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  • Springer  (4,504)
  • Elsevier  (1,494)
  • Blackwell Publishing Ltd  (415)
  • American Association for the Advancement of Science  (228)
  • Annual Reviews  (126)
  • Springer Science + Business Media
  • 1980-1984  (6,767)
  • 1981  (6,767)
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Keywords
Publisher
Years
  • 1980-1984  (6,767)
Year
  • 11
    Electronic Resource
    Electronic Resource
    Induction and development of mouse liver glutathione S-transferase activity (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 445-446 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mouse liver glutathione S-transferase activity at birth was 1/10 that of adults, and increased steadily with each successive week of age until adult values were reached at 8 weeks. Activity was inducible with phenobarbital; however, the percentage increase in activity was dependent upon substrate. 2 distinct peaks of transferase activity were obtained on CM-cellulose chromatography. The ratios of transferase activity observed for each peak demonstrated that glutathione S-transferase activity in mouse liver is associated with at least 2 distinct proteins with differing substrate specificities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986122
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  • 12
    Electronic Resource
    Electronic Resource
    RNA synthesis as a measure of microbial growth in aquatic environments. I. Evaluation, verification and optimization of methods (1981)
    Springer
    Marine biology 64 (1981), S. 1-12 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Measurement of rates of microbial (bacteria and unicellular algae) ribonucleic acid (RNA) synthesis in environmental samples by radioactive tracers requires several assumptions that we test and evaluate herein. After addition of 3H-adenine to water samples from eutrophic freshwater or pelagic and oceanic ecosystems, microorganisms assimilate it without (1) any luxury uptake or (2) any expansion of intracellular adenine nucleotide pools. The calculated rate of stable RNA synthesis tends to be overestimated during the initial time periods of labeling (i.e., less than 30 s for cultures of Serratia marinorubra, and less than 20 min for most environmental samples) due to kinetic compartmentalization of the nucleic acid precursor (ATP) pool. Time-series analyses are recommended because the effects of compartmentalization decrease with increasing incubation. The kinetics of 3H-adenine uptake and aspects of its subsequent assimilation, intermediary metabolism and breakdown are described in bacteria and natural assemblages of microorganisms. Mass-balance radioactivity inventories greatly facilitate interpretation of nucleic acid precursor assimilation. Finally, we demonstrate that independent measurements of precursor (ATP) specific radioactivity are required for any elucidation of rates of stable RNA synthesis (and thus microbial growth) in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394075
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  • 13
    Electronic Resource
    Electronic Resource
    Background hydrocarbon residues in fishes from the Great Lakes and eastern Montana (1981)
    Springer
    Bulletin of environmental contamination and toxicology 26 (1981), S. 724-728 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622162
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  • 14
    Electronic Resource
    Electronic Resource
    Protracted benzene exposure causes a proliferation of myeloblasts and/or promyelocytes in CD-1 mice (1981)
    Springer
    Bulletin of environmental contamination and toxicology 27 (1981), S. 17-22 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01610980
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  • 15
    Electronic Resource
    Electronic Resource
    First manned submersible dives on the East Pacific Rise at 21°N (project RITA): General results (1981)
    Springer
    Marine geophysical researches 4 (1981), S. 345-379 
    Details
    ISSN: 1573-0581
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A submersible study has been conducted in February–March 1978 at the axis of the East Pacific Rise near 21°N. The expedition CYAMEX, the first submersible program to be conducted on the East Pacific Rise, is part of the French-American-Mexican project RITA (Rivera-Tamayo), a 3-year study devoted to detailed geological and geophysical investigations of the East Pacific Rise Crest. On the basis of the 15 dives made by CYANA in the axial area of the Rise, a morphological and tectonic zonation can be established for this moderately-fast spreading center. A narrow, 0.6 to 1.2 km wide zone of extrusion (zone 1), dominated by young lava flows, is flanked by a highly fissured and faulted zone of extension (zone 2) with a width of 1 to 2 km. Further out, zone 3 is dominated by outward tilted blocks bounded by inward-facing fault scarps. Active or recent faults extend up to 12 km from the axis of extrusion of the East Pacific Rise. This represents the first determination from direct field evidence of the width of active tectonism associated with an accreting plate boundary. Massive sulfide deposits, made principally of zinc, copper and iron, were found close to the axis of the Rise. Other signs of the intense hydrothermal activity included the discovery of benthic fauna of gian size similar to that found at the axis of the Galapagos Rift. We emphasize the cyclic character of the volcanicity. The main characteristics of the geology of this segment of the East Pacific Rise can be explained by the thermal structure at depth below this moderately-fast spreading center. The geological observations are compatible with the existence of a shallow magma reservoir centered at the axis of the Rise with a half-width of the order of 10 km.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286034
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  • 16
    Electronic Resource
    Electronic Resource
    Clinical pharmacokinetics of chlordiazepoxide in patients with alcoholic hepatitis (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 279-285 
    Details
    ISSN: 1432-1041
    Keywords: chlordiazepoxide ; alcoholic liver disease ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The clearance of chlordiazepoxide from the systemic circulation was studied in 20 subjects which included 15 patients with alcoholic hepatitis and 5 normal volunteers. The half-life for the appearance of the drug in the systemic circulation was found to increase exponentially with age (r=0.73, P〈0.0005) and was independent of the presence of alcoholic hepatitis. The metabolic clearance of chlordiazepoxide was significantly lower in the patients than in the normal subjects (7.6 compared to 13.8 ml/kg-h, P〈0.005). Linear regression analysis revealed a significant correlation between clearance and albumin (r=0.77, P〈0.00005). However, the predictive value of this relationship was shown to be minimal. Multiple regression analysis produced only a slight improvement in the correlation when both albumin and lactate dehydrogenase were used as variables (r=0.83, P〈0.00005). In six of the patients, a second clearance study was conducted three weeks following their initial one. All repeat subjects showed improvement both clinically and as reflected by their laboratory tests for liver injury, but there was not a significant change in their clearance of chlordiazepoxide. Multiple regression analysis of the clearance data on the initial and repeat subjects showed a significant correlation between clearance and the variables age, albumin, and lactate dehydrogenase (r=0.91, P〈0.0025). This relationship suggests that over a short period of time (where age can be considered constant) changes in albumin and lactate dehydrogenase could be potentially useful in predicting clearance changes in a single individual.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562805
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  • 17
    Electronic Resource
    Electronic Resource
    Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha1lipoprotein level after aminophylline in man (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 349-351 
    Details
    ISSN: 1432-1041
    Keywords: aminophylline ; plasma free fatty acids ; plasma post-heparin lipases ; alpha1-lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Intravenous aminophylline 0.48 g produced a sharp increase in plasma free fatty acids. After three days of treatment with aminophylline 0.96 g/day i. v., plasma post-heparin lipoprotein lipase was significantly reduced, and post-heparin hepatic triglyceridase remained unchanged. Alpha1lipoprotein was reduced by treatment, in parallel with lipoprotein lipase, while other lipoprotein fractions, serum cholesterol and triglycerides were unaffected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544585
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  • 18
    Electronic Resource
    Electronic Resource
    RNA synthesis as a measure of microbial growth in aquatic environments. II. Field applications (1981)
    Springer
    Marine biology 64 (1981), S. 13-21 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Rates of stable ribonucleic acid (RNA) synthesis have been calculated from time-series measurements of the uptake of 3H-adenine and labeling of the intracellular adenosine triphosphate (ATP) and stable RNA pools for microbial communities from a variety of freshwater and marine ecosystems. Total rates of microbial RNA synthesis ranged from 6.6 pmol to 3.8x105 pmol of adenine incorporated into RNA l−1 h−1. Most of the variation was attributable to differences in microbial biomass; if total rate data are normalized to living microbial carbon (based on ATP measurements), the variation in specific rates of RNA synthesis is decreased by a factor of 100 to 1 000 for microbial communities from diverse environments. Light/dark experiments indicated that the uptake and incorporation of 3H-adenine are uncoupled from photophosphorylation. The measurement of rates of stable RNA synthesis of microbial assemblages in nature can yield useful information concerning in situ growth rates and the response of communities to changes in environmental conditions such as nutrient additions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394076
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  • 19
    Electronic Resource
    Electronic Resource
    Ultrastructure of the sperms ofPlumbago zeylanica (1981)
    Springer
    Protoplasma 107 (1981), S. 85-107 
    Details
    ISSN: 1615-6102
    Keywords: Male cytoplasmic inheritance ; Plumbago ; Pollen grain ; Pollen tube ; Sperm ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Male gametes ofPlumbago zeylanica were examined in pollen grains and tubes using light and electron microscopy of chemically and physically fixed tissues, and Nomarski interference microscopy of isolated, living sperm cells. Male gametes are elongate, spindleshaped cells containing a nucleus, mitochondria, ER, ribosomes, vesicles, dictyosomes, probable microfilaments, and a variable number of plastids. In mature pollen grains ofP. zeylanica, the two sperm cells are directly linked; they share a transverse cell wall with plasmodesmata and are enclosed together by the inner vegetative cell plasma membrane. One of these two sperms is also associated with the vegetative nucleus as a consistent feature of pollen grain organization. The basis of this association appears to be a long, narrow projection of the sperm cell (averaging 〈 1 μm wide and about 30 μm long) which wraps around the periphery of the vegetative nucleus and occupies embayments of that nucleus. This association is maintained throughout pollen tube growth but becomes less extensive near the completion of tube growth and is severed following tube discharge. The consistent occurrence of the sperm-vegetative nucleus association in pollen grains, tubes and isolated pollen cytoplasm suggests that the two structures may be directly connected, but attempts to visualize this type of connection were unsuccessful. Possibly, the entwining nature and extent of complementary interfaces between vegetative nucleus and sperm may have a role in stabilizing their association. Functionally, the two sperms and vegetative nucleus appear to travel as a linked unit within the pollen tube, possibly increasing the effectiveness of gamete delivery and helping to ensure nearly simultaneous transmission of sperms into the receptive megagametophyte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275610
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  • 20
    Electronic Resource
    Electronic Resource
    The use of the restriction endonucleaseDdeI for mapping related DNAs (1981)
    Springer
    Bioscience reports 1 (1981), S. 223-228 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Restriction endonuclease mapping of BK virus strain GS using DdeI has allowed us to correct and extend the previously published map.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01114908
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