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  • Mutation  (10)
  • Mice  (9)
  • Numerical Methods and Modeling  (7)
  • Binding Sites  (6)
  • 1995-1999  (26)
  • 1997  (26)
  • 1
    Electronic Resource
    Electronic Resource
    Homogenization of a spectral problem for a pile foundation structure (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 979-988 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The subject of this paper is the study of free oscillations of a composite material consisting of an elastic medium and a large number of elastic piles periodically immersed in a part of the medium. The ends of piles lying on the boundary of the medium are clamped to a force-free rigid plate. Such a partially composite structure arises in pile foundation mechanics. Assuming that the period of pile structure tends to zero, we obtain the macroscopic equations for free oscillations by homogenization method and prove the corresponding convergence result. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 2 Ill.
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  • 2
    Electronic Resource
    Electronic Resource
    Solution of torsion crack problem of an orthotropic rectangular bar by using computing compliance method (1997)
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 13 (1997), S. 655-663 
    Details
    ISSN: 1069-8299
    Keywords: stress intensity factors ; computing compliance method ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: For a cracked orthotropic torsion bar, the torsion compliance C is evaluated numerically in this paper. The dependence of the compliance C with respect to the crack length A will give the stress intensity factor at the crack tip. Numerical examples are given to demonstrate the influence of the elastic material constants of orthotropic materials. ©1997 John Wiley & Sons, Ltd.
    Additional Material: 5 Ill.
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  • 3
    Electronic Resource
    Electronic Resource
    Lanczos-type Methods for Continuation Problems (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Numerical Linear Algebra with Applications 4 (1997), S. 23-41 
    Details
    ISSN: 1070-5325
    Keywords: Lanczos methods ; conjugate gradient methods ; continuation methods ; eigenvalue problems ; bifurcation ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study the Lanczos type methods for continuation problems. First we indicate how the symmetric Lanczos method may be used to solve both positive definite and indefinite linear systems. Furthermore, it can be used to monitor the simple bifurcation points on the solution curve of the eigenvalue problems. This includes computing the minimum eigenvalue, the minimum singular value, and the condition number of the partial tridiagonalizations of the coefficient matrices. The Ritz vector thus obtained can be applied to compute the tangent vector at the bifurcation point for branch-switching. Next, we indicate that the block or band Lanczos method can be used to monitor the multiple bifurcations as well as to solve the multiple right hand sides. We also show that the unsymmetric Lanczos method can be exploited to compute the minimum eigenvalue of a nearly symmetric matrix, and therefore to detect the simple bifurcation point as well. Some preconditioning techniques are discussed. Sample numerical results are reported. Our test problems include second order semilinear elliptic eigenvalue problems. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 10 Tab.
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of 3D crack problems by mapping semi-analytical BEM (1997)
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 13 (1997), S. 827-834 
    Details
    ISSN: 1069-8299
    Keywords: crack ; stress intensity factor ; semi-analytical boundary element method ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: By continuous transformation for a domain, this paper develops a new boundary element technique, mapping semi-analytical BEM. Applied to static/dynamic analysis of 3D embedded arbitrarily shaped crack problems, it only needs one-dimensional discretization, so the computational work can be considerably reduced. Some typical examples demonstrate its effectiveness. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 3 Ill.
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  • 5
    Electronic Resource
    Electronic Resource
    TREE-COTREE DECOMPOSITIONS FOR FIRST-ORDER COMPLETE TANGENTIAL VECTOR FINITE ELEMENTS (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 1667-1685 
    Details
    ISSN: 0029-5981
    Keywords: finite elements ; vector elements ; magnetostatics ; tree ; cotree ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Edge-based finite elements have important applications in modelling both quasi-static and high-frequency electromagnetic problems. Recent work has demonstrated that formulations that exploit the graph structure of the edge-based finite element mesh may be extended to higher-order elements. This paper presents the details of how such an extension to a first-order complete finite element is accomplished and illustrates its application in two-dimensional magnetostatics. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 10 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    Minimum time-step size for diffusion problem in FEM analysis (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 3865-3880 
    Details
    ISSN: 0029-5981
    Keywords: heat conduction equation ; finite element solution ; minimum time-step size ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper oscillation of results arising from the use of a time-step size which is less than the minimum required is examined. The phenomenon is summarised to give two requirements that the solution of boundary problems has to satisfy. An approach to derive the minimum time-step size for various kinds of elements is developed. A theoretical verification is presented for the one-dimensional two-noded element case and a numerical examination of the criteria explored for the two-dimensional eight-noded element case. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 10 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    NUMERICAL STUDY OF EFFECTS OF PULSATILE AMPLITUDE ON UNSTEADY LAMINAR FLOWS IN RIGID PIPE WITH RING-TYPE CONSTRICTIONS (1997)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 24 (1997), S. 275-290 
    Details
    ISSN: 0271-2091
    Keywords: pulsatile flow ; ring-type constrictions ; numerical experimentation ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The effects of pulsatile amplitude on sinusoidal laminar flows through a rigid pipe with sharp-edged ring-type constrictions have been studied numerically. The parameters considered are: mean Reynolds number (Re) of the order of 100; Strouhal number (St) in the range 0·0-3·98; Womersley number (Nw) in the range 0·0-50·0. The pulsatile amplitude (A) varies in the range 0·0-2·0. The flow characteristics were studied through the pulsatile contours of streamline, vorticity, shear stress and isobars. Within a pulsatile cycle the relations between instantaneous flow rate (Q) and instantaneous pressure gradient (dp/dz) are observed to be elliptic. The relations between instantaneous flow rate (Q) and pressure loss (Ploss) are quadratic. Linear relations exist between instantaneous flow rate (Q) and maximum velocity, maximum vorticity and maximum shear stress. © by 1997 John Wiley & Sons, Ltd.
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  • 8
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    Requirement of the DEAD-Box protein ded1p for messenger RNA translation (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-07
    Description: The DED1 gene, which encodes a putative RNA helicase, has been implicated in nuclear pre-messenger RNA splicing in the yeast Saccharomyces cerevisiae. It is shown here by genetic and biochemical analysis that translation, rather than splicing, is severely impaired in two newly isolated ded1 conditional mutants. Preliminary evidence suggests that the protein Ded1p may be required for the initiation step of translation, as is the distinct DEAD-box protein, eukaryotic initiation factor 4A (eIF4A). The DED1 gene could be functionally replaced by a mouse homolog, PL10, which suggests that the function of Ded1p in translation is evolutionarily conserved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chuang, R Y -- Weaver, P L -- Liu, Z -- Chang, T H -- GM48752/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Mar 7;275(5305):1468-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular, Cellular, and Developmental Biology Program, Ohio State University, Columbus, OH 43210, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9045610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytoplasm/metabolism ; DEAD-box RNA Helicases ; Eukaryotic Initiation Factor-4A ; Genes, Fungal ; Mice ; Mutation ; Peptide Initiation Factors/genetics/metabolism ; Phenotype ; *Protein Biosynthesis ; RNA Helicases ; RNA Nucleotidyltransferases/genetics/*metabolism ; RNA Splicing ; RNA, Fungal/*genetics ; RNA, Messenger/*genetics ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/enzymology/*genetics ; *Saccharomyces cerevisiae Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: On the basis of x-ray diffraction data to a resolution of 2.9 angstroms, atomic models of most protein components of the bovine cytochrome bc1 complex were built, including core 1, core 2, cytochrome b, subunit 6, subunit 7, a carboxyl-terminal fragment of cytochrome c1, and an amino-terminal fragment of the iron-sulfur protein. The positions of the four iron centers within the bc1 complex and the binding sites of the two specific respiratory inhibitors antimycin A and myxothiazol were identified. The membrane-spanning region of each bc1 complex monomer consists of 13 transmembrane helices, eight of which belong to cytochrome b. Closely interacting monomers are arranged as symmetric dimers and form cavities through which the inhibitor binding pockets can be accessed. The proteins core 1 and core 2 are structurally similar to each other and consist of two domains of roughly equal size and identical folding topology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xia, D -- Yu, C A -- Kim, H -- Xia, J Z -- Kachurin, A M -- Zhang, L -- Yu, L -- Deisenhofer, J -- GM 30721/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):60-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimycin A/metabolism/pharmacology ; Binding Sites ; Cattle ; Crystallography, X-Ray ; Cytochrome b Group/chemistry ; Cytochromes c1/chemistry ; Dimerization ; Electron Transport Complex III/*chemistry/metabolism ; Intracellular Membranes/enzymology ; Iron/metabolism ; Methacrylates ; Mitochondria, Heart/*enzymology ; Models, Molecular ; Molecular Sequence Data ; Oxidation-Reduction ; *Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thiazoles/metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-30
    Description: Despite myriads of biological activities ascribed to uteroglobin (UG), a steroid-inducible secreted protein, its physiological functions are unknown. Mice in which the uteroglobin gene was disrupted had severe renal disease that was associated with massive glomerular deposition of predominantly multimeric fibronectin (Fn). The molecular mechanism that normally prevents Fn deposition appears to involve high-affinity binding of UG with Fn to form Fn-UG heteromers that counteract Fn self-aggregation, which is required for abnormal tissue deposition. Thus, UG is essential for maintaining normal renal function in mice, which raises the possibility that an analogous pathogenic mechanism may underlie genetic Fn-deposit human glomerular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Z -- Kundu, G C -- Yuan, C J -- Ward, J M -- Lee, E J -- DeMayo, F -- Westphal, H -- Mukherjee, A B -- HL47620/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 May 30;276(5317):1408-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development (NICHD), National Insitutes of Health (NIH), Bethesda, MD 20892-1830, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9162006" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Crosses, Genetic ; Fibronectins/*metabolism ; Gene Targeting ; Humans ; Kidney Diseases/embryology/genetics/pathology ; *Kidney Glomerulus/embryology/metabolism/ultrastructure ; Mice ; Mice, Inbred C57BL ; Uteroglobin/deficiency/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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