Publication Date:
1998-08-07
Description:
Circadian rhythms control many physiological activities. The environmental entrainment of rhythms involves the immediate responses of clock components. Levels of the clock protein FRQ were measured in Neurospora at various temperatures; at higher temperatures, the amount of FRQ oscillated around higher levels. Absolute FRQ amounts thus identified different times at different temperatures, so temperature shifts corresponded to shifts in clock time without immediate synthesis or turnover of components. Moderate temperature changes could dominate light-to-dark shifts in the influence of circadian timing. Temperature regulation of clock components could explain temperature resetting of rhythms and how single transitions can initiate rhythmicity from characteristic circadian phases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Y -- Merrow, M -- Loros, J J -- Dunlap, J C -- GM34985/GM/NIGMS NIH HHS/ -- MH01186/MH/NIMH NIH HHS/ -- MH44651/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1998 Aug 7;281(5378):825-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755-3844, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9694654" target="_blank"〉PubMed〈/a〉
Keywords:
Biological Clocks/*physiology
;
Blotting, Northern
;
*Circadian Rhythm
;
Darkness
;
Fungal Proteins/biosynthesis/genetics/*metabolism
;
Immunoblotting
;
Kinetics
;
Light
;
Neurospora/genetics/metabolism/*physiology
;
RNA, Fungal/genetics/metabolism
;
RNA, Messenger/genetics/metabolism
;
Temperature
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
