Publication Date:
1996-06-14
Description:
Mitogen-activated protein kinase (MAPK) cascades, termed MAPK modules, channel extracellular signals into specific cellular responses. Chimeric molecules were constructed between p38 and p44 MAPKs, which transduce stress and growth factor signals, respectively. A discrete region of 40 residues located in the amono-terminal p38MAPK lobe directed the specificity of response to extracellular signals, whereas the p44MAPK chimera, expressed in vivo, redirected stress signals into early mitogenic responses, demonstrating the functional independence of these domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brunet, A -- Pouyssegur, J -- New York, N.Y. -- Science. 1996 Jun 14;272(5268):1652-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Biochemie-CNRS, UMR134, Parc Valrose, Faculte des Sciences, Nice, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658140" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Anisomycin/pharmacology
;
Binding Sites
;
Calcium-Calmodulin-Dependent Protein Kinases/genetics/*metabolism
;
Cell Division
;
Cell Line
;
Cricetinae
;
Cricetulus
;
Enzyme Activation
;
Gene Expression Regulation
;
Genes, fos
;
Growth Substances/metabolism
;
Mice
;
Mitogen-Activated Protein Kinase 3
;
*Mitogen-Activated Protein Kinases
;
Molecular Sequence Data
;
Phosphorylation/drug effects
;
Protein Kinases/metabolism
;
Protein-Serine-Threonine Kinases/metabolism
;
Recombinant Fusion Proteins/genetics/metabolism
;
Ribosomal Protein S6 Kinases
;
Signal Transduction
;
Sorbitol/pharmacology
;
Substrate Specificity
;
p38 Mitogen-Activated Protein Kinases
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
