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  • 1
    Online Resource
    Online Resource
    Coronary Artery Disease: Therapeutics and Drug Discovery (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    URL: https://doi.org/10.1007/978-981-15-2517-9
    DOI: 10.1007/978-981-15-2517-9
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Pediatric Pharmacotherapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    URL: https://doi.org/10.1007/978-3-030-50494-6
    DOI: 10.1007/978-3-030-50494-6
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Reactive Oxygen Species : Network Pharmacology and Therapeutic Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    URL: https://doi.org/10.1007/978-3-030-68510-2
    DOI: 10.1007/978-3-030-68510-2
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    Organotypic Models in Drug Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    URL: https://doi.org/10.1007/978-3-030-70063-8
    DOI: 10.1007/978-3-030-70063-8
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Vaccination Strategies Against Highly Variable Pathogens (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    URL: https://doi.org/10.1007/978-3-030-58004-9
    DOI: 10.1007/978-3-030-58004-9
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Drug Stability and Chemical Kinetics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.
    Abstract: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
    Type of Medium: Online Resource
    Pages: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564260
    URL: https://doi.org/10.1007/978-981-15-6426-0
    DOI: 10.1007/978-981-15-6426-0
    DDC: 615
    Language: English
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  • 7
    Online Resource
    Online Resource
    Handbook of 200 Medicinal Plants : A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Medicinal Chemistry.
    Description / Table of Contents: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.
    Abstract: This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective. Chemical constituents of each plant with the putative active constituent, and available up to date pharmacological studies (until 2017 on PubMed) with each medical activity explored and its relationship with traditional uses, are described for each plant. Any variations in chemical constituents and their effects on pharmacological studies outcome have been highlighted. All clinical trials conducted, with sufficient details, have been included. Nationalities and racial identities of participants of clinical trials are identified to impress upon the social, cultural and dietary influences on the clinical outcomes. Toxicity studies and potential interactions with prescribed drugs, and full spectrum of references are included.
    Type of Medium: Online Resource
    Pages: XXX, 2156 p. 199 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030168070
    URL: https://doi.org/10.1007/978-3-030-16807-0
    DOI: 10.1007/978-3-030-16807-0
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Therapeutic Applications of Dopamine D3 Receptor Function : New Insight After 30 Years Of Research (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.
    Abstract: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031230585
    Series Statement: Current Topics in Behavioral Neurosciences, 60
    URL: https://doi.org/10.1007/978-3-031-23058-5
    DOI: 10.1007/978-3-031-23058-5
    DDC: 615
    Language: English
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  • 9
    Online Resource
    Online Resource
    Approaching Complex Diseases : Network-Based Pharmacology and Systems Approach in Bio-Medicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Bioinformatics. ; Oncology. ; Medicine Philosophy. ; Pharmacology. ; Computational and Systems Biology. ; Oncology. ; Philosophy of Medicine.
    Description / Table of Contents: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).
    Abstract: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
    Type of Medium: Online Resource
    Pages: XVI, 483 p. 49 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030328573
    Series Statement: Human Perspectives in Health Sciences and Technology, 2
    URL: https://doi.org/10.1007/978-3-030-32857-3
    DOI: 10.1007/978-3-030-32857-3
    DDC: 615
    Language: English
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  • 10
    Online Resource
    Online Resource
    Pharmacology of Potassium Channels (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    URL: https://doi.org/10.1007/978-3-030-84052-5
    DOI: 10.1007/978-3-030-84052-5
    DDC: 615
    Language: English
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  • 11
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    Online Resource
    Nutritional Toxicology (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nutrition   . ; Food science. ; Pharmacology. ; Nutrition. ; Food Science.
    Description / Table of Contents: 1 Preface -- 2 Effects of Nutrients/nutrition on Toxicants/toxicity -- 3 Effects of Xenobiotics on Nutrition -- 4 Effects of Antinutritional Factors on the Digestibility, Bioavailability and Quality of Protein -- 5 Natural Toxicants Originating from Food/Diet -- 6 Food contaminants -- 7 Food additives -- 8 Food contact materials -- 9 Genetically modified food -- 10 Tolerable upper limits of nutrients -- 11 Risk assessment and Risk-benefit assessment -- 12 Nutrients/Nutrition and Drug Interaction -- 13 Phytochemicals and Health -- 14 Adverse Effects of Phytochemicals.
    Abstract: This book provides a broad overview of the chemicals in food that have the potential to induce adverse health effects. Nutritional Toxicology is an interaction of nutrition, toxicology, biochemistry and food science, etc. Its main research scope involves the effects of nutrients on metabolisms of toxicants and their mechanisms, the interaction of the toxicants and contaminants originated from diet with nutrients and nutrition process, the adverse health outcome of nutrients excess, as well as methodology of research and related food and nutrition regulation process. Also the risk assessment of toxicants and contaminants in foods, and risk benefit assessment of nutrients (dietary supplementation) has become an emerging topic. This book provides novel and provocative insights into the fields of nutrition, food science and toxicology. It also offers a state-of-the-art report on recent discoveries concerning nutritional toxicology and where the field is going. It mainly focuses on advances made over the past 20 years. It will benefit graduate students, researchers and food and nutrition related regulation parties.
    Type of Medium: Online Resource
    Pages: X, 384 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811908729
    URL: https://doi.org/10.1007/978-981-19-0872-9
    DOI: 10.1007/978-981-19-0872-9
    DDC: 615
    Language: English
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  • 12
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    Online Resource
    Network Pharmacology (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    URL: https://doi.org/10.1007/978-981-16-0753-0
    DOI: 10.1007/978-981-16-0753-0
    DDC: 615
    Language: English
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  • 13
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    Online Resource
    Environment and Female Reproductive Health (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Midwifery. ; Public health. ; Pharmacology. ; Midwifery. ; Public Health.
    Description / Table of Contents: Part I Environmental Harmful Factors -- 1 Introduction to Environmental Harmful Factors -- Part II Female Reproductive Processes and Diseases -- 2 Introduction of Female Reproductive Processes and Reproductive Diseases -- Part III Effects of Environmental Factors on Reproductive Process -- 3 The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality -- 4 Effects of environment and lifestyle factors on premature ovarian failure -- 5 Effects of Environment and Lifestyle Factors on Anovulatory Disorder -- 6 Effects of Cigarette Smoking on Preimplantation Embryo Development -- 7 Toxicical effects of BPDE on dysfunctions of female trophoblast cells -- 8 The Roles of Stress-Induced Immune Response in Female Reproduction -- 9 Effects of Environmental EDCs on Oocyte Quality, Embryo Development and the Outcome in Human IVF Process -- Part IV Effects of Environmental Factors on Reproductive Diseases -- 10 Effects of environmental endocrine-disrupting chemicals on female reproductive health -- 11 Definition and Multiple Factors of Recurrent Spontaneous Abortion -- 12 The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and their Diagnosis Strategy -- Part V Effects of Environmental Factors on Fertility Preservation -- 13 The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.
    Abstract: This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.
    Type of Medium: Online Resource
    Pages: XI, 313 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341876
    Series Statement: Advances in Experimental Medicine and Biology, 1300
    URL: https://doi.org/10.1007/978-981-33-4187-6
    DOI: 10.1007/978-981-33-4187-6
    DDC: 615
    Language: English
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  • 14
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    Online Resource
    Organic Cation Transporters in the Central Nervous System (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Molecular biology. ; Pharmacology. ; Human Physiology. ; Molecular Biology.
    Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
    Abstract: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030829841
    Series Statement: Handbook of Experimental Pharmacology, 266
    URL: https://doi.org/10.1007/978-3-030-82984-1
    DOI: 10.1007/978-3-030-82984-1
    DDC: 615
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  • 15
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    Online Resource
    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    URL: https://doi.org/10.1007/978-3-030-79511-5
    DOI: 10.1007/978-3-030-79511-5
    DDC: 615
    Language: English
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  • 16
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    Online Resource
    Pharmacology of the WNT Signaling System (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Physiology. ; Oncology. ; Neurosciences. ; Developmental biology. ; Pharmacology. ; Physiology. ; Oncology. ; Neuroscience. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.
    Abstract: This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
    Type of Medium: Online Resource
    Pages: VIII, 422 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030854997
    Series Statement: Handbook of Experimental Pharmacology, 269
    URL: https://doi.org/10.1007/978-3-030-85499-7
    DOI: 10.1007/978-3-030-85499-7
    DDC: 615
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  • 17
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    Online Resource
    The Art of Carbohydrate Analysis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Chemistry, Organic. ; Food science. ; Biotechnology. ; Pharmacology. ; Organic Chemistry. ; Food Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .
    Abstract: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
    Type of Medium: Online Resource
    Pages: XXV, 350 p. 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777913
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-77791-3
    DOI: 10.1007/978-3-030-77791-3
    DDC: 615
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  • 18
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    Online Resource
    Polypharmacology : Principles and Methodologies (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Neuropharmacology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Neuropharmacology.
    Description / Table of Contents: PART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles -- Basics of Polypharmacology -- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C) -- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF) -- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD) -- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD -- Anti-cancer Polypharmacology -- Cardiovascular Polypharmacology -- Neuronal Polypharmacology -- Pulmonary Polypharmacology -- Polypharmacology of Metabolic Disease -- Polypharmacology of Infectious Disease -- Polypharmacology of Inflammation -- Anti-psychotics Polypharmacology -- Anti-aging Polypharmacology -- Polypharmacology in Drug Repurposing -- Polypharmacology and Unintended Drug Promiscuity -- Polypharmacology Pharmacokinetics -- The Future of Polypharmacology -- PART II. Polypharmacology in New Drug Development: Strategies and Protocols -- Designed MTSD Discovery Process -- Designed MTSD Discovery Strategies -- Designed MTSD Discovery Technologies -- Designed MTSD Discovery Databases -- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation -- Designed MTSD Lead Identification and Optimization -- Designed MTSD Discovery Protocols -- Natural Products in MTSD Discovery -- Polypharmacology Procedures for Drug Repurposing -- Polypharmacology Procedures for Drug Promiscuity Discovery.
    Abstract: There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on Polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology on Polypharmacology. This book aims to meet the needs of making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of Polypharmacology targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy. Rich in illustrations and tables to showcase readers for better understanding the concepts and technologies related to Polypharmacology; Provides comprehensive, systemic, holistic, and explicit explanations and discussion of the fundamental knowledge, background information, conceptual evolution, and updated methodology, as well as in-depth mechanisms behind the knowledge and methodology of Polypharmacology; Main emphasis on rationally designed Polypharmacology or “multi-target, single-drug (MTD)” pharmacology, which represents the major future direction of Polypharmacology and Pharmacology; Describes the clinical applications of Polypharmacology to various human diseases in the clinical and preclinical settings; Contains a wide collection of the state-of-the-art Polypharmacology technologies applicable to the designed MTD discovery and the step-by-step descriptions of drug discovery process applying Polypharmacology principles and methodologies.
    Type of Medium: Online Resource
    Pages: XXV, 856 p. 12 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031049989
    URL: https://doi.org/10.1007/978-3-031-04998-9
    DOI: 10.1007/978-3-031-04998-9
    DDC: 615
    Language: English
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  • 19
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    Online Resource
    Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nanobiotechnology. ; Biomedical engineering. ; Drug delivery systems. ; Pharmaceutical chemistry. ; Pharmacology. ; Nanobiotechnology. ; Biomedical Engineering and Bioengineering. ; Drug Delivery. ; Pharmaceutics.
    Description / Table of Contents: Chapter 1. An introduction to respiratory diseases and an emerging need for efficient drug delivery systems -- Chapter 2. Inflammatory respiratory diseases: Correlation between Lung cancer and CoVid-19 -- Chapter 3. Advancements in translational respiratory research using nanotechnology -- Chapter 4. Chemical moieties as advanced therapeutics for targeting respiratory disorders -- Chapter 5. Phytochemicals and their nanoformulations targeted for pulmonary diseases -- Chapter 6. Nanocarriers: an advanced and highly effective approach for targeting chronic lung diseases -- Chapter 7. Vesicular drug delivery systems in respiratory diseases -- Chapter 8. Nanoparticles in chronic respiratory diseases -- Chapter 9. Applications of nanotechnology in pulmonary disease diagnosis -- Chapter 10. Nanotechnology in pulmonary disease diagnosis -- Chapter 11. Recent trends in Nanomedicine for diagnosis and treatment of pulmonary diseases -- Chapter 12. Strategies for enhanced drug targeting to inflamed lungs: Novel perspectives -- Chapter 13. Solid-Lipid Nanocarriers (SLN’s) based drug delivery for treating various pulmonary diseases -- Chapter 14. Microparticles, microspheres and microemulsions as pulmonary drug delivery systems for the treatment of respiratory diseases -- Chapter 15. Microparticles, microspheres and microemulsions in respiratory diseases -- Chapter 16. Advanced drug delivery systems targeting the immune system at cellular level in chronic respiratory diseases -- Chapter 17. Targeted Micellar Systems for Pulmonary Disease Intervention -- Chapter 18. Polymeric and inorganic nanoparticles targeting chronic respiratory diseases -- Chapter 19. Mucoadhesive drug delivery system in chronic respiratory diseases -- Chapter 20. Liposomal Drug Delivery: Therapeutic Applications in Chronic Respiratory Diseases -- Chapter 21. Biologics and vaccines for nasal and pulmonary drug delivery -- Chapter 22. Drug delivery systems for respiratory infections -- Chapter 23. Cell and Gene Therapies for Chronic Inflammatory Lung Diseases - Emerging Technological Trends and Advancements in Respiratory Medicine -- Chapter 24. Targeting biofilms in respiratory diseases using novel drug delivery systems -- Chapter 25. Advanced nanomaterials for drug delivery in chronic respiratory disorders -- Chapter 26. Emerging technological trends and advancements in respiratory medicine -- Chapter 27. Pulmonary pharmacokinetics and Biophysics -- Chapter 28. Clinical trials on novel advanced drugs for chronic respiratory disorders.
    Abstract: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
    Type of Medium: Online Resource
    Pages: X, 655 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811643927
    URL: https://doi.org/10.1007/978-981-16-4392-7
    DOI: 10.1007/978-981-16-4392-7
    DDC: 615
    Language: English
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  • 20
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    Online Resource
    Data Monitoring Committees (DMCs) : Past, Present, and Future (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    URL: https://doi.org/10.1007/978-3-031-28760-2
    DOI: 10.1007/978-3-031-28760-2
    DDC: 615
    Language: English
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  • 21
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    Macrophage Targeted Delivery Systems : Basic Concepts and Therapeutic Applications (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Cytology. ; Toxicology. ; Immunology. ; Pharmacology. ; Pharmaceutics. ; Cell Biology. ; Toxicology. ; Immunology.
    Description / Table of Contents: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .
    Abstract: The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
    Type of Medium: Online Resource
    Pages: XVIII, 556 p. 76 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030841645
    URL: https://doi.org/10.1007/978-3-030-84164-5
    DOI: 10.1007/978-3-030-84164-5
    DDC: 615
    Language: English
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  • 22
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    Online Resource
    Synbiotics for the Management of Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Cancer. ; Cancer Treatment. ; Pharmacology. ; Cancers. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Effect of anticancer treatment approches on gut microbiota -- Chapter 3_Synbiotic: A promising approach for the treatment of cancer -- Chapter 4_Correlation between ROS and Synbiotics for effective treatment of cancer -- Chapter 5_Influence of synbiotics on inflammation and immune microenvironment for the treatment of cancer -- Chapter 6_Synbiotics in colorectal cancer -- Chapter 7_Synbiotics in cervical cancer -- Chapter 8_Synbiotics in prostate cancer -- Chapter 9_Synbiotics in gastric cancer -- Chapter 10_Synbiotics in lung cancer -- Chapter 11_Synbiotics in small cell pancretatic cancer -- Chapter 12_Synbiotics in breast cancer -- Chapter 13_Synbiotics in hepatocellular carcinoma -- Chapter 14_Synbiotics in ovarian cancer -- Chapter 15_Regulatory issues of synbiotics in cancer.
    Abstract: This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.
    Type of Medium: Online Resource
    Pages: XVII, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811975509
    URL: https://doi.org/10.1007/978-981-19-7550-9
    DOI: 10.1007/978-981-19-7550-9
    DDC: 615
    Language: English
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  • 23
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    Online Resource
    Recent Advances in Pharmaceutical Innovation and Research (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Nanobiotechnology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Nanobiotechnology.
    Description / Table of Contents: Part 1. Pharmaceutical Innovation and Research -- Chapter 1. Innovation in stabilization of biopharmaceuticals -- Chapter 2. Concepts in pharmacogenomics: tools and applications -- Chapter 3. Pharmacogenetics–a new approach for the selection of the right drug -- Chapter 4. Meeting the unmet challenges of pharmaceutical research using artificial intelligence -- Chapter 5. Pharmaceutical innovation and research in ayurved -- Chapter 6. Ayurveda intervention in perimenopausal syndrome -- Part 2. Drug Discovery and Development -- Chapter 7. Innovative strategies in drug discovery and pharmacoinformatics -- Chapter 8. Advances in peptide synthesis -- Chapter 9. Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs -- Chapter 10. Diverse Pharmacological Activities of 4-aminoquinoline and its Derivatives -- Chapter 11. Thiourea catalysts for synthesis of active pharmaceutical ingredients -- Chapter 12. The Chemistry and Pharmacology of Mandarin Orange -- Chapter 13. Recent progress in the pharmacology of phytoestrogens: emerging neuromodulators for treating anxiety and depression -- Chapter 14. Next-generation cell-based therapies to combat metastaticbrain tumor -- Chapter 15. Pharmacokinetics and Pharmacodynamics: Fundamentals and Role(s) in Drug Discovery and Development -- Chapter 16. An update on pharmacokinetic models -- Chapter 17. Pharmacodynamics: Basics and Applications in Drug Research -- Part 3. Drug Delivery and Nanotechnology -- Chapter 18. Technological innovations in pharmaceutical drug nanocrystals -- Chapter 19. Fixed Dose Combinations: Innovations and Research -- Chapter 20. Significance of Intranasal Drug Delivery Systems: Recent Trends and Clinical Investigations in Brain Disorders -- Chapter 21. Current challenges and nanotechnology-based pharmaceutical approaches for the treatment and control of visceral leishmaniasis -- Chapter 22. Polymeric Nanoparticles-based Drug Delivery Systems for Anticancer Therapy. Chapter 23. Carbon nanotubes: a review of toxicity and applicability in biomedical applications -- Chapter 24. Recent trends in topical herbal nanotherapeutics for psoriasis -- Part 4. Pharmaceutical Microbiology -- Chapter 25. Antibiotics: past, present, future, and clinical pipeline -- Chapter 26. Innovative strategies to tackle antimicrobial resistance -- Chapter 27. Molecular and mechanistic insights of yeast flocculation -- Chapter 28. Management of hepatitis virus C: current and future treatments -- Chapter 29. Tuberculosis: experimental models, innovations and challenges -- Chapter 30. Targeting outer membrane to tackle multi-drug resistant bacterial pathogens -- Chapter 31. Diphtheria-A Paradigmatic Vaccine Preventable Toxigenic Disease with Changing Epidemiology -- Chapter 32. Emerging and re-emerging infections: an overview.
    Abstract: This book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.
    Type of Medium: Online Resource
    Pages: XXI, 770 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819923021
    URL: https://doi.org/10.1007/978-981-99-2302-1
    DOI: 10.1007/978-981-99-2302-1
    DDC: 615
    Language: English
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  • 24
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    Online Resource
    Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nanobiotechnology. ; Drug delivery systems. ; Pharmacology. ; Nanobiotechnology. ; Drug Delivery.
    Description / Table of Contents: Ch 1 Introduction to block co-polymers -- Ch 2 Role of block co-polymers in drug delivery -- Ch 3 Role of block co-polymers in enhancement of poor solubility of drugs -- Ch 4 Synthesis and Self–assembly of block copolymers -- Ch 5 Role of block co-polymers in treatment of brain disorders -- Ch 6 Role of block co-polymers in treatment of neurodegenerative disorders -- Ch 7 Role of block co-polymers in colon cancer -- Ch 8 Role of block co-polymers in lung cancer -- Ch 9 Role of block co-polymers in IBD -- Ch 10 Role of block co-polymers in vaccine -- Ch 11 Role of block co-polymers in treatment of GIT disorders -- Ch 12 Role of block co-polymers in topical drug delivery -- Ch 13 Role of block co-polymers in targeted drug delivery -- Ch 14 Role of block co-polymers in ocular drug delivery -- Ch 15 Role of block co-polymeric micelles in drug delivery -- Ch 16 Applications of block co-polymers as Stimuli Responsive Copolymers -- Ch 17 Patented block co-polymers for various Therapeutics Applications.
    Abstract: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.
    Type of Medium: Online Resource
    Pages: XVII, 429 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819969173
    URL: https://doi.org/10.1007/978-981-99-6917-3
    DOI: 10.1007/978-981-99-6917-3
    DDC: 615
    Language: English
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  • 25
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    Online Resource
    Pharmacology of Immunotherapeutic Drugs (2020)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.
    Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.
    Abstract: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
    Type of Medium: Online Resource
    Pages: XIX, 399 p. 118 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030199227
    URL: https://doi.org/10.1007/978-3-030-19922-7
    DOI: 10.1007/978-3-030-19922-7
    DDC: 615
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  • 26
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    Online Resource
    Biomedical Applications and Toxicity of Nanomaterials (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nanobiotechnology. ; Nanomedicine. ; Pharmacology. ; Nanobiotechnology. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Chapter 1. Macroporous cryogel-based systems for water treatment applications and Safety: nanocomposite-based cryogels and bacteria-based bioreactors -- Chapter 2. One dimensional Semiconducting Nanomaterials: Toxicity and Clinical Applications -- Chapter 3. Prospects of Safe use of Nanomaterials in Biomedicalapplications -- Chapter 4. Hyaluronic acid-based nanotechnologies for delivery and treatment -- Chapter 5. Theranostics nanomaterials for safe cancer treatment -- Chapter 6. Cardiovascular safety assessment of new chemical entities: current perspective and emerging technologies -- Chapter 7. Toxicology of pharmaceutical products during drug development -- Chapter 8. Safety and Risk assessment of food items -- Chapter 9. Non toxic Natural products as regulators of tumour suppressor gene function -- Chapter 10. Advancements in the safety of Plant medicine: Back to nature -- Chapter 11. Chemicals and their interaction in the aquaculture system -- Chapter 12. Zebrafish as a biomedical model to define developmental origins of chemical toxicity -- Chapter 13. Green synthesis of non toxic nanoparticles -- Chapter 14. Synthesis, characterisation and safety of titanium oxide nanoparticles -- Chapter 15. Characterisation of non toxic nanomaterials for biological applications -- Chapter 16. Toxicity assessment of nanoparticle -- Chapter 17. Safety of nanoparticles: emphasis on antimicrobial properties -- Chapter 18. Quantum dots for imaging and its safety -- Chapter 19. Genotoxicity evaluation of nanosized materia -- Chapter 20. Scaffoldmaterials and toxicity -- Chapter 21 Biological Safety and Cellular interactions of nanoparticles -- Chapter 22. Role of artificial intelligence in the toxicity prediction of drugs -- Chapter 23. Chemicals and rodent models for the safety study of alzheimer’s disease -- Chapter 24. Mitochondria-targeted liposomal delivery in Parkinson's disease: safety concerns -- Chapter 25. Routes of Nano-drug Administration and Nano-based drug delivery system and toxicity -- Chapter 26. Green Synthesised silver nanoparticles phytotoxicity and applications in agriculture: An overview -- Chapter 27 status of safety concerns of microplastic detection strategies -- Chapter 28. Impact of insecticides on man and environment.
    Abstract: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
    Type of Medium: Online Resource
    Pages: XVIII, 768 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811978340
    URL: https://doi.org/10.1007/978-981-19-7834-0
    DOI: 10.1007/978-981-19-7834-0
    DDC: 615
    Language: English
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  • 27
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    Online Resource
    Pharmacology of Drug Stereoisomers (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Biotechnology. ; Biochemical engineering. ; Pharmacology. ; Medicinal Chemistry. ; Pharmaceutics. ; Biotechnology. ; Bioprocess Engineering.
    Description / Table of Contents: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
    Abstract: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
    Type of Medium: Online Resource
    Pages: XI, 207 p. 174 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811923203
    Series Statement: Progress in Drug Research, 76
    URL: https://doi.org/10.1007/978-981-19-2320-3
    DOI: 10.1007/978-981-19-2320-3
    DDC: 615
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  • 28
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    Online Resource
    Rabies and Rabies Vaccines (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology. ; Immunology.
    Description / Table of Contents: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.
    Abstract: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. .
    Type of Medium: Online Resource
    Pages: VII, 205 p. 15 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030210847
    URL: https://doi.org/10.1007/978-3-030-21084-7
    DOI: 10.1007/978-3-030-21084-7
    DDC: 615
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  • 29
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    Online Resource
    Principles of Forensic Toxicology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Forensic sciences. ; Medical jurisprudence. ; Pharmacology. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.
    Abstract: The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.
    Type of Medium: Online Resource
    Pages: XIII, 691 p. 188 illus., 23 illus. in color. , online resource.
    Edition: 5th ed. 2020.
    ISBN: 9783030429171
    URL: https://doi.org/10.1007/978-3-030-42917-1
    DOI: 10.1007/978-3-030-42917-1
    DDC: 615
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  • 30
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    Online Resource
    Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Pharmacology. ; Toxicology. ; Pharmaceutics.
    Description / Table of Contents: Therapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions.
    Abstract: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges .
    Type of Medium: Online Resource
    Pages: XVIII, 381 p. 43 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031123986
    URL: https://doi.org/10.1007/978-3-031-12398-6
    DOI: 10.1007/978-3-031-12398-6
    DDC: 615
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  • 31
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    From PharmD to Industry : A Fellowship Guide (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Career education. ; Pharmacology. ; Pharmacy. ; Career Skills.
    Description / Table of Contents: Fellowship 101 -- The First Professional Year (P1) -- The Second Professional Year (P2) -- The Third Professional Year (P3) -- The Fourth Professional Year (P4) -- Midyear Applications, Interviews, and Receptions -- Transitioning from Student to Fellow -- Navigating the Virtual Landscape.
    Abstract: For many Doctor of Pharmacy (PharmD) candidates, post-graduate training is a highly prestigious and sought after experience that can further one’s pre-existing education. Some of these post-graduate training opportunities include but are not limited to pharmacy residencies, pharmaceutical industry fellowships, and PhD/Masters programs. There is a large gap in the current Doctor of Pharmacy curriculum about pharmaceutical industry fellowship programs and potential pharmaceutical industry opportunities. Through the eyes of current industry fellows and professionals, this book serves as a resource to learn more about fellowship opportunities and their respective application processes. In addition, this manual aims to provide a clear and concise roadmap to achieving a career in industry through a fellowship program. Whether you are a current student pharmacist, post-graduate pharmacy trainee (pharmacy resident), or industry professional, this manual addresses the current landscape of industry fellowship programs, an overview of industry opportunities, and a glimpse into what being a fellow entails. Readers of this book can expect to gain: An overview of pharmaceutical industry fellowship programs and opportunities Helpful advice and insight from current fellows and industry professionals A streamlined pathway to navigating the fellowship application process An understanding of the journey from being a student, to achieving a fellowship, to becoming an industry professional This book bridges the gap in education surrounding pharmaceutical industry fellowships and pharmacy careers in industry and increases access to first-hand information and real-world perspectives of current professionals to provide a firm foundation for those interested in pursuing a career in industry or learning more about fellowship programs.
    Type of Medium: Online Resource
    Pages: XIX, 92 p. 4 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031357879
    Series Statement: SpringerBriefs in Pharmaceutical Science & Drug Development,
    URL: https://doi.org/10.1007/978-3-031-35787-9
    DOI: 10.1007/978-3-031-35787-9
    DDC: 615
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  • 32
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    Online Resource
    Contract Research and Development Organizations-Their History, Selection, and Utilization (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmacology. ; Pharmacy.
    Description / Table of Contents: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .
    Abstract: This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
    Type of Medium: Online Resource
    Pages: XIII, 519 p. 19 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030430733
    URL: https://doi.org/10.1007/978-3-030-43073-3
    DOI: 10.1007/978-3-030-43073-3
    DDC: 615
    Language: English
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    Toll-like Receptors in Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Immunology. ; Inflammation. ; Pharmacology. ; Immunology. ; Inflammation.
    Description / Table of Contents: Intracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells -- Toll-like receptors as drug targets in the intestinal epithelium -- Innate immune memory-priming, tolerance and exhaustion-in health and disease -- TLRs in brain immunity -- TLRs in cerebrovascular diseases -- TLRs in stem cells or progenitor cells -- TLRs in adaptive immunity -- Overview on TLRs in immunity -- TLR10 and its role in immunity.
    Abstract: The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
    Type of Medium: Online Resource
    Pages: VIII, 314 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065125
    Series Statement: Handbook of Experimental Pharmacology, 276
    URL: https://doi.org/10.1007/978-3-031-06512-5
    DOI: 10.1007/978-3-031-06512-5
    DDC: 615
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    Prebiotics, Probiotics and Nutraceuticals (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Clinical medicine Research. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Clinical Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Potentiality of Probiotics in Inactivation of Tetrodotoxin -- Chapter 2. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 3. Plant based Bioactive compounds in Cancer Therapeutics -- Chapter 4. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 5. Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immunobiological perspectives -- Chapter 6. The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery -- Chapter 7. The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study -- Chapter 8. Prebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives -- Chapter 9. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases. Chapter 10. Implications of probiotics and prebiotics on immune functions -- Chapter 11. Recent Trends in Natural Medicines and Nutraceuticals Research -- Chapter 12. Nutraceuticals-are alternative to modern medicines- Chapter 13. Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban -- Chapter 14. Drosophila melanogaster as an in-vivo model for the investigation of host microbiota interaction -- Chapter 15. Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development of Aquaculture.
    Abstract: The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.
    Type of Medium: Online Resource
    Pages: XVI, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811689901
    URL: https://doi.org/10.1007/978-981-16-8990-1
    DOI: 10.1007/978-981-16-8990-1
    DDC: 615
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    Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Surgery. ; Dentistry. ; Veterinary medicine. ; Neurology . ; Orthopedic surgery. ; Pharmacology. ; Surgery. ; Dentistry. ; Veterinary Science. ; Neurology. ; Surgical Orthopedics.
    Description / Table of Contents: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.
    Abstract: All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine and furnishes the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.
    Type of Medium: Online Resource
    Pages: VIII, 398 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506919
    URL: https://doi.org/10.1007/978-3-030-50691-9
    DOI: 10.1007/978-3-030-50691-9
    DDC: 615
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    Metabolomics and Its Impact on Health and Diseases (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Biochemical markers. ; Cytology. ; Analytical biochemistry. ; Pharmacology. ; Biomarkers. ; Cell Biology. ; Analytical Biochemistry.
    Description / Table of Contents: Preface -- Practical Aspects of NMR-Based Metabolomics -- Compound Identification in Mass Spectrometry-Based Metabolomics -- METABOLOMICS USING NMR – Avoiding the ‘Black-Box’ -- Natural products drug discovery: on silica or in silico?- Quantitative NMR Methods in Metabolomics -- Advancements in pulsed stable isotope resolved metabolomics -- Metabolomics in Cell Biology -- NMR-based metabolomics to evaluate individual response to treatments -- Pharmacometabolomics of Asthma as a road map to Precision Medicine -- Prospective metabolomic studies in precision medicine -- Chemotherapy-induced Peripheral Neuropathy -- Metabolomics of Respiratory Diseases.
    Abstract: This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.
    Type of Medium: Online Resource
    Pages: VIII, 384 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031268595
    Series Statement: Handbook of Experimental Pharmacology, 277
    URL: https://doi.org/10.1007/978-3-031-26859-5
    DOI: 10.1007/978-3-031-26859-5
    DDC: 615
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    Structure and Health Effects of Natural Products on Diabetes Mellitus (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Botanical chemistry. ; Bioorganic chemistry. ; Pharmacology. ; Plant Biochemistry. ; Bioorganic Chemistry.
    Description / Table of Contents: Chapter 1. Introduction of diabetes melitus and future prospects of natural products on diabetes melitus -- Chapter 2. Anoverview of hypoglycemic modern drugs -- Chapter 3. An overview of hypoglycemic biological drugs -- Chapter 4. An overview of hypoglycemic traditionaldrugs -- Chapter 5. Glycosides from natural sources in the treatment of diabetes mellitus -- Chapter 6. Isolation and Structure Elucidation of Hypoglycemic Compounds -- Chapter 7. Structural Characterization and Health Effects of Polysaccharides from Momordica charantia on Diabetes Mellitus -- Chapter 8. Effects of polysaccharides on reducing blood glucose based on gut microbiota alteration -- Chapter 9. An Overview of Polysaccharides and the influencefactors of Hypoglycemic Activity -- Chapter 10. Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity. - Chapter 11. Rhinacanthin-C and Its Potential to Control Diabetes Mellitus -- Chapter 12. Regeneration of beta cells by inhibition of pro-apoptotic proteins through phytocompound in STZ induced diabetic albino wistar rats-invivo and insilico approach. - Chapter 13. Nitrogenous Compounds from Plant Origin in Management of -- Chapter 14. Plant Alkaloids with Antidiabetic Potential -- Chapter 15. The role of Alkaloids in the Management of Diabetes Mellitus -- Chapter 16. Traditional Indian Herbs for the Management of Diabetes Mellitus and their Herb-Drug Interaction Potentials: An Evidence-Based Review -- Chapter 17. Role of Micronutrients and Trace elements in Diabetes mellitus: A Review.
    Abstract: The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.
    Type of Medium: Online Resource
    Pages: VIII, 307 p. 85 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811587917
    URL: https://doi.org/10.1007/978-981-15-8791-7
    DOI: 10.1007/978-981-15-8791-7
    DDC: 615
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    Pharmacology of Immunosuppression (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Human physiology. ; Immunology. ; Surgery. ; Pharmacology. ; Human Physiology. ; Immunology. ; Surgery.
    Description / Table of Contents: Review of the Pathophysiology of the Alloimmune response -- A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation -- Anti-proliferative Agents -- Mechanistic Target of Rapamycin (mTOR) Inhibitors -- Corticosteroids -- Induction therapy and antibodies -- Immunosuppression and Heart Transplantation -- Immunosuppression and Lung Transplantation -- Immunosuppression and renal transplant recipients -- Immunosuppression in Rheumatologic and Auto-immune Disease -- Immunosuppression in Bone Marrow Transplantation -- Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders -- Novel immunosuppressive agents for the treatment of organ transplants -- Adverse Effects of Immunosuppression: Infections -- Malignancy: An Adverse Effect of Immunosuppression -- Adverse Effects of Immunosuppression:Nephrotoxicity, Hypertension and Metabolic Disease.
    Abstract: The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.
    Type of Medium: Online Resource
    Pages: VIII, 348 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031051180
    Series Statement: Handbook of Experimental Pharmacology, 272
    URL: https://doi.org/10.1007/978-3-031-05118-0
    DOI: 10.1007/978-3-031-05118-0
    DDC: 615
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    Evidence Based Validation of Traditional Medicines : A comprehensive Approach (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medical microbiology. ; Medicinal chemistry. ; Pharmacovigilance. ; Pharmacology. ; Medical Microbiology. ; Medicinal Chemistry. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Global Approach for Drug Discovery and Development from Indian Traditional Medicine -- Chapter 2. Bioactive Natural Leads TargetingCancer Cell Metabolism -- Chapter 3. Omics Technologies and Development of Anti-diabetic Therapies from Prospective Natural Products -- Chapter 4. Amaryllidaceae Alkaloids as Anti-inflammatory Agents Targeting Cholinergic Anti-inflammatory Pathway: Mechanisms and Prospects -- Chapter 5. Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin -- Chapter 6. Role of Phytomolecules on the Basic Biology of Aging -- Chapter 7. Role of phytomedicine in alleviating oxidative stress mediated vascular complications in diabetes -- Chapter 8. Plant Based -Secretase (BACE-1) Inhibitors: A Mechanistic Approach to Encounter Alzheimer's Disorder -- Chapter 9. Bioactive Compounds of Mangroves as Potent Drug and in Nanoparticle Synthesis - Play a Pivotal Role in Combating Human Pathogens. Chapter 10. Medicinal Plants: A Rich Source of Bioactive Molecules Used in Drug Development -- Chapter 11. Cell-based Assays in Natural Product-based Drug Discovery -- Chapter 12. Allelochemicals: An Emerging Tool for Weed Management -- Chapter 13. Secondary Metabolites of Higher Plants as Green Preservatives of Herbal Raw Materials and Their Active Principles During Postharvest Processing -- Chapter 14. Importance of Chromatography Techniques in Phytomedicine Research -- Chapter 15. Reverse Pharmacology – A Tool for Drug Discovery From Traditional Medicine -- Chapter 16. Role of Modern Biological Techniques in Evidence-Based Validation of Ayurvedic Herbometallic Preparations -- Chapter 17. HPTLC Fingerprinting analysis of Phytoconstituents from Indigenous Medicinal Plants -- Chapter 18. Climate Change,Geographical Location and Other Allied Triggering Factors Modulate the Standardization and Characterization of Traditional Medicinal Plants: AChallenges and Prospect for Phyto-Drug Development -- Chapter 19. Molecular Docking Studies of Plant-Derived Bioactive Compounds: A Comprehensive in silico Standardization Approach -- Chapter 20. Standardization and Quality Evaluation of Botanicals with Special Reference to Marker Components -- Chapter 21. Analytical Standardization of Haridra Formulation by UV-VIS Spectrophotometry and RP-HPLC -- Chapter 22. Ethnobotanical survey: the foundation to evidence based validation of medicinal plants -- Chapter 23. Phytotherapeutics: The Rising Role of Drug Transporters in Herb-Drug Interactions with Botanical Supplements -- Chapter 24. An Insight into Herb Interactions: Clinical Evidence Based Overview -- Chapter 25. Pharmacovigilance of Herbal Medicines: An Overview -- Chapter 26. Herbal Drugs: Efficacy, Toxicity and Safety Issues -- Chapter 27. Herbal Drug Patenting -- Chapter 28. Safety and Regulatory Issues on Traditional Medicine Entrusted Drug Discovery -- Chapter 29. Pharmacovigilance of Herbal Medicine: An Evolving Discipline -- Chapter 30. Toxicity Studies Related to Medicinal Plants -- Chapter 31. Herb-Drug Interactions -- Chapter 32. Plant Based Traditional Herbal Contraceptive Use in India: Safety and Regulatory Issues -- Chapter 33. Traditional Medicine Stability and Pharmacokinetic Issue -- Chapter 34. Pharmacovigilance: Methods in developing the safety and acceptability of traditional medicines -- Chapter 35. Zoopharmacognosy (Plant-Animal Interaction) -- Chapter 36. Significance of Stability and Pharmacokinetic issues in Traditional Medicine -- Chapter 37. Pharmaceutical Formulations Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health Care Services -- Chapter 38. Evaluation of bioactivity of green nanoparticles synthesized from traditionally used medicinal plants: a review -- Chapter 39. Physicochemical, Micromeritics, Biomedical and Pharmaceutical Applications of Assam Bora Rice Starch -- Chapter 40. Natural Excipients in Pharmaceutical Formulations -- Chapter 41. A Wonder Plant Withania: Pharmacological and Chemical Perspectives -- Chapter 42. Immunomodulators and Phyto Drugs -- Chapter 43. Combined Effects of Plant Extracts on Ovarian Cell Functioning -- Chapter 44. Pterocarpussantalinus: A Wonder Gift of Nature -- Chapter 45. Phytochemicals And Investigations On Traditionally Used Medicinal Mushrooms -- Chapter 46. A Review On Investigational Studies Of Marine Macroalgae Spogomorpha Indica L -- Chapter 47. Validation of Traditional Claim of Oxalis debilis Kunth., An Ethnomedicinal Plant from North-eastern Region of India -- Chapter 48. Traditional Herbal Medicine Practiced in Plateau-Fringe and Rarh Districts of West Bengal, India -- Chapter 49. Pharmacology and Mechanisms of Natural Medicine in Treatment of Type 2 Diabetes Mellitus -- Chapter 50. Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy. .
    Abstract: The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine. .
    Type of Medium: Online Resource
    Pages: XII, 1151 p. 378 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581274
    URL: https://doi.org/10.1007/978-981-15-8127-4
    DOI: 10.1007/978-981-15-8127-4
    DDC: 615
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    From Obesity to Diabetes (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Metabolism Disorders. ; Pharmacology. ; Metabolic Disease.
    Description / Table of Contents: Part I Obesity. Epidemiology of Obesity -- The Circadian Clock and Obesity -- Nutrition and Microbiome -- From Obesity to Diabetes: The Role of the Adipose Organ -- Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy -- The Enteroendocrine System in Obesity -- Insights from Studies of White Adipose Tissue Using Single-Cell Approaches -- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction -- Obesity, Senescence, and Senolytics -- Obesity and Obstructive Sleep Apnea -- Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance -- Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes -- NAFLD and NASH: The Metabolically Diseased Liver -- Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities -- Diabetic Peripheral Neuropathy -- Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies -- Physical Activity, Obesity and Weight Loss Maintenance -- Bariatric/Metabolic Surgery -- Drugs for Treating Obesity -- Novel Drugs for Diabetes Therapy -- Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function -- Precision Medicine and Obesity -- Targeting the Enteroendocrine System for Treatment of Obesity.
    Abstract: Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.
    Type of Medium: Online Resource
    Pages: VIII, 513 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030999957
    Series Statement: Handbook of Experimental Pharmacology, 274
    URL: https://doi.org/10.1007/978-3-030-99995-7
    DOI: 10.1007/978-3-030-99995-7
    DDC: 615
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    Immunity Boosting Medicinal Plants of the Western Himalayas (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Natural products. ; Botany. ; Ethnology. ; Pharmacology. ; Natural Products. ; Plant Science. ; Ethnography.
    Description / Table of Contents: 1. Introduction to Western Himalayas -- 2. Achillea millefolium L., Common Yarrow -- 3. Arisaema jacquemontii Blume, Jacquemont's Cobra Lily -- 4. Species of Arnebia genus found in the western Himalayas -- 5. Species of the Berberis genus found in the western Himalayas -- 6. Dactylorhiza hatagirea (D.Don) Soo – Himalayan Marsh Orchid -- 7. Fritillaria roylei Hook.f.: Himalayan Fritillary -- 8. Gentiana kurroo Royle: Himalayan Gentian -- 9. Habenaria intermedia D.Don and Habenaria edgeworthii Hook., f. ex Collett.: The Western Himalayan medicinal Plants -- 10. Humulus lupulus L.: Beer plant -- 11. Inula racemosa Hook. f. – Puskarmool: Its ethnobotanical uses, phytochemicals and pharmacological activities -- 12. Juniperus recurva Buch.-Ham. ex D.Don and Juniperus squamata D. Don: Himalayan Juniper -- 13. Lancea tibetica Hook.f. & Thomson: Ethnobotany, phytochemistry and pharmacology -- 14. Malaxis muscifera (Lindley) O. Kuntze. and Malaxis acuminata D. Don.: Jeevak -- 15. Picrorhiza kurroa Royle ex Benth.: Kutki -- 16. Species of the genus Polygonatum found in the Western Himalayas -- 17. Species of the genus Rhodiola found in the Western Himalayas -- 18. Saussurea lappa C.B. Clarke: Kushta/Kut -- 19. Saussurea lappa C.B. Clarke: Kushta/Kut -- 20. Species of the genus Selinum found in the western Himalayas -- 21. Swertia chirayita (Roxb. ex Flem.): Chirayata/Chiretta -- 22. Taxus wallichiana Zucc.: The Himalayan yew -- 23. Tribulus terrestris L.: Gokshur /Gokharu -- 24. Species the Genus Viola found in Western Himalayas.
    Abstract: This book presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology. The book offers a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, and the pharmaceutical sciences. The main purpose of the present book is to draw on the rich culture, folklore, and biodiversity of immunity-boosting medicinal plants of the Western Himalayas, with particular emphasis on the Indian Trans-Himalayan and Western Himalayan region. All the plants included in the present book are extensively used by the local tribes and people for their health-promoting properties from ancient times. This book will be a substantial contribution to the knowledge of the region and the country. Also, the book will be very useful to scientists, graduates, and undergraduates, along with researchers in the fields of natural products, herbal medicines, ethnobotany, pharmacology, chemistry, and biology. Further, it is an equally significant resource for a person working in different traditional medicinal systems; doctors (especially those engaged in Ayurveda, Chinese traditional medicinal system, Amchi, and allopathy); the pharmaceutical industry (for drug design and synthesis); biochemistry and biotechnology sciences; and the agricultural sciences. .
    Type of Medium: Online Resource
    Pages: XIX, 609 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995019
    URL: https://doi.org/10.1007/978-981-19-9501-9
    DOI: 10.1007/978-981-19-9501-9
    DDC: 615
    Language: English
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    Online Resource
    Nanoformulations in Human Health : Challenges and Approaches (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Therapeutics. ; Pharmacology. ; Therapeutics.
    Description / Table of Contents: Nano-technological Platforms and Manipulations for the Emerging Ocular Manifestations -- Phytonanomedicines as Topical Alternatives for the Treatment of Skin Cancer -- Nano-sized Labile and Particulate Ingredients in Topical Formulations: A Strategic Approach Against Photoageing and Photocarcinogenisis -- Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances -- Nano-carriers for Natural Therapeutics in the Management of Neuropathic Pain -- Advances in the Delivery of Therapeutic Peptides -- Nanoformulations and Their Role in Colon Targeting -- Theranostic Nanoformulations: Merging Diagnostics and Therapeutics -- The Role of Nanoformulations in Nose-To-Brain Drug Delivery -- Cubic Lyotropic Liquid Crystalline Nanostructures: A Versatile Platform for Delivery -- Preformulation Challenges: The Concept Behind the Selection, Design, and Preparation of Nanoformulations -- Nanoethosomes for Topical Fungal Therapeutics -- Comparison of Therapeutic Efficiency of Nanoformulations of Curcumin vs. Tetrahydrocurcumin in Various Disorders -- Nanomedicinal Approaches of Phytotherapeutics to Treat Alzheimers Disease -- Nanoparticulate Approaches to Exploit the Pathophysiology of Rheumatoid and Osteoarthritis -- Emerging Nanotechnology in Chronic Respiratory Diseases -- Conventional and Non-conventional Approaches of Site-specific Targeting of Therapeutics in Some Infectious Diseases and Metabolic Disorders -- Nanoformulations in Human Health Conditions: The Paradigm Shift -- Magnetic Nanoparticles Nanoformulation for Alternative Therapy of Cancer by Super-paramagnetic Hyperthermia -- Nano-weapons Against Tuberculosis -- Drug-Excipient Interactions in Nanoformulations with Special Focus on Impurity Control per ICH guidelines.
    Abstract: This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
    Type of Medium: Online Resource
    Pages: XVIII, 548 p. 106 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030418588
    URL: https://doi.org/10.1007/978-3-030-41858-8
    DOI: 10.1007/978-3-030-41858-8
    DDC: 615
    Language: English
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    Online Resource
    Emerging Technologies for Nanoparticle Manufacturing (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Nanotechnology. ; Nanochemistry. ; Pharmacology. ; Nanotechnology. ; Nanochemistry.
    Description / Table of Contents: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.
    Abstract: This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .
    Type of Medium: Online Resource
    Pages: XV, 611 p. 155 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030507039
    URL: https://doi.org/10.1007/978-3-030-50703-9
    DOI: 10.1007/978-3-030-50703-9
    DDC: 615
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  • 44
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    Online Resource
    Antiviral Drug Discovery and Development (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    URL: https://doi.org/10.1007/978-981-16-0267-2
    DOI: 10.1007/978-981-16-0267-2
    DDC: 615
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  • 45
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    Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Medical genetics. ; Human physiology. ; Pharmacology. ; Medical Genetics. ; Human Physiology.
    Description / Table of Contents: Preface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.
    Abstract: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
    Type of Medium: Online Resource
    Pages: XII, 316 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031384370
    Series Statement: Handbook of Experimental Pharmacology, 279
    URL: https://doi.org/10.1007/978-3-031-38437-0
    DOI: 10.1007/978-3-031-38437-0
    DDC: 615
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  • 46
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    Edible Plants in Health and Diseases : Volume II : Phytochemical and Pharmacological Properties (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Food science. ; Medicinal chemistry. ; Pharmacology. ; Food Science. ; Medicinal Chemistry.
    Description / Table of Contents: 1 Zingiber officinale - Its Ethanobotanical Uses, Phytochemistry and Pharmacology -- 2 An Insight in to the Phytochemistry, Traditional uses and Pharmacology of Ziziphus spina-christi (L) Willd. (Sidr): An Edible wild plant of Arabian Peninsula -- 3 Traditional Uses, Phytochemistry and Pharmacological Profile of Salvadora persica Linn -- 4 Phytochemistry, Pharmacology and Applications of Ocimum sanctum (Tulsi) -- 5 Nigella sativa: Its Ethnobotany, Phytochemistry and Pharmacology -- 6 A Review on Ethnomedicinal, Phytochemistry and Pharmacological Activities of Rumex hastatus D. Don -- 7 Chemical Composition and Biological Uses of Crocus sativus L.(Saffron) -- 8 Positive Health Benefits of Saponins from Edible Legumes: Phytochemistry and Pharmacology -- 9 Taraxcum officinale: The Esculent Dandelion as Herbal Medicine -- 10 Arctium lappa: A Review on its Phytochemistry and Pharmacology -- 12 Cichorium intybus: A Comprehensive Review on its Pharmacological Activity and Phytochemistry -- 13 Phytochemical and Pharmacological Properties of Picrorhiza kurroa -- 14 Lady's Purse (Capsella bursa-pastoris L.)-Current perspective on its ethanopharmacological, therapeutic potential and phytochemistry -- 15 Ethnopharmaology, Phytochemistry and Biological Activities of Achillea millefolium: A Comprehensive Review -- 16 A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Verbascum thapsus -- 17 Acorus calamus - A Review on Its Phytochemical and Pharmacological Profile.
    Abstract: The book provides essential information on some of the promising edible medicinal plants and how these possess both nutritional as well as therapeutic value. The significance of the edible plants in traditional medicine and the importance of the distribution of their chemical constituents are discussed systematically concerning the role of these plants in ethnomedicine in different regions of the world. The current volume deals with the individual plants' phytochemical and pharmacological properties, emphasizing human health. The title would demonstrate the value of natural edible plants and introduce readers to state-of-the-art developments and trends in omics-driven research. This book is a single-source scientific reference to explore the specific factors that contribute to these potential health benefits and discuss how to maximize those potential benefits. Chemists, food technologists, pharmacologists, phytochemists, and all professionals involved with quality control and standardization will find in this book a valuable and updated basis for their work.
    Type of Medium: Online Resource
    Pages: IX, 522 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811649592
    URL: https://doi.org/10.1007/978-981-16-4959-2
    DOI: 10.1007/978-981-16-4959-2
    DDC: 615
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  • 47
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    The Kappa Opioid Receptor (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: From the contents. Preface.-Part I: Molecular aspects of KOR -- Part II: Preclinical research on pharmacology of KOR agonists and antagonists in animals -- Part III: KOR agonists and antagonists in clinical use and in past and present clinical trials.
    Abstract: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 577 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030890742
    Series Statement: Handbook of Experimental Pharmacology, 271
    URL: https://doi.org/10.1007/978-3-030-89074-2
    DOI: 10.1007/978-3-030-89074-2
    DDC: 615
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  • 48
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    Behavioral Neurobiology of GABAB Receptor Function (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Abstract: It has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.
    Type of Medium: Online Resource
    Pages: VII, 329 p. 70 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030913359
    Series Statement: Current Topics in Behavioral Neurosciences, 52
    URL: https://doi.org/10.1007/978-3-030-91335-9
    DOI: 10.1007/978-3-030-91335-9
    DDC: 615
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  • 49
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    Marine Biomaterials : Drug Delivery and Therapeutic Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Biomaterials. ; Pharmacy. ; Biomedical engineering. ; Pharmacology. ; Biomedical Research. ; Biomaterials. ; Pharmacy. ; Translational Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Marine biopolymers for oral delivery of drug -- Chapter 2. Marine polymer based nanocarriers for drug delivery application -- Chapter 3. Alginate: A promising biopolymer in drug delivery system -- Chapter 4. Chitosan Based Nanocomposite as Targeted drug delivery Carrier -- Chapter 5. Marine Biopolymer Based Oral In situ Gel: Drug Delivery Applications -- Chapter 6. Marine biopolymers for transdermal drug delivery -- Chapter 7. Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions -- Chapter 8. Marine collagen: promising biomaterial in delivery of therapeutics for cancer therapy -- Chapter 9. Chitosan based gel for ocular drug delivery. Chapter 10. Marine based biopolymers for central nervous system drug delivery -- Chapter 11. Marine Biopolymers Based Anticancer Drug Delivery Systems -- Chapter 12. Marine-Derived polysaccharides: prospects for future pharmaceuticals and drug delivery systems.
    Abstract: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 453 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647871
    URL: https://doi.org/10.1007/978-981-16-4787-1
    DOI: 10.1007/978-981-16-4787-1
    DDC: 615
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  • 50
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    Online Resource
    Parkinsonism and the Environment (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Neurosciences. ; Pharmacology. ; Neuroscience.
    Description / Table of Contents: Experimental evidence for pesticide contribution in the pathogenesis of Parkinsonism: an update -- Epidemiological evidence for pesticide involvement in the etiology of Parkinson’s Disease: current state of affairs?” -- Manganese induced Parkinsonism: cellular and molecular mechanisms -- Manganese overexposures in occupational and environmental settings and Parkinsonism: where do we stand -- Aberrant dopamine metabolism as a focal point in the mechanism of environmental contaminant-induced dopaminergic dysfunction -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Protein kinase C-delta (PKC-delta): a major molecular target for disparate dopaminergic toxicants -- Environmental contribution to redox dyshomeostasis in Parkinsonism.
    Abstract: “The book is comprised of individual reviews with the common goal of providing up-to-date state of the knowledge information on the role the environment plays in the pathogenesis of parkinsonism. The reviews focus on recent advances in the quest of deciphering the molecular and cellular mechanisms of parkinsonian dysfunction, highlight specific emerging dopaminergic toxicants and an alternative experimental model to study the link between environmental exposures and parkinsonism, and provide an update from epidemiological and experimental points of view related to the pesticide exposures and parkinsonism/Parkinson’s Disease association. Foremost experts in their respective fields are the senior authors on each chapter and the book fills a critical void that now exists as a book of similar nature has not been published in the last 15 years. Researchers and clinicians with an interest in Parkinson's Disease and related disorders, as well as toxicologists, graduate students, and the general public who are interested in the contribution of environmental factors to neurological dysfunction are among the readership for this book.”.
    Type of Medium: Online Resource
    Pages: V, 158 p. 14 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030874513
    Series Statement: Molecular and Integrative Toxicology,
    URL: https://doi.org/10.1007/978-3-030-87451-3
    DOI: 10.1007/978-3-030-87451-3
    DDC: 615
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  • 51
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    Ethnopharmacology and Drug Discovery for COVID-19: Anti-SARS-CoV-2 Agents from Herbal Medicines and Natural Products (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Natural products. ; Nanobiotechnology. ; Bioinformatics. ; Diseases Causes and theories of causation. ; Molecular biology. ; Pharmacology. ; Natural Products. ; Nanobiotechnology. ; Bioinformatics. ; Pathogenesis. ; Molecular Biology.
    Description / Table of Contents: 1. COVID-19: An overview of virology, mutations, pathology, epidemiology, diagnosis, preventions and treatments -- 2. The recent development of therapeutic strategies against COVID-19 -- 3. Plant immunoenhancers: Promising ethnopharmacological candidates for anti-SARS-CoV-2 activity -- 4. Herbal formulations in fighting against the SARS-CoV-2 infection -- 5. Rejuvenation of traditional medicine in the 21st century against SARS-CoV-2 -- 6. Traditional herbal medicines and their active constituents in combating SARS-CoV-2 infection -- 7. Antiviral phytocompounds against animal-to-human transmittable SARS-CoV-2 -- 8. Plants-derived bioactive compounds as potential ACE-2 inhibitors against SARS-CoV-2 infection -- 9. Insights into in silico methods to explore plant bioactive substances in combating SARS-CoV-2 -- 10. Dietary plants, spices and fruits in curbing SARS-CoV-2 virulence -- 11. Therapeutic potential of selected medicinal plants for neurological disorders after the infection of COVID-19 -- 12. Glycyrrhizae Radix et Rhizoma (Gan Cao) for the management of COVID-19 -- 13. COVID-19-induced kidney disease: Ethnopharmacological intervention to ameliorate kidney damage and improve kidney function -- 14. Phytochemicals and nutraceuticals targeting SARS-CoV-2: An in silico analysis -- 15. Therapeutic and prophylactic effects of plant derivatives against SARS-CoV-2 -- 16. Therapeutic potential of essential oils against SARS-CoV-2 infection -- 17. Antiviral properties of South Indian plants against SARS-CoV-2 -- 18. Immune-boosting plants used in Turkish folk medicine and their potential against COVID-19 -- 19. A comparison study of medicinal plants used against SARS-CoV-2 and those recommended against malaria in Africa -- 20. Exploring the potential antiviral properties of Nigella sativa L. against SARS-CoV-2: Mechanisms and prospects -- .
    Abstract: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".
    Type of Medium: Online Resource
    Pages: IX, 590 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819936649
    URL: https://doi.org/10.1007/978-981-99-3664-9
    DOI: 10.1007/978-981-99-3664-9
    DDC: 615
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    Novel Drug Targets With Traditional Herbal Medicines : Scientific and Clinical Evidence (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Medicinal chemistry. ; Natural products. ; Pharmacology. ; Toxicology. ; Pharmaceutics. ; Medicinal Chemistry. ; Natural Products.
    Description / Table of Contents: Chapter 1: Achillea biebersteinii Afan -- Chapter 2: Aesculus hippocastanum L. -- Chapter 3: Berberis crataegina DC. -- Chapter 4: Calendula officinalis L. -- Chapter 5: Camellia sinensis (L.) Kuntze -- Chapter 6: Capsella bursa-pastoris (L.) Medik. -- Chapter 7: Capsicum annuum L. -- Chapter 8: Cedrus libani A.Rich. -- Chapter 9: Chelidonium majus L. -- Chapter 10: Cichorium intybus L. -- Chapter 11: Cistus laurifolius L. -- Chapter 12: Coriandrum sativum L. -- Chapter 13: Cornus mas L. -- Chapter 14: Curcuma longa L..-Chapter 15: Cydonia oblonga Mill. -- Chapter 16: Cynara scolymus L. -- Chapter 17: Equisetum arvense L. -- Chapter 18: Foeniculum vulgare Mill. -- Chapter 19: Fraxiınus ornus L. -- Chapter 20: Fumaria officinalis L. -- Chapter 21: Helichrysum plicatum DC. -- Chapter 22: Hyoscyamus niger L. -- Chapter 23: Juglans regia L. -- Chapter 24: Laurus nobilis L. -- Chapter 25: Liquidambar orientalis Miller -- Chapter 26: Matricaria chamomilla L. -- Chapter 27: Melissa officinalis L. -- Chapter 28: Momordica charantia L. -- Chapter 29: Nigella sativa L. -- Chapter 30: Olea europaea L. -- Chapter 31: Papaver somniferum L. -- Chapter 32: Rheum ribes L. -- Chapter 33: Rosa canina L. -- Chapter 34: Rosmarinus officinalis L. -- Chapter 35: Silybum marianum L. Gaertn. -- Chapter 36: Urtica dioica L -- Chapter 37: Valeriana officinalis L. -- Chapter 38: Viburnum opulus L.
    Abstract: This book collects information about the most popular ethnomedicinal plants, which are common in Turkey and around the world. It presents the ethnopharmacological records, in vivo and in vitro studies, side effects, chemical compositions and clinical studies of these medicinal plants. Its special focus is on the novel drug targets for disease and their possible mechanisms of action. It covers botanical descriptions the status of the plants, and food or drug interactions including precautions and warnings about the plants and the available market products. It provides an explanation of recorded and known plant administration dosages. Also, the gap between the traditional practice and scientific/clinical evidences in the use of ethnomedicinal plant is acknowledged. It is well known that traditional knowledge of the use of the medicinal plants in therapy is an important resource for the discovery of novel treatment options and drug targets. The main purpose of this book is to draw attention to ethnomedicinal plant species. Data on the therapeutic potentials of these medicinal plants can now be accessed from a single source. It provides an important resource for future research opportunities for harnessing the full potential of these plants.
    Type of Medium: Online Resource
    Pages: XII, 588 p. 119 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031077531
    URL: https://doi.org/10.1007/978-3-031-07753-1
    DOI: 10.1007/978-3-031-07753-1
    DDC: 615
    Language: English
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    Online Resource
    Herb-Drug Combinations : A New Complementary Therapeutic Strategy (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Alternative medicine. ; Pharmacovigilance. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Complementary and Alternative Medicine. ; Drug Safety and Pharmacovigilance. ; Medicinal Chemistry.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Measuring Herb-drug interaction and Synergy -- Chapter 3. Herb-Herb and Food-drug interactions -- Chapter 4. Pharmacokinetic interactions in synergistic herb-drug combinations -- Chapter 5. Antagonistic Herb-drug interactions -- Chapter 6. Synergistic Herb-drug interactions against bacteria -- Chapter 7. Synergistic herb-drug interactions against tuberculosis -- Chapter 8. Synergistic herb-drug interactions against viral diseases -- Chapter 9. Synergistic herb interactions with cardiovascular drugs -- Chapter 10. Synergistic herb interactions with anticancer drugs -- Chapter 11. Synergistic herb interactions with antidiabetic drugs -- Chapter 12. Synergistic herb-drug interactions against obesity -- Chapter 13. Synergistic Herb-Drug Interactions in Neurological Disorders -- Chapter 14. Synergistic Herb-drug interactions with antifungal and antiparasitic agents -- Chapter 15. Computational methods to study herb-drug interactions -- Chapter 16. Regulations and guidelines involving synergistic plant-drug interactions -- Chapter 17. Clinical trials on synergistic herb-drug interactions -- Chapter 18. QFuture prospects on synergistic herb-drug interactions -- Chapter 19. Conclusion.
    Abstract: Plant extracts or their pure natural constituents have been used traditionally for thousands of years for treating diseases with considerable success in India and other Asian countries. In addition, they have also been used as complements or supplements with conventional medicine. This book discusses the latest research in the application of combination therapy, namely herbs and drugs, in the treatment of a range of communicable and non-communicable diseases to achieve a synergistic effect. This synergy may help in reducing the amount of drug, its toxicity, side effects, and development of resistance as well as improve its efficacy. The book also discusses the pharmacodynamic and pharmacokinetic parameters, experimental tools to determine the impact of combination, computational approaches to identify synergy, statistical analysis of data, and clinical and regulatory issues. The book is useful for researchers in the fields of pharmacology, pharmacy and medicinal chemistry and those working in pharmaceutical and nutraceutical industries. This book could open up new strategies to focus on multiple targets to combat complex diseases unlike the single targeted drugs that are being currently marketed by the pharmaceuticals industries.
    Type of Medium: Online Resource
    Pages: XV, 276 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811951251
    URL: https://doi.org/10.1007/978-981-19-5125-1
    DOI: 10.1007/978-981-19-5125-1
    DDC: 615
    Language: English
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    Online Resource
    Sex and Gender Effects in Pharmacology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Immunology. ; Neurology . ; Endocrinology. ; Cardiology. ; Pharmacology. ; Immunology. ; Neurology. ; Endocrinology. ; Cardiology.
    Description / Table of Contents: Part 1 Pharmacological Basic Principles -- The impact of sex and gender in medicine and pharmacology -- Sex differences in pharmacokinetics -- Clinical pharmacological considerations in transgender medicine -- Sex and gender differences in the pharmacology of the overactive urinary bladder -- Part 2 Pathologies of the Brain -- Sex differences in the evaluation and treatment of stroke -- Sex differences in pain and its treatment -- Therapeutics For Substance-Using Women: The Need To Elucidate Sex-Specific Targets For Better-Tailored Treatments -- Intersection of sex and depression: pathogenesis, presentation and treatments -- Biological and clinical implications of sex-specific differences in Alzheimer’s disease -- Part 3 Diabetes, metabolic diseases & cardiovascular risk -- Gender Differences In Cardiovascular Health: Hormonal Effects on Cardiovscular Risk And Management. - Sex Differences in Glucose Homeostasis -- Sex-gender-based differences in metabolic diseases -- Hypothalamic pituitary gonadal axis disorders impacting fertility in both sexes and the potential of kisspeptin-based therapies to treat them.
    Abstract: Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031426483
    Series Statement: Handbook of Experimental Pharmacology, 282
    URL: https://doi.org/10.1007/978-3-031-42648-3
    DOI: 10.1007/978-3-031-42648-3
    DDC: 615
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    Pharmacogenomics in Precision Medicine : From a Perspective of Ethnic Differences (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Pharmacology. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chapter 1. Introduction and Principles of Pharmacogenomics and Precision medicine -- Chapter 2. Pharmacogenomics in Cardiovascular Diseases -- Chapter 3. Pharmacogenomics of Antitumor Chemotherapeutic Agents -- Chapter 4. Pharmacogenomics of Antitumor Targeted Agent and Immunotherapy -- Chapter 5. Pharmacogenomics of Immunosuppressant -- Chapter 6. Pharmacogenomics of Psychiatric drugs -- Chapter 7. Pharmacogenomics of Anti-Infective Agents -- Chapter 8. Pharmacogenomics of Antithrombotic drugs -- Chapter 9. Pharmacogenomics in Therapeutic Drug Monitoring -- Chapter 10. Pharmacomicrobiomics -- Chapter 11. Genotyping technology in Pharmacogenomics -- Chapter 12. The Ethical, Legal and Regulatory Issues Associated with Pharmacogenomics -- Chapter 13. Cost-effectiveness of pharmacogenetic-guided treatment -- Chapter 14. Application of pharmacogenomics in drug discovery and development -- Chapter 15. Barriers and Solutions in Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine.
    Abstract: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. 33 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538957
    URL: https://doi.org/10.1007/978-981-15-3895-7
    DOI: 10.1007/978-981-15-3895-7
    DDC: 615
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    Mushrooms with Therapeutic Potentials : Recent Advances in Research and Development (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Therapeutics. ; Internal medicine. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Pharmacology. ; Therapeutics. ; Internal Medicine. ; Fungi. ; Medical Microbiology.
    Description / Table of Contents: Chapter 1. Mushrooms as Promising Therapeutic Resources: Review and Future Perspectives -- Chapter 2. Medicinal Mushrooms for Respiratory Health -- Chapter 3. Therapeutic and Prophylactic Potential of Medicinal Mushrooms in COVID-19 -- Chapter 4. Influences of Edible Mushrooms on Dynamic and Diversity of Gut Microbiota -- Chapter 5. Mushrooms – From Traditional Remedies to the Modern Therapeutics -- Chapter 6. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health -- Chapter 7. Anticancer Potential of Ganoderma lucidum and İts Relevant Modes of Action -- Chapter 8. Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias -- Chapter 9. Potential of Medicinal Mushrooms in Human Health and Welfare: An Overview -- Chapter 10. Mycotherapeutics Reduce Nephrotoxicity and Renal Diseases -- Chapter 11. Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms -- Chapter 12. Cordyceps militaris (L.): Medicinal aspects in terms of ethnobotanical and pharmacological perspectives -- Chapter 13. Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection -- Chapter 14. Biological Activities of Some Edible Mushrooms -- Chapter 15. Nephroprotective Effects of Four Ganoderma Species -- Chapter 16. Mechanisms Involved in Edible Mushrooms' Health Beneficial Effects -- Chapter 17. Mycotherapy (Medicinal Mushrooms) as a Potential Treatment for Epilepsy -- Chapter 18. Natural vs. Synthetic Psilocybin: The Same or Completely Different? -- Chapter 19. Preventative and Curative Properties of Reishi and Maitake Mushrooms in Cancer.
    Abstract: The book presents new and novel perceptions about ailments alleviating the effects of several mushroom species. Also, the book highlights the curative role of medicinal mushrooms on some peripheral and central diseases. Various chapters in the book (primarily reviews) have been dedicated to providing the therapeutic efficacy of mushrooms against respiratory illnesses, gut microbiota, COVID-19, dementia, epilepsy, mental ailments, cancers, cardiovascular, kidney-related diseases, and other common pathologies. Thus, medicinal mushrooms are current and future consumable healthcare products that usually exhibit nourishing properties and possess prophylactic and therapeutic values with minimal adverse effects and contraindications. The book focuses on Sustainable Development Goal (SDG 3) to promote healthy lives and well-being for all. Medical, pharmacy, nursing, and CAM (complementary and alternative medicine) students, practitioners, scholars, researchers, other healthcare professionals, and general readers are this book’s potential audience. The book can be adopted as a textbook for undergraduate and graduate courses so that the therapeutic potential of mushrooms can reach a wider audience. This book strives to create a new resource for the future use of medicinal mushrooms in various disorders. .
    Type of Medium: Online Resource
    Pages: XX, 509 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995507
    URL: https://doi.org/10.1007/978-981-19-9550-7
    DOI: 10.1007/978-981-19-9550-7
    DDC: 615
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    Endolysosomal Voltage-Dependent Cation Channels (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Physiology. ; Cytology. ; Life sciences. ; Pharmacology. ; Physiology. ; Cell Biology. ; Life Sciences.
    Description / Table of Contents: Part I: Physiological Functions of Endo-lysosomal Cation Channels -- NAADP-Mediated Ca2+ Signalling -- NAADP-Dependent TPC Current -- NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis -- TPC Functions in the Immune System -- Lysosomal Ion Channels and Lysosome– 1 Organelle Interactions -- TRPML1 and TFEB, an Intimate Affair -- Lysosomal Potassium Channels -- Part II Structure and Composition of TPC and TRPML Channels -- Structure and Function of Plant and Mammalian TPC Channels -- A Structural Overview of TRPML1 and the TRPML Family -- Endo-Lysosomal Two-Pore Channels and Their Protein Partners -- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels -- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels -- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels -- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels -- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.
    Abstract: This book covers the molecular structures and the cellular and in vivo function of endosomes and lysosomes, i.e. intracellular vesicles which are involved in many cellular processes such as endocytosis, intracellular trafficking, degradation of material from inside (e.g. autophagy) and outside the cell as well as exocytosis. Membranes of endolysosomal organelles contain an amazing number and diversity of ion channels. These ion channels are the topic of the present book that focusses on describing the structure, the biophysical properties, physiological functions of endolysosomal ion channels at the molecular, cellular and in vivo level. .
    Type of Medium: Online Resource
    Pages: X, 304 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031315237
    Series Statement: Handbook of Experimental Pharmacology, 278
    URL: https://doi.org/10.1007/978-3-031-31523-7
    DOI: 10.1007/978-3-031-31523-7
    DDC: 615
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    Nanotechnology in Skin, Soft Tissue, and Bone Infections (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical microbiology. ; Dermatology. ; Orthopedic surgery. ; Pharmacology. ; Medical Microbiology. ; Dermatology. ; Surgical Orthopedics.
    Description / Table of Contents: Part 1-Nanotechnology in Skin Infections -- Atopic dermatitis and current trends in pharmacological treatment - a nanoparticulate approach -- Acne vulgaris - recent trends on pharmacological and nanotechnological approaches in therapeutics -- Nitric oxide nanoparticles on skin infections: Current State and Future Prospects -- Metal Nanoparticles Based Antibacterial Nanocomposites for Skin Infections -- Combination therapy using metal nanoparticles for skin infection -- Applications of nanometals in cutaneous infections -- Antifungal nanotherapy: a novel approach to combat superficial fungal infections -- Biocompatible polymers for skin Nanomedicines -- Part 2-Nanotechnology on Soft-Tissue Infections -- Nanotechnological approach to manage diabetic foot ulcer -- Metal nanoparticles in wound infections -- Advances in nanomedicine for burn wound infection treatment -- Applications of chitosan in formulation of novel antibacterial agents and wound dressings -- Polymeric nanocomposites for skin and soft tissues -- Nanoformulations of polyphenols for the treatment of soft tissues infections -- Cutting Edge Nanotechnologies for Targeting Liver Disorders -- NanoCurcumin compounds formulations: Perspectives in skin and soft tissues infections -- Nanobiotechnology strategies for the treatment tegumentary and visceral leishmaniases, and emergence resistance -- Part 3-Nanotechnology in Bone Infections -- Artificial Scaffolds for Bone Tissue Engineering -- The bone biology and the nanotechnology for bone infections and bone engineering -- Part 4-Nanotechnology and Toxicity -- Genotoxicity studies of Silver Nanoparticles in in vivo and in vitro models.
    Abstract: The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.
    Type of Medium: Online Resource
    Pages: XI, 285 p. 39 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030351472
    URL: https://doi.org/10.1007/978-3-030-35147-2
    DOI: 10.1007/978-3-030-35147-2
    DDC: 615
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    Lipid Signaling in Human Diseases (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cancer. ; Clinical biochemistry. ; Pharmacology. ; Cancer Biology. ; Medical Biochemistry.
    Description / Table of Contents: Part 1. New Roles for Sphingolipid Signaling and Cell Function -- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma -- 2. Exploring the Therapeutic Landscape of Sphingomyelinases -- 3. Sphingosine kinases as druggable targets -- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease -- 4. Prospects for PLD inhibition in cancer and thrombotic disease -- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer -- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease -- Part 3. Lipid Kinases and Novel Regulatory Pathways -- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors -- 8. Functions of Nuclear Polyphosphoinositides -- Part 4. Bioactive Lipids in Health and Disease -- 9. Platelet-Activating Factor as an Effector for Environmental Stressors -- 10. Phospholipase D and Choline Metabolism -- Part 5- Lipids and Membrane Microdomains -- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology -- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs -- Part 6. Nuclear Trafficking of Lipids -- 13. Inositide-Dependent Nuclear Signalling in Health and Disease -- 14. Lipids in Exosome Biology.
    Abstract: Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. .
    Type of Medium: Online Resource
    Pages: XIV, 336 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336684
    Series Statement: Handbook of Experimental Pharmacology, 259
    URL: https://doi.org/10.1007/978-3-030-33668-4
    DOI: 10.1007/978-3-030-33668-4
    DDC: 615
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    Early-life Environmental Exposure and Disease : Facts and Perspectives (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Gynecology . ; Environmental health. ; Pharmacology. ; Gynecology. ; Environmental Health.
    Description / Table of Contents: Preface -- Environmental Exposure Measurements and Evaluations -- Prenatal Smoke Exposure and Child Health -- Prenatal Pesticide Exposure and Child Health -- Prenatal Metal Exposure and Child Health -- Prenatal Stress and Child Health -- The Special Vulnerabilities of Child to Environmental Hazards -- Early-life Environmental Influences on Growth -- Early-life Environmental Influences on Neural Development -- Early-life Environmental Influences on Allergic Diseases -- Early-life Social and Economic Adversities on Health -- Endocrine Disrupting Chemical Exposure and Later-onset Diseases -- Paternal Specific Exposure and Child Health -- Molecular Mechanism of Early-life Chemical Exposure Induced Harmful Effects -- Transgenerational Effects on Developmental Origins of Diseases.
    Abstract: This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring’s health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health. .
    Type of Medium: Online Resource
    Pages: XVI, 239 p. 22 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811537974
    URL: https://doi.org/10.1007/978-981-15-3797-4
    DOI: 10.1007/978-981-15-3797-4
    DDC: 615
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    Forskolin : Natural Sources, Pharmacology and Biotechnology (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Medicinal chemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Medicinal Chemistry. ; Pharmacy.
    Description / Table of Contents: Chapter 1. Coleus forskohlii – A multipurpose medicinal plant -- Chapter 2. Botany of Coleus forskohlii -- Chapter 3. Traditional Medicinal Uses and Pharmacognosy of Coleus forskohlii -- Chapter 4. Chemistry of Coleus forskohlii Briq. -- Chapter 5. Pharmacology of Coleus forskohlii and Forskolin -- Chapter 6. Micropropagation of Coleus forskohlii -- Chapter 7. In Vitro Production of Forskolin -- Chapter 8. Assessment of Coleus forskohlii Genetic Diversity Using Molecular Markers -- Chapter 9. Endophytes for the enhanced growth of Coleus forskohlii and enhanced production of Forskolin -- Chapter 10. Propagation Methods of Coleus forskohlii -- Chapter 11. Success stories and Trade and Commerce of Coleus forskohlii.
    Abstract: This monograph compiles updated information about forskolin, a labdane diterpene that is produced by the Coleus plant. Forskolin has a large number of practical uses and the book delves into the various aspects of this chemical. It includes topics such as the botanical source of forskolin and the cultivation of Coleus forskohlii, source. It also covers the biosynthetic pathways in natural sources and also through different biotechnological applications. Chapters include the potential and products in the Forskolin market. The book also covers the methods for enhanced production of forskolin from natural sources and through tissue culture methods for improvement of the plant for higher content of forskolin. It discusses the role of endophytes in the production of forskolin. The book is useful for students and researchers in the field of botany, pharmacology and biochemistry. It also serves scientists in various pharmaceutical industries.
    Type of Medium: Online Resource
    Pages: XI, 177 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811965210
    URL: https://doi.org/10.1007/978-981-19-6521-0
    DOI: 10.1007/978-981-19-6521-0
    DDC: 615
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    The Science and Business of Drug Discovery : Demystifying the Jargon (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacovigilance. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Drug Safety and Pharmacovigilance. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: Introduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline – discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline – clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters.
    Abstract: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .
    Type of Medium: Online Resource
    Pages: XVII, 402 p. 102 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030578145
    URL: https://doi.org/10.1007/978-3-030-57814-5
    DOI: 10.1007/978-3-030-57814-5
    DDC: 615
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    Interpenetrating Polymer Network: Biomedical Applications (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicinal chemistry. ; Polymers. ; Biotechnology. ; Pharmacology. ; Medicinal Chemistry. ; Polymers. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Interpenetrating Polymer Network in Microparticulate Systems: Drug Delivery and Biomedical Application -- Chapter 2. Interpenetrating Polymer Network (IPN) Nanoparticles for Drug Delivery Applications -- Chapter 3. Fabrication Technology of Chitosan-Based IPN: Drug Delivery Application -- Chapter 4. Alginate based Interpenetrating Network Carriers for Biomedical Applications -- Chapter 5. pH Sensed Interpenetrating Polymeric Network: Application in drug delivery -- Chapter 6. IPN Dendrimers in Drug Delivery -- Chapter 7. BioproteinBased IPN Nanoparticles as Potential Vehicles for Anticancer Drug Delivery: Fabrication Technology -- Chapter 8. Semi-IPN systems for drug delivery -- Chapter 9. IPN Systems for Cancer Therapy -- Chapter 10. Semi-interpenetrating networks based on (meth)acrylate, itaconic acid and poly(vinyl pyrrolidone) hydrogels for biomedical applications -- Chapter 11. Biomedical Applications of Interpenetrating Polymer Network Gels -- Chapter 12. Bio-Nanocomposite IPN for Biomedical Application.-.
    Abstract: The book focuses on novel interpenetrating polymer network (IPN)/semi-IPN technologies for drug delivery and biomedical applications. The dynamism of the design and development of interpenetrating network polymers is based on their ability to provide free volume for the easy encapsulation of drugs in the three-dimensional network structure obtained by cross-linking two or more polymer networks. Natural polymer-based IPNs can deliver drugs at a controlled rate over an extended period of time, while novel IPNs ensure better mechanical strength and sustained/ controlled drug-delivery properties. This book presents an overview of the use of this technology to fabricate nanomedicine, hydrogels, nanoparticles, and microparticles, thereby unlocking IPN’s potential in the area of drug delivery and biomedical engineering. It also discusses applications of IPN systems in cancer therapy and tissue engineering, and describes the various IPN systems and their wide usage and applications in drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 59 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811502835
    URL: https://doi.org/10.1007/978-981-15-0283-5
    DOI: 10.1007/978-981-15-0283-5
    DDC: 615
    Language: English
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    Model Organisms to Study Biological Activities and Toxicity of Nanoparticles (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Nanotechnology. ; Biology Technique. ; Pharmacology. ; Human Physiology. ; Nanotechnology. ; Experimental Organisms.
    Description / Table of Contents: Chapter 1. Nanotechnology : Application in biology and medicine -- Chapter 2. Biological activities of nanoparticles and mechanism of action -- Chapter 3. Application of nanoparticles in Drug delivery -- Chapter 4. Antimicrobial activity of metallic nanoparticles using prokaryotic model organisms -- Chapter 5. Modelling nanoparticles parameters for antibacterial activities -- Chapter 6. Saccharomyces cerevisiae as model organism to study biological activities of nanoparticles -- Chapter 7. Investigation of Biological activities of Nanoparticles using Cell Lines -- Chapter 8. Caenorhabditis elegans: a model organism to decipher biological activities of nanoparticles -- Chapter 9. Zebra fish model system to investigate biological activities of nanoparticles -- Chapter 10. Drosophila melanogaster - A model organism to understand biological activities of nanoparticles -- Chapter 11. Understanding the biological activities of nanoparticles using murine models -- Chapter 12. Insecticidal activity nanoparticles and mechanism of action -- Chapter 13. Routes of Exposures and Toxicity of Nanoparticles -- Chapter 14. Toxicological evaluation of nanoparticles using prokaryotic model organisms -- Chapter 15. Evaluation of Toxicity Nanoparticles using Cell lines -- Chapter 16. Saccharomyces cerevisiae : Model organism to evaluate nanoparticles toxicity -- Chapter 17. Caenorhabditis elegans: Evaluation of nanoparticle toxicity -- Chapter 18. Zebra fish: A laboratory model to evaluate Nanoparticle Toxicity -- Chapter 19. Evaluation of toxicity of nanoparticles using Brine Shrimp -- Chapter 20. Drosophila Model to Decipher the Toxicity of Nanoparticles -- Chapter 21. Murine models to understand the toxicity of nanoparticles -- Chapter 22. Challenges and future perspectives of Nanotoxicology.
    Abstract: This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
    Type of Medium: Online Resource
    Pages: XIII, 466 p. 64 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811517020
    URL: https://doi.org/10.1007/978-981-15-1702-0
    DOI: 10.1007/978-981-15-1702-0
    DDC: 615
    Language: English
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    Computer-Aided Drug Design (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Bioinformatics. ; Proteins. ; Pharmacology. ; Computational and Systems Biology. ; Proteins.
    Description / Table of Contents: 1 Computational Approaches in Drug Discovery and Design -- 2 Molecular Modeling of Proteins: Methods, Recent Advances and Future Prospects -- 3 Cavity/Binding Site Prediction Approaches, and their Applications -- 4 Role of ADMET Tools in Current Scenario; Application and Limitations -- 5 Database Resources for Drug Discovery -- 6 Molecular Docking and Structure-Based Drug Design -- 7 Molecular Dynamics Simulation of Protein and Protein-Ligand Complexes -- 8 Computational Approaches for Drug Target Identification -- 9 Computational Screening Techniques for Lead Design and Development -- 10 Advances in Pharmacophore Modeling and its Role in Drug Designing -- 11 In Silico Designing of Vaccines: Methods, Tools and Their Limitations -- 12 Machine learning Approaches to Rational Drug Design. .
    Abstract: This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
    Type of Medium: Online Resource
    Pages: XIII, 306 p. 80 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811568152
    URL: https://doi.org/10.1007/978-981-15-6815-2
    DOI: 10.1007/978-981-15-6815-2
    DDC: 615
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    Macro, Micro, and Nano-Biosensors : Potential Applications and Possible Limitations (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Biomaterials. ; Life sciences. ; Pharmaceutical chemistry. ; Pharmacology. ; Biomaterials. ; Life Sciences. ; Pharmaceutics.
    Description / Table of Contents: Macro-, micro- and nanosensors based on biological / chemical materials -- Bactericidal, fungicidal and immunomodulating activity of nano-surfaces -- Enzymatic Tissue Biotests (MAO and AChE biotests) and Bioindicators -- Is it possible to detect less than one bacterial cell? -- SERS for bacterial, virus and protein bio-sensing -- Biosensors for virus detection -- Specific immobilization of rotaviruses for atomic force microscopy with using Langmuir antibody films based on amphiphilic polyelectrolytes -- Fluorimetric and SERS sensor systems for diagnostics and monitoring of catecholamines-dependent diseases -- Enhanced sensitivity rapid tests for the detection of sepsis marker procalcitonin -- Analytical capabilities of some biosensors for the determination of drugs -- Electrochemical DNA sensors based on nanostructured polymeric materials for determination of antitumor drugs -- Variants of amperometric biosensors in the determination of some micotoxins: analytical capabilities -- New class of diagnostic systems based on polyelectrolyte microcapsules for urea detection -- Bioluminescent nano- and micro-biosensing elements for detection of organophosphorous compounds -- Nano- and microelectrochemical biosensors for determining blood glucose -- Micro-Electrochemical SMBG Biosensor Chip Design Development for Sustainable Mass Production based on the Strategic Platform Patent Map -- Biological Fuel Cells: Applications in Health Service and Ecology -- Recent Trends in Fabrication and Applications of Wearable Bioelectronics for Early-Stage Disease Monitoring and Diagnosis -- Self-powered biosensors in medicine and ecology -- Self-powered implantable biosensors – a review of recent advancements and future perspectives.
    Abstract: This book includes an international group of researchers who present the latest achievements in the field of enzyme, immune system, and microbial and nano-biosensors. It highlights the experimental evidence for formation of biological fuel cells (BFCs)-which has a dual purpose – as a device that produces electricity and the systems which produce it simultaneously cleaning up the environment from polluting organic compounds. Considering the work in the field of macro, micro and nano-biosensors, considerable attention is paid to the use of nanomaterials for the modification of working electrodes. Nanomaterials in some cases can significantly improve the parameters of analytical systems. Readers will be interested in the projection of the presented theoretical and experimental materials in the field of practical application of modern analytical developments. The presented results in many cases imply the possibility of using the created models of macro, micro and nano-biosensors, and biofuel elements in the field of health, and protection/restoration of the environment. It includes information about all existing types of transducers of signals in biosensors – electrochemical, optical and quantum-optics, thermoelectric, data of atomic force microscopy, piezoelectric, and more. On the basis of these principles, descriptions are given about the functioning of macro, micro and nano- biosensors for the detection of compounds used in medicine, detection of compounds that clog the environment, and thus affect human health, for compounds that are potentially the basis for the production of drugs, for the selection of compounds that have medicinal activity, for immunodetection, and to assess the quality of food. These questions form the basis of research carried out in the field of biosensors in the world. Since the described models of biosensors have high sensitivity, high measurement speed and selectivity, the described results attract the attention of both the ordinary reader and business class specialists who create and implement analytical technologies. This book is very useful for researchers in life sciences, chemical sciences, physics, and engineering. In addition, it will be useful for the persons working in industry. Advanced technologies specialists will be attracted by the novelty of the proposed solutions and their relevance and ease of implementation. Since the studies contain sections describing the parameters of different biosensors, BFCs, they are easily navigated into assessing the effectiveness of the practical use of the proposed device. The relevant sections indicate such characteristics as detection ranges, life span, type of biological material used, the method of formation of the bio-receptor part. These parameters are of interest to both developers of new models of biosensors and BFC, and their manufacturers.
    Type of Medium: Online Resource
    Pages: XVIII, 415 p. 122 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030554903
    URL: https://doi.org/10.1007/978-3-030-55490-3
    DOI: 10.1007/978-3-030-55490-3
    DDC: 615
    Language: English
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    Botulinum Toxin Therapy (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Psychiatry. ; Neurosciences. ; Pharmacology. ; Psychiatry. ; Neuroscience.
    Description / Table of Contents: Part 1. Basic Science -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- Botulinum Neurotoxins: Mechanism of Action -- Manufacturing and Clinical Formulations of Botulinum Neurotoxins -- Novel Native and Engineered Botulinum Neurotoxins -- Part 2. Clinical Practice -- Clinical Pharmacology of Botulinum Toxin Drugs -- The Use of Botulinum Toxin for Treatment of the Dystonias -- The Use of Botulinum Toxin for Treatment of Spasticity -- Use of Botulinum Toxin in Ophthalmology -- Hyperhidrosis and Aesthetics -- Use of Botulinum Toxin in Genitourinary System -- Gastrointestinal Uses of Botulinum Toxin -- The Use of Botulinum Toxin in the Management of Headache Disorders -- Botulinum Toxin and Pain -- The Use of Botulinum Toxin for Treatment of Depression.
    Abstract: In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663063
    Series Statement: Handbook of Experimental Pharmacology, 263
    URL: https://doi.org/10.1007/978-3-030-66306-3
    DOI: 10.1007/978-3-030-66306-3
    DDC: 615
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    Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Human Physiology. ; Biotechnology. ; Biomedical Research.
    Description / Table of Contents: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial -- Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer -- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial -- Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis -- Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits -- Updated review on the role of curcumin in gastrointestinal cancers -- Curcumin can bind and interact with CRP: an in silico study -- Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates -- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial -- Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial -- Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19 -- Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress -- Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review -- Plants with anti-addictive potential -- Use of Plant-Derived Natural Products in Sleep Disturbances -- The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review -- Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health -- Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease -- Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats -- Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine -- The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review -- Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review -- Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM) -- Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review -- Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review -- Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review -- Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology -- Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial -- In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.
    Abstract: Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal of this contributed volume is to present a comprehensive collection on most important therapeutic aspects of plant-derived natural products and their molecular mechanisms of action.
    Type of Medium: Online Resource
    Pages: X, 603 p. 814 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030648725
    Series Statement: Advances in Experimental Medicine and Biology, 1308
    URL: https://doi.org/10.1007/978-3-030-64872-5
    DOI: 10.1007/978-3-030-64872-5
    DDC: 615
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    Protein Instability at Interfaces During Drug Product Development : Fundamental Understanding, Evaluation, and Mitigation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: 1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives. .
    Abstract: Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas. .
    Type of Medium: Online Resource
    Pages: VIII, 338 p. 58 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571771
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 43
    URL: https://doi.org/10.1007/978-3-030-57177-1
    DOI: 10.1007/978-3-030-57177-1
    DDC: 615
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    Biotechnology of Anti-diabetic Medicinal Plants (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Biotechnology. ; Metabolism, Secondary. ; Plants. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy. ; Biotechnology. ; Plant Secondary Metabolism.
    Description / Table of Contents: 1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa -- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds -- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects -- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant -- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana -- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions -- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities -- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production -- 9 Saffron: A prized herb with therapeutic potential against diabetes -- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors -- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future -- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants -- 13 Production of anti-diabetic lignans in flax cell cultures -- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect -- 15 Cryopreservation of Anti-diabetic plants. .
    Abstract: This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.
    Type of Medium: Online Resource
    Pages: XVI, 469 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811635298
    URL: https://doi.org/10.1007/978-981-16-3529-8
    DOI: 10.1007/978-981-16-3529-8
    DDC: 615
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    Polymeric Micelles: Principles, Perspectives and Practices (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery.
    Description / Table of Contents: 1. Synthesis, self-assembly and functional chemistry of Amphiphilic block copolymers -- 2. Advances in polymer optimisation for enhanced drug delivery -- 3. Dynamics of Micelle Formation -- 4. Types of Polymeric Micelles for Controlled Drug Release -- 5. Drug Solubilization and Drug Release from Polymeric Micelles -- 6. Physical and Analytical Techniques used for the Characterization of Polymeric Micelles -- 7.Stimuli-sensitive polymeric micelles for biomedical applications -- 8.Nucleic acid-based micellar therapy for the treatment of different diseases -- 9. Polymeric micelles in the delivery of therapeutic phytoconstituents -- 10. Diagnostic applications of surface-engineered polymeric micelles -- 11. Ligand conjugated polymeric micelles for targeted delivery of drug payloads in cancer therapy -- 12. Polymeric Micelles in the Delivery of Proteins -- 13. Regulatory aspects for polymeric micelles -- 14. Toxicological and regulatory challenges in design and development of polymeric micelles -- 15. Stability of polymeric micelles and their regulatory status.
    Abstract: This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
    Type of Medium: Online Resource
    Pages: XV, 294 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903610
    URL: https://doi.org/10.1007/978-981-99-0361-0
    DOI: 10.1007/978-981-99-0361-0
    DDC: 615
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    Winning Grants (2023)
    Cham :Springer Nature Switzerland :
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    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: Preface -- Abbreviations -- Chapter 1 – Why you need this book and why I wrote it -- Chapter 2 – What you need to do before you write a grant -- Chapter 3 – The idea -- Chapter 4 – Go solo or collaborate? -- Chapter 5 – What the entrepreneur needs to know -- Chapter 6 – The grant package -- Chapter 7 – The main event – writing it -- Chapter 8 – Edit / Polish / Shine / Repeat -- Chapter 9 – Are you ready to submit it? -- Chapter 10 - Post submission steps to win the grant -- Afterthoughts -- Index -- About the Author.
    Abstract: As an academic or a small business owner, you will need to write grants at some point in your career. Writing them though is not enough, what you also need to know is how to win grants. Much has been written about writing grants, the mysterious special ability called ‘grantsmanship’, so it occurred to me that there is a need to come at this differently and spill the beans. The difficulty in getting a grant, in particular an NIH grant like an R01 in the USA is often described, it is competitive and gets tougher every year. Your proposal therefore must stand out, it must connect with the reviewers. This is true for all types of grants, give the reviewer what they want always. But also, you need to connect to the program officer, the committee that ultimately makes funding decisions and you must take care of a myriad of other details outside of the main event which is describing the “science”. This means you cannot rely on just out-writing the competition, it is more than that as you have to out-think, out-strategize and out-schmooze them. If you have been continually funded for decades that is terrific, but if you want to keep being funded there is no guarantee what got you there will keep you there. What was a hot technology 4-5 years ago is not the new thing anymore, you will need to do something different, but what? You therefore need to not only think about writing great grants, you need to put it into practice and win them. Having written and won grants from the NIH and DOD over the past 17 years (and longer by the time you read this) I possess a valuable perspective. Each grant and study section will be different. Whether a big or small grant it does not seem to make a difference the reviewers will critique your efforts, they may not like it, they may reject your ideas or they may love it. You have some small degree of control until the proposal leaves your hands or more correctly you click ‘submit’. You will need to differentiate your grant from the hundreds of others in many ways, but you cannot change who you are, your history so how you describe yourself and team will also have an impact. You could spend hundreds of hours on your proposal or just a day and the outcome might still be the same. This small book is a summary of my own personal experiences and will provide some advice that will help you learn how to do a better job of winning grants. This book is written by a scientist who writes the grants and develops commercial products; Provides a unique perspective on what you need to write better grants; Teaches you how to continually win grants; This book provides examples from the authors own grant applications; The reader will be inspired to start a company to win small business grants.
    Type of Medium: Online Resource
    Pages: XIX, 106 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031275166
    Series Statement: AAPS Introductions in the Pharmaceutical Sciences, 17
    URL: https://doi.org/10.1007/978-3-031-27516-6
    DOI: 10.1007/978-3-031-27516-6
    DDC: 615
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    Edible Plants in Health and Diseases : Volume 1 : Cultural, Practical and Economic Value (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Food science. ; Medicinal chemistry. ; Pharmacology. ; Food Science. ; Medicinal Chemistry.
    Description / Table of Contents: Chapter 1. The Folklore Uses and Economic Importance of Some Selected Edible Medicinal, Plants Native to Oman. A Brief Review -- Chapter 2. Socio-economic Importance of Some Promising Edible Medicinal Plants from (Rajasthan) India -- Chapter 3. Traditional and Economic Valuation of Edible Plants Used for Treatment of Diabetes -- Chapter 4. Cultural and Socio-economic Perspective of Some Promising Edible Plants from Northern Pakistan -- Chapter 5. Medicinal Plants and their Contribution In Socio-Economic Upliftment of the Household in Gurez Valley (J&K) -- Chapter 6. Comprehensive overview of Some Edible Medicinal Plants from Kashmir Valley – Cultural, Economic and Pharmacological Importance -- Chapter 7. High Altitude Edible Plants: A Great Resource for Human Health and their Socio-economic Significance -- Chapter 8. Cultural, Practical and Socio-economic Importance of Edible Medicinal Plants Native to Central India -- Chapter 9. Cultural and Scio-economic Perspective of Some Promising Edible Plants from Uttarakhand Himalaya. Chapter 10. Edible Medicinal Plants from Chhattisgarh (India) and their Economic Significance -- Chapter 11. Ethno-botanical and Economic Significance of Edible Plants Used as Food by Tribal Community of the Western Himalaya -- Chapter 12. Cultural, Practical and Economic Value of Edible Plants used by Mizo Tribes of Mizoram -- Chapter 13. Isoflavones of Soy: Chemistry and Health Benefits -- Chapter 14. Account of Some Important Edible Medicinal Plants and their Socio-Economic Importance -- Chapter 15. Cultural, Practical and Economic Significance of Some Edible Medicinal Plants from Gilgit-Baltistan Pakistan.
    Abstract: The book provides significant information on some of the promising edible medicinal plants and how these possess both nutritive as well as medicinal value. The significance of these edible plants in traditional medicine, their distribution in different regions and the importance of their chemical constituents are discussed systematically concerning the role of these plants in ethnomedicine in different regions of the world. The current volume focuses on the economic and culturally important medicinal uses of edible plants and a detailed survey of the literature on scientific researches of pharmacognostical characteristics, traditional uses, scientific validation, and phytochemical composition, and pharmacological activities. This book is a single-source scientific reference to explore the specific factors that contribute to these potential health benefits, as well as discussing how to maximize those potential benefits. Chemists, food technologists, pharmacologists, phytochemists as well as all professionals involved with quality control and standardization will find in this book a valuable and updated basis for their work.
    Type of Medium: Online Resource
    Pages: XI, 388 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811648809
    URL: https://doi.org/10.1007/978-981-16-4880-9
    DOI: 10.1007/978-981-16-4880-9
    DDC: 615
    Language: English
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    The Mesentery and Inflammation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Medical genetics. ; Clinical health psychology. ; Human physiology. ; Pharmacology. ; Neuroscience. ; Psychiatry. ; Medical Genetics. ; Health Psychology. ; Human Physiology.
    Description / Table of Contents: Introduction -- Development, anatomy and histology of the mesentery -- The mesenteric intersitium -- Mesnteric organ lymphatics -- The mesentery as an immunological organ -- Bacterial translocation to the mesentery -- The microbiome of mesenteric lymh nodes -- Mesenteric Adenopathy and adenitis -- The effects of mesenteric inflammation on the intestine -- The mesentery as an ADME organ -- Targteing the mesentery using surgery -- Future directions.
    Abstract: The volume summarizes the most recent advances in our understanding of the mesentery and explains the how these are important in inflammation. It comprises a series of state of the art chapters by leading authorities in each area. It explains how recent advances in our understanding of the mesenteric organ, have advanced the diagnosis and treatment abdominal and systemic conditions including cancer, inflammatory bowel disease and endocrine conditions such as diabetes, and circulatory disorders such as atherosclerosis. .
    Type of Medium: Online Resource
    Pages: X, 226 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031177743
    Series Statement: Progress in Inflammation Research, 90
    URL: https://doi.org/10.1007/978-3-031-17774-3
    DOI: 10.1007/978-3-031-17774-3
    DDC: 615
    Language: English
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  • 75
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    Online Resource
    Marine Biomaterials : Therapeutic Potential (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Therapeutics. ; Pharmaceutical chemistry. ; Biomaterials. ; Pharmacology. ; Translational Research. ; Therapeutics. ; Pharmaceutics. ; Biomaterials.
    Description / Table of Contents: Chapter 1. Marine biomaterials: resources, categories and applications -- Chapter 2. Cross-linked marine biopolymers for delivery of therapeutics -- Chapter 3. Chitosan and Chitooligosaccharides: Preparation, Characteristics and their Potential Application as Therapeutic Agents -- Chapter 4. Marine collagen for delivery of therapeutics -- Chapter 5. Marine Biopolymers for delivery of Gene -- Chapter 6. Hydrogel scaffolds based on alginate, gelatin, and 2-hydroxyethyl methacrylate for tissue regeneration -- Chapter 7. Tissue Engineering application of marine based materials -- Chapter 8. Marine biopolymer for theranostic applications -- Chapter 9. Marine biomaterials as carrier of drugs/biomolecules for management of bone disorders -- Chapter 10. Expanding Role of Marine Natural Compounds in Immunomodulation: Challenges and Future Perspectives -- Chapter 11. Marine origin Bioactive Peptides: novel advances in the therapeutic potential.
    Abstract: This book provides updated information on marine-based biomedical carriers and their therapeutic potential. Marine biomaterials and bio-based carriers show wide application in pharmaceutical and biomedical fields to deliver small and large molecules. Biomaterial-based composites, scaffolds, or matrix systems are sound systems for controlled and prolonged drug release in target sites and control the premature release of drugs or bioactive compounds. This book discusses essential topics such as the therapeutic potential of marine collagen, management of bone disorders, gene delivery, natural marine compounds in immunomodulation, theranostic applications, tissue engineering, and regeneration. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. Marine biomaterial-based systems are popular for tissue engineering and biomedical imaging. This book is ideal for industry experts, students, and researchers in pharmaceutical sciences and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 392 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811653742
    URL: https://doi.org/10.1007/978-981-16-5374-2
    DOI: 10.1007/978-981-16-5374-2
    DDC: 615
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    Essentials of Industrial Pharmacy (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacy. ; Pharmacology. ; Pharmaceutics. ; Pharmacy.
    Description / Table of Contents: Drying -- Mixing -- Comminution -- Filtration -- Pharmaceutical Packaging -- Oral Emulsion -- Oral Suspensions -- Tablets and Capsules -- Oral Inhalers -- Topically Applied Products -- Sterile Products -- Industrial Hazards -- Modified Release Drug Delivery Systems -- Novel Drug Delivery System -- Polymer for Biomedical Applications -- Biotechnology Based Drugs.
    Abstract: Essentials of Industrial Pharmacy is an attempt to comprehensively present, in a single book, various pharmaceutical processes and equipment that are frequently used for production of pharmaceutical dosage forms, along with quality control tests of these dosage forms. Pictorial/graphical illustrations provide easier understanding of complex pharmaceutical concepts, manufacturing processes of pharmaceutical dosage forms. Since it is imperative for pharmacy students to have a clear understanding of the basic concepts used in development of drugs into suitable and stable dosage forms. This book offers a wealth of information regarding basic aspects of pharmaceutical processes and dosage forms, in a single book, for undergraduate pharmacy students or science students (with no pharmacy background) intended to work in the pharmaceutical Industry.
    Type of Medium: Online Resource
    Pages: XV, 298 p. 135 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030849771
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 46
    URL: https://doi.org/10.1007/978-3-030-84977-1
    DOI: 10.1007/978-3-030-84977-1
    DDC: 615
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    Meta-analysis in Clinical Research: Principles and Procedures (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Biologicals. ; Biopharmaceutics. ; Pharmacology. ; Preclinical Research. ; Biologics.
    Description / Table of Contents: Chapter 1_Introduction -- Chapter2_Systematic literature review (SLR) -- Chapter 3_Registration and software’s -- Chapter 4_Quality Assessment of Studies -- Chapter 5_Extraction and Analysis of data -- Chapter 6_Models in Meta-analysis -- Chapter 7_Heterogeneity and Publications bias -- Chapter 8_Sensitivity and subgroup analysis -- Chapter 9_Meta-regression -- Chapter 10_Plots in Meta-analysis -- Chapter 11_Network Meta-analysis -- Chapter 12_Common mistakes -- Chapter 13_Challenges -- Chapter 14_Future Perspectives -- Chapter 15_Future perspectives.
    Abstract: This book provides conceptual information on the various processes involved in meta-analysis. It examines the importance of meta-analysis for the analyses of clinical data to draw a valid conclusion using suitable software. The initial sections of the book introduce meta-analysis, how to perform a systematic literature review (SLR), quality assessment of studies, extraction, and analysis of data. The subsequent section of the book contains information on advanced topics including, meta-regression, network meta-analysis, issues, mistakes, and future perspectives. In summary, the book provides a statistical method for combining the results of different studies on the same topic and resolving conflicts among studies. This book is written with the intent to allow a wide range of readers including students, researchers, and health care professionals, including physicians, nurses, pharmacists, and paramedical, and is also helpful for a beginner who would like to do a meta-analysis.
    Type of Medium: Online Resource
    Pages: XXII, 119 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819923700
    URL: https://doi.org/10.1007/978-981-99-2370-0
    DOI: 10.1007/978-981-99-2370-0
    DDC: 615
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    Opioids : Pharmacology, Abuse, and Addiction (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Neurology . ; Pain medicine. ; Pharmacology. ; Neuroscience. ; Neurology. ; Pain Medicine.
    Description / Table of Contents: Part I. Social aspects of opioid use -- Chapter 1: A brief history of opioids and the evolution of concepts associated with substance use disorders -- Chapter 2: The two sides of opioid use: Unmet needs of opioids for pain management and the role of opioids in substance use disorders -- Chapter 3: Opioid markets and special populations -- Chapter 4: Towards a new drug policy agreement -- Chapter 5: The opioid crises -- Chapter 6: Persons who misuse opioids -- Chapter 7: The need for structural interventions for persons who misuse opioids -- Part II. Pharmacological and medical aspects of opioid use -- Chapter 8: Opioid effects and classification -- Chapter 9: Opioid receptors and neuronal signal transduction -- Chapter 10: Opioids in Pain -- Chapter 11: Opioids in Palliative Care -- Chapter 12: Opioids and the immune system -- Chapter 13: Opioid dependence, tolerance, and withdrawal -- Chapter 14: Medication-Assisted Treatment (MAT) 1: Opioid substitution therapy -- Chapter 15: Medication-Assisted Treatment for Opioid Use Disorders 2. Detoxification -- Chapter 16: Synthetic Opioids as New Psychoactive Substances (NPS).
    Abstract: Opioids are the mainstay in pain treatment and can be invaluable medications in palliative care. However, they are also responsible for the vast majority of preventable deaths related to drug use. This book presents an overview of the social and pharmacological aspects of opioid effects, aiming to provide researchers and health professionals with a firm understanding of their effects and mechanisms of action. The first section reviews the history of opioids from ancient civilizations to the current opioid crisis, gives voice to opioid users through first-hand testimonies, analyzes the existing international drug treatment agreements, and presents structured interventions for persons who misuse opioids. The second section covers state-of-the-art advances in the medical use of opioids, opioid-induced signal transduction, opioids in pain management, opioid use disorders and their treatment. It also presents an updated view of opioids as regulators of inflammation and host defense against pathogens and damage. The overall aim of this book is to provide the reader with a deeper knowledge of this field despite the complexities associated with the existence of numerous ligands, receptor subtypes, and complex pharmacological profiles. To this end, the chapter authors are specialists in the field who also have extensive experience in teaching, hoping to lend their expertise in translating complex concepts into comprehensive and clear explanations.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 36 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031099366
    URL: https://doi.org/10.1007/978-3-031-09936-6
    DOI: 10.1007/978-3-031-09936-6
    DDC: 615
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    Cannabis/Marijuana for Healthcare (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medical care. ; Therapeutics. ; Neurology . ; Medicine Research. ; Biology Research. ; Pharmacology. ; Health Care. ; Therapeutics. ; Neurology. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. A Complete Patent Analysis of Cannabis/Marijuana in Drug Delivery and Disease Conditions -- Chapter 2. Neuropharmacological Approaches to Modulate Cannabinoid Neurotransmission -- Chapter 3. Cannabinoids in Cancer: Cross-talk Between Cannabinoids and miRNAs -- Chapter 4. Cannabis As A Potent Therapeutic Agent For Pharmaceutical Drugs: Recent Advancement In Drug Discovery And Human Healthcare -- Chapter 5. Cannabinoid-Based Innovative Prophylactic and Therapeutic Interventions for Neuropathic Pain and Migraine -- Chapter 6. The Legality of Use and Consumption of Cannabis (Marijuana) in the United States of America -- Chapter 7. Cannabis in Healthcare: Ethnobotanical and Pharmaceutical Perspectives and Legal Status in Turkey and The Middle East -- Chapter 8. Understanding the Pharmacokinetics, Safety Profile, and Scope of the Concerned Issue to Evade the Consumption of Cannabis/Marijuana -- Chapter 9. Traditional Uses of Cannabis in The Middle East and The Pathway to Cannabis-Based Healthcare in Israel -- Chapter 10. Traditional and Modern Health Uses of Cannabis sativa L. in Africa and its Phytochemical and Pharmacological Profile -- Chapter 11. Traditional Claims on Cannabis: An Indian and Global Scenario -- Chapter 12. Cannabis (Bhanga) in Classical Text of Ayurveda: An Evidence-Based Rationale -- Chapter 13. Cannabis-Based Cosmetic Products and Their Uses -- Chapter 14. Cannabis as A Unique and Valuable Nutraceutical Formulation for the Current and Future Global Wellbeing -- Chapter 15. Traditional, Cultural, and Nutraceutical Aspects of Cannabis in India.
    Abstract: The book contains review articles providing a comprehensive overview of cannabis/marijuana’s diverse healing aspects in human healthcare (medicinal, nutraceutical, skincare, etc.). The research articles include the role of cannabis in cancer treatment, drug discovery, cosmeceutical potential, prophylactic and therapeutic use for treating neuropathic pain and migraine, pharmacokinetics, safety profile, and issues related to the consumption of cannabis/marijuana.Another salient feature of the book is a complete mapping and region- and sector-wise critical analysis of cannabis/marijuana patents on healthcare and future directions for the benefit of researchers and businesses/entrepreneurs interested in the rapidly advancing area of cannabis. The text describes cannabis/marijuana’s detailed legal aspects, production prospects, and applications for healthcare and recreational purposes in the USA. It traces the traditional roots of cannabis use in Turkey, Israel, the Middle East, Africa, and India. This unique compendium of articles will be useful as a reference book for students, researchers, academics, business houses, and all individuals interested in medicinal, nutraceutical, cosmeceutical, traditional, legal, and commercial aspects of cannabis usage.
    Type of Medium: Online Resource
    Pages: XIX, 319 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688225
    URL: https://doi.org/10.1007/978-981-16-8822-5
    DOI: 10.1007/978-981-16-8822-5
    DDC: 615
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    Precision Medicine (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Internal medicine. ; Cancer. ; Pharmacology. ; Internal Medicine. ; Cancer Biology.
    Description / Table of Contents: Part 1. Pharmacogenomics -- Building evidence in RCTs Implementation of pharmacogenomics in healthcare in the UK -- Part 2. Precision medicine in clinical entities -- Precision medicine in therapy of non-solid cancer -- Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia -- Precision medicine in Asthma -- Precision medicine in Diabetes -- Precision Medicine in Antidepressants Treatment -- Precision Medicine in Neuropathic Pain -- Part 3. Techniques in Precision Medicine -- Imaging techniques in pharmacological precision medicine -- Challenges to use NGS data to optimize drug therapy -- Part 4. Economics -- Pharmacoeconomics in precision medicine. .
    Abstract: The rapidly increased understanding of the molecular background of complex diseases facilitated the development of highly advanced therapeutic concepts. Such concepts aiming to consider individual signatures of genomic and proteomic biomarkers including pharmacogenomics as well as advanced diagnostic tools have been successfully implemented in clinical practice in various fields leading to significant improvement of treatment successes. This volume gives an up-to-date overview on applications of precision medicine in various clinical entities, on advanced techniques as well as on economic considerations.
    Type of Medium: Online Resource
    Pages: X, 283 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031400476
    Series Statement: Handbook of Experimental Pharmacology, 280
    URL: https://doi.org/10.1007/978-3-031-40047-6
    DOI: 10.1007/978-3-031-40047-6
    DDC: 615
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    Photoprotective Green Pharmacology: Challenges, Sources and Future Applications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Medicinal chemistry. ; Pharmacology. ; Pharmaceutics. ; Medicinal Chemistry.
    Description / Table of Contents: Chapter 1: Radiation biology: historical background, sources and complications -- Chapter 2: Algal radioprotective phytochemicals: Sources and potential applications -- Chapter 3: Bio-prospecting of photoprotective compounds in algae -- Chapter 4: Unraveling fungal radioprotectants and their applications -- Chapter 5: Recent advances in metabolomics and molecular genomics for the production of photoprotective compounds -- Chapter 6: Bioprospecting and evolutionary significance of radioprotectors in non-flowering lower plants -- Chapter 7: Radioprotective phytochemicals: diversity, efficacy, application and commercialization -- Chapter 8: Impacts of climate alterations in the biosynthesis of defensive natural products -- Chapter 9: Cancer therapeutics: mechanism of action, radiation toxicity and drug formulation -- Chapter 10: Role of nanotechnology in the development of radioprotective formulations -- Chapter 11: Radioprotective effects of nutraceuticals and food products -- Chapter 12: Bioprospecting of radioprotective compounds in bacterial community -- Chapter 13: Pharmacology of synthetic and natural radioprotactants: application and consequences in cancer therapeutics -- Chapter 14: Immunochemistry: consequences and mechanism of protection in chemotherapeutics -- Chapter 15: Radioprootective therapeutics: recent trends and future applications.
    Abstract: This book illustrates the role of photoprotective and radioprotective metabolites from natural sources. Various classes of radioprotective metabolites derived from cyanobacteria, algae, fungi, bryophytes, pteridophytes, gymnosperms, and higher plants have been explained to reinforce the current knowledge in this field. In addition, the book elucidates the potential applications of these metabolites in pharmaceutics, cosmetics, and biomedical sciences that will help develop commercial products in modern anti-radiation therapeutics. Topics such as stress tolerance environmental strategies, evolutionary tendency, and biosynthetic route of radioprotective compounds for cost-effective large-scale industrial production of the metabolites are also covered in the book. This book will add to the understanding of radioprotective mechanisms and curative measures for various deleterious diseases leading to cancer development. This volume also offers the latest insights into current and upcoming issues that arise from solar and atomic radiations and their amelioration by inherent radioprotective mechanisms of green plants. This book benefits readers from academia, industry, colleges, and research students to better understand the impacts of various radiations and the development of radioprotective green compounds.
    Type of Medium: Online Resource
    Pages: XIII, 264 p. 62 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819907496
    URL: https://doi.org/10.1007/978-981-99-0749-6
    DOI: 10.1007/978-981-99-0749-6
    DDC: 615
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    Circadian Pharmacokinetics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medical sciences. ; Drug development. ; Pharmacology. ; Pharmacy. ; Preclinical Research.
    Description / Table of Contents: Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
    Abstract: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
    Type of Medium: Online Resource
    Pages: VII, 253 p. 59 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811588075
    URL: https://doi.org/10.1007/978-981-15-8807-5
    DOI: 10.1007/978-981-15-8807-5
    DDC: 615
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    Plants and Phytomolecules for Immunomodulation : Recent Trends and Advances (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Immunology. ; Metabolism, Secondary. ; Plants. ; Botany. ; Pharmacology. ; Immunology. ; Plant Secondary Metabolism. ; Plant Science.
    Description / Table of Contents: Chapter 1. Immune system and mechanism of Immuno-modulation -- Chapter 2. Insights into the modulation of immune response, chemistry, and mechanisms of action of immuno-modulatory phytomolecules -- Chapter 3. Bioprospection and Clinical Investigations of Immunomodulatory Molecules -- Chapter 4. Pathway and genomics of immunomodulator natural products -- Chapter 5. Phytomolecules and metabolomics of immunomodulation - Recent Trends and Advances -- Chapter 6. Knowledge of African Traditional Medicine System: Immunomodulation -- Chapter 7. Middle Eastern diets as a potential source of immunomodulators -- Chapter 8. Immuno-Stimulant Properties of Some Commonly Used Indian Spices and Herbs with Special Reference to Region Specific Cuisines -- Chapter 9. Traditional Indian Knowledge of immunity from plants -- Chapter 10. Select Global Immune-Boosting Plants Used in Folklore Medicine -- Chapter 11. Immunomodulatory role of terpenoids and phytosteroids -- Chapter 12. Rhizomatous Plants – Curcuma longa and Zingiber officinale in affording immunity -- Chapter 13. Fruits as Boosters of Immune System -- Chapter 14. Solanaceous Plants for Immunomodulation -- Chapter 15. Food and vegetables as source of phytoactives for immunomodulation -- Chapter 16. Immunomodulation potential of woody plants -- Chapter 17. Biotechnological approaches for the production of immunomodulating phytomolecules -- Chapter 18. Technological mapping of plant-derived immunomodulator drugs: A patent-guided overview about species and its main compounds.
    Abstract: This book describes the process of immunomodulation and the plants which possess immunomodulation properties to boost the immune system. The immunomodulation process is highly relevant to address emerging as well as existing diseases in humans. A better immune system triggers the cellular responses for neutralizing and combating the onset of disease conditions. Chapters in the book discuss plants that have profound effects on the health and well-being of humans. They discuss the natural phytochemicals that have immense diversity and uniqueness of molecules. Molecules belonging to phenylpropanoids, terpenoids, steroids, alkaloids, and tannins etc possess a variety of pharmacological activities. The chapters describe how bioactive exert effects even when taken as part of the diet, supplement, and or as traditional herbal medicine. This book provides up-to-date scientific knowledge about the activities and mechanisms and leads in the area of medicinal plants and phytochemicals with immunomodulation properties. This book is meant for students, academics, researchers, and industry professionals interested in pharmacology, immunology, and plant secondary metabolites.
    Type of Medium: Online Resource
    Pages: XV, 541 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811681172
    URL: https://doi.org/10.1007/978-981-16-8117-2
    DOI: 10.1007/978-981-16-8117-2
    DDC: 615
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    Aquaporins (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Proteins . ; Human physiology. ; Biological transport. ; Cell membranes. ; Pharmacology. ; Protein Biochemistry. ; Human Physiology. ; Membrane Trafficking.
    Description / Table of Contents: 1. Classification and Gene Structure of Aquaporins -- 2. Protein Structure and Modification of Aquaporins -- 3. Expression Regulation and Trafficking of Aquaporins -- 4. Transport Characteristics of Aquaporins -- 5. Non-transport Functions of Aquaporins -- 6. The Evolutionary Aspects of Aquaporin Superfamily -- 7. Aquaporins in Nervous System -- 8. Aquaporins in Cardiovascular System -- 9. Aquaporins in Respiratory System -- 10. Aquaporins in Digestive System -- 11. Aquaporins in Urinary System -- 12. Aquaporins in Reproductive System -- 13. Aquaporins in Immune System.-14. Aquaporins in Eye -- 15. Aquaporins in Skin -- 16. Aquaporins in Glandular Secretion -- 17. Aquaporins in Fetal Development -- 18. Aquaporins in Diabetes Insipidus -- 19. Aquaporins in Edema -- 20. Aquaporins in Obesity.-21. Aquaporins in Tumor -- 22. Aquaporin Inhibitors -- 23. Non-aquaporin Water Channels.-24. Methods to Measure Water Permeability.
    Abstract: This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 – AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 30 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions. In the second version, fourteen chapters will be updated base on the most recent research articles. Ten new chapters will be added.
    Type of Medium: Online Resource
    Pages: VIII, 365 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811974151
    Series Statement: Advances in Experimental Medicine and Biology, 1398
    URL: https://doi.org/10.1007/978-981-19-7415-1
    DOI: 10.1007/978-981-19-7415-1
    DDC: 615
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    Introduction to Basics of Pharmacology and Toxicology : Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medical microbiology. ; Neurosciences. ; Pharmacology. ; Pharmacy. ; Medical Microbiology. ; Neuroscience.
    Description / Table of Contents: Part 1. Autonomic Nervous System -- Chapter 1. Cholinoceptor Agonists and Anticholinesterase Agents -- Chapter 2. Cholinoceptor Antagonists -- Chapter 3. Adrenergic Agonists -- Chapter 4. Adrenergic Antagonists -- Part 2. Central and Peripheral Nervous System -- Chapter 5. Neurotransmitters and Neurotransmission. Chapter 6. Hypnotics and Sedatives -- Chapter 7. Pharmacotherapy of Seizures -- Chapter 8. General Anesthetics -- Chapter 9. Drug Therapy of Psychosis and Mania -- Chapter 10. Pharmacotherapy of Depression and Anxiety Disorders Chapter 11. Pharmacotherapy of Neurodegenerative Disorders -- Chapter 12. Opioid Agonists and Antagonists -- Chapter 13. Cognition enhancers, Psychostimulants and Psychedelic Drugs -- Chapter 14. Drug Dependence and Abuse -- Chapter 15. Local Anesthetics -- Chapter 16. Skeletal muscle relaxants. Part 3. Autacoids and Other Chemical Mediators -- Chapter 17. Histamine, Serotonin, Bradykinin, and the Ergot Alkaloids -- Chapter 18. Prostaglandins, Leukotrienes and Related Compounds -- Chapter 19. Non-Steroidal Anti-Inflammatory Medicines -- Chapter 20. Drugs Used in Rheumatoid Arthritis -- Chapter 21. Pharmacotherapy of Gout -- Chapter 22. Nitric oxide, Vasoactive Peptides and Purines -- Part 4. Cardiovascular and Renal Pharmacology -- Chapter 23. Drugs Affecting Renal Excretory Function -- Chapter 24. Antihypertensive Agents -- Chapter 25. Treatment of Ischemic Heart Disease -- Chapter 26. Drugs Used in Heart Failure -- Chapter 27. Drugs Used in Cardiac Arrhythmias -- Chapter 28. Pharmacotherapy of Shock and Drugs Used in Cardiopulmonary Resuscitation -- Chapter 29. Treatment of Pulmonary Arterial Hypertension -- Chapter 30. Antiplatelets, Anticoagulants and Fibrinolytics -- Chapter 31. Drugs Used in Dyslipidemias -- Part 5. Pulmonary Pharmacology -- Chapter 32. Treatment of Asthma and COPD -- Chapter 33. Drugs Used in Cough and Rhinitis -- Part 6 Gastrointestinal Pharmacology -- Chapter 34. Drugs Used in Acid-Peptic Disorders -- Chapter 35. Drugs Affecting Gastrointestinal Motility -- Chapter 36. Antiemetics -- Chapter 37. Drug Therapy for Constipation -- Chapter 38. Antidiarrheal Agents -- Chapter 39. Irritable Bowel Syndrome -- Chapter 40. Pharmacotherapy of Inflammatory Bowel Disease -- Chapter 41. Miscellaneous Drugs Acting on the Gastrointestinal System -- Part 7. Endocrine Pharmacology -- Chapter 42. Hypothalamic and Pituitary Hormones -- Chapter 43. Pharmacotherapy of Diabetes Mellitus -- Chapter 44. Thyroid and Antithyroid Drugs -- Chapter 45. Adrenocorticosteroids and Their Antagonists -- Chapter 46. Gonadal Hormones and Their Inhibitors -- Chapter 47. Pharmacotherapy of Obesity -- Chapter 48. Drugs Affecting Bone Mineral Homeostasis -- Part 8. Hematopoietic System -- Chapter 49. Pharmacotherapy of Iron Deficiency and Other Related Anaemias -- Chapter 50. Pharmacotherapy of Vitamin B12 and Folic Acid Deficiency -- Chapter 51. Drug-Induced Blood Dyscrasias -- Part 9. Chemotherapy of Microbial Diseases -- Chapter 52. General Principles of Antimicrobial Therapy -- Chapter 53. Sulfonamides, Quinolones and Agents For Urinary Tract Infections -- Chapter 54. Penicillins, Cephalosporins and Other β-Lactam Antibiotics -- Chapter 55. Protein Synthesis Inhibitors -- Chapter 56. Antimycobacterial Drugs -- Chapter 57. Antifungal Drugs -- Chapter 58. Antiviral Drugs -- Chapter 59. Miscellaneous Antimicrobial Agents -- Chapter 60. Chemotherapy of Malaria and Other Protozoal Diseases -- Chapter 61. Chemotherapy of Helminthiasis -- Part 10. Pharmacotherapy of Neoplastic Disease -- Chapter 62. General Principles of Cancer Chemotherapy -- Chapter 63. Cytotoxic Drugs -- Chapter 64. Targeted Chemotherapy -- Chapter 65. Hormones Agents in the Pharmacotherapy of Cancer -- Chapter 66. Immunopharmacology -- Chapter 67. Dermatological Pharmacology -- Chapter 68. Ocular Pharmacology -- Chapter 69. Nutritional Supplements and Herbal Medicines -- Chapter 70. Immunoglobulins and Vaccines. .
    Abstract: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. .
    Type of Medium: Online Resource
    Pages: XXIV, 1175 p. 152 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360099
    URL: https://doi.org/10.1007/978-981-33-6009-9
    DOI: 10.1007/978-981-33-6009-9
    DDC: 615
    Language: English
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    The 'Big Four’ Snakes of India : Venom Composition, Pharmacological Properties and Treatment of Envenomation (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Invertebrates. ; Medicine Research. ; Biology Research. ; Epidemiology. ; Biochemistry. ; Pharmacology. ; Invertebrate Zoology. ; Biomedical Research. ; Epidemiology. ; Biochemistry.
    Description / Table of Contents: Chapter 1. Introduction: The snakebite problem -- Chapter 2. Evolution of snakes and systematics of Big Four venomous snakes of India -- Chapter 3. Snake venom: Composition, evolution, function, and biomedical applications -- Chapter 4. Indian spectacled cobra (Naja naja) -- Chapter 5. Indian common Krait (Bungarus cerelus) -- Chapter 6. Indian Russell’s viper (Daboia russelii) -- Chapter 7. Indian Saw-scaled viper (Echis carinatus) -- Chapter 8. Prevention and Treatment of Big Four Snakebite in India.
    Abstract: This book provides detailed and updated knowledge about medically important ‘Big Four’ venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell’s viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing ‘Big Four’ venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of ‘Big Four’ venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms. .
    Type of Medium: Online Resource
    Pages: XI, 161 p. 55 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811628962
    URL: https://doi.org/10.1007/978-981-16-2896-2
    DOI: 10.1007/978-981-16-2896-2
    DDC: 615
    Language: English
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    Good Research Practice in Non-Clinical Pharmacology and Biomedicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Cardiology. ; Oncology. ; Pharmacology. ; Neuroscience. ; Cardiology. ; Oncology.
    Description / Table of Contents: 1. Quality in Non-GxP Research Environment -- 2. Guidelines & Initiatives for Good Research Practice -- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices -- 4. General Principles of Preclinical Study Design -- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research -- 6. Blinding and Randomization -- 7. Out of control? Managing baseline variability in experimental studies with control groups -- 8. Quality of Research Tools -- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies -- 10. Building robustness intro translational research -- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research -- 12. Minimum Information in In Vivo Research -- 13. A reckless guide to P-values: Local evidence, global errors -- 14. Electronic Lab Notebooks and Experimental Design Assistants -- 15. Data storage -- 16. Design of meta-analysis studies -- 17. Publishers’ responsibilities in promoting data quality and reproducibility -- 18. Quality governance in biomedical research -- 19. Good Research Practice – Lessons from Animal Care & Use -- 20. Research collaborations and quality in research: foes or friends? -- 21. Costs of implementing quality in research practice.
    Abstract: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
    Type of Medium: Online Resource
    Pages: X, 423 p. 34 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336561
    Series Statement: Handbook of Experimental Pharmacology, 257
    URL: https://doi.org/10.1007/978-3-030-33656-1
    DOI: 10.1007/978-3-030-33656-1
    DDC: 615
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  • 88
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    Substance Use Disorders : From Etiology to Treatment (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: 1. Methods for Population Research on Substance Use and Consequences -- 2. Translational Molecular Approaches in Substance Abuse Research -- 3. Small Molecule Neuropeptide-S and Melanocortin Receptor Ligands As Potential Treatments for Substance Use Disorders -- 4. Emerging Insights into Mu Opioid Pharmacology -- 5. Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors -- 6. The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research -- 7. Clinical Trials for Opioid Use Disorder -- 8. Modelling Differential Vulnerability to Substance Use Disorder in Rodents: Neurobiological Mechanisms -- 9. Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder -- 10. Molecular Mechanisms of Amphetamines -- 11. Clinical Trials for Stimulant Use Disorders: Addressing Heterogeneities That May Undermine Treatment Outcomes -- 12. Molecular Mechanism and Cannabinoid Pharmacology -- 13. Pharmacotherapies for Cannabis Use Disorders: Clinical Challenges and Promising Therapeutic Agents -- 14. Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence -- 15. Randomized Clinical Trials Investigating Innovative Interventions for Smoking Cessation in the Last Decade -- 16. Adolescent Vulnerability to Alcohol Use Disorder: Neurophysiological Mechanisms from Preclinical Studies -- 17. Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies -- 18. Newly Emerging Drugs of Abuse.
    Abstract: The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.
    Type of Medium: Online Resource
    Pages: X, 502 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336790
    Series Statement: Handbook of Experimental Pharmacology, 258
    URL: https://doi.org/10.1007/978-3-030-33679-0
    DOI: 10.1007/978-3-030-33679-0
    DDC: 615
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    Interaction of Nanomaterials with the Immune System (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Immunology. ; Nanotechnology. ; Pharmacology. ; Immunology. ; Nanotechnology.
    Description / Table of Contents: Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure -- Engineered nanomaterials: synthesis, characterization, uses and exposure -- Impact of nanomaterials on barrier function -- Complement activation and inflammation -- Macrophage function and phagocytosis -- Mast cells -- Impact on dendritic cell - lymphocyte function -- Impact on host pathogen response and microbiome -- Allergy/autoimmunity -- Pre-existing allergic or bacterial-induced lung disease -- Nanomaterial effects on viral infection -- Immunotoxicity and carcinogenesis -- In vivo animal models (nude mice, transgenic models) -- In vitro cell culture models -- In silico computational modeling -- Summary of mechanisms of immune modulation. .
    Abstract: This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs. .
    Type of Medium: Online Resource
    Pages: X, 223 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339623
    Series Statement: Molecular and Integrative Toxicology,
    URL: https://doi.org/10.1007/978-3-030-33962-3
    DOI: 10.1007/978-3-030-33962-3
    DDC: 615
    Language: English
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    The Pharmacology of Taste (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Abstract: The Pharmacology of Taste is comprised of contributions by leading scientists from the field of chemosensory research, presented all together in the context of pharmacological principles of receptor function. The chapters cover all levels of scientific inquiry, from molecular and physiological mechanisms underlying taste signaling to its manifestation in overt behavior. The overarching objective of this volume is to inspire the application of concepts and methods of pharmacology to the study of the chemosenses.
    Type of Medium: Online Resource
    Pages: XII, 351 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031064500
    Series Statement: Handbook of Experimental Pharmacology, 275
    URL: https://doi.org/10.1007/978-3-031-06450-0
    DOI: 10.1007/978-3-031-06450-0
    DDC: 615
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    Physiology, Pharmacology and Pathology of the Blood-Brain Barrier (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Medical microbiology. ; Pathology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Medical Microbiology. ; Pathology. ; Neuroscience.
    Description / Table of Contents: From the contents: Preface -- Part I: Background on the Blood Brain Barrier – structure/function.-Part II: Challenges with finding drugs to cross the BBB/not cross BBB -- Part III: Experimental Methods to study BBB – in vitro and in vivo -- Part IV: BBB and Diseases: Novel treatment approaches from a BBB perspective. .
    Abstract: This book presents a comprehensive collection of current knowledge and leading research about the blood-brain barrier. The chapters are organized in four main parts providing basic information and novel insights about the physiology of the blood-brain barrier, the challenges related to finding and developing drugs crossing the blood-brain barrier, experimental methods to study the blood-brain barrier and the role of the blood-brain barrier in disease mechanisms and its consequences for drug development. In the first part the readers will discover the structure, function and developmental aspects of the blood-brain barrier and gain novel insights into the complexity and functionality of the neurovascular unit and energy metabolism of brain endothelial cells. Chapters of the second part focus on translational challenges from the bench to the bedside in CNS drug development, shed light on the importance to understand the brain distribution of drugs related to their efficacy, elaborate on general pharmacokinetic considerations for CNS drugs and introduce current and novel drug delivery strategies to overcome the blood-brain barrier. The experimental part of the book covers mathematical and in vitro models as well as animal and human methods in blood-brain barrier research. Specific emphasis is set on the description of the methods, the role of species differences for data interpretation, novel human models based on stem cells with the potential for personalized medicine and technical considerations and tips helpful for readers interested in working with these models. In the fourth part particular attentions is given to the blood-brain barrier, its changes and participation during disease progression. Chapters summarize alterations of the blood-brain barrier that are present in common disorders such as Alzheimer’s disease, multiple sclerosis, stroke, traumatic brain injury, epilepsy and brain tumors. Present therapies will be discussed and the consequences for novel treatment approaches that need to bypass the blood-brain-barrier will be explored. In addition, experts discuss the question in how far changes at the blood-brain barrier are causally linked to disease progressions and consequently could serve as therapeutic targets. This collection is designed to appeal to a wide readership from students through basic and applied scientist to pharmacologists, medical doctors and stakeholders from the pharmaceutical industry and regulatory affairs. Due its comprehensive content the book has the potential to become a standard work in the field of blood-brain barrier research.
    Type of Medium: Online Resource
    Pages: VIII, 364 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030996543
    Series Statement: Handbook of Experimental Pharmacology, 273
    URL: https://doi.org/10.1007/978-3-030-99654-3
    DOI: 10.1007/978-3-030-99654-3
    DDC: 615
    Language: English
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    Viral Vectors in Veterinary Vaccine Development : A Textbook (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Veterinary microbiology. ; Virology. ; Pharmacology. ; Veterinary Microbiology. ; Virology.
    Description / Table of Contents: Chapter 1. Introduction to Veterinary Vaccines -- Chapter 2. "What is Required to Develop a Viral Vector Vaccine: Key Components of Vaccine-Induced Immune Responses" -- Chapter 3. Viruses and the evolution of viral vectors -- Chapter 4. The role of adjuvants in the application of viral vector vaccines -- Chapter 5. Adenovirus Vectors -- Chapter 6. Poxvirus Vectors -- Chapter 7. The Construction and Evaluation of Herpesvirus Vectors -- Chapter 8. Paramyxoviruses as Vaccine Vectors -- Chapter 9. Rhabdoviruses as vaccine vectors for veterinary pathogens -- Chapter 10. Coronaviruses as Vaccine Vector for Veterinary Pathogens -- Chapter 11. Alphavirus-Based Vaccines -- Chapter 12. Manufacturing and Control of Viral Vectored Vaccines: Challenges -- Chapter 13. Regulatory strategies and factors affecting veterinary viral vector development -- Chapter 14. "Emerging Viral Vectored Technology Future potential of capripoxvirus and African swine fever virus as viral vectors". .
    Abstract: This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology. .
    Type of Medium: Online Resource
    Pages: XI, 230 p. 35 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030519278
    URL: https://doi.org/10.1007/978-3-030-51927-8
    DOI: 10.1007/978-3-030-51927-8
    DDC: 615
    Language: English
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    Bone Regulators and Osteoporosis Therapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cytology. ; Cytokines. ; Diseases. ; Proteins. ; Endocrinology. ; Pharmacology. ; Cell Biology. ; Cytokines and Growth Factors. ; Diseases. ; Proteins. ; Endocrinology.
    Description / Table of Contents: The cells of bone their interactions -- Parathyroid hormone and bone -- Vitamin D and bone -- Gonadal hormones and bone -- Thyroid hormones, glucocorticoids, insulin, and bone -- Growth factors and bone -- Prostaglandins and bone -- Cytokines and bone: osteoimmunology -- Chemokines and bone -- Calcium and bone -- FGF-23 and bone and mineral metabolism -- Nervous system mediators and bone -- Genetics of bone disorders -- Osteoporosis pathogenesis -- Structural and metabolic assessment of bone status -- Osteoporosis Therapeutics 2019 -- New targets and emergent therapies for osteoporosis -- Drugs causing bone loss -- Natural Products as potential bone therapies.
    Abstract: This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments. .
    Type of Medium: Online Resource
    Pages: X, 518 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030573782
    Series Statement: Handbook of Experimental Pharmacology, 262
    URL: https://doi.org/10.1007/978-3-030-57378-2
    DOI: 10.1007/978-3-030-57378-2
    DDC: 615
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    Protein Kinase-mediated Decisions Between Life and Death (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: Protein kinase-mediated decision between life and death -- Aging, cellular senescence and protein kinases -- Oxidative stress-related endothelial cell death and protein kinases -- Signal transduction in immune cells and protein kinases -- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity -- Metabolic stress and immunity -- Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection -- Protein kinase inhibitors in traumatic brain injury and repair -- Amyloid beta toxicity in Alzheimer’s Disease and neuronal death-associated protein kinases -- Glucolipotoxicity-related beta cell death and protein kinases -- Protein kinases and cell death in hematological disorders -- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy -- Bile acid toxicity and protein kinases -- Nanoparticle toxicity: Protein kinases and cell death -- Two-component signal transduction systems in antibiotic resistance -- ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival. .
    Abstract: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 415 p. 30 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030498443
    Series Statement: Advances in Experimental Medicine and Biology, 1275
    URL: https://doi.org/10.1007/978-3-030-49844-3
    DOI: 10.1007/978-3-030-49844-3
    DDC: 615
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    Drug Discovery and Drug Development : The Indian Narrative (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biologicals. ; Biopharmaceutics. ; Toxicology. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biologics. ; Toxicology. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Traditional Medical System (TMS) for Sustainable Healthcare in India -- Chapter 2. Modern Drug Discovery and Development for TB- The India Narrative -- Chapter 3. Indian Discovery Effort in the Quest of Novel Antibiotics -- Chapter 4. New Drug Discovery and Development in India to Counter Malaria -- Chapter 5. Modern Drug Discovery and Development in the area of Leishmaniasis -- Chapter 6. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part I – Introduction to Diabetes and Prevalence in India -- Chapter 7. Modern Drug Discovery and Development: Diabetes and lifestyle disorder Part II Type 2 Diabetes Mellitus: Marketed drugs and mechanisms -- Chapter 8. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part III Anti-diabetes research in India: Contributions from industrial organizations -- Chapter 9. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part IV Indian Academia Tryst with Cardio-metabolic Drug Discovery and Development -- Chapter 10. Modern drug discovery and development in the area of Cancer: Indian context -- Chapter 11. Biopharmaceutical development in India: recommendations on collaboration and innovation to enable affordable healthcare -- Chapter 12. Regulatory requirements and Quality Standards in India’s Clinical Trials Journey -- Chapter 13. Indian Pharma Perspective: New Drug Discovery and Development- Indian Pharmaceutical Industry.
    Abstract: Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .
    Type of Medium: Online Resource
    Pages: XIII, 376 p. 191 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811580024
    URL: https://doi.org/10.1007/978-981-15-8002-4
    DOI: 10.1007/978-981-15-8002-4
    DDC: 615
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    Gold and its Complexes in Anticancer Chemotherapy (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Medicinal chemistry. ; Cancer. ; Microtechnology. ; Microelectromechanical systems. ; Pharmacovigilance. ; Pharmacology. ; Medicinal Chemistry. ; Cancer Biology. ; Microsystems and MEMS. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Cancer -- Chapter 2. Types of cancer -- Chapter 3. Classification -- Chapter 4. Cancer or tumor nomenclature -- Chapter 5. Heterogeneity -- Chapter 6. Invasion and metastasis -- Chapter 7. How cancer arises? -- Chapter 8. Epidemiology -- Chapter 9. Economic burden -- Chapter 10. Treatment modalities -- Chapter 11. Chemotherapy -- Chapter 12. Properties of metals and metal complexes -- Chapter 13. Platinum based anticancer agents -- Chapter 14. Chemistry of cisplatin -- Chapter 15. Mechanism of action of platinum drugs -- Chapter 16. Non-platinum anticancer agents -- Chapter 17. Chemistry of gold -- Chapter 18. Gold and its complexes in medicine -- Chapter 19. Auranofin and its analogues -- Chapter 20. Classes of gold complexes -- Chapter 21. Mechanisms of action of anticancer gold complexes -- Chapter 22. Perspectives.
    Abstract: This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.
    Type of Medium: Online Resource
    Pages: IX, 173 p. 124 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813363144
    URL: https://doi.org/10.1007/978-981-33-6314-4
    DOI: 10.1007/978-981-33-6314-4
    DDC: 615
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    Molecularly Imprinted Polymers as Advanced Drug Delivery Systems : Synthesis, Character and Application (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers -- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices -- Chapter 4. Water Compatible Molecularly Imprinted Polymers -- Chapter 5. Stimuli Responsive Imprinted DDS -- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery -- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents -- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs -- Chapter 9. MIP as Drug Delivery Systems for Special Application -- Chapter 10. Outlook.
    Abstract: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives.
    Type of Medium: Online Resource
    Pages: VII, 216 p. 108 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602276
    URL: https://doi.org/10.1007/978-981-16-0227-6
    DOI: 10.1007/978-981-16-0227-6
    DDC: 615
    Language: English
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  • 98
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    Plant Secondary Metabolites : Physico-Chemical Properties and Therapeutic Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Metabolism, Secondary. ; Plants. ; Agricultural biotechnology. ; Plant biotechnology. ; Pharmacology. ; Plant Secondary Metabolism. ; Agricultural Biotechnology. ; Plant Biotechnology.
    Description / Table of Contents: Chapter 1. Plant Secondary Metabolites: An Introduction of their Chemistry and Biological significance with Physico-Chemical aspect -- Chapter 2. Natural sources of plant secondary metabolites and role of plant polyphenols in the green photosynthesis of metallic nanoparticles -- Chapter 3. Plant secondary metabolites determination through analytical chromatographic techniques: Recent trends and advancement -- Chapter 4. Role of plant secondary metabolites as Anticancer and Chemopreventive agent -- Chapter 5. Plant Secondary Metabolites: Natural Compounds As Cosmetic Ingredients And Their Potential Activity In Skin Cancer -- Chapter 6. Natural remedies for a healthy heart. The evidence based beneficial effects of polyphenols -- Chapter 7. Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects -- Chapter 8. Role of plant secondary metabolites in metabolic disorders -- Chapter 9. Metal Complexes of plant secondary metabolites with therapeutic potential. Chapter 10. Phytoalexins: Implications in plant defense and human health -- Chapter 11. Secondary metabolites from plants: Role in plant diseases and health care -- Chapter 12. Plant Secondary metabolites: Their food and therapeutic importance -- Chapter 13. Role of plant secondary metabolites as modulators of multidrug resistance in cancer thera -- Chapter 14. Plant Secondary Metabolites: functions in plants and pharmacological importance -- Chapter 15. Plant Secondary Metabolities in Antiviral Applications.
    Abstract: Plant secondary metabolites are plant-based natural products that display a variety of pharmacological effects. This book discusses the invaluable bioactivity and multifaceted potential of these compounds. The book describes the physico-chemical and biochemical aspects of the plant secondary metabolites along with the chemistry, therapeutics and future perspectives of these plant secondary metabolites. Moreover, the book also discusses about various sources of plant secondary metabolites, and the metabolite determination through various analytical techniques. It further describes the potential applications of plant secondary metabolites as anticancer and chemo preventive agents, their role as cosmetic ingredients and activity in skin cancer therapy. Further chapters emphasize upon the plethora of roles of plant secondary metabolites, including those as antivirals, anti-bacterial, anti-inflammatory drugs, cardioprotective agents etc. The book culminates with chapters on the impact of certain plant secondary metabolites in plant defence and human healthcare. This book is meant for researchers and students in the field of pharmacology and plant sciences. Moreover, this book is also useful for industry experts especially working in the field of herbal therapeutics.
    Type of Medium: Online Resource
    Pages: IX, 482 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647796
    URL: https://doi.org/10.1007/978-981-16-4779-6
    DOI: 10.1007/978-981-16-4779-6
    DDC: 615
    Language: English
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  • 99
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    Online Resource
    Drug Target Selection and Validation (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drugs Design. ; Medicinal chemistry. ; Molecular biology. ; Pharmacology. ; Pharmaceutics. ; Structure-Based Drug Design. ; Medicinal Chemistry. ; Molecular Biology.
    Description / Table of Contents: Drug discovery paradigms: target-based drug discovery -- Drug discovery paradigms: phenotypic-based drug discovery -- Target Identification Approaches in Drug Discovery -- Introduction to target validation -- Structure-based binding pocket detection and druggability assessment -- Network-Based Target Identification -- The Current State of Precision Medicine and Targeted-Cancer Therapies – Where are We? -- Metabolic Control Analysis for drug target selection against human diseases -- Progress on open chemoinformatic tools for drug discovery.
    Abstract: The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
    Type of Medium: Online Resource
    Pages: XV, 257 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030958954
    Series Statement: Computer-Aided Drug Discovery and Design, 1
    URL: https://doi.org/10.1007/978-3-030-95895-4
    DOI: 10.1007/978-3-030-95895-4
    DDC: 615
    Language: English
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  • 100
    Online Resource
    Online Resource
    Novel Drug Delivery Systems for Chinese Medicines (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Alternative medicine. ; Pharmacy. ; Pharmacology. ; Complementary and Alternative Medicine. ; Pharmacy.
    Abstract: This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
    Type of Medium: Online Resource
    Pages: XIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811634444
    URL: https://doi.org/10.1007/978-981-16-3444-4
    DOI: 10.1007/978-981-16-3444-4
    DDC: 615
    Language: English
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