Publication Date:
1997-08-15
Description:
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kimura, K D -- Tissenbaum, H A -- Liu, Y -- Ruvkun, G -- R01AG14161/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):942-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9252323" target="_blank"〉PubMed〈/a〉
Keywords:
Adipose Tissue/metabolism
;
Amino Acid Sequence
;
Animals
;
Caenorhabditis elegans/chemistry/*genetics/growth & development/metabolism
;
Caenorhabditis elegans Proteins
;
Chromosome Mapping
;
Conserved Sequence
;
Energy Intake
;
*Genes, Helminth
;
Glucose/metabolism
;
Humans
;
Insulin/metabolism
;
Larva/genetics/growth & development/metabolism
;
Longevity/*genetics
;
Molecular Sequence Data
;
Mutation
;
Phosphatidylinositol 3-Kinases
;
Phosphatidylinositol Phosphates/metabolism
;
Phosphorylation
;
Phosphotransferases (Alcohol Group Acceptor)/metabolism
;
Receptor, IGF Type 1/chemistry/genetics
;
Receptor, Insulin/chemistry/*genetics/metabolism
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
