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Induction and development of mouse liver glutathione S-transferase activity (1981)

Dale Shoemaker, D. ; Dietrick, D. D. ; Cysyk, R. L.

Springer

Cellular and molecular life sciences 37 (1981), S. 445-446

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Mouse liver glutathione S-transferase activity at birth was 1/10 that of adults, and increased steadily with each successive week of age until adult values were reached at 8 weeks. Activity was inducible with phenobarbital; however, the percentage increase in activity was dependent upon substrate. 2 distinct peaks of transferase activity were obtained on CM-cellulose chromatography. The ratios of transferase activity observed for each peak demonstrated that glutathione S-transferase activity in mouse liver is associated with at least 2 distinct proteins with differing substrate specificities.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01986122

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