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  • American Association for the Advancement of Science (AAAS)  (2)
  • National Academy of Sciences  (1)
  • American Chemical Society
  • 2000-2004  (3)
  • 1990-1994
  • 1925-1929
  • 2002  (3)
  • 1
    Publication Date: 2002-04-16
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2002-01-19
    Description: Immigrants to habitats occupied by conspecific organisms are usually expected to be competitively inferior, because residents may be locally adapted. If residents are inbred, however, mating between immigrants and residents results in offspring that may enjoy a fitness advantage from hybrid vigor. We demonstrate this effect experimentally in a natural Daphnia metapopulation in which genetic bottlenecks and local inbreeding are common. We estimate that in this metapopulation, hybrid vigor amplifies the rate of gene flow several times more than would be predicted from the nominal migration rate. This can affect the persistence of local populations and the entire metapopulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ebert, Dieter -- Haag, Christoph -- Kirkpatrick, Mark -- Riek, Myriam -- Hottinger, Jurgen W -- Pajunen, V Ilmari -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):485-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoologisches Institut, Universitat Basel, Rheinsprung 9, 4051 Basel, Switzerland. dieter.ebert@unifr.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799241" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Daphnia/*genetics/growth & development/physiology ; Demography ; *Ecosystem ; Female ; Finland ; Genetic Markers ; Genetics, Population ; Genotype ; *Hybrid Vigor ; Hybridization, Genetic ; *Inbreeding ; Life Cycle Stages ; Male ; Reproduction ; Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2002-10-26
    Description: We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actions of sex steroid receptors are dispensable for their bone protective effects, but essential for their effects on reproductive tissues. A synthetic ligand (4-estren-3alpha,17beta-diol) that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription, increases bone mass and strength in ovariectomized females above the level of the estrogen-replete state and is at least as effective as dihydrotestosterone in orchidectomized males, without affecting reproductive organs. Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected].〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kousteni, S -- Chen, J R -- Bellido, T -- Han, L -- Ali, A A -- O'Brien, C A -- Plotkin, L -- Fu, Q -- Mancino, A T -- Wen, Y -- Vertino, A M -- Powers, C C -- Stewart, S A -- Ebert, R -- Parfitt, A M -- Weinstein, R S -- Jilka, R L -- Manolagas, S C -- KO2-AR02127/AR/NIAMS NIH HHS/ -- P01-AG13918/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):843-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Bone Density/*drug effects ; Bone and Bones/*drug effects/physiology ; Breast Neoplasms/pathology ; Cell Division/drug effects ; Cells, Cultured ; Compressive Strength/drug effects ; Dihydrotestosterone/pharmacology ; Estradiol/pharmacology ; Estrenes/metabolism/*pharmacology ; Female ; Humans ; Male ; Mice ; Orchiectomy ; Organ Size/drug effects ; Osteoblasts/*drug effects/physiology ; Osteocalcin/blood ; Osteoclasts/*drug effects/physiology ; Osteogenesis/drug effects ; Osteoporosis/drug therapy ; Ovariectomy ; Pyrazoles/pharmacology ; Receptors, Estrogen/metabolism ; Seminal Vesicles/drug effects ; Transcription, Genetic/drug effects ; Tumor Cells, Cultured ; Uterus/drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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