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Induction and development of mouse liver glutathione S-transferase activity

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Summary

Mouse liver glutathione S-transferase activity at birth was 1/10 that of adults, and increased steadily with each successive week of age until adult values were reached at 8 weeks. Activity was inducible with phenobarbital; however, the percentage increase in activity was dependent upon substrate. 2 distinct peaks of transferase activity were obtained on CM-cellulose chromatography. The ratios of transferase activity observed for each peak demonstrated that glutathione S-transferase activity in mouse liver is associated with at least 2 distinct proteins with differing substrate specificities.

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Authors and Affiliations

  1. Laboratory of Chemical Pharmacology, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, 20205, Bethesda, Maryland, USA

    D. Dale Shoemaker, D. D. Dietrick & R. L. Cysyk

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  1. D. Dale Shoemaker
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  2. D. D. Dietrick
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  3. R. L. Cysyk
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Acknowledgment. The authors wish to acknowledge the assistance of Mrs Carol Goad in the preparation of this manuscript.

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Dale Shoemaker, D., Dietrick, D.D. & Cysyk, R.L. Induction and development of mouse liver glutathione S-transferase activity. Experientia 37, 445–446 (1981). https://doi.org/10.1007/BF01986122

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