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  • Articles  (11)
  • Rat
  • Wheat
  • healthy volunteers
  • Springer  (11)
  • American Chemical Society
  • Annual Reviews
  • Cambridge University Press
  • Elsevier
  • 1980-1984  (11)
  • 1970-1974
  • 1982  (11)
Collection
  • Articles  (11)
Publisher
  • Springer  (11)
  • American Chemical Society
  • Annual Reviews
  • Cambridge University Press
  • Elsevier
Years
  • 1980-1984  (11)
  • 1970-1974
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 21 (1982), S. 433-441 
    ISSN: 1432-1041
    Keywords: antipyrine ; antipyrine metabolites ; drug metabolism ; route of administration ; healthy volunteers ; urinary excretion ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of antipyrine in plasma and saliva, and urinary excretion of its major metabolites, were studied following i.v. and oral administration of antipyrine 500 mg to 6 healthy volunteers. Data from both plasma and saliva showed that the oral bioavailability of antipyrine given as an aqueous solution was complete. The saliva/plasma concentration ratio was constant with time from about 3 h onwards, with a mean value of 0.87 after oral and 0.91 after i.v. administration. It is concluded that the pharmacokinetic parameters of antipyrine can be satisfactorily established on the basis of salivary data, although the volume of distribution and clearance values are then slightly too high. After i.v. administration, 3.8±1.9% of the dose was excreted in urine as unchanged antipyrine in 48h, 24.9±6.3% as 4-hydroxyantipyrine, 16.5±3.2% as norantipyrine, 13.0±2.2% as 3-hydroxymethyl-antipyrine and 5.8±1.0% as 3-carboxy-antipyrine. No significant differences were observed following oral administration. The half-lives calculated from the linear part of the urinary excretion rate curves of the metabolites were about the same for oral and i.v. administration, and were of the same order of magnitude as the elimination half-life of parent drug in plasma and saliva. It is important for determination of the ultimate metabolite ratio that urine is collected for at least 36h, because there is a delay in the excretion of 3-hydroxymethyl-antipyrine in urine.
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  • 2
    ISSN: 1573-5036
    Keywords: Gaeumannomyces graminis ; Hydroponics ; Ion uptake ; Radionuclides ; Root pathogens ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Triple-labelled nutrient solution was used to compare the effects of seven root-infecting fungi on uptake of K, Ca and P by wheat. Plants grown in sand or hydroponic culture were transferred to solutions that contained42K,45Ca and32P for 24 h, then dried, ashed and digested in 6M HCl. To distinguish radiation emitted by42K,45Ca and32P plant digests were counted on two channels of a liquid scintillation counter immediately and 7 days later, after the decay of42K radiation. Plants infected byGaeumannomyces graminis took up and translocated less K, Ca and P to their shoots than uninfected plants. Other root-infecting fungi had little effect on uptake of these ions.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 34 (1982), S. 376-381 
    ISSN: 1432-0827
    Keywords: Matrix vesicles ; Bone ; Actin ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Preliminary indications of the occurrence of actin and myosin in crude matrix vesicle preparations have been reported previously. In the present study extracellular matrix vesicles from rat alveolar bone were isolated. They were further purified by a sucrose density gradient. SDS-polyacrylamide gel electrophoresis of the purified vesicles revealed the presence of a polypeptide with a molecular weight of 43 K daltons and with electrophoretic mobility identical to that of blood platelet actin. The limited proteolysis of both 43 K dalton vesicular polypeptide and actin byStaphylococcus aureus-V8-protease revealed three fragments with identical electrophoretic mobility. In addition, the vesicular preparations inhibited the activity of DNase I, a property typical of actin monomers. Filamentous material extracted from matrix vesicles showed ultrastructural features of F-actin. Reaction of this material with heavy meromyosin resulted in arrowhead formation, which is characteristic of acto-heavy meromyosin. The occurrence of actin in extracellular matrix vesicles may account for their budding from the osteoblastic plasma membrane, their possible motility in the matrix, and maintenance of the spherical shape.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 21 (1982), S. 517-520 
    ISSN: 1432-1041
    Keywords: mianserin ; blood ; plasma ; oral kinetic parameters ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 µg/l at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3–2.8), (t1/2)α 2.5 h (0.9–4.7), (t1/2)β 21 h (14–33), (Vd)β 27.5 l/kg (16.8–46.5) and Cloral 0.98 l/kg/h (0.47–1.75). Blood/plasma concentration ratios ranged from 0.50–0.74.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 23 (1982), S. 249-252 
    ISSN: 1432-1041
    Keywords: mecillinam ; bacmecillinam ; pivmecillinam ; pharmacokinetics ; pro-drug ; healthy volunteers ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of bacmecillinam and pivmecillinam were studied in healthy fasting volunteers given tablets in a cross-over, randomized order. The mean (±SD) peak levels of plasma mecillinam were 1.43±0.34, 2.73±0.43, and 4.62±1.41 mg/l after bacmecillinam 100, 200, and 400 mg and 2.38±0.65 mg/l after pivmecillinam 400 mg. The corresponding areas under plasma Vs time curves (AUC) were 2.21±0.19, 3.99±0.63, and 7.74±1.38 mg·h·l−1 for bacmecillinam and 5.35±0.93 mg·h·l−1 for pivmecillinam. The elimination half-lives were 0.8–1.1h for bacmecillinam and 0.7h for pivmecillinam. The 12 h urinary recovery of unchanged mecillinam after the 400 mg doses was 41% for bacmecillinam and 30% for pivmecillinam. The 400 mg dose of bacmecillinam gave a significantly higher plasma peak (p〈0.001), AUC (p〈0.001) and urinary recovery (p〈0.001) than did pivmecillinam 400 mg. The plasma peaks appeared earlier and the rate of absorption was higher after bacmecillinam than after pivmecillinam (p〈0.05). In conclusion, bacmecillinam had a better bioavailability than pivmecillinam in the tablet formulations studied. The AUC increased linearly with increasing doses of bacmecillinam.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 63 (1982), S. 227-233 
    ISSN: 1432-2242
    Keywords: C-banding ; Wheat ; Rye ; Triticale
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Using different stains, wheat chromosomes could be distinguished from rye chromosomes by preferential staining. C-bands of rye chromosomes were preferentially stained with Giemsa while those of wheat chromosomes were preferentially stained with either Leishman or Wright stain. Preferential staining aids the identification of wheat and rye chromosomes and chromosome segments and in particular the recognition of wheat/rye chromosome substitutions and translocations.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 62 (1982), S. 121-126 
    ISSN: 1432-2242
    Keywords: Wheat ; Quality ; Dwarfism ; Gibberellin ; α-amylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The effects of the Tom Thumb dwarfing gene, Rht3, on the quality and quantity of grain α-amylase produced during germination and by induction with exogenous gibberellic acid are described. In a season conducive to high sprouting damage the gene reduced α-amylase levels in the field by 77%. Selection among random Rht3 genotypes showed that other genetic factors can be combined with the dwarfing gene to further increase sprouting damage resistance.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 65 (1982), S. 433-436 
    ISSN: 1573-5036
    Keywords: Copper-nutrition ; Nitrogen ; Phosphorus ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary In a pot culture study, copper addition to soil increased the crop yield only in presence of nitrogen. The latter increased the utilization of both native as well as applied copper but more that of applied. It also minimised the adverse effect of applied phosphorus on copper utilization. Phosphorus at the rate 45 ppm had the tendency of decreasing copper uptake by wheat if applied without nitrogen or with its low level.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 66 (1982), S. 233-241 
    ISSN: 1573-5036
    Keywords: Barley ; Chloride ; Phosphorus ; Salinity ; Sulphate ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The study was conducted in a greenhouse and under field conditions. In the greenoouse, barley was grown to maturity in pots on a sandy soil which contained 80 and 120 meq/l of chloride and sulphate dominant salts in its saturation extract, to which 0, 10, 25 and 50 ppm P were added. In the field study, wheat was grown on loamy sand soils having 0, 25, 50 and 75 kg/ha added P levels and irrigated with either Cl- or SO4-dominant saline waters (EC=15−19 mmhos/cm). The results of the greenhouse study indicated that at maturity barley straw and grain yield was significantly increased by 50 ppm of added P both on the non-saline control and the Cl-treatments. However, 25 ppm P was optimal on the SO4-treatments. The Cl content of plants was significantly decreased and S was increased with the increase in the P content of soil. A synergistic relation between the S and P content of barley shoots was observed. In the field study wheat grain yield responded significantly to P applications upto 50 kg/ha level on the Cl-site and there was no response to applied P on the SO4-site, although the former contained more Olsen's P than the latter. The results suggested that P requirement of wheat and barley was greater on Cl- than on SO4-salinity.
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  • 10
    ISSN: 1432-0878
    Keywords: Pudendal nerve ; Sensory neurones ; Spinal ganglion ; Transganglionic labelling (HRP) ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The morphology and distribution of the sensory neurones of the pudendal nerve within the spinal ganglia of rats were investigated by use of horseradish peroxidase (HRP). The labelling was visualized in diaminobenzidine (DAB) or tetramethyl-benzidine (TMB)-stained sections. Injection of HRP directly into the pudendal nerve labelled perikarya predominantly in the sixth lumbar DRG (L6). Following injection of HRP into the scrotal skin, however, additional cells were labelled in L5 and SI. Labelling was invariably unilateral. Approximately equal numbers of small (〈30 μm) and large neurones (〉40 μm) were labelled following subcutaneous injections although injections into the nerve marked twice as many small cells as large cells. This suggests that, in the rat, most of the small-diameter fibres within the pudendal nerve ascend through L6. Although a cluster of neurones was observed in one experiment, the remaining 25 experiments did not reveal any somatotopic arrangement since the labelled perikarya were distributed evenly throughout the ganglion. Similar numbers of retrogradely labelled neurones (somatopetal transport of the tracer) were observed in both DAB- and TMB-stained sections, although TMB allowed the demonstration of anterograde (somatofugal) HRP transport by terminal labelling in the superficial laminae of the lumbar spinal cord, extending into laminae II–IV.
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