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  • 1
    Keywords: Human physiology. ; Immune system. ; Cellular signal transduction. ; Respiratory organs. ; Physiology. ; Diseases. ; Human Physiology. ; Immune Cell Signalling. ; Respiratory Physiology. ; Diseases.
    Description / Table of Contents: Chapter 1. Introduction to Lung Diseases -- Chapter 2. Targeting molecular and cellular mechanisms in asthma.-Chapter 3. Various cellular and molecular axis involved in the pathogenesis of asthma -- Chapter 4. Targeting molecular and cellular mechanisms in steroid resistant asthma -- Chapter 5. Targeting molecular and cellular mechanisms in chronic obstructive pulmonary disease -- Chapter 6. Probing the cellular and molecular mechanisms underlying in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) -- Chapter 7. Chronic obstructive pulmonary disease: Molecular basis of pathogenesis and targeted therapeutic approaches -- Chapter 8. Exploring the ‘dormancy-activation switch’ in the tumour microenvironment for metastatic lung cancer: The possible role of microRNA -- Chapter 9. Therapeutic strategies targeting signalling pathways in lung cancer -- Chapter 10. Modulation of signalling pathways by immunotherapeutics in lung cancer -- Chapter 11. Underpinning the Cellular and Molecular Mechanisms with Nanotheronstics for Lung Cancer -- Chapter 12. Targeting molecular and cellular mechanisms in Idiopathic Pulmonary Fibrosis.-Chapter 13. A refined approach to target the molecular and cellular mechanisms in pulmonary fibrosis.-Chapter 14. Targeting molecular and cellular mechanisms in tuberculosis -- Chapter 15. Cellular and Molecular Mechanisms of Repurposed antidiabetic drug as adjunctive treatment for tuberculosis -- Chapter 16. Targeting host and bacterial signaling pathways in tuberculosis: An effective strategy for the development of novel anti-tubercular therapies -- Chapter 17. Targeting molecular and cellular mechanisms in pulmonary hypertension -- Chapter 18. Targeting molecular and cellular mechanisms in pulmonary arterial hypertension -- Chapter 19. Potential cellular targets associated with the signaling and therapeutics of the pulmonary hypertension -- Chapter 20. Targeting molecular and cellular mechanisms in influenza A virus infections -- Chapter 21. Understanding the Biology of Non-typeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease through the Lens of Genomics -- Chapter 22. Targeting molecular and cellular mechanisms in rhinovirus infection -- Chapter 23. Targeting molecular and cellular mechanisms in respiratory syncytial virus (RSV) infection -- Chapter 24. Targeting molecular and cellular mechanisms SARS-CoV2 novel corona (COVID-19) virus infection -- Chapter 25. Underpinning the rudimentary mechanisms involved in the pathogenesis of SARS-CoV2 (COVID-19) in human lung cells -- Chapter 26. Targeting molecular and cellular mechanisms in SARS-CoV2 novel corona (COVID-19) virus infection -- Chapter 27. Special features of human lung ACE2 sensitivity to SARS CoV-2 spike glycoprotein -- Chapter 28. Implications of Phosphoinositide 3-kinase (PI3K) Signalling in cellular and molecular mechanisms of respiratory diseases -- Chapter 29. The role of the cholinergic system in lung diseases -- Chapter 30. The Nrf2-Keap1 signaling pathway in lung cancer -- Chapter 31. Role of Toll like receptor (LTR) in molecular and cellular mechanism of respiratory diseases -- Chapter 32. Biomarkers of Oxidative Stress -- Chapter 33. Targeting chronic lung diseases using advanced drug delivery systems -- Chapter 34. Plant based chemical moieties targeting cellular signalling pathways in chronic lung diseases -- Chapter 35. Role of phytoconstituents in targeting cytokines for managing pathophysiology of lung diseases -- Chapter 36. Targeting Cellular Signaling Pathways in Lung Cancer and Role of Phytochemicals as Novel Therapeutic Approach -- Chapter 37. Natural compounds targeting major signalling pathways in lung cancer -- Chapter 38. Drug delivery in respiratory diseases: Current opportunities, Molecular and cellular mechanism, and Future challenges -- Chapter 39. Future prospects and challenges in targeting cellular and molecular mechanisms in respiratory diseases.
    Abstract: The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.
    Type of Medium: Online Resource
    Pages: XIV, 926 p. 149 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813368279
    DDC: 612
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cytology. ; Stress (Physiology). ; Human physiology. ; Cancer. ; Diseases. ; Neurosciences. ; Nanotechnology. ; Cellular Stress. ; Human Physiology. ; Cancer Biology. ; Diseases. ; Neuroscience. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Oxidative stress and oral diseases -- Chapter 2. Role of Oxidative stress in Chronic Liver Diseases -- Chapter 3. In-vitro and In-vivo Antioxidant activity of nanoparticles -- Chapter 4. Oxidative stress in neurology and neurodegenerative processes -- Chapter 5. The role of oxidative stress in respiratory diseases -- Chapter 6. Role of Synbiotics in alleviating oxidative stress in colorectal cancer -- Chapter 7. Oxidative Stress and Immunological Complexities in Multi-Drug Resistant Tuberculosis -- Chapter 8. Infection-induced Oxidative Stress in Chronic Respiratory Diseases -- Chapter 9. Oxidative stress in neuropsychiatric and neurodegenerative diseases -- Chapter 10. Oxidative stress monitoring in in vitro and in vivo models -- Chapter 11. Effects of Yoga on Aging.
    Abstract: This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.
    Type of Medium: Online Resource
    Pages: X, 297 p. 48 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811515682
    DDC: 571.6
    Language: English
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  • 3
    Keywords: Microbial populations. ; Inflammation. ; Respiratory organs. ; Physiology. ; Cancer. ; Microbial Communities. ; Inflammation. ; Respiratory Physiology. ; Cancer Biology.
    Description / Table of Contents: Introduction to Lung Diseases -- Introduction to Microbiome -- Role of Microbiome in Inflammation -- The interplay of microbiome, inflammation, and immunity in inflammatory lung diseases -- Microbiome in Asthma -- Microbiome in Chronic Obstructive Pulmonary Disease -- Microbiome in Asthma-COPD Overlap syndrome (ACO) -- Microbiome in ARDS (Acute Respiratory Distress Syndrome) -- Role of brain-gut- microbiome axis in Depression co-morbid with COPD or Asthma -- Microbiome in Lung Cancer -- Microbiome in Pulmonary Tuberculosis -- Lung Microbiome: Friend or Foe of Mycobacterium tuberculosis -- Microbiome in Idiopathic Pulmonary Fibrosis. Microbiome in SARS-Cov2 (Covid-19) -- Status of the microbiome in SARS-Cov2 (Covid-19) -- Microbiome in Influenza-A Virus Infection -- Microbiome in Upper Respiratory Tract Infection (URTI) -- Challenges in understanding the lung microbiota -- Microbiome in Inflammatory Lung Diseases: Challenges and Future Prospects -- Microbiota targeted via nanotechnology for lung cancer therapy: Challenges and future perspectives.
    Abstract: This book reviews the role of the lung microbiome in the development and progression of lung diseases. It deals with the role of microbiota dysbiosis in influencing host defense and immunity leading to resistance, colonization, and disease exacerbation. The book delineates the complex interaction between pathogen and lung residual microbiota during disease conditions. It further highlights the potential role of lung microbiota as the key modulator of lung carcinogenesis and immune response against cancer cells. Lastly, it reviews technological developments for unraveling the lung microbiome that profoundly impacts clinical diagnostics. This book is an essential resource for the scientists working in pulmonary diseases, pharmaceutical & clinical sciences, and pulmonary clinicians.
    Type of Medium: Online Resource
    Pages: XIV, 377 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811689574
    DDC: 579.1788
    Language: English
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  • 4
    Keywords: Pharmacology. ; Cancer. ; Cancer Treatment. ; Pharmacology. ; Cancers. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Effect of anticancer treatment approches on gut microbiota -- Chapter 3_Synbiotic: A promising approach for the treatment of cancer -- Chapter 4_Correlation between ROS and Synbiotics for effective treatment of cancer -- Chapter 5_Influence of synbiotics on inflammation and immune microenvironment for the treatment of cancer -- Chapter 6_Synbiotics in colorectal cancer -- Chapter 7_Synbiotics in cervical cancer -- Chapter 8_Synbiotics in prostate cancer -- Chapter 9_Synbiotics in gastric cancer -- Chapter 10_Synbiotics in lung cancer -- Chapter 11_Synbiotics in small cell pancretatic cancer -- Chapter 12_Synbiotics in breast cancer -- Chapter 13_Synbiotics in hepatocellular carcinoma -- Chapter 14_Synbiotics in ovarian cancer -- Chapter 15_Regulatory issues of synbiotics in cancer.
    Abstract: This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.
    Type of Medium: Online Resource
    Pages: XVII, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811975509
    DDC: 615
    Language: English
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  • 5
    Keywords: Human physiology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Human Physiology. ; Pharmaceutics. ; Drug Delivery.
    Description / Table of Contents: Chapter 1. Immunopathology of respiratory diseases -- Chapter 2. Introduction to Chronic Respiratory Diseases: A Pressing Need for Novel Therapeutic Approaches -- Chapter 3. Role of Indian Herbal Medicine in the treatment of Pulmonary Diseases -- Chapter 4. Asthma-induced inflammatory responses and reversal by botanicals -- Chapter 5. Medicinal plants in targeting asthma -- Chapter 6. Incipient need of medicinal plants in targeting chronic obstructive pulmonary disease -- Chapter 7. Utilization of Natural Compounds for Treatment of Tuberculosis-I -- Chapter 8. Medicinal plants in the treatment of Tuberculosis-II -- Chapter 9. Medicinal Plants in the Treatment of tuberculosis-III -- Chapter 10.Natural compounds as versatile potential therapeutic agents of lung cancer -- Chapter 11. Exploring the potential of medicinal plants in Lung Cancer -- Chapter 12. Effect of Medicinal Plants against Lung Cancer -- Chapter 13. Medicinal Plants used in the treatment of pulmonary hypertension- I -- Chapter 14. Medicinal Plants used in the treatment of pulmonary hypertension-II -- Chapter 15. Herbal bioactives for the treatment of idiopathic pulmonary fibrosis -- Chapter 16. Medicinal Plants targeting Bronchitis -- Chapter 17. Role of medicinal plants in the treatment of pulmonary edema -- Chapter 18. Medicinal Plants Used in the Treatment of Influenza a Virus Infections -- Chapter 19. Medicinal Plants used in the treatment of influenza A virus infections -- Chapter 20. COVID-19 pandemic panic: prophylactic as well as therapeutic management with traditional ethnic phytopharmaceuticals with challenging nano-spray inhaler and advanced drug delivery system -- Chapter 21. Targeting SARS-CoV2 novel corona (COVID-19) virus infection using medicinal plants -- Chapter 22. Promising plant based bioactive natural products in combating SARS-CoV2 novel corona (COVID-19) virus infection -- Chapter 23. Medicinal plant based advanced drug delivery system for the treatment of chronic lung diseases -- Chapter 24. Medicinal Plant Based Advanced Drug Delivery System for the Treatment of Chronic Lung Diseases -- Chapter 25. Application of nanodrugs derived from active metabolites of medicinal plants for the treatment of inflammatory and lung diseases: Recent advances.
    Abstract: This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.
    Type of Medium: Online Resource
    Pages: XIV, 622 p. 159 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813368507
    DDC: 612
    Language: English
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  • 6
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery.
    Description / Table of Contents: 1. Synthesis, self-assembly and functional chemistry of Amphiphilic block copolymers -- 2. Advances in polymer optimisation for enhanced drug delivery -- 3. Dynamics of Micelle Formation -- 4. Types of Polymeric Micelles for Controlled Drug Release -- 5. Drug Solubilization and Drug Release from Polymeric Micelles -- 6. Physical and Analytical Techniques used for the Characterization of Polymeric Micelles -- 7.Stimuli-sensitive polymeric micelles for biomedical applications -- 8.Nucleic acid-based micellar therapy for the treatment of different diseases -- 9. Polymeric micelles in the delivery of therapeutic phytoconstituents -- 10. Diagnostic applications of surface-engineered polymeric micelles -- 11. Ligand conjugated polymeric micelles for targeted delivery of drug payloads in cancer therapy -- 12. Polymeric Micelles in the Delivery of Proteins -- 13. Regulatory aspects for polymeric micelles -- 14. Toxicological and regulatory challenges in design and development of polymeric micelles -- 15. Stability of polymeric micelles and their regulatory status.
    Abstract: This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
    Type of Medium: Online Resource
    Pages: XV, 294 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903610
    DDC: 615
    Language: English
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  • 7
    Keywords: Pharmacology. ; Epigenetics. ; Respiratory organs. ; Physiology. ; Pharmacology. ; Epigenetics. ; Respiratory Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Lung Diseases -- Chapter 2. Introduction to Epigenetics -- Chapter 3._Epigenetic mechanisms in Inflammation -- Chapter 4. Epigenetic regulator of inflammatory gene expression -- Chapter 5. Epigenetics of Asthma -- Chapter 6_. Epigenetic optimization in chronic obstructive pulmonary disease (COPD -- Chapter 7. Epigenetics of Lung Cancer -- Chapter 8. Epigenetics of Pulmonary Tuberculosis -- Chapter 9. Epigenetics of Idiopathic Pulmonary Fibrosis -- Chapter 10. Epigenetics of influenza-A virus infection -- Chapter 11. Epigenetics of rhinovirus -- Chapter 12. Epigenetics of SARS-Cov2 (Covid-19) -- Chapter 13. Epigenetics of Haemophilus Influenzae -- Chapter 14. Future Prospects and Challenges -- Chapter 15. Targeting epigenetics in pulmonary arterial hypertension.
    Abstract: This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.
    Type of Medium: Online Resource
    Pages: XV, 266 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819947805
    DDC: 615
    Language: English
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  • 8
    Publication Date: 2014-04-27
    Print ISSN: 0300-8177
    Electronic ISSN: 1573-4919
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 9
    Publication Date: 2020-06-26
    Description: Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
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  • 10
    Publication Date: 2021-08-20
    Description: Seaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. Padina tetrastromatica is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as food by some coastal communities. This study investigates the nutritional and antihyperglycaemic potential of P. tetrastromatica extracts, which is generally accepted as an important functional food. In our methodology, we induced diabetes intraperitoneally in experimental animals with a dose of 65 mg kg−1 body weight of streptozotocin. Oral treatment with 200 and 400 mg kg−1 of P. tetrastromatica ethanolic and ethyl acetate extracts were initiated, respectively, to experimental rats once daily for 18 days. Metformin was used as the positive control. Biochemical estimations and histopathological analysis were included in this study. Treatment with P. tetrastromatica extracts significantly lowered the plasma glucose levels in Streptozotocin-induced diabetic rats. In addition, P. tetrastromatica extract treatment also showed a significant reduction in serum alanine transaminase levels. However, no significant changes were observed in serum aspartate transaminase levels. The ethyl acetate extract of P. tetrastromatica at 400 mg kg−1 dose shows some nephroprotective effect, which is observed from the significant increase in the plasma albumin levels. Histopathological evaluation revealed no marked morphological changes in tissues of the isolated organs of the ethyl acetate extract-treated group, revealing the safe nature of P. tetrastromatica.
    Electronic ISSN: 2304-8158
    Topics: Chemistry and Pharmacology
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