remote Sensing  (3)
  • Electronics and Electrical Engineering
  • Extraterrestrial Environment
  • Mice
  • 2015-2019
  • 2000-2004  (17)
  • 2004  (12)
  • 2003  (5)
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Erscheinungszeitraum
  • 2015-2019
  • 2000-2004  (17)
Jahr
  • 1
    Publikationsdatum: 2004-10-30
    Beschreibung: The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnbaum, S G -- Yuan, P X -- Wang, M -- Vijayraghavan, S -- Bloom, A K -- Davis, D J -- Gobeske, K T -- Sweatt, J D -- Manji, H K -- Arnsten, A F T -- AG06036/AG/NIA NIH HHS/ -- P50 MH068789/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):882-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520-8001, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514161" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenergic alpha-Agonists/pharmacology ; Alkaloids ; Animals ; Benzophenanthridines ; Carbolines/pharmacology ; Electrophysiology ; Enzyme Activation ; Female ; Imidazoles/pharmacology ; Lithium Carbonate/pharmacology ; Macaca mulatta ; Male ; Memory/drug effects/*physiology ; Neurons/drug effects/physiology ; Phenanthridines/pharmacology ; Prefrontal Cortex/enzymology/*physiology ; Protein Kinase C/antagonists & inhibitors/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha-1/physiology ; Signal Transduction ; Stress, Physiological/physiopathology ; Tetradecanoylphorbol Acetate/pharmacology ; Valproic Acid/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2004-12-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, Mark A -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1891.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591186" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Awards and Prizes ; Female ; Humans ; Male ; Men ; *National Institutes of Health (U.S.) ; *Prejudice ; United States ; *Women
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2004-09-09
    Beschreibung: Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kipling, David -- Davis, Terence -- Ostler, Elizabeth L -- Faragher, Richard G A -- New York, N.Y. -- Science. 2004 Sep 3;305(5689):1426-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15353794" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging ; Animals ; Cell Aging ; Cell Division ; DNA Helicases/genetics/physiology ; Exodeoxyribonucleases ; Female ; Gene Expression ; Humans ; Male ; Mice ; Models, Animal ; Mutation ; Phenotype ; RecQ Helicases ; Telomere/metabolism ; *Werner Syndrome/genetics/pathology/physiopathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2004-08-07
    Beschreibung: The precise location and relative elevation of Spirit during its traverses from the Columbia Memorial station to Bonneville crater were determined with bundle-adjusted retrievals from rover wheel turns, suspension and tilt angles, and overlapping images. Physical properties experiments show a decrease of 0.2% per Mars solar day in solar cell output resulting from deposition of airborne dust, cohesive soil-like deposits in plains and hollows, bright and dark rock coatings, and relatively weak volcanic rocks of basaltic composition. Volcanic, impact, aeolian, and water-related processes produced the encountered landforms and materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arvidson, R E -- Anderson, R C -- Bartlett, P -- Bell, J F 3rd -- Blaney, D -- Christensen, P R -- Chu, P -- Crumpler, L -- Davis, K -- Ehlmann, B L -- Fergason, R -- Golombek, M P -- Gorevan, S -- Grant, J A -- Greeley, R -- Guinness, E A -- Haldemann, A F C -- Herkenhoff, K -- Johnson, J -- Landis, G -- Li, R -- Lindemann, R -- McSween, H -- Ming, D W -- Myrick, T -- Richter, L -- Seelos, F P 4th -- Squyres, S W -- Sullivan, R J -- Wang, A -- Wilson, J -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):821-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Planetary Sciences, Washington University, St. Louis, MO 63130, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297662" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Extraterrestrial Environment ; Geologic Sediments ; *Mars ; Volcanic Eruptions ; Water ; Wind
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2004-12-18
    Beschreibung: The amygdala was more responsive to fearful (larger) eye whites than to happy (smaller) eye whites presented in a masking paradigm that mitigated subjects' awareness of their presence and aberrant nature. These data demonstrate that the amygdala is responsive to elements of.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whalen, Paul J -- Kagan, Jerome -- Cook, Robert G -- Davis, F Caroline -- Kim, Hackjin -- Polis, Sara -- McLaren, Donald G -- Somerville, Leah H -- McLean, Ashly A -- Maxwell, Jeffrey S -- Johnstone, Tom -- 01866/PHS HHS/ -- 069315/PHS HHS/ -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2061.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, W. M. Keck Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, USA. pwhalen@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604401" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Amygdala/*physiology ; *Facial Expression ; *Fear ; Female ; Happiness ; Humans ; Magnetic Resonance Imaging ; Male ; Pattern Recognition, Visual ; Perceptual Masking ; *Sclera
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2004-02-21
    Beschreibung: Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the small intestine is poorly defined. We show that Niemann-Pick C1 Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol. NPC1L1 expression is enriched in the small intestine and is in the brush border membrane of enterocytes. Although otherwise phenotypically normal, NPC1L1-deficient mice exhibit a substantial reduction in absorbed cholesterol, which is unaffected by dietary supplementation of bile acids. Ezetimibe, a drug that inhibits cholesterol absorption, had no effect in NPC1L1 knockout mice, suggesting that NPC1L1 resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altmann, Scott W -- Davis, Harry R Jr -- Zhu, Li-Ji -- Yao, Xiaorui -- Hoos, Lizbeth M -- Tetzloff, Glen -- Iyer, Sai Prasad N -- Maguire, Maureen -- Golovko, Andrei -- Zeng, Ming -- Wang, Luquan -- Murgolo, Nicholas -- Graziano, Michael P -- New York, N.Y. -- Science. 2004 Feb 20;303(5661):1201-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiovascular/Endocrine Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033-0539, USA. scott.altmann@spcorp.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976318" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Anticholesteremic Agents/pharmacology ; Azetidines/pharmacology ; Cholesterol/*metabolism ; Cholesterol, Dietary/*metabolism ; Cholic Acid/administration & dosage/pharmacology ; Computational Biology ; Enterocytes/*metabolism ; Ezetimibe ; Female ; Gene Expression Profiling ; Humans ; *Intestinal Absorption/drug effects ; Intestine, Small/metabolism ; Jejunum/metabolism ; Liver/metabolism ; Male ; Membrane Proteins/chemistry/genetics/*metabolism ; Membrane Transport Proteins/chemistry/genetics/*metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Proteins/chemistry/genetics/*metabolism ; Rats ; Rats, Sprague-Dawley
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2004-12-04
    Beschreibung: The location of the Opportunity landing site was determined to better than 10-m absolute accuracy from analyses of radio tracking data. We determined Rover locations during traverses with an error as small as several centimeters using engineering telemetry and overlapping images. Topographic profiles generated from rover data show that the plains are very smooth from meter- to centimeter-length scales, consistent with analyses of orbital observations. Solar cell output decreased because of the deposition of airborne dust on the panels. The lack of dust-covered surfaces on Meridiani Planum indicates that high velocity winds must remove this material on a continuing basis. The low mechanical strength of the evaporitic rocks as determined from grinding experiments, and the abundance of coarse-grained surface particles argue for differential erosion of Meridiani Planum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arvidson, R E -- Anderson, R C -- Bartlett, P -- Bell, J F 3rd -- Christensen, P R -- Chu, P -- Davis, K -- Ehlmann, B L -- Golombek, M P -- Gorevan, S -- Guinness, E A -- Haldemann, A F C -- Herkenhoff, K E -- Landis, G -- Li, R -- Lindemann, R -- Ming, D W -- Myrick, T -- Parker, T -- Richter, L -- Seelos, F P 4th -- Soderblom, L A -- Squyres, S W -- Sullivan, R J -- Wilson, J -- New York, N.Y. -- Science. 2004 Dec 3;306(5702):1730-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Planetary Sciences, Washington University, St. Louis, MO 63130, USA. arvidson@wunder.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15576608" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Extraterrestrial Environment ; Geologic Sediments ; *Mars ; Spacecraft ; Wind
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Publikationsdatum: 2003-06-14
    Beschreibung: Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, approximately 83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ranz, Jose M -- Castillo-Davis, Cristian I -- Meiklejohn, Colin D -- Hartl, Daniel L -- New York, N.Y. -- Science. 2003 Jun 13;300(5626):1742-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12805547" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bayes Theorem ; Drosophila/*genetics ; Drosophila melanogaster/*genetics ; *Evolution, Molecular ; Female ; *Gene Expression ; Gene Expression Profiling ; Genes, Insect ; *Genome ; Male ; Mutation ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics/metabolism ; Selection, Genetic ; Sex Characteristics ; Species Specificity ; *Transcription, Genetic ; X Chromosome/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Publikationsdatum: 2018-06-08
    Schlagwort(e): Earth Resources and Remote Sensing
    Materialart: International Geoscience and Remote Sensing Symposium (IGARSS); Toulouse; France
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 2019-07-18
    Beschreibung: The major flood events in the United States in the past few years have made it apparent that many floodplain maps being used by State governments are outdated and inaccurate. In response, many Stated have begun to update their Federal Emergency Management Agency (FEMA) Digital Flood Insurance Rate Maps. Accurate topographic data is one of the most critical inputs for floodplain analysis and delineation. Light detection and ranging (LIDAR) altimetry is one of the primary remote sensing technologies that can be used to obtain high-resolution and high-accuracy digital elevation data suitable for hydrologic and hydraulic (H&H) modeling, in part because of its ability to "penetrate" various cover types and to record geospatial data from the Earth's surface. However, the posting density or spacing at which LIDAR collects the data will affect the resulting accuracies of the derived bare Earth surface, depending on terrain type and land cover type. For example, flat areas are thought to require higher or denser postings than hilly areas to capture subtle changes in the topography that could have a significant effect on flooding extent. Likewise, if an area has dense understory and overstory, it may be difficult to receive LIDAR returns from the Earth's surface, which would affect the accuracy of that bare Earth surface and thus would affect flood model results. For these reasons, NASA and FEMA have partnered with the State of North Carolina and with the U.S./Mexico Foundation in Texas to assess the effect of LIDAR point density on the characterization of topographic variation and on H&H modeling results for improved floodplain mapping. Research for this project is being conducted in two areas of North Carolina and in the City of Brownsville, Texas, each with a different type of terrain and varying land cover/land use. Because of various project constraints, LIDAR data were acquired once at a high posting density and then decimated to coarser postings or densities. Quality assurance/quality control analyses were performed on each dataset. Cross sections extracted form the high density and then the decimated datasets were individually input into an H&H model to determine the model's sensitivity to topographic variation and the effect of that variation on the resulting water profiles. Additional analysis was performed on the Brownsville, Texas, LIDAR data to determine the percentage of returns that "penetrated" various types of canopy or vegetative cover. It is hoped that the results of these studies will benefit state and local communities as they consider the post spacing at which to acquire LIDAR data (which affects cost) and will benefit FEMA as the Agency assesses the use of different technologies for updating National Flood Insurance Program and related products.
    Schlagwort(e): Earth Resources and Remote Sensing
    Materialart: SSTI-2220-0003-ESAD
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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