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  • Articles  (20)
  • Bioinformatics  (2)
  • Science Advances  (1)
  • Science  (1)
  • Science. 274(5293): 1692-4.  (1)
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  • Articles  (20)
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  • 1
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    Seismic Evidence for a Detached Indian Lithospheric Mantle Beneath Tibet (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-26
    Description: P-to-S converted teleseismic waves recorded by temporary broadband networks across Tibet show a north-dipping interface that begins 50 kilometers north of the Zangbo suture at the depth of the Moho (80 kilometers) and extends to a depth of 200 kilometers beneath the Bangong suture. Under northern Tibet a segmented south-dipping structure was imaged. These observations suggest a different form of detachment of the Indian and Asian lithospheric mantles caused by differences in their composition and buoyancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kosarev -- Kind -- Sobolev -- Yuan -- Hanka -- Oreshin -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1306-1309.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of the Physics of the Earth, Russian Academy of Sciences, B. Gruzinskaya 10, 128810 Moscow, Russia. GeoForschungsZentrum Potsdam, Telegrafenberg, 14473 Potsdam, Germany. Freie Universitat Berlin, Geophysik, Malteser Strasse 74-100, 12249 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10037597" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Cellular and subcellular structure of neoproterozoic animal embryos (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-14
    Description: Stereoblastic embryos from the Doushantuo Formation of China exhibit occasional asynchronous cell division, with diminishing blastomere volume as cleavage proceeded. Asynchronous cell division is common in modern embryos, implying that sophisticated mechanisms for differential cell division timing and embryonic cell lineage differentiation evolved before 551 million years ago. Subcellular structures akin to organelles, coated yolk granules, or lipid vesicles occur in these embryos. Paired reniform structures within embryo cells may represent fossil evidence of cells about to undergo division. Embryos exhibit no evidence of epithelial organization, even in embryos composed of approximately 1000 cells. Many of these features are compatible with metazoans, but the absence of epithelialization is consistent only with a stem-metazoan affinity for Doushantuo embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hagadorn, James W -- Xiao, Shuhai -- Donoghue, Philip C J -- Bengtson, Stefan -- Gostling, Neil J -- Pawlowska, Maria -- Raff, Elizabeth C -- Raff, Rudolf A -- Turner, F Rudolf -- Chongyu, Yin -- Zhou, Chuanming -- Yuan, Xunlai -- McFeely, Matthew B -- Stampanoni, Marco -- Nealson, Kenneth H -- New York, N.Y. -- Science. 2006 Oct 13;314(5797):291-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology, Amherst College, Amherst, MA 01002, USA. jwhagadorn@amherst.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17038620" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastomeres/cytology ; Cell Division ; Cell Lineage ; Cell Shape ; China ; Embryo, Nonmammalian/*cytology/ultrastructure ; Embryonic Development ; Epithelium/embryology ; *Fossils ; Gastrula/cytology/ultrastructure ; Invertebrates/*embryology ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Organelles/ultrastructure ; Tomography, X-Ray Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Optimizing ecosystem services in China (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitsch, William J -- Lu, Jianjian -- Yuan, Xingzhong -- He, Wenshan -- Zhang, Li -- New York, N.Y. -- Science. 2008 Oct 24;322(5901):528. doi: 10.1126/science.322.5901.528b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18948520" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Animals ; China ; *Ecosystem ; Fishes ; *Rivers ; *Wetlands
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Adaptive evolution of an sRNA that controls Myxococcus development (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-22
    Description: Small RNA (sRNA) molecules regulate a vast array of processes in biology, but evidence for adaptive evolution of sRNA sequences has been indirect. Here, we identify an sRNA, Pxr, that negatively regulates fruiting body development in Myxococcus xanthus. We further show that a spontaneous evolutionary mutation in Pxr abolished its regulatory function and thereby adaptively restored developmental proficiency to a socially defective M. xanthus cheater. In wild-type M. xanthus, development is initiated only upon starvation, but deletion of pxr allows development to proceed even while nutrients remain abundant. Thus, Pxr serves as a major checkpoint controlling the transition from growth to development in the myxobacteria. These findings show that an sRNA molecule governs a complex form of multicellular development in prokaryotes and directly demonstrate the ability of sRNA regulators to facilitate evolutionary adaptations of major phenotypic effect.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027070/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027070/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, Yuen-Tsu N -- Yuan, Xi -- Velicer, Gregory J -- GM079690/GM/NIGMS NIH HHS/ -- R01 GM079690/GM/NIGMS NIH HHS/ -- R01 GM079690-01/GM/NIGMS NIH HHS/ -- R01 GM079690-02/GM/NIGMS NIH HHS/ -- R01 GM079690-03/GM/NIGMS NIH HHS/ -- R01 GM079690-04/GM/NIGMS NIH HHS/ -- R01 GM079690-05/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 May 21;328(5981):993. doi: 10.1126/science.1187200.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Indiana University, Bloomington, IN 47405, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20489016" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; *Evolution, Molecular ; Gene Deletion ; Genes, Bacterial ; Microbial Interactions ; Mutation ; Myxococcus xanthus/*genetics/*growth & development/physiology ; Phenotype ; RNA, Bacterial/chemistry/genetics/*physiology ; RNA, Untranslated/chemistry/genetics/*physiology ; Spores, Bacterial/growth & development
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Comment on "Fossilized nuclei and germination structures identify Ediacaran 'animal embryos' as encysting protists" (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-10
    Description: On the basis of putative nuclei and endospores, Huldtgren et al. (Reports, 23 December 2011, p. 1696) propose that embryo-like Doushantuo microfossils are nonmetazoan holozoans akin to mesomycetozoeans. However, both size and preservation preclude interpretation of internal structures as nuclei. Moreover, the authors may have conflated two different populations; some specimens display a pseudoparenchymatous organization incompatible with a mesomycetozoean comparison.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xiao, Shuhai -- Knoll, Andrew H -- Schiffbauer, James D -- Zhou, Chuanming -- Yuan, Xunlai -- New York, N.Y. -- Science. 2012 Mar 9;335(6073):1169; author reply 1169. doi: 10.1126/science.1218814.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geosciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. xiao@vt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22403373" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/*ultrastructure ; Eukaryota/*growth & development ; *Fossils
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  • 6
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    Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4 (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: Proteinases and the innate immune receptor Toll-like receptor 4 (TLR4) are essential for expression of allergic inflammation and diseases such as asthma. A mechanism that links these inflammatory mediators is essential for explaining the fundamental basis of allergic disease but has been elusive. Here, we demonstrate that TLR4 is activated by airway proteinase activity to initiate both allergic airway disease and antifungal immunity. These outcomes were induced by proteinase cleavage of the clotting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway epithelial cells and macrophages. Thus, allergic airway inflammation represents an antifungal defensive strategy that is driven by fibrinogen cleavage and TLR4 activation. These findings clarify the molecular basis of allergic disease and suggest new therapeutic strategies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898200/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898200/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millien, Valentine Ongeri -- Lu, Wen -- Shaw, Joanne -- Yuan, Xiaoyi -- Mak, Garbo -- Roberts, Luz -- Song, Li-Zhen -- Knight, J Morgan -- Creighton, Chad J -- Luong, Amber -- Kheradmand, Farrah -- Corry, David B -- AI057696/AI/NIAID NIH HHS/ -- AI070973/AI/NIAID NIH HHS/ -- CA125123/CA/NCI NIH HHS/ -- HL75243/HL/NHLBI NIH HHS/ -- K02 HL075243/HL/NHLBI NIH HHS/ -- R01 AI057696/AI/NIAID NIH HHS/ -- R01 HL095382/HL/NHLBI NIH HHS/ -- R01 HL117181/HL/NHLBI NIH HHS/ -- R25GM56929/GM/NIGMS NIH HHS/ -- T32 GM088129/GM/NIGMS NIH HHS/ -- T32GM088129/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):792-6. doi: 10.1126/science.1240342.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aspergillus niger/growth & development/*immunology ; Aspergillus oryzae/enzymology ; Bronchoalveolar Lavage Fluid/cytology ; Epithelial Cells/immunology/metabolism ; Fibrinogen/*metabolism ; Immunity, Innate ; Ligands ; Macrophage Activation ; Macrophages/immunology/metabolism/microbiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Peptide Hydrolases/immunology/*metabolism ; Respiratory Hypersensitivity/*immunology/*metabolism ; Respiratory Mucosa/cytology/immunology/metabolism ; Th2 Cells/immunology ; Toll-Like Receptor 4/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 7
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    Protein kinase C overactivity impairs prefrontal cortical regulation of working memory (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-30
    Description: The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnbaum, S G -- Yuan, P X -- Wang, M -- Vijayraghavan, S -- Bloom, A K -- Davis, D J -- Gobeske, K T -- Sweatt, J D -- Manji, H K -- Arnsten, A F T -- AG06036/AG/NIA NIH HHS/ -- P50 MH068789/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):882-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520-8001, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514161" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic alpha-Agonists/pharmacology ; Alkaloids ; Animals ; Benzophenanthridines ; Carbolines/pharmacology ; Electrophysiology ; Enzyme Activation ; Female ; Imidazoles/pharmacology ; Lithium Carbonate/pharmacology ; Macaca mulatta ; Male ; Memory/drug effects/*physiology ; Neurons/drug effects/physiology ; Phenanthridines/pharmacology ; Prefrontal Cortex/enzymology/*physiology ; Protein Kinase C/antagonists & inhibitors/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha-1/physiology ; Signal Transduction ; Stress, Physiological/physiopathology ; Tetradecanoylphorbol Acetate/pharmacology ; Valproic Acid/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Lichen-like symbiosis 600 million years ago (2005)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2005-05-14
    Description: The fossil record of fungi and lichens is scarce. Here we report the discovery of lichen-like fossils, involving filamentous hyphae closely associated with coccoidal cyanobacteria or algae, preserved in marine phosphorite of the Doushantuo Formation (between 551 and 635 million years old) at Weng'an, South China. These fossils indicate that fungi developed symbiotic partnerships with photoautotrophs before the evolution of vascular plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuan, Xunlai -- Xiao, Shuhai -- Taylor, T N -- New York, N.Y. -- Science. 2005 May 13;308(5724):1017-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nanjing Institute of Geology and Palaeontology, Nanjing 210008, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890881" target="_blank"〉PubMed〈/a〉
    Keywords: China ; Cyanobacteria/*isolation & purification/physiology ; *Fossils ; Fungi/cytology/*isolation & purification/physiology ; Hyphae/cytology ; Lichens/*isolation & purification/physiology ; *Symbiosis
    Print ISSN: 0036-8075
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  • 9
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    Seismic images of crust and upper mantle beneath Tibet: evidence for Eurasian plate subduction (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-09
    Description: Seismic data from central Tibet have been combined to image the subsurface structure and understand the evolution of the collision of India and Eurasia. The 410- and 660-kilometer mantle discontinuities are sharply defined, implying a lack of a subducting slab beneath the plateau. The discontinuities appear slightly deeper beneath northern Tibet, implying that the average temperature of the mantle above the transition zone is about 300 degrees C hotter in the north than in the south. There is a prominent south-dipping converter in the uppermost mantle beneath northern Tibet that might represent the top of the Eurasian mantle lithosphere underthrusting the northern margin of the plateau.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kind, R -- Yuan, X -- Saul, J -- Nelson, D -- Sobolev, S V -- Mechie, J -- Zhao, W -- Kosarev, G -- Ni, J -- Achauer, U -- Jiang, M -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1219-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉GeoForschungsZentrum Potsdam, Telegrafenberg, 14473 Potsdam, Germany. kind@gfz-potsdam.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424374" target="_blank"〉PubMed〈/a〉
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  • 10
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    An Early Cretaceous tribosphenic mammal and metatherian evolution (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-13
    Description: Derived features of a new boreosphenidan mammal from the Lower Cretaceous Yixian Formation of China suggest that it has a closer relationship to metatherians (including extant marsupials) than to eutherians (including extant placentals). This fossil dates to 125 million years ago and extends the record of marsupial relatives with skeletal remains by 50 million years. It also has many foot structures known only from climbing and tree-living extant mammals, suggesting that early crown therians exploited diverse niches. New data from this fossil support the view that Asia was likely the center for the diversification of the earliest metatherians and eutherians during the Early Cretaceous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luo, Zhe-Xi -- Ji, Qiang -- Wible, John R -- Yuan, Chong-Xi -- New York, N.Y. -- Science. 2003 Dec 12;302(5652):1934-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Carnegie Museum of Natural History, Pittsburgh, PA 15213, USA. luoz@carnegiemuseums.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14671295" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Animals ; *Biological Evolution ; Biomechanical Phenomena ; Bone and Bones/anatomy & histology ; China ; Dentition ; *Fossils ; Geography ; Locomotion ; *Mammals/anatomy & histology/classification/physiology ; *Marsupialia/anatomy & histology/classification/physiology ; Paleodontology ; Paleontology ; Phylogeny ; Time
    Print ISSN: 0036-8075
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