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  • Animals  (12)
  • Male  (4)
  • LUNAR AND PLANETARY EXPLORATION
  • 2010-2014
  • 1995-1999  (13)
  • 1997  (13)
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  • 2010-2014
  • 1995-1999  (13)
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  • 1
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    Multiple and ancient origins of the domestic dog (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-06-13
    Beschreibung: Mitochondrial DNA control region sequences were analyzed from 162 wolves at 27 localities worldwide and from 140 domestic dogs representing 67 breeds. Sequences from both dogs and wolves showed considerable diversity and supported the hypothesis that wolves were the ancestors of dogs. Most dog sequences belonged to a divergent monophyletic clade sharing no sequences with wolves. The sequence divergence within this clade suggested that dogs originated more than 100,000 years before the present. Associations of dog haplotypes with other wolf lineages indicated episodes of admixture between wolves and dogs. Repeated genetic exchange between dog and wolf populations may have been an important source of variation for artificial selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vila, C -- Savolainen, P -- Maldonado, J E -- Amorim, I R -- Rice, J E -- Honeycutt, R L -- Crandall, K A -- Lundeberg, J -- Wayne, R K -- New York, N.Y. -- Science. 1997 Jun 13;276(5319):1687-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Los Angeles, CA 90095-1606, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9180076" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; *Biological Evolution ; Breeding ; Carnivora/*genetics ; Crosses, Genetic ; DNA, Mitochondrial/*genetics ; Dogs/classification/*genetics ; Female ; Haplotypes ; Male ; Molecular Sequence Data ; Phylogeny ; Sequence Homology, Nucleic Acid
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    STATs and gene regulation (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-09-12
    Beschreibung: STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase). Mouse genetics experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Darnell, J E Jr -- AI32489/AI/NIAID NIH HHS/ -- AI34420/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1630-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9287210" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; DNA/*metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Dimerization ; *Gene Expression Regulation ; Humans ; Nuclear Proteins/metabolism ; Phosphorylation ; Phosphotyrosine/metabolism ; *Signal Transduction ; Trans-Activators/chemistry/genetics/*metabolism ; *Transcriptional Activation ; src Homology Domains
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-06-20
    Beschreibung: Transport of macromolecules into and out of nuclei, essential steps in gene expression, are potential points of control. The matrix protein (M protein) of vesicular stomatitis virus (VSV) was shown to block transport of RNAs and proteins between the nucleus and cytoplasm of Xenopus laevis oocytes. The pattern of inhibition indicated that M protein interfered with transport that is dependent on the ras-like nuclear guanosine triphosphatase (GTPase) Ran-TC4 and its associated factors. This inhibition of nuclear transport by M protein explains several observations about the effects of VSV infection on host cell gene expression and suggests that RNA export is closely coupled to protein import.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Her, L S -- Lund, E -- Dahlberg, J E -- GM30220/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1845-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188527" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Transport, Active ; Cell Nucleus/*metabolism ; Cytoplasm/metabolism ; GTP Phosphohydrolases/*metabolism ; Nuclear Envelope/metabolism ; Nuclear Proteins/*metabolism ; Oocytes ; Proteins/*metabolism ; RNA/*metabolism ; RNA Caps ; RNA Precursors/metabolism ; RNA, Messenger/metabolism ; RNA, Ribosomal/metabolism ; RNA, Small Nuclear/metabolism ; RNA, Transfer, Amino Acid-Specific/metabolism ; *Vesicular stomatitis Indiana virus ; Viral Matrix Proteins/*physiology ; Wheat Germ Agglutinins/pharmacology ; Xenopus laevis ; alpha Karyopherins ; ran GTP-Binding Protein
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Separate neural bases of two fundamental memory processes in the human medial temporal lobe (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-04-11
    Beschreibung: The participation of medial temporal-lobe structures in memory performance was examined by functional magnetic resonance imaging of local blood oxygenation level-dependent signals. Signals were measured during encoding into memory complex scenes or line drawings and during retrieval from memory of previously studied line drawings or words. Encoding tasks yielded increased signals for unfamiliar information in a posterior medial-temporal region that were focused in the parahippocampal cortex. Retrieval tasks yielded increased signals for successfully remembered information in an anterior medial-temporal region that were focused in the subiculum. These results indicate that separate components of the human medial temporal-lobe memory system are active during distinct memory processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gabrieli, J D -- Brewer, J B -- Desmond, J E -- Glover, G H -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):264-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology and Neuroscience Program, Stanford University, Stanford, CA 94305, USA. gabrieli@psych.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9092477" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain Mapping ; Female ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory/*physiology ; Mental Recall/*physiology ; Temporal Lobe/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-11-21
    Beschreibung: The gene responsible for autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive hearing loss in a large Costa Rican kindred was previously localized to chromosome 5q31 and named DFNA1. Deafness in the family is associated with a protein-truncating mutation in a human homolog of the Drosophila gene diaphanous. The truncation is caused by a single nucleotide substitution in a splice donor, leading to a four-base pair insertion in messenger RNA and a frameshift. The diaphanous protein is a profilin ligand and target of Rho that regulates polymerization of actin, the major component of the cytoskeleton of hair cells of the inner ear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lynch, E D -- Lee, M K -- Morrow, J E -- Welcsh, P L -- Leon, P E -- King, M C -- R01-DC01076/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1315-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Washington, Seattle, WA 98195, USA. eric@lynch.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9360932" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/*metabolism ; *Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; Animals ; Base Sequence ; Carrier Proteins/chemistry/*genetics/physiology ; Chromosome Mapping ; Chromosomes, Human, Pair 5 ; Cochlea/metabolism ; *Contractile Proteins ; Deafness/*genetics/metabolism/pathology ; Drosophila/genetics ; *Drosophila Proteins ; Female ; Frameshift Mutation ; GTP-Binding Proteins/metabolism ; Gene Expression ; Hair Cells, Auditory/*metabolism/ultrastructure ; Humans ; Male ; Microfilament Proteins/metabolism ; Molecular Sequence Data ; Pedigree ; Profilins ; RNA Splicing ; RNA, Messenger/genetics/metabolism ; X Chromosome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Thermoregulation in the mouths of feeding gray whales (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-11-14
    Beschreibung: Vascular structures for heat conservation in the tongue of the gray whale (Eschrichtius robustus) are reported here. Numerous individual countercurrent heat exchangers are found throughout the massive tongue. These converge at the base of the tongue to form a bilateral pair of retia. Temperature measurements from the oral cavity of a live gray whale indicate that more heat may be lost through the blubber layer over the body than through the tongue, despite the fact that the tongue is far more vascularized and has much less insulation. These heat exchangers substantially reduce heat loss when these whales feed in cold waters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heyning, J E -- Mead, J G -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1138-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Vertebrates, Natural History Museum of Los Angeles County, 900 Exposition Boulevard, Los Angeles, CA 90007, USA. heyning@bcf.usc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9353198" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipose Tissue/physiology ; Animals ; Body Temperature ; Body Temperature Regulation/*physiology ; Regional Blood Flow ; Temperature ; Tongue/*blood supply/*physiology ; Whales/anatomy & histology/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-05-30
    Beschreibung: STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine. STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation. Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfeffer, L M -- Mullersman, J E -- Pfeffer, S R -- Murti, A -- Shi, W -- Yang, C H -- New York, N.Y. -- Science. 1997 May 30;276(5317):1418-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9162009" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acute-Phase Proteins/*genetics ; Amino Acid Sequence ; Androstadienes/pharmacology ; Animals ; Binding Sites ; COS Cells ; Cell Line ; Cloning, Molecular ; Conserved Sequence ; DNA-Binding Proteins/genetics/*metabolism ; Enzyme Inhibitors/pharmacology ; Membrane Proteins ; Molecular Sequence Data ; Phosphatidylinositol 3-Kinases ; Phosphorylation ; Phosphotransferases (Alcohol Group Acceptor)/antagonists & ; inhibitors/genetics/*metabolism ; Point Mutation ; Protein Binding ; Receptor, Interferon alpha-beta ; Receptors, Interferon/*metabolism ; Recombinant Fusion Proteins/genetics/metabolism ; STAT3 Transcription Factor ; Signal Transduction ; Trans-Activators/genetics/*metabolism ; Tyrosine/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Left-right asymmetry (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-02-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robertson, E J -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1280.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064786" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Activin Receptors ; Animals ; Body Patterning/*genetics ; Chick Embryo ; Embryonic Induction ; *Gene Expression Regulation, Developmental ; Heart/*embryology ; Hedgehog Proteins ; Mesoderm/metabolism ; Nodal Protein ; Proteins/genetics/physiology ; Receptors, Growth Factor/genetics/physiology ; *Trans-Activators ; *Transforming Growth Factor beta ; Zinc Fingers/*genetics/physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    A macrophage invasion mechanism of pathogenic mycobacteria (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-08-22
    Beschreibung: Tuberculosis is the leading cause of death due to an infectious organism, killing an estimated 3 million people annually. Mycobacterium tuberculosis, the causative agent of tuberculosis, and other pathogenic mycobacteria require entry into host macrophages to initiate infection. An invasion mechanism was defined that was shared among pathogenic mycobacteria including M. tuberculosis, M. leprae, and M. avium but not by nonpathogenic mycobacteria or nonmycobacterial intramacrophage pathogens. This pathway required the association of the complement cleavage product C2a with mycobacteria resulting in the formation of a C3 convertase. The mycobacteria-associated C2a cleaved C3, resulting in C3b opsonization of the mycobacteria and recognition by macrophages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schorey, J S -- Carroll, M C -- Brown, E J -- AI33348/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1997 Aug 22;277(5329):1091-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9262476" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Complement C2/*physiology ; Complement C2a ; Complement C3/metabolism ; Complement C3-C5 Convertases/metabolism ; Complement C3b/immunology ; Horses ; Humans ; In Vitro Techniques ; Isoflurophate/pharmacology ; Macrophages/immunology/*microbiology ; Mice ; Molecular Sequence Data ; Mycobacterium/*pathogenicity ; Mycobacterium avium Complex/immunology/*pathogenicity ; Mycobacterium bovis/immunology/pathogenicity ; Mycobacterium leprae/immunology/pathogenicity ; Mycobacterium tuberculosis/immunology/pathogenicity ; Opsonin Proteins ; Virulence
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-05-30
    Beschreibung: Despite myriads of biological activities ascribed to uteroglobin (UG), a steroid-inducible secreted protein, its physiological functions are unknown. Mice in which the uteroglobin gene was disrupted had severe renal disease that was associated with massive glomerular deposition of predominantly multimeric fibronectin (Fn). The molecular mechanism that normally prevents Fn deposition appears to involve high-affinity binding of UG with Fn to form Fn-UG heteromers that counteract Fn self-aggregation, which is required for abnormal tissue deposition. Thus, UG is essential for maintaining normal renal function in mice, which raises the possibility that an analogous pathogenic mechanism may underlie genetic Fn-deposit human glomerular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Z -- Kundu, G C -- Yuan, C J -- Ward, J M -- Lee, E J -- DeMayo, F -- Westphal, H -- Mukherjee, A B -- HL47620/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 May 30;276(5317):1408-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development (NICHD), National Insitutes of Health (NIH), Bethesda, MD 20892-1830, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9162006" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Crosses, Genetic ; Fibronectins/*metabolism ; Gene Targeting ; Humans ; Kidney Diseases/embryology/genetics/pathology ; *Kidney Glomerulus/embryology/metabolism/ultrastructure ; Mice ; Mice, Inbred C57BL ; Uteroglobin/deficiency/genetics/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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